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Number of items: 102.
A
Abdolvand, Nima;
(2017)
Retinal Differentiation of Human Induced Pluripotent Stem Cells in a Continuously Perfused Microfluidic Culture Device.
Doctoral thesis (Ph.D), UCL (University College London).
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Affaticati, PE;
(2017)
Engineering Transketolase for Industrial Biotechnology.
Doctoral thesis , UCL (University College London).
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Artim-Esen, B;
Smoktunowicz, N;
McDonnell, T;
Ripoll, VM;
Pericleous, C;
Mackie, I;
Robinson, E;
... Giles, I; + view all
(2017)
Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome.
Scientific Reports
, 7
(1)
, Article 10788. 10.1038/s41598-017-11315-9.
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Auta, HA;
(2017)
Ultra scale-down process synthesis of microalgae primary recovery operations.
Doctoral thesis , UCL (University College London).
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B
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Barisa, M;
Kramer, AM;
Majani, Y;
Moulding, D;
Saraiva, L;
Bajaj-Elliott, M;
Anderson, J;
(2017)
E. coli promotes human Vγ9Vδ2 T cell transition from cytokine-producing bactericidal effectors to professional phagocytic killers in a TCR-dependent manner.
Science Reports
, 7
(1)
, Article 2805. 10.1038/s41598-017-02886-8.
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Barisa, Marta;
(2017)
Human peripheral γδT cell phenotypic and functional shift in response to stimulation with E.coli.
Doctoral thesis (Ph.D), UCL (University College London).
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Baud, D;
Jeffries, JWE;
Moody, TS;
Ward, JM;
Hailes, HC;
(2017)
A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines.
Green Chemistry
, 19
(4)
pp. 1134-1143.
10.1039/c6gc02769e.
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Bayir, N;
(2017)
Modelling of integrated de-novo pathways for amino alcohol synthesis.
Doctoral thesis , UCL (University College London).
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Beneroso, D;
Monti, T;
Kostas, ET;
Robinson, J;
(2017)
Microwave pyrolysis of biomass for bio-oil production: Scalable processing concepts.
[Review].
Chemical Engineering Journal
, 316
pp. 481-498.
10.1016/j.cej.2017.01.130.
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Binti Suhaili, Nurashikin;
(2017)
Characterisation of biocatalyst production within an integrated biorefinery context.
Doctoral thesis (Ph.D), UCL (University College London).
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Bochenkova, AV;
Mooney, CRS;
Parkes, MA;
Woodhouse, JL;
Zhang, L;
Lewin, R;
Ward, JM;
... Fielding, HH; + view all
(2017)
Mechanism of resonant electron emission from the deprotonated GFP chromophore and its biomimetics.
Chemical Science
, 8
(4)
pp. 3154-3163.
10.1039/C6SC05529J.
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Bourke, LT;
McDonnell, T;
McCormick, J;
Pericleous, C;
Ripoll, VM;
Giles, I;
Rahman, A;
... Ioannou, Y; + view all
(2017)
Antiphospholipid antibodies enhance rat neonatal cardiomyocyte apoptosis in an in vitro hypoxia/reoxygenation injury model via p38 MAPK.
Cell Death & Disease
, 8
(1)
, Article e2549. 10.1038/cddis.2016.235.
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C
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Caplan, AI;
Mason, C;
Reeve, B;
(2017)
The 3Rs of Cell Therapy.
Stem Cells Translational Medicine
, 6
(1)
pp. 17-21.
10.5966/sctm.2016-0180.
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Capsomidis, A;
Benthall, G;
Van Acker, HH;
Fisher, J;
Kramer, AM;
Abeln, Z;
Majani, Y;
... Anderson, J; + view all
(2017)
Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation.
Molecular Therapy
10.1016/j.ymthe.2017.12.001.
(In press).
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Cárdenas-Fernández, M;
Bawn, M;
Hamley-Bennett, C;
Bharat, PKV;
Subrizi, F;
Suhaili, N;
Ward, DP;
... Lye, GJ; + view all
(2017)
An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates.
Faraday Discuss
, 202
pp. 415-431.
10.1039/c7fd00094d.
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Carvalho, F;
Marques, M;
Fernandes, P;
(2017)
Sucrose Hydrolysis in a Bespoke Capillary Wall-Coated Microreactor.
Catalysts
, 7
(2)
, Article 42. 10.3390/catal7020042.
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D
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de Lamotte, A;
Delafosse, A;
Calvo, S;
Delvigne, F;
Toye, D;
(2017)
Investigating the effects of hydrodynamics and mixing on mass transfer through the free-surface in stirred tank bioreactors.
Chemical Engineering Science
, 172
pp. 125-142.
10.1016/j.ces.2017.06.028.
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Dimov, N;
Kastner, E;
Hussain, M;
Perrie, Y;
Szita, N;
(2017)
Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system.
Scientific Reports
, 7
(1)
, Article 12045. 10.1038/s41598-017-11533-1.
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Dunbabin, A;
Subrizi, F;
Ward, JM;
Sheppard, TD;
Hailes, HC;
(2017)
Furfurylamines from biomass: Transaminase catalysed upgrading of furfurals.
Green Chemistry
, 19
(2)
pp. 397-404.
10.1039/c6gc02241c.
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E
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Eastwood, TA;
Baker, K;
Brooker, HR;
Frank, S;
Mulvihill, DP;
(2017)
An enhanced recombinant amino-terminal acetylation system and novel in vivo high-throughput screen for molecules affecting α-synuclein oligomerisation.
FEBS Letters
, 591
(6)
pp. 833-841.
10.1002/1873-3468.12597.
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Erdmann, V;
Lichmann, BR;
Zhao, J;
Simon, RC;
Kroutil, W;
Ward, JM;
Hailes, HC;
(2017)
Enzymatic and chemoenzymatic 3-step cascades for the synthesis of stereochemically complementary trisubstituted tetrahydroisoquinolines.
Angewandte Chemie International Edition
, 56
(41)
pp. 12503-12507.
10.1002/anie.201705855.
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Eva Fritzsche, E;
Gruber, P;
Schutting, S;
Fischer, JP;
Strobl, M;
Müller, JD;
Borisov, SM;
(2017)
Highly Sensitive Poisoning-Resistant Optical Carbon Dioxide Sensors for Environmental Monitoring.
Analytical Methods
, 9
(1)
pp. 55-65.
10.1039/C6AY02949C.
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F
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Fisher, J;
Abramowski, P;
Wisidagamage Don, ND;
Flutter, B;
Capsomidis, A;
Cheung, GW-K;
Gustafsson, K;
(2017)
Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor.
Molecular Therapy
, 25
(3)
pp. 1234-1247.
10.1016/j.ymthe.2017.03.002.
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G
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Gaciarz, A;
Khatri, NK;
Velez-Suberbie, ML;
Saaranen, MJ;
Uchida, Y;
Keshavarz-Moore, E;
Ruddock, LW;
(2017)
Efficient soluble expression of disulfide bonded proteins in the cytoplasm of Escherichia coli in fed-batch fermentations on chemically defined minimal media.
Microbial Cell Factories
, 16
, Article 108. 10.1186/s12934-017-0721-x.
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Goldrick, S;
Holmes, W;
Bond, N;
Lewis, G;
Kuiper, M;
Turner, R;
Farid, SS;
(2017)
Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody-peptide fusion.
Biotechnology and Bioengineering
, 144
(10)
pp. 2222-2234.
10.1002/bit.26339.
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Goldrick, S;
Joseph, A;
Mollet, M;
Turner, R;
Gruber, D;
Farid, SS;
Titchener-Hooker, NJ;
(2017)
Predicting performance of constant flow depth filtration using constant pressure filtration data.
Journal of Membrane Science
, 531
pp. 138-147.
10.1016/j.memsci.2017.03.002.
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Gruber, P;
Marques, M;
Szita, N;
Mayr, T;
(2017)
Integration and Application of Optical Chemical Sensors in Microbioreactors.
Lab on a Chip
, 17
(16)
pp. 2693-2712.
10.1039/C7LC00538E.
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Gruber, P;
Marques, MP;
Sulzer, P;
Wohlgemuth, R;
Mayr, T;
Baganz, F;
Szita, N;
(2017)
Real-time pH monitoring of industrially relevant enzymatic reactions in a microfluidic side-entry reactor (μSER) shows potential for pH control.
Biotechnology Journal
, 12
(6)
, Article 1600475. 10.1002/biot.201600475.
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Gruber, P;
Marques, MPC;
O'Sullivan, B;
Baganz, F;
Wohlgemuth, R;
Szita, N;
(2017)
Conscious coupling: The challenges and opportunities of cascading enzymatic microreactors.
Biotechnology Journal
10.1002/biot.201700030.
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Guitart, AV;
Panagopoulou, TI;
Villacreces, A;
Vukovic, M;
Sepulveda, C;
Allen, L;
Carter, RN;
... Kranc, KR; + view all
(2017)
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.
Journal of Experimental Medicine
, 214
(3)
pp. 719-735.
10.1084/jem.20161087.
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H
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Harrison, RP;
Ruck, S;
Medcalf, N;
Rafiq, QA;
(2017)
Decentralized manufacturing of cell and gene therapies: Overcoming challenges and identifying opportunities.
Cytotherapy
, 19
(10)
pp. 1140-1151.
10.1016/j.jcyt.2017.07.005.
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Hooker, A;
Splevins, A;
Horrocks, P;
Dalby, P;
Farid, SS;
(2017)
An evaluation of the cGMP manufacturing process economics and high-throughput characterisation of Targeted Secretion Inhibitors.
Presented at: TOXINS 2017, Madrid, Spain.
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Husson, G;
Delangle, A;
O'Hara, J;
Cianférani, S;
Gervais, A;
Van Dorsselaer, A;
Bracewell, DG;
(2017)
Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development.
Analytical Chemistry
, 90
(2)
pp. 1241-1247.
10.1021/acs.analchem.7b03965.
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J
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Jaccard, N;
Szita, N;
Griffin, LD;
(2017)
Segmentation of phase contrast microscopy images based on multi-scale local Basic Image Features histograms.
Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization
, 5
(5)
pp. 359-367.
10.1080/21681163.2015.1016243.
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Jacob, SI;
Khogeer, B;
Bampos, N;
Sheppard, T;
Schwartz, R;
Lowe, CR;
(2017)
Development and Application of Synthetic Affinity Ligands for the Purification of Ferritin-Based Influenza Antigens.
Bioconjugate Chemistry
, 28
(7)
pp. 1931-1943.
10.1021/acs.bioconjchem.7b00253.
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Jeffries, JWE;
(2017)
Functional metagenomics: metagenome mining for industrial biocatalysis.
Doctoral thesis , UCL (University College London).
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Jenkins, MJ;
Fedechko, RW;
Ho, SV;
Farid, S;
(2017)
Decision-support tools for cost-effective bioprocess design in the cell therapy sector.
Presented at: ECI Scale-up and manufacturing of cell-based therapies V, San Diego, USA.
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Johnson, TF;
Levison, PR;
Shearing, PR;
Bracewell, DG;
(2017)
X-ray computed tomography of packed bed chromatography columns for three dimensional imaging and analysis.
Journal of Chromatography A
, 1487
pp. 108-115.
10.1016/j.chroma.2017.01.013.
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Joseph, A;
Goldrick, S;
Mollet, M;
Turner, R;
Bender, J;
Gruber, D;
Farid, SS;
(2017)
An automated laboratory-scale methodology for the generation of sheared mammalian cell culture samples.
Biotechnology Journal
, 12
(5)
10.1002/biot.201600730.
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Joseph, AVA;
(2017)
Scale-down characterisation and modelling of harvest operations in mammalian cell culture processes.
Doctoral thesis , UCL (University College London).
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K
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Kinna, AW;
(2017)
Improved production and purification of recombinant proteins from mammalian expression systems.
Doctoral thesis , UCL (University College London).
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Kiparissides, A;
Hatzimanikatis, V;
(2017)
Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks.
Metabolic Engineering
, 39
pp. 117-127.
10.1016/j.ymben.2016.11.006.
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Kolmar, JF;
(2017)
Microscale tools for rapid evaluation of two-liquid phase bio-oxidations of volatile alkanes.
Doctoral thesis , UCL (University College London).
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Kolmar, JF;
Thum, O;
Baganz, F;
(2017)
Customized microscale approach for optimizing two-phase bio-oxidations of alkanes with high reproducibility.
Microbial Cell Factories
, 16
, Article 174. 10.1186/s12934-017-0788-4.
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Konstantinidis, S;
Titchener-Hooker, N;
Velayudhan, A;
(2017)
Simplex-based optimization of numerical and categorical inputs in early bioprocess development: Case studies in HT chromatography.
Biotechnology Journal
, 12
(8)
10.1002/biot.201700174.
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Kostas, ET;
Beneroso, D;
Robinson, JP;
(2017)
The application of microwave heating in bioenergy: A review on the microwave pre-treatment and upgrading technologies for biomass.
Renewable and Sustainable Energy Reviews
, 77
pp. 12-27.
10.1016/j.rser.2017.03.135.
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Kostas, ET;
White, DA;
Cook, DJ;
(2017)
Development of a bio-refinery process for the production of speciality chemical, biofuel and bioactive compounds from Laminaria digitata.
Algal Research
, 28
pp. 211-219.
10.1016/j.algal.2017.10.022.
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Kostas, ET;
Wilkinson, SJ;
White, DA;
Cook, DJ;
(2017)
Complete Acid-Based Hydrolysis Assay for Carbohydrate Quantification in Seaweed: A Species-Specific Optimized Approach.
Methods in Molecular Biology
, 1980
pp. 181-190.
10.1007/7651_2017_105.
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Kulsharova, G;
Dimov, N;
Marques, MPC;
Szita, N;
Baganz, F;
(2017)
Simplified immobilisation method for histidine-tagged enzymes in poly(methyl methacrylate) microfluidic devices.
New Biotechnology
10.1016/j.nbt.2017.12.004.
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L
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Lambert, AB;
Smith, FT;
Velayudhan, A;
(2017)
A Simplified Model of Glycoprotein Production within Cell Culture.
European Journal of Applied Mathematics
, 28
(4)
pp. 535-561.
10.1017/S0956792516000437.
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Lanna, A;
Gomes, DC;
Muller-Durovic, B;
McDonnell, T;
Escors, D;
Gilroy, DW;
Lee, JH;
... Akbar, AN; + view all
(2017)
A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.
Nature Immunology
, 18
(3)
pp. 354-363.
10.1038/ni.3665.
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Lechner, H;
Soriano, P;
Poschner, R;
Hailes, HC;
Ward, JM;
Kroutil, W;
(2017)
Library of norcoclaurine synthases and their immobilization for biocatalytic transformations.
Biotechnology Journal
10.1002/biot.201700542.
(In press).
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Liang, M;
Frank, S;
Lünsdorf, H;
Warren, MJ;
Prentice, MB;
(2017)
Bacterial microcompartment-directed polyphosphate kinase promotes stable polyphosphate accumulation in E. coli.
Biotechnology Journal
, 12
(3)
, Article 1600415. 10.1002/biot.201600415.
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Lichman, BR;
Sula, A;
Pesnot, T;
Hailes, HC;
Ward, JM;
Keep, NH;
(2017)
Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase.
Biochemistry
, 56
(40)
pp. 5274-5277.
10.1021/acs.biochem.7b00769.
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Lichman, BR;
Zhao, J;
Hailes, HC;
Ward, JM;
(2017)
Enzyme catalysed Pictet-Spengler formation of chiral 1,1 '-disubstituted- and spiro-tetrahydroisoquinolines.
Nature Communications
, 8
, Article 14883. 10.1038/ncomms14883.
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Lipsitz, YY;
Milligan, WD;
Fitzpatrick, I;
Stalmeijer, E;
Farid, SS;
Tan, KY;
Smith, D;
... Fink, J; + view all
(2017)
A roadmap for cost-of-goods planning to guide economic production of cell therapy products.
Cytotherapy
, 19
(12)
pp. 1383-1391.
10.1016/j.jcyt.2017.06.009.
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Liu, S;
Ruban, L;
Zhou, Y;
Wang, Y;
Nesbeth, DN;
(2017)
Establishing elements of a synthetic biology platform for Vaccinia virus production: BioBrickTM design, serum-free virus production and microcarrier-based cultivation of CV-1 cells.
Heliyon
, 3
(2)
, Article e00238. 10.1016/j.heliyon.2017.e00238.
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M
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Marques, MPC;
Szita, N;
(2017)
Bioprocess microfluidics: applying microfluidic devices for bioprocessing.
[Review].
Current Opinion in Chemical Engineering
, 18
pp. 61-68.
10.1016/j.coche.2017.09.004.
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Marsh, DTJ;
(2017)
Engineering Characterisation of a Rocked Bag Bioreactor for Improved Process Development and Scale-Up.
Doctoral thesis , UCL (University College London).
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Marsh, DTJ;
Odeleye, AOO;
Ducci, A;
Osborne, MD;
Lye, GJ;
Micheletti, M;
(2017)
Fluid Dynamic Characterization of a Laboratory Scale Rocked Bag Bioreactor.
AIChE Journal
, 63
(9)
pp. 4177-4187.
10.1002/aic.15734.
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Masri, MF;
Lawrence, K;
Wall, I;
Hoare, M;
(2017)
An ultra scale-down methodology to characterize aspects of the response of human cells to processing by membrane separation operations.
Biotechnology and Bioengineering
, 114
(6)
pp. 1241-1251.
10.1002/bit.26257.
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Mazzer, AR;
Clifton, LA;
Perevozchikova, T;
Butler, PD;
Roberts, CJ;
Bracewell, DG;
(2017)
Neutron reflectivity measurement of protein A-antibody complex at the solid-liquid interface.
Journal of Chromatography A
, 1499
pp. 118-131.
10.1016/j.chroma.2017.03.084.
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McInally, AD;
(2017)
Investigating the use of fusion partners to enhance the expression and recovery of a domain antibody from Escherichia coli.
Doctoral thesis , UCL (University College London).
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Migani, D;
(2017)
Proteomics Based Process And Cell Line Development Applied To A Mammalian Therapeutic Enzyme.
Doctoral thesis , UCL (University College London).
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Migani, D;
Smales, CM;
Bracewell, DG;
(2017)
Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein (HCP) release in Chinese hamster ovary cells.
Biotechnology Progress
, 33
(3)
pp. 666-676.
10.1002/btpr.2455.
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Miller, KE;
(2017)
Design and Characterisation of a Novel Internally Illuminating Photobioreactor.
Doctoral thesis , UCL (University College London).
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N
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Newton, JM;
Vlahopoulou, J;
Zhou, Y;
(2017)
Investigating and modelling the effects of cell lysis on the rheological properties of fermentation broths.
Biochemical Engineering Journal
, 121
pp. 38-48.
10.1016/j.bej.2017.01.009.
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Nweke, MC;
McCartney, RG;
Bracewell, DG;
(2017)
Mechanical characterisation of agarose-based chromatography resins for biopharmaceutical manufacture.
Journal of Chromatography A
, 1530
pp. 129-137.
10.1016/j.chroma.2017.11.038.
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O
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Ogonah, OW;
Polizzi, KM;
Bracewell, DG;
(2017)
Cell free protein synthesis: a viable option for stratified medicines manufacturing?
Current Opinion in Chemical Engineering
, 18
pp. 77-83.
10.1016/j.coche.2017.10.003.
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Othman, M;
Ariff, AB;
Rios-Solis, L;
Halim, M;
(2017)
Extractive fermentation of lactic acid in lactic acid bacteria cultivation: A review.
Frontiers in Microbiology
, 8
p. 2285.
10.3389/fmicb.2017.02285.
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Oyebolu, FB;
van Lidth de Jeude, J;
Siganporia, C;
Farid, SS;
Allmendinger, R;
Branke, J;
(2017)
A new lot sizing and scheduling heuristic for multi-site biopharmaceutical production.
Journal of Heuristics
, 23
(4)
pp. 231-256.
10.1007/s10732-017-9338-9.
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P
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Paredes, LA;
Flores Fernández, CN;
Zavaleta, AI;
(2017)
OPTIMIZACIÓN DEL MEDIO PARA LA PRODUCCIÓN DE PROTEASAS EXTRACELULARES POR Pseudomonas sp. M211 EN FERMENTACIÓN SUMERGIDA.
Revista de la Sociedad Química del Perú
, 83
(4)
pp. 449-462.
10.37761/rsqp.v83i4.217.
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Parker, L;
Mansfield, S;
Sneddon, K;
Charles, B;
Rafiq, Q;
(2017)
Advances and challenges in umbilical cord blood and tissue bioprocessing: procurement and storage.
Cell and Gene Therapy Insights
, 3
(6)
pp. 489-508.
10.18609/cgti.2017.042.
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Pathak, M;
Lintern, K;
Chopda, V;
Bracewell, DG;
Rathore, AS;
(2017)
Fluorescence based real time monitoring of fouling in process chromatography.
SCIENTIFIC REPORTS
, 7
(ARTN 456)
10.1038/srep45640.
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Pesnot, T;
Gershater, MC;
Edwards, M;
Ward, JM;
Hailes, HC;
(2017)
One-Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors.
Molecules
, 22
(4)
, Article 626. 10.3390/molecules22040626.
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Peticone, C;
Thompson, DDS;
Owens, GJ;
Kim, H-W;
Micheletti, M;
Knowles, JC;
Wall, I;
(2017)
Towards modular bone tissue engineering using Ti-Co-doped phosphate glass microspheres: cytocompatibility and dynamic culture studies.
Journal of Biomaterials Applications
, 32
(3)
pp. 295-310.
10.1177/0885328217720812.
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Pollock, J;
Coffman, J;
Ho, SV;
Farid, SS;
(2017)
Integrated continuous bioprocessing: Economic, operational, and environmental feasibility for clinical and commercial antibody manufacture.
Biotechnology Progress
, 33
(4)
pp. 854-866.
10.1002/btpr.2492.
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R
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Rafiq, QA;
Davies, OG;
(2017)
Considerations for the bioprocessing, manufacture and translation of extracellular vesicles for therapeutic applications.
Cell and Gene Therapy Insights
, 3
(6)
pp. 683-694.
10.18609/cgti.2017.066.
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Rafiq, QA;
Hanga, MP;
Heathman, TRJ;
Coopman, K;
Nienow, AW;
Williams, DJ;
Hewitt, CJ;
(2017)
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