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Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain

Andoniadou, CL; Signore, M; Sajedi, E; Gaston-Massuet, C; Kelberman, D; Burns, AJ; Itasaki, N; ... Martinez-Barbera, JP; + view all (2007) Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. DEVELOPMENT , 134 (8) 1499 - 1508. 10.1242/dev.02829. Green open access

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Abstract

The homeobox gene Hesx1 is an essential repressor that is required within the anterior neural plate for normal forebrain development in mouse and humans. Combining genetic cell labelling and marker analyses, we demonstrate that the absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development. Our data suggest that the mechanism underlying this transformation is the ectopic activation of Wnt/beta-catenin signalling within the Hesx1 expression domain in the AFB. When ectopically expressed in the developing mouse embryo, Hesx1 alone cannot alter the normal fate of posterior neural tissue. However, conditional expression of Hesx1 within the AFB can rescue the forebrain defects observed in the Hesx1 mutants. The results presented here provide new insights into the function of Hesx1 in forebrain formation.

Type: Article
Title: Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dev.02829
Publisher version: http://ukpmc.ac.uk/abstract/MED/17360769
Keywords: PROSENCEPHALIC NEURAL PLATE, MOUSE EMBRYO, NEGATIVE REGULATOR, VISCERAL ENDODERM, VERTEBRATE HEAD, EYE DEVELOPMENT, BETA-CATENIN, WNT, EXPRESSION, INDUCTION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept
UCL > Provost and Vice Provost Offices > VP: Health
UCL > Provost and Vice Provost Offices > VP: Health > Translational Research Office
URI: https://discovery.ucl.ac.uk/id/eprint/8129
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