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Design of a Novel Two-Component Hybrid Dermal Scaffold for the Treatment of Pressure Sores

Sharma, V; Kohli, N; Moulding, D; Afolabi, H; Hook, L; Mason, C; Garcia-Gareta, E; (2017) Design of a Novel Two-Component Hybrid Dermal Scaffold for the Treatment of Pressure Sores. Macromolecular Bioscience , 17 (11) , Article 1700185. 10.1002/mabi.201700185. Green open access

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Abstract

The aim of this study is to design a novel two‐component hybrid scaffold using the fibrin/alginate porous hydrogel Smart Matrix combined to a backing layer of plasma polymerized polydimethylsiloxane (Sil) membrane to make the fibrin‐based dermal scaffold more robust for the treatment of the clinically challenging pressure sores. A design criteria are established, according to which the Sil membranes are punched to avoid collection of fluid underneath. Manual peel test shows that native silicone does not attach to the fibrin/alginate component while the plasma polymerized silicone membranes are firmly bound to fibrin/alginate. Structural characterization shows that the fibrin/alginate matrix is intact after the addition of the Sil membrane. By adding a Sil membrane to the original fibrin/alginate scaffold, the resulting two‐component scaffolds have a significantly higher shear or storage modulus G′. In vitro cell studies show that dermal fibroblasts remain viable, proliferate, and infiltrate the two‐component hybrid scaffolds during the culture period. These results show that the design of a novel two‐component hybrid dermal scaffold is successful according to the proposed design criteria. To the best of the authors' knowledge, this is the first study that reports the combination of a fibrin‐based scaffold with a plasma‐polymerized silicone membrane.

Type: Article
Title: Design of a Novel Two-Component Hybrid Dermal Scaffold for the Treatment of Pressure Sores
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mabi.201700185
Publisher version: https://doi.org/10.1002/mabi.201700185
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Pressure sores, dermal scaffold, fibrin, silicone, hybrid
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10058833
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