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Bioprocess microfluidics: applying microfluidic devices for bioprocessing

Marques, MPC; Szita, N; (2017) Bioprocess microfluidics: applying microfluidic devices for bioprocessing. [Review]. Current Opinion in Chemical Engineering , 18 pp. 61-68. 10.1016/j.coche.2017.09.004. Green open access

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Abstract

Scale-down approaches have long been applied in bioprocessing to resolve scale-up problems. Miniaturized bioreactors have thrived as a tool to obtain process relevant data during early-stage process development. Microfluidic devices are an attractive alternative in bioprocessing development due to the high degree of control over process variables afforded by the laminar flow, and the possibility to reduce time and cost factors. Data quality obtained with these devices is high when integrated with sensing technology and is invaluable for scale-translation and to assess the economical viability of bioprocesses. Microfluidic devices as upstream process development tools have been developed in the area of small molecules, therapeutic proteins, and cellular therapies. More recently, they have also been applied to mimic downstream unit operations.

Type: Article
Title: Bioprocess microfluidics: applying microfluidic devices for bioprocessing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coche.2017.09.004
Publisher version: http://doi.org/10.1016/j.coche.2017.09.004
Language: English
Additional information: Copyright © 2017 The Authors. Published by Elsevier Ltd. This article is published under Attribution 4.0 International (CC BY 4.0)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10042533
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