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Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects

Busch, R; Hobbs, BD; Zhou, J; Castaldi, PJ; McGeachie, MJ; Hardin, ME; Hawrylkiewicz, I; ... NETT Genetics, ECLIPSE, ICGN, and COPDGene Investigators, .; + view all (2017) Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. American Journal of Respiratory Cell and Molecular Biology , 57 (1) pp. 35-46. 10.1165/rcmb.2016-0331OC. Green open access

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Abstract

The heritability of chronic obstructive pulmonary disease (COPD) cannot be fully explained by recognized genetic risk factors identified as achieving genome-wide significance. In addition, the combined contribution of genetic variation to COPD risk has not been fully explored. We sought to determine 1) whether studies of variants from previous studies of COPD or lung function in a larger sample could identify additional associated variants, particularly for severe COPD, and 2) the impact of genetic risk scores on COPD. We genotyped 3,346 single nucleotide polymorphisms (SNP) in 2,588 cases (1,803 severe COPD) and 1,782 controls from four cohorts, and performed association testing with COPD, combining these results with existing genotyping data from 6,633 cases (3,497 severe COPD) and 5,704 controls. Additionally, we developed genetic risk scores from SNPs associated with lung function and COPD and tested their discriminatory power for COPD-related measures. We identified significant associations between SNPs near PPIC (p=1.28x10-8) and PPP4R4/SERPINA1 (p=1.01x10-8) and severe COPD; the latter association may be driven by recognized variants in SERPINA1. Genetic risk scores based on SNPs previously associated with COPD and lung function had a modest ability to discriminate COPD (AUC ~0.6), and accounted for a mean 0.9-1.9% lower FEV1 percent-predicted for each additional risk allele. In a large genetic association analysis, we identified associations with severe COPD near PPIC and SERPINA1. A risk score based on combining genetic variants had modest but significant effects on risk of COPD and lung function.

Type: Article
Title: Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1165/rcmb.2016-0331OC
Publisher version: https://doi.org/10.1165/rcmb.2016-0331OC
Language: English
Additional information: Copyright © 2017 by the American Thoracic Society. Originally Published in American Journal of Respiratory Cell and Molecular Biology as: [Busch, R; Hobbs, BD; Zhou, J; Castaldi, PJ; McGeachie, MJ; Hardin, ME; Hawrylkiewicz, I;(2017) Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. American Journal of Respiratory Cell and Molecular Biology; 10.1165/rcmb.2016-0331OC.]. The final publication is available at http://www.atsjournals.org/doi/abs/10.1165/rcmb.2016-0331OC
Keywords: alpha-1 antitrypsin, chronic obstructive pulmonary disease, genetic epidemiology, genetic risk factors, genetic risk score
UCL classification: UCL
UCL > Provost and Vice Provost Offices > VP: Health
URI: https://discovery.ucl.ac.uk/id/eprint/1540896
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