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Number of items: 89.
A
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Abadir, Peter M;
Bandeen-Roche, Karen;
Bergeman, Cindy;
Bennett, David;
Davis, Daniel;
Kind, Amy;
LeBrasseur, Nathan;
... Whitson, Heather E; + view all
(2023)
An overview of the resilience world: Proceedings of the American Geriatrics Society and National Institute on Aging State of Resilience Science Conference.
Journal of the American Geriatrics Society
10.1111/jgs.18388.
(In press).
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Al-Sheikhli, Jaffar;
Winter, James;
Luque, Ivo Roca;
Lambiase, Pier D;
Orini, Michele;
Porta-Sánchez, Andreu;
Dhanjal, Tarvinder;
(2023)
Optimization of decrementing evoked potential mapping for functional substrate identification in ischaemic ventricular tachycardia ablation.
EP Europace
, Article euad092. 10.1093/europace/euad092.
(In press).
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Allan, L;
O’Connell, A;
Raghuraman, S;
Bingham, A;
Laverick, A;
Chandler, K;
Connors, J;
... Clare, L; + view all
(2023)
A rehabilitation intervention to improve recovery after an episode of delirium in adults over 65 years (RecoverED): study protocol for a multi-centre, single-arm feasibility study.
Pilot and Feasibility Studies
, 9
, Article 162. 10.1186/s40814-023-01387-y.
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 |
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Allinson, James Peter;
Chaturvedi, Nishi;
Wong, Andrew;
Shah, Imran;
Donaldson, Gavin Christopher;
Wedzicha, Jadwiga Anna;
Hardy, Rebecca;
(2023)
Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study.
The Lancet
, 401
(10383)
pp. 1183-1193.
10.1016/S0140-6736(23)00131-9.
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Althobiani, Malik A;
Ranjan, Yatharth;
Jacob, Joseph;
Orini, Michele;
Dobson, Richard James Butler;
Porter, Joanna C;
Hurst, John R;
(2023)
Evaluating a Remote Monitoring Program for Respiratory Diseases: Prospective Observational Study.
JMIR Formative Research
, 7
, Article e51507. 10.2196/51507.
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Anbar, R;
Chaturvedi, N;
Eastwood, SV;
Tillin, T;
Hughes, AD;
(2023)
Carotid atherosclerosis in people of European, South Asian and African Caribbean ethnicity in the Southall and Brent revisited study (SABRE).
Frontiers in Cardiovascular Medicine
, 9
, Article 1002820. 10.3389/fcvm.2022.1002820.
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Anderson, Emma L;
Williams, Dylan M;
(2023)
Drug target Mendelian randomisation: are we really instrumenting drug use?
[Letter].
Diabetologia
, 66
(6)
pp. 1156-1158.
10.1007/s00125-023-05875-x.
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Antonelli, M;
Penfold, RS;
Canas, LDS;
Sudre, C;
Rjoob, K;
Murray, B;
Molteni, E;
... Steves, C; + view all
(2023)
SARS-CoV-2 infection following booster vaccination: Illness and symptom profile in a prospective, observational community-based case-control study.
Journal of Infection
10.1016/j.jinf.2023.08.009.
(In press).
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B
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Bass, Cher;
Silva, Mariana da;
Sudre, Carole H;
Williams, Logan ZJ;
Sousa, Helena S;
Tudosiu, Petru-Daniel;
Alfaro-Almagro, Fidel;
... Robinson, Emma C; + view all
(2023)
ICAM-Reg: Interpretable Classification and Regression With Feature Attribution for Mapping Neurological Phenotypes in Individual Scans.
IEEE Transactions on Medical Imaging
, 42
, Article 4. 10.1109/TMI.2022.3221890.
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Bellini, S;
Guarrera, S;
Matullo, G;
Schalkwijk, C;
Stehouwer, CD;
Chaturvedi, N;
Soedamah-Muthu, SS;
... Gruden, G; + view all
(2023)
Serum MicroRNA-191-5p Levels in Vascular Complications of Type 1 Diabetes: The EURODIAB Prospective Complications Study.
The Journal of clinical endocrinology and metabolism
, 109
(1)
e163-e174.
10.1210/clinem/dgad468.
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Bhanu, Cini;
Petersen, Irene;
Orlu, Mine;
Davis, Daniel;
Sofat, Reecha;
Bazo-Alvarez, J;
Walters, Kate;
(2023)
Drug-induced Postural Hypotension: cluster analysis of co-prescription patterns in older people in UK primary care.
Pharmacoepidemiology & Drug Safety
, 33
(1)
, Article e5730. 10.1002/pds.5730.
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Bowyer, Ruth CE;
Huggins, Charlotte;
Toms, Renin;
Shaw, Richard J;
Hou, Bo;
Thompson, Ellen J;
Kwong, Alex SF;
... CONVALESCENCE Study, .; + view all
(2023)
Characterising patterns of COVID-19 and long COVID symptoms: evidence from nine UK longitudinal studies.
European Journal of Epidemiology
, 38
pp. 199-210.
10.1007/s10654-022-00962-6.
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Božić-Iven, Maša;
Rapacchi, Stanislas;
Tao, Qian;
Pierce, Iain;
Thornton, George;
Nitsche, Christian;
Treibel, Thomas A;
... Weingärtner, Sebastian; + view all
(2023)
Improved reproducibility for myocardial ASL: Impact of physiological and acquisition parameters.
Magnetic Resonance in Medicine
10.1002/mrm.29834.
(In press).
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C
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Canas, LS;
Molteni, E;
Deng, J;
Sudre, CH;
Murray, B;
Kerfoot, E;
Antonelli, M;
... Modat, M; + view all
(2023)
Profiling post-COVID-19 condition across different variants of SARS-CoV-2: a prospective longitudinal study in unvaccinated wild-type, unvaccinated alpha-variant, and vaccinated delta-variant populations.
The Lancet Digital Health
, 5
(7)
e421-e434.
10.1016/S2589-7500(23)00056-0.
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Chandrasekar, Rahul;
Lacey, Rebecca E;
Chaturvedi, Nishi;
Hughes, Alun D;
Patalay, Praveetha;
Khanolkar, Amal R;
(2023)
Adverse childhood experiences and the development of multimorbidity across adulthood—a national 70-year cohort study.
Age Ageing
, 52
(4)
, Article afad062. 10.1093/ageing/afad062.
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Cheetham, Nathan J;
Penfold, Rose;
Giunchiglia, Valentina;
Bowyer, Vicky;
Sudre, Carole H;
Canas, Liane S;
Deng, Jie;
... Steves, Claire J; + view all
(2023)
The effects of COVID-19 on cognitive performance in a community-based cohort: a COVID symptom study biobank prospective cohort study.
eClinicalMedicine
, Article 102086. 10.1016/j.eclinm.2023.102086.
(In press).
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Chen, Yun;
Wang, Jingyi;
Lin, Haijiang;
Richards, Marcus;
Yang, Xiulu;
Wang, Tingting;
Chen, Xiaoxiao;
(2023)
Network structure of emotional and behavioral problems, loneliness, and suicidal thoughts in adolescents at the school closure and reopening stage in China.
Translational Pediatrics
, 12
(7)
pp. 1373-1385.
10.21037/tp-23-33.
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Chung, Hsin-Fang;
Dobson, Annette J;
Hayashi, Kunihiko;
Hardy, Rebecca;
Kuh, Diana;
Anderson, Debra J;
van der Schouw, Yvonne T;
... Mishra, Gita D; + view all
(2023)
Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies.
Diabetes Care
, Article dc231209. 10.2337/dc23-1209.
(In press).
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Coath, William;
Modat, Marc;
Cardoso, M Jorge;
Markiewicz, Pawel J;
Lane, Christopher A;
Parker, Thomas D;
Keshavan, Ashvini;
... Alzheimer's Disease Neuroimaging Initiative; + view all
(2023)
Operationalizing the centiloid scale for [18F]florbetapir PET studies on PET/MRI.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
, 15
(2)
, Article e12434. 10.1002/dad2.12434.
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D
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Dale, Caroline E;
Takhar, Rohan;
Carragher, Raymond;
Katsoulis, Michail;
Torabi, Fatemeh;
Duffield, Stephen;
Kent, Seamus;
... CVD-COVID-UK Consortium; + view all
(2023)
The impact of the COVID-19 pandemic on cardiovascular disease prevention and management.
Nature Medicine
, 29
pp. 219-225.
10.1038/s41591-022-02158-7.
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De Stavola, Bianca L;
Gomes, Manuel;
Katsoulis, Michail;
(2023)
Transparency and Rigor: Target Trial Emulation Aims to Achieve Both.
Epidemiology
10.1097/EDE.0000000000001638.
(In press).
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Domínguez-Barragán, Jorge;
Fernández-Sanlés, Alba;
Hernáez, Álvaro;
Llauradó-Pont, Joana;
Marrugat, Jaume;
Robinson, Oliver;
Tzoulaki, Ioanna;
... Lassale, Camille; + view all
(2023)
Blood DNA methylation signature of diet quality, and association with cardiometabolic traits.
European Journal of Preventive Cardiology
, Article zwad317. 10.1093/eurjpc/zwad317.
(In press).
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E
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Eisenmann, M;
Reinke, A;
Weru, V;
Tizabi, MD;
Isensee, F;
Adler, TJ;
Ali, S;
... Maier-Hein, L; + view all
(2023)
Why is the Winner the Best?
In:
2023 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR).
(pp. pp. 19955-19966).
IEEE: Vancouver, BC, Canada.
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El Baou, Céline;
Desai, Roopal;
Cooper, Claudia;
Marchant, Natalie L;
Pilling, Steve;
Richards, Marcus;
Saunders, Rob;
... Stott, Joshua; + view all
(2023)
Psychological therapies for depression and cardiovascular risk: evidence from national healthcare records in England.
European Heart Journal
10.1093/eurheartj/ehad188.
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F
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Fyles, M;
Vihta, KD;
Sudre, CH;
Long, H;
Das, R;
Jay, C;
Wingfield, T;
... House, T; + view all
(2023)
Diversity of symptom phenotypes in SARS-CoV-2 community infections observed in multiple large datasets.
Scientific Reports
, 13
, Article 21705. 10.1038/s41598-023-47488-9.
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G
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Garfield, Victoria;
Salzmann, Antoine;
Burgess, Stephen;
Chaturvedi, Nish;
(2023)
A Guide for Selection of Genetic Instruments in Mendelian Randomization Studies of Type 2 Diabetes and HbA1c: Toward an Integrated Approach.
Diabetes
, 72
(2)
pp. 175-183.
10.2337/db22-0110.
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Gatehouse, PD;
Captur, G;
Nielles-Vallespin, S;
Pennell, DJ;
(2023)
Field camera input to virtual phantom (ViP) scanner acquisitions for quality assurance of derived MRI quantities: first implementation and proof-of-principle.
Magnetic Resonance Materials in Physics, Biology and Medicine
10.1007/s10334-023-01136-5.
(In press).
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Ghezzi, Erica S;
Psaltis, Peter J;
Loetscher, Tobias;
Davis, Daniel;
Boord, Monique S;
Greaves, Danielle;
Montarello, Joseph;
... Keage, Hannah AD; + view all
(2023)
Factors associated with cognitive decline and delirium after transcatheter aortic valve implantation: Preliminary evidence.
Delirium Communications
10.56392/001c.74542.
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Greaves, Danielle;
Astley, Jack;
Psaltis, Peter J;
Lampit, Amit;
Davis, Daniel HJ;
Ghezzi, Erica S;
Smith, Ashleigh E;
... Keage, Hannah AD; + view all
(2023)
The effects of computerised cognitive training on post-CABG delirium and cognitive change: A prospective randomised controlled trial.
Delirium
10.56392/001c.67976.
(In press).
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Green, Rebecca E;
Lord, Jodie;
Scelsi, Marzia A;
Xu, Jin;
Wong, Andrew;
Naomi-James, Sarah;
Handy, Alex;
... Insight 46 study team; + view all
(2023)
Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease.
Alzheimer's Research and Therapy
, 15
, Article 38. 10.1186/s13195-023-01184-y.
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H
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Hao, Meng;
Zhang, Hui;
Li, Yi;
Hu, Xiaoxi;
Hu, Zixin;
Jiang, Xiaoyan;
Wang, Jiucun;
... Wang, Xiaofeng; + view all
(2023)
Using physiological system networks to elaborate resilience across frailty states.
The Journals of Gerontology: Series A
10.1093/gerona/glad243.
(In press).
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Holz, Nathalie E;
Zabihi, Mariam;
Kia, Seyed Mostafa;
Monninger, Maximillian;
Aggensteiner, Pascal-M;
Siehl, Sebastian;
Floris, Dorothea L;
... Marquand, Andre F; + view all
(2023)
A stable and replicable neural signature of lifespan adversity in the adult brain.
Nature Neuroscience
10.1038/s41593-023-01410-8.
(In press).
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Hudson, Lee D;
Al-Khairulla, Hind;
Maicoo, Matthew;
Borja, Mario Cortina;
Rapala, Alicja;
Viner, Russell;
Nicholls, Dasha;
... Hughes, Alun; + view all
(2023)
Pulse wave velocity during re-feeding and with weight gain in underweight female adolescents with anorexia nervosa.
Journal of Human Hypertension
, 37
pp. 1126-1128.
10.1038/s41371-023-00848-4.
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I
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Ibitoye, Temi;
Jackson, Thomas A;
Davis, Daniel;
MacLullich, Alasdair MJ;
(2023)
Trends in delirium coding rates in older hospital inpatients in England and Scotland: full population data comprising 7.7M patients per year show substantial increases between 2012 and 2020.
Delirium Communications
10.56392/001c.84051.
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J
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Jacinto, RP;
Ding, T;
Stafford, J;
Baio, G;
Kirkbride, JB;
(2023)
The incidence of psychotic disorders in the Republic of Ireland: a systematic review.
Irish Journal of Psychological Medicine
10.1017/ipm.2023.35.
(In press).
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James, Sarah-Naomi;
Chiou, Yu-Jie;
Fatih, Nasri;
Needham, Louisa P;
Schott, Jonathan M;
Richards, Marcus;
(2023)
Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort.
Journal of Neurology, Neurosurgery & Psychiatry
10.1136/jnnp-2022-329955.
(In press).
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James, Sarah-Naomi;
Manning, Emily N;
Storey, Mathew;
Nicholas, Jennifer M;
Coath, William;
Keuss, Sarah E;
Cash, David M;
... Schott, Jonathan M; + view all
(2023)
Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds.
Brain Communications
, Article fcad225. 10.1093/braincomms/fcad225.
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Joy, George;
Kelly, Christopher I;
Webber, Matthew;
Pierce, Iain;
Teh, Irvin;
McGrath, Louise;
Velazquez, Paula;
... Lopes, Luis R; + view all
(2023)
Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy.
Circulation
10.1161/CIRCULATIONAHA.123.063835.
(In press).
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K
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Katsoulis, M;
Lai, AG;
Kipourou, DK;
Gomes, M;
Banerjee, A;
Denaxas, S;
Lumbers, RT;
... Diaz-Ordaz, K; + view all
(2023)
On the estimation of the effect of weight change on a health outcome using observational data, by utlilising the target trial emulation framework.
International Journal of Obesity
10.1038/s41366-023-01396-0.
(In press).
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 |
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King, Derek;
Gronholm, Petra C;
Knapp, Martin;
Hoffmann, Mauricio S;
Bonin, Eva-Maria;
Brimblecombe, Nicola;
Kadel, Rajendra;
... Evans-Lacko, Sara; + view all
(2023)
Effects of mental health status during adolescence on primary care costs in adulthood across three British cohorts.
Social Psychiatry and Psychiatric Epidemiology
10.1007/s00127-023-02507-y.
(In press).
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Krogseth, Maria;
Davis, Daniel;
Jackson, Thomas Andrew;
Zetterberg, Henrik;
Watne, Leiv Otto;
Lindberg, Morten;
Chitalu, Petronella;
... Wyller, Torgeir Bruun; + view all
(2023)
Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort.
The Lancet Healthy Longevity
, 4
(8)
e399-e408.
10.1016/S2666-7568(23)00098-3.
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L
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Lau, C;
Gul, U;
Liu, B;
Captur, G;
Hothi, SS;
(2023)
Cardiovascular Magnetic Resonance Imaging in Familial Dilated Cardiomyopathy.
Medicina
, 59
(3)
, Article 439. 10.3390/medicina59030439.
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Legdeur, N;
Moonen, JE;
Badissi, M;
Sudre, CH;
Pelkmans, W;
Gordon, MF;
Barkhof, F;
... Muller, M; + view all
(2023)
Is the association between blood pressure and cognition in the oldest-old modified by physical, vascular or brain pathology markers? The EMIF-AD 90 + Study.
BMC Geriatrics
, 23
(1)
, Article 733. 10.1186/s12877-023-04440-w.
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Lemanska, Agnieszka;
Andrews, Colm;
Fisher, Louis;
Bacon, Seb;
Frampton, Adam E;
Mehrkar, Amir;
Inglesby, Peter;
... OpenSAFELY, Collaborative; + view all
(2023)
Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP.
eLife
, 12
, Article e85332. 10.7554/eLife.85332.
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Lessof, C;
Cooper, R;
Wong, A;
Bendayan, R;
Caleyachetty, R;
Cheshire, H;
Cosco, T;
... Hardy, R; + view all
(2023)
Comparison of devices used to measure blood pressure, grip strength and lung function: A randomised cross-over study.
PLoS ONE
, 18
(12)
, Article e0289052. 10.1371/journal.pone.0289052.
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Liu, Yiwen;
Hatch, Stephani L;
Patalay, Praveetha;
Schott, Jonathan M;
Richards, Marcus;
(2023)
A lifecourse approach in examining the association between accumulation of adversity and mental health in older adulthood.
Journal of Affective Disorders
, 339
pp. 211-218.
10.1016/j.jad.2023.07.001.
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Liu, Yiwen;
Patalay, Praveetha;
Stafford, Jean;
Schott, Jonathan M;
Richards, Marcus;
(2023)
Lifecourse investigation of the cumulative impact of adversity on cognitive function in old age and the mediating role of mental health: longitudinal birth cohort study.
BMJ Open
, 13
(11)
, Article e074105. 10.1136/bmjopen-2023-074105.
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Lu, Yao;
Kiechl, Sophia J;
Wang, Jie;
Xu, Qingbo;
Kiechl, Stefan;
Pechlaner, Raimund;
The Global Pulse Wave Velocity Study Group;
(2023)
Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participants.
eBioMedicine
, 92
, Article 104619. 10.1016/j.ebiom.2023.104619.
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M
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Maddock, Jane;
Gallo, Federico;
Wolters, Frank J;
Stafford, Jean;
Marseglia, Anna;
Dekhtyar, Serhiy;
Lenart-Bugla, Marta;
... SHARED, Consortium; + view all
(2023)
Social Health and Change in Cognitive Capability among Older Adults: Findings from Four European Longitudinal Studies.
Gerontology
10.1159/000531969.
(In press).
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Mahalingam, Gowsaly;
Samtani, Suraj;
Lam, Ben Chun Pan;
Lipnicki, Darren M;
Lima-Costa, Maria Fernanda;
Blay, Sergio Luis;
Castro-Costa, Erico;
... SHARED consortium for the Cohort Studies of Memory in an Interna; + view all
(2023)
Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
10.1002/alz.13072.
(In press).
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Mansfield, Rosie;
Di Gessa, Giorgio;
Patel, Kishan;
McElroy, Eoin;
Wels, Jaques;
Henderson, Morag;
Maddock, Jane;
... Patalay, Praveetha; + view all
(2023)
Examining the inter-relationships between social isolation and loneliness and their correlates among older British adults before and during the COVID-19 lockdown: Evidence from four British longitudinal studies.
Innovation in Aging
, Article igad126. 10.1093/geroni/igad126.
(In press).
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Marseglia, Anna;
Kalpouzos, Grégoria;
Laukka, Erika J;
Maddock, Jane;
Patalay, Praveetha;
Wang, Hui-Xin;
Bäckman, Lars;
... on the behalf of the SHARED Consortium, .; + view all
(2023)
Social health and cognitive change in old age: the role of brain reserve.
Annals of Neurology
10.1002/ana.26591.
(In press).
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McCartney, H;
Noble, E;
MacLullich, AMJ;
Davis, DHJ;
Evans, J;
Shenkin, SD;
Muniz-Terrera, G;
... Tieges, Z; + view all
(2023)
A systematic review of studies reporting on neuropsychological and functional domains used for assessment of recovery from delirium in acute hospital patients.
International Journal of Geriatric Psychiatry
, 38
(6)
, Article e5943. 10.1002/gps.5943.
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Monkhouse, Christopher;
Wharmby, Amy;
Carter, Zoe;
Hunter, Ross;
Dhinoja, Mehul;
Chow, Anthony;
Creta, Antonio;
... Lambiase, Pier D; + view all
(2023)
Exploiting SMART pass filter deactivation detection to minimize inappropriate subcutaneous implantable cardioverter defibrillator therapies: a real-world single-centre experience and management guide.
Europace
, Article euad040. 10.1093/europace/euad040.
(In press).
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Moulton, V;
Sullivan, A;
Patalay, P;
Fitzsimons, E;
Henderson, M;
Bann, D;
Ploubidis, GB;
(2023)
Association between psychological distress trajectories from adolescence to midlife and mental health during the pandemic: evidence from two British birth cohorts.
Psychological Medicine
10.1017/S0033291722003877.
(In press).
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N
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Nakanishi, Miharu;
Stanyon, Daniel;
Richards, Marcus;
Yamasaki, Syudo;
Ando, Shuntaro;
Endo, Kaori;
Hosozawa, Mariko;
... Nishida, Atsushi; + view all
(2023)
Informal Caregiving in Adolescents from 10 to 16 Years Old: A Longitudinal Study Using Data from the Tokyo Teen Cohort.
International Journal of Environmental Research and Public Health
, 20
(15)
, Article 6482. 10.3390/ijerph20156482.
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Needham, Louisa P;
Lu, Kirsty;
Nicholas, Jennifer M;
Schott, Jonathan M;
Richards, Marcus;
James, Sarah-Naomi;
(2023)
A comprehensive assessment of age at menopause with well-characterized cognition at 70 years: A population-based British birth cohort.
Maturitas
, 170
pp. 31-38.
10.1016/j.maturitas.2023.01.009.
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Norris, Tom;
Salzmann, Antoine;
Henry, Albert;
Garfield, Victoria;
Pereira, Snehal M Pinto;
(2023)
Correction to: The relationship between adiposity and cognitive function: a bidirectional Mendelian randomization study in UK Biobank.
[Corrigendum].
International Journal of Epidemiology
, 52
(4)
p. 1297.
10.1093/ije/dyad070.
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O
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O'Nions, Elizabeth;
Lewer, Dan;
Petersen, Irene;
Brown, Jude;
Buckman, Joshua EJ;
Charlton, Rebecca;
Cooper, Claudia;
... Stott, Joshua; + view all
(2023)
Estimating life expectancy and years of life lost for autistic
people in the UK: a matched cohort study.
The Lancet Regional Health - Europe
, Article 100776. 10.1016/j.lanepe.2023.100776.
|
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O'Nions, Elizabeth;
Petersen, Irene;
Buckman, Joshua EJ;
Charlton, Rebecca;
Cooper, Claudia;
Corbett, Anne;
Happé, Francesca;
... Stott, Joshua; + view all
(2023)
Autism in England: assessing underdiagnosis in a population-based cohort study of prospectively collected primary care data.
The Lancet Regional Health - Europe
, 29
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Changes to healthcare utilisation and symptoms for common mental health problems over the first 21 months of the COVID-19 pandemic: parallel analyses of electronic health records and survey data in England.
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Accelerated DNA methylation age plays a role in the impact of cardiovascular risk factors on the human heart.
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