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The role of biopreservation in cell and gene therapy bioprocessing

Rafiq, QA; Nienow, AW; Hewitt, CJ; Coopman, K; (2017) The role of biopreservation in cell and gene therapy bioprocessing. Cell and Gene Therapy Insights , 3 (5) pp. 335-344. 10.18609/cgti.2017.037. Green open access

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Abstract

Cell and gene-based therapies represent a novel therapeutic modality that has the potential to provide a treatment option for a range of medical conditions. There are, however, numerous processing and manufacturing challenges that must be addressed before such therapies are considered commercially and clinically viable. A significant challenge associated with the manufacture of such therapies is ensuring cell quality and the product’s critical quality attributes are retained throughout the entire bioprocess. Biopreservation is an important aspect of cell and gene-based therapy bioprocessing, which enables the development of cell banks. It increases process flexibility by providing a shelf-life to the product, enables the storage of intermediates and provides breakpoints within the process. In this article, we summarize the advances and challenges associated with biopreservation of cell and gene therapies.

Type: Article
Title: The role of biopreservation in cell and gene therapy bioprocessing
Open access status: An open access version is available from UCL Discovery
DOI: 10.18609/cgti.2017.037
Publisher version: https://doi.org/10.18609/cgti.2017.037
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10040266
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