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Alpha₁-Antitrypsin Deficiency

Strnad, P; McElvaney, NG; Lomas, DA; (2020) Alpha₁-Antitrypsin Deficiency. The New England Journal of Medicine , 382 (15) pp. 1443-1455. 10.1056/NEJMra1910234. Green open access

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Abstract

AAT is a protease inhibitor targeting neutrophil elastase. It prevents the destruction of tissue, particularly in the lung, from elastase activity. AAT deficiency is a genetic disorder characterized by pulmonary disease, especially emphysema and bronchiectasis, and hepatic disease.

Type: Article
Title: Alpha₁-Antitrypsin Deficiency
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1056/NEJMra1910234
Publisher version: https://doi.org/10.1056/NEJMra1910234
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > VP: Health
URI: https://discovery.ucl.ac.uk/id/eprint/10095434
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