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The under-appreciated world of the serpin family of serine proteinase inhibitors

Bouton, Marie-Christine; Geiger, Margarethe; Sheffield, William P; Irving, James A; Lomas, David A; Song, Sihong; Satyanarayanan, Ritvik S; ... Lucas, Alexandra R; + view all (2023) The under-appreciated world of the serpin family of serine proteinase inhibitors. EMBO Molecular Medicine , Article e17144. 10.15252/emmm.202217144. Green open access

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Abstract

In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in turn, regulate these proteases. The serpins are a family of proteins with a shared tertiary structure, whose members largely act as serine protease inhibitors, found in all forms of life, ranging from viruses, bacteria, and archaea to plants and animals. These proteins represent up to 2-10% of proteins in the human blood and are the third most common protein family.

Type: Article
Title: The under-appreciated world of the serpin family of serine proteinase inhibitors
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.15252/emmm.202217144
Publisher version: https://doi.org/10.15252/emmm.202217144
Language: English
Additional information: ©2023 The Authors. Published under the terms of the CC BY 4.0 license
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > VP: Health
URI: https://discovery.ucl.ac.uk/id/eprint/10169741
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