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Integration and Application of Optical Chemical Sensors in Microbioreactors

Gruber, P; Marques, M; Szita, N; Mayr, T; (2017) Integration and Application of Optical Chemical Sensors in Microbioreactors. Lab on a Chip , 17 (16) pp. 2693-2712. 10.1039/C7LC00538E. Green open access

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Abstract

The quantification of key variables such as oxygen, pH, carbon dioxide, glucose, and temperature provides essential information for biological and biotechnological applications and their development. Microfluidic devices offer an opportunity to accelerate research and development in these areas due to their small scale, and the fine control over the microenvironment, provided that these key variables can be measured. Optical sensors are well-suited for this task. They offer non-invasive and non-destructive monitoring of the mentioned variables, and the establishment of time-course profiles without the need for sampling from the microfluidic devices. They can also be implemented in larger systems, facilitating cross-scale comparison of analytical data. This tutorial review presents an overview of the optical sensors and their technology, with a view to support current and potential new users in microfluidics and biotechnology in the implementation of such sensors. It introduces the benefits and challenges of sensor integration, including, for example, their application for microbioreactors. Sensor formats, integration methods, device bonding options, and monitoring options are explained. Luminescent sensors for oxygen, pH, carbon dioxide, glucose and temperature are showcased alongside other optical detection methods, such as Raman and surface plasmon resonance. Areas where further development is needed are highlighted with the intent to guide future development efforts towards analytes for which reliable, stable, or easily integrated detection methods are not yet available.

Type: Article
Title: Integration and Application of Optical Chemical Sensors in Microbioreactors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/C7LC00538E
Publisher version: http://doi.org/10.1039/C7LC00538E
Language: English
Additional information: Copyright © Authors 2017. Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Keywords: Microfluidics, optical sensors, optodes, optrodes, pH, oxygen, glucose, carbon dioxide, temperature, online monitoring, micro biosystems
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1565181
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