UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Progress towards a public chemogenomic set for protein kinases and a call for contributions

Drewry, DH; Wells, CI; Andrews, DM; Angell, R; Al-Ali, H; Axtman, AD; Capuzzi, SJ; ... Willson, TM; + view all (2017) Progress towards a public chemogenomic set for protein kinases and a call for contributions. PLOS ONE , 12 (8) , Article e0181585. 10.1371/journal.pone.0181585. Green open access

[thumbnail of journal.pone.0181585.pdf]
Preview
Text
journal.pone.0181585.pdf - Published Version

Download (8MB) | Preview

Abstract

Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases.

Type: Article
Title: Progress towards a public chemogenomic set for protein kinases and a call for contributions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0181585
Publisher version: https://doi.org/10.1371/journal.pone.0181585
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, CANCER-CELLS, INHIBITOR, IDENTIFICATION, INTERROGATION, SENSITIVITY, SELECTIVITY, DEPENDENCY, TARGETS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > VP: Health
UCL > Provost and Vice Provost Offices > VP: Health > Translational Research Office
URI: https://discovery.ucl.ac.uk/id/eprint/10078246
Downloads since deposit
43Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item