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Considerations for the bioprocessing, manufacture and translation of extracellular vesicles for therapeutic applications

Rafiq, QA; Davies, OG; (2017) Considerations for the bioprocessing, manufacture and translation of extracellular vesicles for therapeutic applications. Cell and Gene Therapy Insights , 3 (6) pp. 683-694. 10.18609/cgti.2017.066. Green open access

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Abstract

There is growing interest in the potential and use of extracellular vesicles (EVs) for a range of diagnostic and therapeutic applications. EVs have been shown, in some instances, to mediate the regenerative effects elicited by stem cell therapies. As such, they are being studied to identify the extent to which these extracellular bodies can be employed as a therapeutic entity, and significant R&D activity is underway to further understand their clinical and commercial potential. However, successful translation will first require further characterization and standardization of EV production, as well as addressing some of the major challenges associated with their reproducible manufacture. This includes the capacity to produce EVs at a scale that is both clinically and commercially effective. This article will highlight some of the bioprocessing and manufacturing considerations and challenges associated with the standardized production of EVs.

Type: Article
Title: Considerations for the bioprocessing, manufacture and translation of extracellular vesicles for therapeutic applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.18609/cgti.2017.066
Publisher version: https://doi.org/10.18609/cgti.2017.066
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10040268
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