Deposit your research

• Open Access
• About UCL Discovery
• UCL Discovery Plus
• REF and open access
• UCL Press
• UCL e-theses guidelines
• Statistics
• FAQs
• Notices and policies
• Contact us

Browse by UCL Department: listings for include files

Export as ASCII CitationBibTeXEndNoteHTML CitationMultiline CSVObject IDsRDF+N-TriplesRDF+N3RDF+XMLReferReference Manager

Atom RSS 1.0 RSS 2.0

Group by: Author | Type | Date

Jump to: A | B | C | D | E | F | G | H | J | K | L | M | O | P | R | S | T | U | V | W | Y | Z

Number of items at this level: 150.

A

Acx, H; Serneels, L; Radaelli, E; Muyldermans, S; Vincke, C; Pepermans, E; Müller, U; ... De Strooper, B; + view all Acx, H; Serneels, L; Radaelli, E; Muyldermans, S; Vincke, C; Pepermans, E; Müller, U; Chávez-Gutiérrez, L; De Strooper, B; - view fewer (2017) Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. EMBO Molecular Medicine , 9 pp. 1088-1099. 10.15252/emmm.201707561.

Aerts, L; Miccoli, B; Delahanty, A; Witters, H; Verstraelen, S; De Strooper, B; Braeken, D; Aerts, L; Miccoli, B; Delahanty, A; Witters, H; Verstraelen, S; De Strooper, B; Braeken, D; Verstreken, P; - view fewer (2022) Do we still need animals? Surveying the role of animal-free models in Alzheimer’s and Parkinson’s disease research. EMBO Journal , Article e110002. 10.15252/embj.2021110002. (In press).

Aghaizu, Nozie D; Jolly, Sarah; Samra, Satinder K; Kalmar, Bernadett; Craessaerts, Katleen; Greensmith, Linda; Salinas, Patricia C; ... Whiting, Paul J; + view all Aghaizu, Nozie D; Jolly, Sarah; Samra, Satinder K; Kalmar, Bernadett; Craessaerts, Katleen; Greensmith, Linda; Salinas, Patricia C; De Strooper, Bart; Whiting, Paul J; - view fewer (2023) Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models. eNeuro 10.1523/ENEURO.0306-22.2022. (In press).

Alibhai, J; Blanco, RA; Barria, MA; Piccardo, P; Caughey, B; Perry, VH; Freeman, TC; Alibhai, J; Blanco, RA; Barria, MA; Piccardo, P; Caughey, B; Perry, VH; Freeman, TC; Manson, JC; - view fewer (2016) Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration. PLOS Biology , 14 (11) , Article e1002579. 10.1371/journal.pbio.1002579.

Arranz, AM; De Strooper, B; (2019) The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications. The Lancet Neurology , 18 (4) pp. 406-414. 10.1016/S1474-4422(18)30490-3.

Askew, K; Li, K; Olmos-Alonso, A; Garcia-Moreno, F; Liang, Y; Richardson, P; Tipton, T; ... Gomez-Nicola, D; + view all Askew, K; Li, K; Olmos-Alonso, A; Garcia-Moreno, F; Liang, Y; Richardson, P; Tipton, T; Chapman, MA; Riecken, K; Beccari, S; Sierra, A; Molnar, Z; Cragg, MS; Garaschuk, O; Perry, VH; Gomez-Nicola, D; - view fewer (2017) Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain. Cell Reports , 18 (2) pp. 391-405. 10.1016/j.celrep.2016.12.041.

B

Baker, D; Pryce, G; Visintin, C; Sisay, S; Bondarenko, AI; Ho, WSV; Jackson, SJ; ... Selwood, DL; + view all Baker, D; Pryce, G; Visintin, C; Sisay, S; Bondarenko, AI; Ho, WSV; Jackson, SJ; Williams, TE; Al-Izki, S; Sevastou, I; Okuyama, M; Graier, WF; Stevenson, LA; Tanner, C; Ross, R; Pertwee, RG; Henstridge, CM; Irving, AJ; Schulman, J; Powell, K; Baker, MD; Giovannoni, G; Selwood, DL; - view fewer (2017) Big conductance calcium-activated potassium channel openers control spasticity without sedation. British Journal of Pharmacology , 174 (16) pp. 2662-2681. 10.1111/bph.13889.

Balusu, Sriram; Praschberger, Roman; Lauwers, Elsa; De Strooper, Bart; Verstreken, Patrik; (2023) Neurodegeneration cell per cell. Neuron , 111 (6) pp. 767-786. 10.1016/j.neuron.2023.01.016.

Benitez, DP; Jiang, S; Wood, J; Wang, R; Hall, CM; Peerboom, C; Wong, N; ... Cummings, DM; + view all Benitez, DP; Jiang, S; Wood, J; Wang, R; Hall, CM; Peerboom, C; Wong, N; Stringer, KM; Vitanova, KS; Smith, VC; Joshi, D; Saito, T; Saido, TC; Hardy, J; Hanrieder, J; De Strooper, B; Salih, DA; Tripathi, T; Edwards, FA; Cummings, DM; - view fewer (2021) Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia. Molecular Neurodegeneration , 16 (1) , Article 47. 10.1186/s13024-021-00457-0.

Brownjohn, PW; Smith, J; Portelius, E; Serneels, L; Kvartsberg, H; De Strooper, B; Blennow, K; ... Livesey, FJ; + view all Brownjohn, PW; Smith, J; Portelius, E; Serneels, L; Kvartsberg, H; De Strooper, B; Blennow, K; Zetterberg, H; Livesey, FJ; - view fewer (2017) Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. Stem Cell Reports , 8 (4) pp. 870-882. 10.1016/j.stemcr.2017.02.006.

C

Calafate, S; Özturan, G; Thrupp, N; Vanderlinden, J; Santa-Marinha, L; Morais-Ribeiro, R; Ruggiero, A; ... de Wit, J; + view all Calafate, S; Özturan, G; Thrupp, N; Vanderlinden, J; Santa-Marinha, L; Morais-Ribeiro, R; Ruggiero, A; Bozic, I; Rusterholz, T; Lorente-Echeverría, B; Dias, M; Chen, WT; Fiers, M; Lu, A; Vlaeminck, I; Creemers, E; Craessaerts, K; Vandenbempt, J; van Boekholdt, L; Poovathingal, S; Davie, K; Thal, DR; Wierda, K; Oliveira, TG; Slutsky, I; Adamantidis, A; De Strooper, B; de Wit, J; - view fewer (2023) Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease. Nature Neuroscience 10.1038/s41593-023-01325-4. (In press).

Cerofolini, L; Ravera, E; Bologna, S; Wiglenda, T; Böddrich, A; Purfürst, B; Benilova, I; ... Luchinat, C; + view all Cerofolini, L; Ravera, E; Bologna, S; Wiglenda, T; Böddrich, A; Purfürst, B; Benilova, I; Korsak, M; Gallo, G; Rizzo, D; Gonnelli, L; Fragai, M; De Strooper, B; Wanker, EE; Luchinat, C; - view fewer (2020) Mixing Aβ(1–40) and Aβ(1–42) peptides generates unique amyloid fibrils. Chemical Communications 10.1039/d0cc02463e. (In press).

Chavez-Gutierrez, L; De Strooper, B; (2016) Probing gamma-secretase-substrate interactions at the single amino acid residue level. EMBO Journal , 35 (15) pp. 1597-1599. 10.15252/embj.201694978.

Chen, W-T; Lu, A; Craessaerts, K; Pavie, B; Sala Frigerio, C; Corthout, N; Qian, X; ... De Strooper, B; + view all Chen, W-T; Lu, A; Craessaerts, K; Pavie, B; Sala Frigerio, C; Corthout, N; Qian, X; Laláková, J; Kühnemund, M; Voytyuk, I; Wolfs, L; Mancuso, R; Salta, E; Balusu, S; Snellinx, A; Munck, S; Jurek, A; Fernandez Navarro, J; Saido, TC; Huitinga, I; Lundeberg, J; Fiers, M; De Strooper, B; - view fewer (2020) Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. Cell , 182 (4) 976-991.e19. 10.1016/j.cell.2020.06.038.

Claes, C; Van Den Daele, J; Boon, R; Schouteden, S; Colombo, A; Monasor, LS; Fiers, M; ... Verfaillie, CM; + view all Claes, C; Van Den Daele, J; Boon, R; Schouteden, S; Colombo, A; Monasor, LS; Fiers, M; Ordovás, L; Nami, F; Bohrmann, B; Tahirovic, S; De Strooper, B; Verfaillie, CM; - view fewer (2018) Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2. Alzheimer's & Dementia 10.1016/j.jalz.2018.09.006.

Cornelissen, T; Spinazzi, M; Martin, S; Imberechts, D; Vangheluwe, P; Bird, M; De Strooper, B; Cornelissen, T; Spinazzi, M; Martin, S; Imberechts, D; Vangheluwe, P; Bird, M; De Strooper, B; Vandenberghe, W; - view fewer (2020) CHCHD2 harboring Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Human Molecular Genetics , 29 (7) pp. 1096-1106. 10.1093/hmg/ddaa028.

D

De Schepper, S; Verheijden, S; Aguilera-Lizarraga, J; Viola, MF; Boesmans, W; Stakenborg, N; Voytyuk, I; ... Boeckxstaens, G; + view all De Schepper, S; Verheijden, S; Aguilera-Lizarraga, J; Viola, MF; Boesmans, W; Stakenborg, N; Voytyuk, I; Smidt, I; Boeckx, B; de Casterle, ID; Baekelandt, V; Dominguez, EG; Mack, M; Depoortere, I; De Strooper, B; Sprangers, B; Himmelreich, U; Soenen, S; Guilliams, M; Vanden Berghe, P; Jones, E; Lambrechts, D; Boeckxstaens, G; - view fewer (2018) Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis. Cell , 175 (2) , Article e13. 10.1016/j.cell.2018.07.048.

E

Enzlein, T; Cordes, J; Munteanu, B; Michno, W; Serneels, L; De Strooper, B; Hanrieder, J; ... Hopf, C; + view all Enzlein, T; Cordes, J; Munteanu, B; Michno, W; Serneels, L; De Strooper, B; Hanrieder, J; Wolf, I; Chávez-Gutiérrez, L; Hopf, C; - view fewer (2020) Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images. Analytical Chemistry , 92 (21) pp. 14484-14493. 10.1021/acs.analchem.0c02585.

Escartin, C; Galea, E; Lakatos, A; O'Callaghan, JP; Petzold, GC; Serrano-Pozo, A; Steinhäuser, C; ... Verkhratsky, A; + view all Escartin, C; Galea, E; Lakatos, A; O'Callaghan, JP; Petzold, GC; Serrano-Pozo, A; Steinhäuser, C; Volterra, A; Carmignoto, G; Agarwal, A; Allen, NJ; Araque, A; Barbeito, L; Barzilai, A; Bergles, DE; Bonvento, G; Butt, AM; Chen, W-T; Cohen-Salmon, M; Cunningham, C; Deneen, B; De Strooper, B; Díaz-Castro, B; Farina, C; Freeman, M; Gallo, V; Goldman, JE; Goldman, SA; Götz, M; Gutiérrez, A; Haydon, PG; Heiland, DH; Hol, EM; Holt, MG; Iino, M; Kastanenka, KV; Kettenmann, H; Khakh, BS; Koizumi, S; Lee, CJ; Liddelow, SA; MacVicar, BA; Magistretti, P; Messing, A; Mishra, A; Molofsky, AV; Murai, KK; Norris, CM; Okada, S; Oliet, SHR; Oliveira, JF; Panatier, A; Parpura, V; Pekna, M; Pekny, M; Pellerin, L; Perea, G; Pérez-Nievas, BG; Pfrieger, FW; Poskanzer, KE; Quintana, FJ; Ransohoff, RM; Riquelme-Perez, M; Robel, S; Rose, CR; Rothstein, JD; Rouach, N; Rowitch, DH; Semyanov, A; Sirko, S; Sontheimer, H; Swanson, RA; Vitorica, J; Wanner, I-B; Wood, LB; Wu, J; Zheng, B; Zimmer, ER; Zorec, R; Sofroniew, MV; Verkhratsky, A; - view fewer (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience , 24 pp. 312-325. 10.1038/s41593-020-00783-4.

Espuny-Camacho, I; Arranz, AM; Fiers, M; Snellinx, A; Ando, K; Munck, S; Bonnefont, J; ... De Strooper, B; + view all Espuny-Camacho, I; Arranz, AM; Fiers, M; Snellinx, A; Ando, K; Munck, S; Bonnefont, J; Lambot, L; Corthout, N; Omodho, L; Eynden, EV; Radaelli, E; Tesseur, I; Wray, S; Ebneth, A; Hardy, J; Leroy, K; Brion, J-P; Vanderhaeghen, P; De Strooper, B; - view fewer (2017) Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neutron , 93 (5) , Article e8. 10.1016/j.neuron.2017.02.001.

F

Fattorelli, N; Martinez-Muriana, A; Wolfs, L; Geric, I; De Strooper, B; Mancuso, R; (2021) Stem-cell-derived human microglia transplanted into mouse brain to study human disease. Nature Protocols , 16 pp. 1013-1033. 10.1038/s41596-020-00447-4.

Fazzari, P; Horre, K; Arranz, AM; Frigerio, CS; Saito, T; Saido, TC; De Strooper, B; (2017) PLD3 gene and processing of APP. Nature , 541 (7638) 10.1038/nature21030.

Ferjentsik, Z; Hayashi, S; Dale, JK; Bessho, Y; Herreman, A; De Strooper, B; del Monte, G; ... Maroto, M; + view all Ferjentsik, Z; Hayashi, S; Dale, JK; Bessho, Y; Herreman, A; De Strooper, B; del Monte, G; de la Pompa, JL; Maroto, M; - view fewer (2009) Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites. PLoS Genetics , 5 (9) , Article e1000662. 10.1371/journal.pgen.1000662.

Foti, S; Hargreaves, I; Carrington, S; Kiely, AP; Houlden, H; Holton, J; (2019) Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson’s disease. Scientific Reports , 9 , Article 6559. 10.1038/s41598-019-42902-7.

Frigerio, CS; De Strooper, B; (2016) Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics. Annual Review of Neuroscience , 39 pp. 57-79. 10.1146/annurev-neuro-070815-014015.

Frigerio, CS; Fiers, M; Voet, T; De Strooper, B; (2017) Identification of Low Allele Frequency Mosaic Mutations in Alzheimer Disease. In: Frade, JM and Gage, FH, (eds.) Genomic Mosaicism in Neurons and Other Cell Types. (pp. 361-378). Humana Press: New York, NY, USA.

G

Galea, I; Perry, VH; (2017) The blood-brain interface: a culture change. Brain, Behavior, and Immunity , 68 pp. 11-16. 10.1016/j.bbi.2017.10.014.

Gallardo, R; Ramakers, M; De Smet, F; Claes, F; Khodaparast, L; Khodaparast, L; Couceiro, JR; ... Rousseau, F; + view all Gallardo, R; Ramakers, M; De Smet, F; Claes, F; Khodaparast, L; Khodaparast, L; Couceiro, JR; Langenberg, T; Siemons, M; Nyström, S; Young, LJ; Laine, RF; Young, L; Radaelli, E; Benilova, I; Kumar, M; Staes, A; Desager, M; Beerens, M; Vandervoort, P; Luttun, A; Gevaert, K; Bormans, G; Dewerchin, M; Van Eldere, J; Carmeliet, P; Vande Velde, G; Verfaillie, C; Kaminski, CF; De Strooper, B; Hammarström, P; Nilsson, KPR; Serpell, L; Schymkowitz, J; Rousseau, F; - view fewer (2016) De novo design of a biologically active amyloid. Science , 354 (6313) , Article aah4949. 10.1126/science.aah4949.

García-León, JA; Cabrera-Socorro, A; Eggermont, K; Swijsen, A; Terryn, J; Fazal, R; Nami, F; ... Verfaillie, CM; + view all García-León, JA; Cabrera-Socorro, A; Eggermont, K; Swijsen, A; Terryn, J; Fazal, R; Nami, F; Ordovás, L; Quiles, A; Lluis, F; Serneels, L; Wierda, K; Sierksma, A; Kreir, M; Pestana, F; Van Damme, P; De Strooper, B; Thorrez, L; Ebneth, A; Verfaillie, CM; - view fewer (2018) Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein tau mutations which displays several phenotypes linked to neurodegeneration. Alzheimer's & Dementia , 14 (10) pp. 1261-1280. 10.1016/j.jalz.2018.05.007.

Gasse, C; Zaarour, M; Noppen, S; Abramov, M; Marliere, P; Liekens, S; De Strooper, B; Gasse, C; Zaarour, M; Noppen, S; Abramov, M; Marliere, P; Liekens, S; De Strooper, B; Herdewijn, P; - view fewer (2018) Modulation of BACE1 Activity by Chemically Modified Aptamers. ChemBioChem , 19 (7) pp. 754-763. 10.1002/cbic.201700461.

Gnanapavan, S; Ho, P; Heywood, W; Jackson, S; Grant, D; Rantell, K; Keir, G; ... Giovannoni, G; + view all Gnanapavan, S; Ho, P; Heywood, W; Jackson, S; Grant, D; Rantell, K; Keir, G; Mills, K; Steinman, L; Giovannoni, G; - view fewer (2013) Progression in multiple sclerosis is associated with low endogenous NCAM. J Neurochem , 125 (5) 766 - 773. 10.1111/jnc.12236.

Guerrero, A; De Strooper, B; Arancibia-Cárcamo, IL; (2021) Cellular senescence at the crossroads of inflammation and Alzheimer's disease. Trends in Neurosciences , 44 (9) pp. 714-727. 10.1016/j.tins.2021.06.007.

Guix, FX; Sannerud, R; Berditchevski, F; Arranz, AM; Horre, K; Snellinx, A; Thathiah, A; ... De Strooper, B; + view all Guix, FX; Sannerud, R; Berditchevski, F; Arranz, AM; Horre, K; Snellinx, A; Thathiah, A; Saido, T; Saito, T; Rajesh, S; Overduin, M; Kumar-Singh, S; Radaelli, E; Corthout, N; Colombelli, J; Tosi, S; Munck, S; Salas, IH; Annaert, W; De Strooper, B; - view fewer (2017) Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Molecular Neurodegeneration , 12 , Article 25. 10.1186/s13024-017-0165-0.

Guo, Wenting; Wang, Haibo; Kumar Tharkeshwar, Arun; Couthouis, Julien; Braems, Elke; Masrori, Pegah; Van Schoor, Evelien; ... Verfaillie, Catherine; + view all Guo, Wenting; Wang, Haibo; Kumar Tharkeshwar, Arun; Couthouis, Julien; Braems, Elke; Masrori, Pegah; Van Schoor, Evelien; Fan, Yannan; Ahuja, Karan; Moisse, Matthieu; Jacquemyn, Maarten; Furtado Madeiro da Costa, Rodrigo; Gajjar, Madhavsai; Balusu, Sriram; Tricot, Tine; Fumagalli, Laura; Hersmus, Nicole; Janky, Rekin's; Impens, Francis; Vanden Berghe, Pieter; Ho, Ritchie; Thal, Dietmar Rudolf; Vandenberghe, Rik; Hegde, Muralidhar L; Chandran, Siddharthan; De Strooper, Bart; Daelemans, Dirk; Van Damme, Philip; Van Den Bosch, Ludo; Verfaillie, Catherine; - view fewer (2022) CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity. Alzheimer's & Dementia 10.1002/alz.12760. (In press).

H

Habets, RA; De Bock, CE; Serneels, L; Lodewijckx, I; Verbeke, D; Nittner, D; Narlawar, R; ... De Strooper, B; + view all Habets, RA; De Bock, CE; Serneels, L; Lodewijckx, I; Verbeke, D; Nittner, D; Narlawar, R; Demeyer, S; Dooley, J; Liston, A; Taghon, T; Cools, J; De Strooper, B; - view fewer (2019) Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition. Science Translational Medicine , 11 (494) , Article eaau6246. 10.1126/scitranslmed.aau6246.

Hammad, H; Vanderkerken, M; Pouliot, P; Deswarte, K; Toussaint, W; Vergote, K; Vandersarren, L; ... Lambrecht, BN; + view all Hammad, H; Vanderkerken, M; Pouliot, P; Deswarte, K; Toussaint, W; Vergote, K; Vandersarren, L; Janssens, S; Ramou, I; Savvides, SN; Haigh, JJ; Hendriks, R; Kopf, M; Craessaerts, K; de Strooper, B; Kearney, JF; Conrad, DH; Lambrecht, BN; - view fewer (2017) Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. Nature Immunology , 18 (3) pp. 313-320. 10.1038/ni.3657.

Hampel, H; Vassar, R; De Strooper, B; Hardy, J; Willem, M; Singh, N; Zhou, J; ... Vergallo, A; + view all Hampel, H; Vassar, R; De Strooper, B; Hardy, J; Willem, M; Singh, N; Zhou, J; Yan, R; Vanmechelen, E; De Vos, A; Nisticò, R; Corbo, M; Imbimbo, BP; Streffer, J; Voytyuk, I; Timmers, M; Tahami Monfared, AA; Irizarry, M; Albala, B; Koyama, A; Watanabe, N; Kimura, T; Yarenis, L; Lista, S; Kramer, L; Vergallo, A; - view fewer (2020) The β-Secretase BACE1 in Alzheimer's Disease. Biological Psychiatry 10.1016/j.biopsych.2020.02.001. (In press).

Hardy, J; De Strooper, B; Escott-Price, V; (2022) Diabetes and Alzheimer's disease: shared genetic susceptibility? The Lancet Neurology , 21 (11) pp. 962-964. 10.1016/S1474-4422(22)00395-7.

Hardy, J; De Strooper, B; (2017) Alzheimer's disease: where next for anti-amyloid therapies? [Editorial comment]. Brain , 140 (4) pp. 853-855. 10.1093/brain/awx059.

Harris, SS; Wolf, F; De Strooper, B; Busche, MA; (2020) Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease. Neuron , 107 (3) pp. 417-435. 10.1016/j.neuron.2020.06.005.

Harrison, Peter W; Lopez, Rodrigo; Rahman, Nadim; Allen, Stefan Gutnick; Aslam, Raheela; Buso, Nicola; Cummins, Carla; ... Apweiler, Rolf; + view all Harrison, Peter W; Lopez, Rodrigo; Rahman, Nadim; Allen, Stefan Gutnick; Aslam, Raheela; Buso, Nicola; Cummins, Carla; Fathy, Yasmin; Felix, Eloy; Glont, Mihai; Jayathilaka, Suran; Kadam, Sandeep; Kumar, Manish; Lauer, Katharina B; Malhotra, Geetika; Mosaku, Abayomi; Edbali, Ossama; Park, Young Mi; Parton, Andrew; Pearce, Matt; Estrada Pena, Jose Francisco; Rossetto, Joseph; Russell, Craig; Selvakumar, Sandeep; Sitjà, Xènia Pérez; Sokolov, Alexey; Thorne, Ross; Ventouratou, Marianna; Walter, Peter; Yordanova, Galabina; Zadissa, Amonida; Cochrane, Guy; Blomberg, Niklas; Apweiler, Rolf; - view fewer (2021) The COVID-19 Data Portal: accelerating SARS-CoV-2 and COVID-19 research through rapid open access data sharing. Nucleic Acids Research , 49 (W1) W619-W623. 10.1093/nar/gkab417.

Ho, H; Kejzar, N; Sasaguri, H; Saito, T; Saido, TC; De Strooper, B; Bauza, M; Ho, H; Kejzar, N; Sasaguri, H; Saito, T; Saido, TC; De Strooper, B; Bauza, M; Krupic, J; - view fewer (2023) A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior. Cell Reports Methods , 3 (7) , Article 100532. 10.1016/j.crmeth.2023.100532.

Holmes, EA; O'Connor, RC; Perry, VH; Tracey, I; Wessely, S; Arseneault, L; Ballard, C; ... Bullmore, E; + view all Holmes, EA; O'Connor, RC; Perry, VH; Tracey, I; Wessely, S; Arseneault, L; Ballard, C; Christensen, H; Cohen Silver, R; Everall, I; Ford, T; John, A; Kabir, T; King, K; Madan, I; Michie, S; Przybylski, AK; Shafran, R; Sweeney, A; Worthman, CM; Yardley, L; Cowan, K; Cope, C; Hotopf, M; Bullmore, E; - view fewer (2020) Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. The Lancet Psychiatry , 7 (6) pp. 547-560. 10.1016/S2215-0366(20)30168-1.

J

Jackson, SJ; Andrews, N; Ball, D; Bellantuono, I; Gray, J; Hachoumi, L; Holmes, A; ... Chapman, K; + view all Jackson, SJ; Andrews, N; Ball, D; Bellantuono, I; Gray, J; Hachoumi, L; Holmes, A; Latcham, J; Petrie, A; Potter, P; Rice, A; Ritchie, A; Stewart, M; Strepka, C; Yeoman, M; Chapman, K; - view fewer (2017) Does age matter? The impact of rodent age on study outcomes. Laboratory Animals , 51 (2) pp. 160-169. 10.1177/0023677216653984.

K

Karran, Eric; De Strooper, Bart; (2022) The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nature Reviews Drug Discovery , 21 pp. 306-318. 10.1038/s41573-022-00391-w.

Karran, E; De Strooper, B; (2016) The amyloid cascade hypothesis: are we poised for success or failure? Journal of Neurochemistry , 139 pp. 237-252. 10.1111/jnc.13632.

Katsnelson, A; De Strooper, B; Zoghbi, HY; (2016) Neurodegeneration: From cellular concepts to clinical applications. Science Translational Medicine , 8 (364) , Article 364ps18. 10.1126/scitranslmed.aal2074.

Kemmerling, N; Wunderlich, P; Theil, S; Linnartz-Gerlach, B; Hersch, N; Hoffmann, B; Heneka, MT; ... Walter, J; + view all Kemmerling, N; Wunderlich, P; Theil, S; Linnartz-Gerlach, B; Hersch, N; Hoffmann, B; Heneka, MT; de Strooper, B; Neumann, H; Walter, J; - view fewer (2017) Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia. Glia , 65 (7) pp. 1103-1118. 10.1002/glia.23147.

Kiely, A; Murray, CE; Asi, Y; Ahmed, Z; Lashley, T; Revesz, T; Holton, J; (2016) Distinct inflammatory profile in brains with multiple system atrophy. In: Proceedings of the 10TH FENS Forum of Neuroscience 2016. Federation of European Neuroscience Societies (FENS): Copenhagen, Denmark.

Kiely, AP; Asi, YT; Kara, E; Limousin, P; Ling, H; Lewis, P; Proukakis, C; ... Holton, JL; + view all Kiely, AP; Asi, YT; Kara, E; Limousin, P; Ling, H; Lewis, P; Proukakis, C; Quinn, N; Lees, AJ; Hardy, J; Revesz, T; Houlden, H; Holton, JL; - view fewer (2013) α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathologica , 125 (5) 753 - 769. 10.1007/s00401-013-1096-7.

Kiely, AP; Ling, H; Asi, YT; Kara, E; Proukakis, C; Schapira, AH; Morris, HR; ... Holton, JL; + view all Kiely, AP; Ling, H; Asi, YT; Kara, E; Proukakis, C; Schapira, AH; Morris, HR; Roberts, HC; Lubbe, S; Limousin, P; Lewis, PA; Lees, AJ; Quinn, N; Hardy, J; Love, S; Revesz, T; Houlden, H; Holton, JL; - view fewer (2015) Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. Molecular Neurodegeneration , 10 , Article 41. 10.1186/s13024-015-0038-3.

Kiely, AP; Miners, JS; Courtney, R; Strand, C; Love, S; Holton, JL; (2019) Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy. Neuropathology and Applied Neurobiology , 45 (4) pp. 347-360. 10.1111/nan.12512.

Kiely, AP; Murray, C; Asi, YT; Ahmed, Z; Lashley, T; Revesz, T; Holton, JL; (2016) NanoString analysis of neuroinflammation in multiple system atrophy. Presented at: 117th meeting of the British Neuropathological Society, London, UK.

Kiely, AP; Murray, CE; Foti, SC; Benson, BC; Courtney, R; Strand, C; Lashley, T; Kiely, AP; Murray, CE; Foti, SC; Benson, BC; Courtney, R; Strand, C; Lashley, T; Holton, JL; - view fewer (2018) Immunohistochemical and Molecular Investigations Show Alteration in the Inflammatory Profile of Multiple System Atrophy Brain. Journal of Neuropathology & Experimental Neurology , 77 (7) pp. 598-607. 10.1093/jnen/nly035.

Koper, Marta J; Tome, Sandra O; Gawor, Klara; Belet, Annelies; Van Schoor, Evelien; Schaeverbeke, Jolien; Vandenberghe, Rik; ... Thal, Dietmar Rudolf; + view all Koper, Marta J; Tome, Sandra O; Gawor, Klara; Belet, Annelies; Van Schoor, Evelien; Schaeverbeke, Jolien; Vandenberghe, Rik; Vandenbulcke, Mathieu; Ghebremedhin, Estifanos; Otto, Markus; von Arnim, Christine AF; Balusu, Sriram; Blaschko, Matthew B; De Strooper, Bart; Thal, Dietmar Rudolf; - view fewer (2022) LATE-NC aggravates GVD-mediated necroptosis in Alzheimer's disease. Acta Neuropathologica Communications , 10 , Article 128. 10.1186/s40478-022-01432-6.

Koper, MJ; Van Schoor, E; Ospitalieri, S; Vandenberghe, R; Vandenbulcke, M; von Arnim, CAF; Tousseyn, T; ... Thal, DR; + view all Koper, MJ; Van Schoor, E; Ospitalieri, S; Vandenberghe, R; Vandenbulcke, M; von Arnim, CAF; Tousseyn, T; Balusu, S; De Strooper, B; Thal, DR; - view fewer (2020) Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer's disease. Acta Neuropathologica , 139 pp. 463-484. 10.1007/s00401-019-02103-y.

L

Lalli, G; Rossor, M; Rowe, JB; De Strooper, B; (2021) The Dementia UK Ecosystem: a call to action. The Lancet Neurology , 20 (9) pp. 699-700. 10.1016/S1474-4422(21)00246-5.

Lalli, G; Schott, JM; Hardy, J; De Strooper, B; (2021) Aducanumab: a new phase in therapeutic development for Alzheimer’s disease? EMBO Molecular Medicine , 13 , Article e14781. 10.15252/emmm.202114781.

Largo-Barrientos, P; Apóstolo, N; Creemers, E; Callaerts-Vegh, Z; Swerts, J; Davies, C; McInnes, J; ... Verstreken, P; + view all Largo-Barrientos, P; Apóstolo, N; Creemers, E; Callaerts-Vegh, Z; Swerts, J; Davies, C; McInnes, J; Wierda, K; De Strooper, B; Spires-Jones, T; De Wit, J; Uytterhoeven, V; Verstreken, P; - view fewer (2021) Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation. Neuron 10.1016/j.neuron.2020.12.016. (In press).

Latif-Hernandez, A; Shah, D; Craessaerts, K; Saido, T; Saito, T; De Strooper, B; Van der Linden, A; Latif-Hernandez, A; Shah, D; Craessaerts, K; Saido, T; Saito, T; De Strooper, B; Van der Linden, A; D'Hooge, R; - view fewer (2017) Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition. Behavioural Brain Research 10.1016/j.bbr.2017.11.017. (In press).

Lauwers, E; Lalli, G; Brandner, S; Collinge, J; Compernolle, V; Duyckaerts, C; Edgren, G; ... De Strooper, B; + view all Lauwers, E; Lalli, G; Brandner, S; Collinge, J; Compernolle, V; Duyckaerts, C; Edgren, G; Haïk, S; Hardy, J; Helmy, A; Ivinson, AJ; Jaunmuktane, Z; Jucker, M; Knight, R; Lemmens, R; Lin, I-C; Love, S; Mead, S; Perry, VH; Pickett, J; Poppy, G; Radford, SE; Rousseau, F; Routledge, C; Schiavo, G; Schymkowitz, J; Selkoe, DJ; Smith, C; Thal, DR; Theys, T; Tiberghien, P; van den Burg, P; Vandekerckhove, P; Walton, C; Zaaijer, HL; Zetterberg, H; De Strooper, B; - view fewer (2020) Potential human transmission of amyloid β pathology: surveillance and risks. The Lancet Neurology , 19 (10) pp. 872-878. 10.1016/S1474-4422(20)30238-6.

Le Guennec, K; Veugelen, S; Quenez, O; Szaruga, M; Rousseau, S; Nicolas, G; Wallon, D; ... Rovelet-Lecrux, A; + view all Le Guennec, K; Veugelen, S; Quenez, O; Szaruga, M; Rousseau, S; Nicolas, G; Wallon, D; Fluchere, F; Frébourg, T; De Strooper, B; Campion, D; Chávez-Gutiérrez, L; Rovelet-Lecrux, A; - view fewer (2017) Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds. Neurobiol Dis , 104 pp. 97-103. 10.1016/j.nbd.2017.04.020.

Leday, GGR; Vertes, PE; Richardson, S; Greene, JR; Regan, T; Khan, S; Henderson, R; ... Bullmore, ET; + view all Leday, GGR; Vertes, PE; Richardson, S; Greene, JR; Regan, T; Khan, S; Henderson, R; Freeman, TC; Pariante, CM; Harrison, NA; Perry, VH; Drevets, WC; Wittenberg, GM; Bullmore, ET; - view fewer (2017) Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder. Biological Psychiatry , 83 (1) pp. 70-80. 10.1016/j.biopsych.2017.01.021.

Leonenko, G; Baker, E; Stevenson-Hoare, J; Sierksma, A; Fiers, M; Williams, J; de Strooper, B; Leonenko, G; Baker, E; Stevenson-Hoare, J; Sierksma, A; Fiers, M; Williams, J; de Strooper, B; Escott-Price, V; - view fewer (2021) Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores. Nature Communications , 12 (1) , Article 4506. 10.1038/s41467-021-24082-z.

Lidster, K; Jackson, SJ; Ahmed, Z; Munro, P; Coffey, P; Giovannoni, G; Baker, MD; Lidster, K; Jackson, SJ; Ahmed, Z; Munro, P; Coffey, P; Giovannoni, G; Baker, MD; Baker, D; - view fewer (2013) Neuroprotection in a Novel Mouse Model of Multiple Sclerosis. PLoS One , 8 (11) , Article e79188. 10.1371/journal.pone.0079188.

Lin, IC; Okun, M; Carandini, M; Harris, KD; (2015) The Nature of Shared Cortical Variability. Neuron , 87 (3) pp. 644-656. 10.1016/j.neuron.2015.06.035.

Liu, T; Zhang, T; Nicolas, M; Boussicault, L; Rice, H; Soldano, A; Claeys, A; ... Hassan, BA; + view all Liu, T; Zhang, T; Nicolas, M; Boussicault, L; Rice, H; Soldano, A; Claeys, A; Petrova, I; Fradkin, L; De Strooper, B; Potier, M-C; Hassan, BA; - view fewer (2021) The amyloid precursor protein is a conserved Wnt receptor. eLife , 10 , Article e69199. 10.7554/eLife.69199.

M

Mancuso, R; Fryatt, G; Cleal, M; Obst, J; Pipi, E; Monzón-Sandoval, J; Ribe, E; ... Perry, VH; + view all Mancuso, R; Fryatt, G; Cleal, M; Obst, J; Pipi, E; Monzón-Sandoval, J; Ribe, E; Winchester, L; Webber, C; Nevado, A; Jacobs, T; Austin, N; Theunis, C; Grauwen, K; Daniela Ruiz, E; Mudher, A; Vicente-Rodriguez, M; Parker, CA; Simmons, C; Cash, D; Richardson, J; NIMA Consortium; Jones, DNC; Lovestone, S; Gómez-Nicola, D; Perry, VH; - view fewer (2019) CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice. Brain , 142 (10) pp. 3243-3264. 10.1093/brain/awz241.

Mancuso, R; Van Den Daele, J; Fattorelli, N; Wolfs, L; Balusu, S; Burton, O; Liston, A; ... De Strooper, B; + view all Mancuso, R; Van Den Daele, J; Fattorelli, N; Wolfs, L; Balusu, S; Burton, O; Liston, A; Sierksma, A; Fourne, Y; Poovathingal, S; Arranz-Mendiguren, A; Sala Frigerio, C; Claes, C; Serneels, L; Theys, T; Perry, VH; Verfaillie, C; Fiers, M; De Strooper, B; - view fewer (2019) Stem-cell-derived human microglia transplanted in mouse brain to study human disease. Nature Neuroscience , 22 pp. 2111-2116. 10.1038/s41593-019-0525-x.

Manoharan, A; Rayner, PJ; Fekete, M; Iali, W; Norcott, P; Perry, VH; Duckett, SB; (2019) Catalyst‐Substrate Effects on Biocompatible SABRE Hyperpolarization. ChemPhysChem , 20 (2) pp. 285-294. 10.1002/cphc.201800915.

Manoharan, A; Rayner, PJ; Iali, W; Burns, MJ; Perry, VH; Duckett, SB; (2018) Achieving Biocompatible SABRE: An invitro Cytotoxicity Study. ChemMedChem , 13 (4) pp. 352-359. 10.1002/cmdc.201700725.

Marino, Marika; Zhou, Lujia; Rincon, Melvin Y; Callaerts-Vegh, Zsuzsanna; Verhaert, Jens; Wahis, Jérôme; Creemers, Eline; ... Holt, Matthew G; + view all Marino, Marika; Zhou, Lujia; Rincon, Melvin Y; Callaerts-Vegh, Zsuzsanna; Verhaert, Jens; Wahis, Jérôme; Creemers, Eline; Yshii, Lidia; Wierda, Keimpe; Saito, Takashi; Marneffe, Catherine; Voytyuk, Iryna; Wouters, Yessica; Dewilde, Maarten; Duqué, Sandra I; Vincke, Cécile; Levites, Yona; Golde, Todd E; Saido, Takaomi C; Muyldermans, Serge; Liston, Adrian; De Strooper, Bart; Holt, Matthew G; - view fewer (2022) AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model. EMBO Molecular Medicine , 14 (4) , Article e09824. 10.15252/emmm.201809824.

Martinez-Muriana, A; Mancuso, R; Francos-Quijorna, I; Olmos-Alonso, A; Osta, R; Perry, VH; Navarro, X; ... Lopez-Vales, R; + view all Martinez-Muriana, A; Mancuso, R; Francos-Quijorna, I; Olmos-Alonso, A; Osta, R; Perry, VH; Navarro, X; Gomez-Nicola, D; Lopez-Vales, R; - view fewer (2016) CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves. Scientific Reports , 6 , Article 25663. 10.1038/srep25663.

McDade, E; Voytyuk, I; Aisen, P; Bateman, RJ; Carrillo, MC; De Strooper, B; Haass, C; ... Lichtenthaler, SE; + view all McDade, E; Voytyuk, I; Aisen, P; Bateman, RJ; Carrillo, MC; De Strooper, B; Haass, C; Reiman, EM; Sperling, R; Tariot, PN; Yan, R; Masters, CL; Vassar, R; Lichtenthaler, SE; - view fewer (2021) The case for low-level BACE1 inhibition for the prevention of Alzheimer disease. Nature Reviews Neurology , 17 (11) pp. 703-714. 10.1038/s41582-021-00545-1.

McInnes, J; Wierda, K; Snellinx, A; Bounti, L; Wang, Y-C; Stancu, I-C; Apóstolo, N; ... Verstreken, P; + view all McInnes, J; Wierda, K; Snellinx, A; Bounti, L; Wang, Y-C; Stancu, I-C; Apóstolo, N; Gevaert, K; Dewachter, I; Spires-Jones, TL; De Strooper, B; De Wit, J; Zhou, L; Verstreken, P; - view fewer (2018) Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron , 97 (4) 823-835.e8. 10.1016/j.neuron.2018.01.022.

Moonen, Sebastiaan; Koper, Marta J; Van Schoor, Evelien; Schaeverbeke, Jolien M; Vandenberghe, Rik; von Arnim, Christine AF; Tousseyn, Thomas; ... Thal, Dietmar Rudolf; + view all Moonen, Sebastiaan; Koper, Marta J; Van Schoor, Evelien; Schaeverbeke, Jolien M; Vandenberghe, Rik; von Arnim, Christine AF; Tousseyn, Thomas; De Strooper, Bart; Thal, Dietmar Rudolf; - view fewer (2022) Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta Neuropathologica 10.1007/s00401-022-02528-y. (In press).

Morgan, AR; Touchard, S; Leckey, C; O'Hagan, C; Nevado-Holgado, AJ; Barkhof, F; Bertram, L; ... Sheridan, H; + view all Morgan, AR; Touchard, S; Leckey, C; O'Hagan, C; Nevado-Holgado, AJ; Barkhof, F; Bertram, L; Blin, O; Bos, I; Dobricic, V; Engelborghs, S; Frisoni, G; Frölich, L; Gabel, S; Johannsen, P; Kettunen, P; Kłoszewska, I; Legido-Quigley, C; Lleó, A; Martinez-Lage, P; Mecocci, P; Meersmans, K; Molinuevo, JL; Peyratout, G; Popp, J; Richardson, J; Sala, I; Scheltens, P; Streffer, J; Soininen, H; Tainta-Cuezva, M; Teunissen, C; Tsolaki, M; Vandenberghe, R; Visser, PJ; Vos, S; Wahlund, LO; Wallin, A; Westwood, S; Zetterberg, H; Lovestone, S; Morgan, BP; Bullmore, ET; Bhatti, J; Chamberlain, SJ; Correia, MM; Crofts, AL; Dickinson, A; Foster, AC; Kitzbichler, MG; Knight, C; Lynall, ME; Maurice, C; O'Donnell, C; Pointon, LJ; St George Hyslop, P; Turner, L; Vertes, P; Widmer, B; Williams, GB; Leckey, CA; Cavanagh, J; Deith, C; Farmer, S; McClean, J; McColl, A; McPherson, A; Scouller, P; Sutherland, M; Boddeke, HWGM; Richardson, JC; Khan, S; Murphy, P; Parker, CA; Patel, J; Jones, D; de Boer, P; Kemp, J; Drevets, WC; Nye, JS; Wittenberg, G; Isaac, J; Bhattacharya, A; Carruthers, N; Kolb, H; Pariante, CM; Turkheimer, F; Barker, GJ; Byrom, H; Cash, D; Cattaneo, A; Gee, A; Hastings, C; Mariani, N; McLaughlin, A; Mondelli, V; Nettis, M; Nikkheslat, N; Randall, K; Sheridan, H; - view fewer (2019) Inflammatory biomarkers in Alzheimer's disease plasma. Alzheimer's and Dementia 10.1016/j.jalz.2019.03.007. (In press).

Murray, CE; Gami, P; Kiely, A; Salih, D; Holton, J; Lashley, T; (2016) Inflammatory gene expression profile in Alzheimer's disease. In: Proceedings of the 49th Miami 2016 Winter Symposium. Elsevier: Miami, FL, USA.

Murray, CE; Gami, P; Kiely, AP; Salih, D; Holton, J; Lashley, T; (2016) Inflammatory gene expression profiles in sporadic, familial and TREM2 variant Alzheimer's disease. Neuropathology and Applied Neurobiology , 42 (S1) , Article O09. 10.1111/nan.12307.

O

Obst, J; Simon, E; Martin-Estebane, M; Pipi, E; Barkwill, LM; Gonzalez-Rivera, I; Buchanan, F; ... Gomez-Nicola, D; + view all Obst, J; Simon, E; Martin-Estebane, M; Pipi, E; Barkwill, LM; Gonzalez-Rivera, I; Buchanan, F; Prescott, AR; Faust, D; Fox, S; Brownlees, J; Taylor, D; Perry, VH; Nuthall, H; Atkinson, PJ; Karran, E; Routledge, C; Gomez-Nicola, D; - view fewer (2020) Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration. Frontiers In Immunology , 11 , Article 579000. 10.3389/fimmu.2020.579000.

P

Paolicelli, RC; Sierra, A; Stevens, B; Tremblay, ME; Aguzzi, A; Ajami, B; Amit, I; ... Wyss-Coray, T; + view all Paolicelli, RC; Sierra, A; Stevens, B; Tremblay, ME; Aguzzi, A; Ajami, B; Amit, I; Audinat, E; Bechmann, I; Bennett, M; Bennett, F; Bessis, A; Biber, K; Bilbo, S; Blurton-Jones, M; Boddeke, E; Brites, D; Brône, B; Brown, GC; Butovsky, O; Carson, MJ; Castellano, B; Colonna, M; Cowley, SA; Cunningham, C; Davalos, D; De Jager, PL; de Strooper, B; Denes, A; Eggen, BJL; Eyo, U; Galea, E; Garel, S; Ginhoux, F; Glass, CK; Gokce, O; Gomez-Nicola, D; González, B; Gordon, S; Graeber, MB; Greenhalgh, AD; Gressens, P; Greter, M; Gutmann, DH; Haass, C; Heneka, MT; Heppner, FL; Hong, S; Hume, DA; Jung, S; Kettenmann, H; Kipnis, J; Koyama, R; Lemke, G; Lynch, M; Majewska, A; Malcangio, M; Malm, T; Mancuso, R; Masuda, T; Matteoli, M; McColl, BW; Miron, VE; Molofsky, AV; Monje, M; Mracsko, E; Nadjar, A; Neher, JJ; Neniskyte, U; Neumann, H; Noda, M; Peng, B; Peri, F; Perry, VH; Popovich, PG; Pridans, C; Priller, J; Prinz, M; Ragozzino, D; Ransohoff, RM; Salter, MW; Schaefer, A; Schafer, DP; Schwartz, M; Simons, M; Smith, CJ; Streit, WJ; Tay, TL; Tsai, LH; Verkhratsky, A; von Bernhardi, R; Wake, H; Wittamer, V; Wolf, SA; Wu, LJ; Wyss-Coray, T; - view fewer (2022) Microglia states and nomenclature: A field at its crossroads. Neuron , 110 (21) pp. 3458-3483. 10.1016/j.neuron.2022.10.020.

Pasciuto, E; Burton, OT; Roca, CP; Lagou, V; Rajan, WD; Theys, T; Mancuso, R; ... Liston, A; + view all Pasciuto, E; Burton, OT; Roca, CP; Lagou, V; Rajan, WD; Theys, T; Mancuso, R; Tito, RY; Kouser, L; Callaerts-Vegh, Z; de la Fuente, AG; Prezzemolo, T; Mascali, LG; Brajic, A; Whyte, CE; Yshii, L; Martinez-Muriana, A; Naughton, M; Young, A; Moudra, A; Lemaitre, P; Poovathingal, S; Raes, J; De Strooper, B; Fitzgerald, DC; Dooley, J; Liston, A; - view fewer (2020) Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell , 182 (3) 625-+. 10.1016/j.cell.2020.06.026.

Paudel, R; Kiely, A; Li, A; Lashley, T; Bandopadhyay, R; Hardy, J; Jinnah, HA; ... Holton, JL; + view all Paudel, R; Kiely, A; Li, A; Lashley, T; Bandopadhyay, R; Hardy, J; Jinnah, HA; Bhatia, K; Houlden, H; Holton, JL; - view fewer (2014) Neuropathological features of genetically confirmed DYT1 dystonia: investigating disease-specific inclusions. Acta Neuropathol Commun , 2 (1) , Article 159. 10.1186/s40478-014-0159-x.

Pegasiou, CM; Zolnourian, A; Gomez-Nicola, D; Deinhardt, K; Nicoll, JAR; Ahmed, AI; Vajramani, G; ... Vargas-Caballero, M; + view all Pegasiou, CM; Zolnourian, A; Gomez-Nicola, D; Deinhardt, K; Nicoll, JAR; Ahmed, AI; Vajramani, G; Grundy, P; Verhoog, MB; Mansvelder, HD; Perry, VH; Bulters, D; Vargas-Caballero, M; - view fewer (2020) Age-Dependent Changes in Synaptic NMDA Receptor Composition in Adult Human Cortical Neurons. Cerebral Cortex , 30 (7) pp. 4246-4256. 10.1093/cercor/bhaa052.

Penicud, K; (2012) The role of ATM regulatory proteins in DNA damage signalling. Doctoral thesis , UCL (University College London).

Petzold, A; Altintas, A; Laura, C; Bartos, A; Achim, F; Blankenstein, MA; Luc, H; ... Teunissen, CE; + view all Petzold, A; Altintas, A; Laura, C; Bartos, A; Achim, F; Blankenstein, MA; Luc, H; Castellazzi, M; Cepok, S; Comabella, M; Constantinescu, CS; Deisenhammer, F; Deniz, G; Gaye, M; Espino, M; Fainardi, E; Franciotta, D; Freedman, MS; Giedraitis, V; Gilhus, NE; Giovannoni, G; Glabinski, A; Grieb, P; Hartung, HP; Hemmer, B; Herukka, SK; Hintzen, R; Ingelsson, M; Jackson, S; Jacobsen, S; Jafari, N; Jalosinski, M; Jarius, S; Kapaki, E; Bernd, CV; Koel-Simmelink, MJA; Kornhuber, J; Kuhle, J; Kurzepa, J; Lalive, PH; Lannfelt, L; Lehmensiek, V; Lewczuk, P; Livrea, P; Marnetto, F; Martino, D; Menge, T; Norgren, N; Papuc, E; Paraskevas, GP; Pirttila, T; Rajda, C; Rejdak, K; Ricny, J; Ripova, D; Rosengren, L; Ruggieri, M; Schraen, S; Shaw, G; Sindic, C; Siva, A; Stigbrand, T; Stonebridge, I; Topcular, B; Trojano, M; Tumani, H; Twaalfhoven, HAM; Vecsei, L; Van Pesch, V; Vanderstichele, H; Vedeler, C; Verbeek, MM; Villar, LM; Weissert, R; Wildemann, B; Yang, C; Yao, K; Teunissen, CE; - view fewer (2010) Neurofilament ELISA validation. J IMMUNOL METHODS , 352 (1-2) 23 - 31. 10.1016/j.jim.2009.09.014.

Pigoni, M; Wanngren, J; Kuhn, P-H; Munro, KM; Gunnersen, JM; Takeshima, H; Feederle, R; ... Lichtenthaler, SF; + view all Pigoni, M; Wanngren, J; Kuhn, P-H; Munro, KM; Gunnersen, JM; Takeshima, H; Feederle, R; Voytyuk, I; De Strooper, B; Levasseur, MD; Hrupka, BJ; Mueller, SA; Lichtenthaler, SF; - view fewer (2016) Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons. Molecular Neurodegeneration , 11 (ARTN 67) 10.1186/s13024-016-0134-z.

Policarpo, R; Sierksma, A; De Strooper, B; d'Ydewalle, C; (2021) From Junk to Function: LncRNAs in CNS Health and Disease. Frontiers in Molecular Neuroscience , 14 , Article 714768. 10.3389/fnmol.2021.714768.

Poppe, L; Rué, L; Timmers, M; Lenaerts, A; Storm, A; Callaerts-Vegh, Z; Courtand, G; ... Lemmens, R; + view all Poppe, L; Rué, L; Timmers, M; Lenaerts, A; Storm, A; Callaerts-Vegh, Z; Courtand, G; De Boer, A; Smolders, S; Van Damme, P; Van den Bosch, L; D'Hooge, R; De Strooper, B; Robberecht, W; Lemmens, R; - view fewer (2019) EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease. Alzheimer's Research & Therapy , 11 , Article 102. 10.1186/s13195-019-0554-4.

Preman, P; Julia, TCW; Calafate, S; Snellinx, A; Alfonso-Triguero, M; Corthout, N; Munck, S; ... Arranz, AM; + view all Preman, P; Julia, TCW; Calafate, S; Snellinx, A; Alfonso-Triguero, M; Corthout, N; Munck, S; Thal, DR; Goate, AM; De Strooper, B; Arranz, AM; - view fewer (2021) Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-beta plaques. Molecular Neurodegeneration , 16 , Article 68. 10.1186/s13024-021-00487-8.

R

Rajewsky, N; Almouzni, G; Gorski, SA; Aerts, S; Amit, I; Bertero, MG; Bock, C; ... LifeTime Community; + view all Rajewsky, N; Almouzni, G; Gorski, SA; Aerts, S; Amit, I; Bertero, MG; Bock, C; Bredenoord, AL; Cavalli, G; Chiocca, S; Clevers, H; De Strooper, B; Eggert, A; Ellenberg, J; Fernández, XM; Figlerowicz, M; Gasser, SM; Hubner, N; Kjems, J; Knoblich, JA; Krabbe, G; Lichter, P; Linnarsson, S; Marine, J-C; Marioni, J; Marti-Renom, MA; Netea, MG; Nickel, D; Nollmann, M; Novak, HR; Parkinson, H; Piccolo, S; Pinheiro, I; Pombo, A; Popp, C; Reik, W; Roman-Roman, S; Rosenstiel, P; Schultze, JL; Stegle, O; Tanay, A; Testa, G; Thanos, D; Theis, FJ; Torres-Padilla, M-E; Valencia, A; Vallot, C; van Oudenaarden, A; Vidal, M; Voet, T; LifeTime Community; - view fewer (2020) LifeTime and improving European healthcare through cell-based interceptive medicine. Nature 10.1038/s41586-020-2715-9. (In press).

Rice, HC; de Malmazet, D; Schreurs, A; Frere, S; Van Molle, I; Volkov, AN; Creemers, E; ... de Wit, J; + view all Rice, HC; de Malmazet, D; Schreurs, A; Frere, S; Van Molle, I; Volkov, AN; Creemers, E; Vertkin, I; Nys, J; Ranaivoson, FM; Comoletti, D; Savas, JN; Remaut, H; Balschun, D; Wierda, KD; Slutsky, I; Farrow, K; De Strooper, B; de Wit, J; - view fewer (2019) Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission. Science , 363 (6423) 10.1126/science.aao4827.

Rice, HC; Marcassa, G; Chrysidou, I; Horré, K; Young-Pearse, TL; Müller, UC; Saito, T; ... De Strooper, B; + view all Rice, HC; Marcassa, G; Chrysidou, I; Horré, K; Young-Pearse, TL; Müller, UC; Saito, T; Saido, TC; Vassar, R; De Wit, J; De Strooper, B; - view fewer (2020) Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular Neurodegeneration , 15 , Article 3. 10.1186/s13024-019-0356-y.

Rué, L; Jaspers, T; Degors, IMS; Noppen, S; Schols, D; De Strooper, B; Dewilde, M; (2023) Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics. Pharmaceutics , 15 (6) , Article 1748. 10.3390/pharmaceutics15061748.

Ryan, NS; Nicholas, JM; Weston, PSJ; Liang, Y; Lashley, T; Guerreiro, R; Adamson, G; ... Fox, NC; + view all Ryan, NS; Nicholas, JM; Weston, PSJ; Liang, Y; Lashley, T; Guerreiro, R; Adamson, G; Kenny, J; Beck, J; Chavez-Gutierrez, L; de Strooper, B; Revesz, T; Holton, J; Mead, S; Rossor, MN; Fox, NC; - view fewer (2016) Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series. LANCET NEUROLOGY , 15 (13) pp. 1326-1335. 10.1016/S1474-4422(16)30193-4.

S

Sachse, SM; Lievens, S; Ribeiro, LF; Dascenco, D; Masschaele, D; Horré, K; Misbaer, A; ... Schmucker, D; + view all Sachse, SM; Lievens, S; Ribeiro, LF; Dascenco, D; Masschaele, D; Horré, K; Misbaer, A; Vanderroost, N; De Smet, AS; Salta, E; Erfurth, M-L; Kise, Y; Nebel, S; Van Delm, W; Plaisance, S; Tavernier, J; De Strooper, B; De Wit, J; Schmucker, D; - view fewer (2019) Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation. The EMBO Journal , 38 (6) , Article e99669. 10.15252/embj.201899669.

Sala Frigerio, C; Wolfs, L; Fattorelli, N; Thrupp, N; Voytyuk, I; Schmidt, I; Mancuso, R; ... De Strooper, B; + view all Sala Frigerio, C; Wolfs, L; Fattorelli, N; Thrupp, N; Voytyuk, I; Schmidt, I; Mancuso, R; Chen, WT; Woodbury, ME; Srivastava, G; Möller, T; Hudry, E; Das, S; Saido, T; Karran, E; Hyman, B; Perry, VH; Fiers, M; De Strooper, B; - view fewer (2019) The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Reports , 27 (4) pp. 1293-1306. 10.1016/j.celrep.2019.03.099.

Salas, IH; Callaerts-Vegh, Z; Arranz, AM; Guix, FX; D'Hooge, R; Esteban, JA; De Strooper, B; Salas, IH; Callaerts-Vegh, Z; Arranz, AM; Guix, FX; D'Hooge, R; Esteban, JA; De Strooper, B; Dotti, CG; - view fewer (2017) Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity. [Corrigendum]. PLoS One , 12 (10) , Article e0187179. 10.1371/journal.pone.0187179.

Salas, IH; Callaerts-Vegh, Z; Arranz, AM; Guix, FX; D'Hooge, R; Esteban, JA; De Strooper, B; Salas, IH; Callaerts-Vegh, Z; Arranz, AM; Guix, FX; D'Hooge, R; Esteban, JA; De Strooper, B; Dotti, CG; - view fewer (2017) Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity. [Corrigendum]. PLoS One , 12 (7) , Article e0178016. 10.1371/journal.pone.0178016.

Salas, IH; Callaerts-Vegh, Z; Arranz, AM; Guix, FX; D'Hooge, R; Esteban, JA; De Strooper, B; Salas, IH; Callaerts-Vegh, Z; Arranz, AM; Guix, FX; D'Hooge, R; Esteban, JA; De Strooper, B; Dotti, CG; - view fewer (2017) Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity. PLoS One , 12 (2) , Article e0171968. 10.1371/journal.pone.0171968.

Salas, IH; Callaerts-Vegh, Z; D'Hooge, R; Saido, TC; Dotti, CG; De Strooper, B; (2018) Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice. Journal of Alzheimer's Disease , 66 (2) pp. 801-809. 10.3233/JAD-180410.

Salas, IH; De Strooper, B; (2019) Diabetes and Alzheimer's Disease: A Link not as Simple as it Seems. Neurochemical Research , 44 (6) pp. 1271-1278. 10.1007/s11064-018-2690-9.

Salas, IH; Weerasekera, A; Ahmed, T; Callaerts-Vegh, Z; Himmelreich, U; D'Hooge, R; Balschun, D; ... De Strooper, B; + view all Salas, IH; Weerasekera, A; Ahmed, T; Callaerts-Vegh, Z; Himmelreich, U; D'Hooge, R; Balschun, D; Saido, TC; De Strooper, B; - view fewer (2018) High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease. Neurobiology of Disease , 113 pp. 82-96. 10.1016/j.nbd.2018.02.001.

Salta, E; De Strooper, B; (2017) microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease. The FASEB Journal , 31 (2) pp. 424-433. 10.1096/fj.201601308.

Salta, E; De Strooper, B; (2017) Noncoding RNAs in neurodegeneration. Nature Reviews Neuroscience , 18 pp. 627-640. 10.1038/nrn.2017.90.

Salta, E; Sierksma, A; Vanden Eynden, E; De Strooper, B; (2016) miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Molecular Medicine , 8 (9) pp. 1005-1018. 10.15252/emmm.201606520.

Sannerud, R; Esselens, C; Ejsmont, P; Mattera, R; Rochin, L; Tharkeshwar, AK; De Baets, G; ... Annaert, W; + view all Sannerud, R; Esselens, C; Ejsmont, P; Mattera, R; Rochin, L; Tharkeshwar, AK; De Baets, G; De Wever, V; Habets, R; Baert, V; Vermeire, W; Michiels, C; Groot, AJ; Wouters, R; Dillen, K; Vints, K; Baatsen, P; Munck, S; Derua, R; Waelkens, E; Basi, GS; Mercken, M; Vooijs, M; Bollen, M; Schymkowitz, J; Rousseau, F; Bonifacino, JS; Van Niel, G; De Strooper, B; Annaert, W; - view fewer (2016) Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool. Cell , 166 (1) pp. 193-208. 10.1016/j.cell.2016.05.020.

Sasaguri, H; Nilsson, P; Hashimoto, S; Nagata, K; Saito, T; De Strooper, B; Hardy, J; ... Saido, TC; + view all Sasaguri, H; Nilsson, P; Hashimoto, S; Nagata, K; Saito, T; De Strooper, B; Hardy, J; Vassar, R; Winblad, B; Saido, TC; - view fewer (2017) APP mouse models for Alzheimer's disease preclinical studies. The EMBO Journal , 36 , Article e201797397. 10.15252/embj.201797397.

Sassi, Y; Avramopoulos, P; Ramanujam, D; Grueter, L; Werfel, S; Giosele, S; Brunner, A-D; ... Engelhardt, S; + view all Sassi, Y; Avramopoulos, P; Ramanujam, D; Grueter, L; Werfel, S; Giosele, S; Brunner, A-D; Esfandyari, D; Papadopoulou, AS; De Strooper, B; Huebner, N; Kumarswamy, R; Thum, T; Yin, X; Mayr, M; Laggerbauer, B; Engelhardt, S; - view fewer (2017) Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nature Communications , 8 , Article 1614. 10.1038/s41467-017-01737-4.

Scheltens, P; De Strooper, B; Kivipelto, M; Holstege, H; Chételat, G; Teunissen, CE; Cummings, J; Scheltens, P; De Strooper, B; Kivipelto, M; Holstege, H; Chételat, G; Teunissen, CE; Cummings, J; van der Flier, WM; - view fewer (2021) Alzheimer's disease. The Lancet , 397 (10284) pp. 1577-1590. 10.1016/S0140-6736(20)32205-4.

Schoonaert, L; Rué, L; Roucourt, B; Timmers, M; Little, S; Chávez-Gutiérrez, L; Dewilde, M; ... Robberecht, W; + view all Schoonaert, L; Rué, L; Roucourt, B; Timmers, M; Little, S; Chávez-Gutiérrez, L; Dewilde, M; Joyce, P; Curnock, A; Weber, P; Haustraete, J; Hassanzadeh-Ghassabeh, G; De Strooper, B; Van Den Bosch, L; Van Damme, P; Lemmens, R; Robberecht, W; - view fewer (2017) Identification and characterization of Nanobodies targeting the EphA4 receptor. Journal of Biological Chemistry , 292 (27) pp. 11452-11465. 10.1074/jbc.M116.774141.

Schottlaender, LV; Bettencourt, C; Kiely, AP; Chalasani, A; Neergheen, V; Holton, JL; Hargreaves, I; Schottlaender, LV; Bettencourt, C; Kiely, AP; Chalasani, A; Neergheen, V; Holton, JL; Hargreaves, I; Houlden, H; - view fewer (2016) Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients. PLoS One , 11 (2) , Article e0149557. 10.1371/journal.pone.0149557.

Sepulveda-Falla, D; Chavez-Gutierrez, L; Portelius, E; Vélez, JI; Dujardin, S; Barrera-Ocampo, A; Dinkel, F; ... Glatzel, M; + view all Sepulveda-Falla, D; Chavez-Gutierrez, L; Portelius, E; Vélez, JI; Dujardin, S; Barrera-Ocampo, A; Dinkel, F; Hagel, C; Puig, B; Mastronardi, C; Lopera, F; Hyman, BT; Blennow, K; Arcos-Burgos, M; de Strooper, B; Glatzel, M; - view fewer (2020) A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease. Acta Neuropathologica 10.1007/s00401-020-02249-0. (In press).

Serneels, Lutgarde; Narlawar, Rajeshwar; Perez-Benito, Laura; Municoy, Marti; Guallar, Victor; T'Syen, Dries; Dewilde, Maarten; ... De Strooper, Bart; + view all Serneels, Lutgarde; Narlawar, Rajeshwar; Perez-Benito, Laura; Municoy, Marti; Guallar, Victor; T'Syen, Dries; Dewilde, Maarten; Bischoff, François; Fraiponts, Erwin; Tresadern, Gary; Roevens, Peter WM; Gijsen, Harrie JM; De Strooper, Bart; - view fewer (2023) Selective inhibitors of the PSEN1–gamma-secretase complex. Journal of Biological Chemistry (JBC) , 299 (6) , Article 104794. 10.1016/j.jbc.2023.104794. (In press).

Serneels, L; T'Syen, D; Perez-Benito, L; Theys, T; Holt, MG; De Strooper, B; (2020) Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease. Molecular Neurodegeneration , 15 , Article 60. 10.1186/s13024-020-00399-z.

Shah, D; Gsell, W; Wahis, J; Luckett, ES; Jamoulle, T; Vermaercke, B; Preman, P; ... De Strooper, B; + view all Shah, D; Gsell, W; Wahis, J; Luckett, ES; Jamoulle, T; Vermaercke, B; Preman, P; Moechars, D; Hendrickx, V; Jaspers, T; Craessaerts, K; Horré, K; Wolfs, L; Fiers, M; Holt, M; Thal, DR; Callaerts-Vegh, Z; D'Hooge, R; Vandenberghe, R; Himmelreich, U; Bonin, V; De Strooper, B; - view fewer (2022) Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease. Cell Reports , 40 (8) , Article 111280. 10.1016/j.celrep.2022.111280.

Shah, D; Latif-Hernandez, A; De Strooper, B; Saito, T; Saido, T; Verhoye, M; D'Hooge, R; Shah, D; Latif-Hernandez, A; De Strooper, B; Saito, T; Saido, T; Verhoye, M; D'Hooge, R; Van der Linden, A; - view fewer (2018) Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP(NL-F/NL-F) knock-in mice. Scientific Reports , 8 , Article 6264. 10.1038/s41598-018-24657-9.

Sierksma, A; Escott-Price, V; De Strooper, B; (2020) Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets. Science , 370 (6512) pp. 61-66. 10.1126/science.abb8575.

Sierksma, A; Lu, A; Mancuso, R; Fattorelli, N; Thrupp, N; Salta, E; Zoco, J; ... Fiers, M; + view all Sierksma, A; Lu, A; Mancuso, R; Fattorelli, N; Thrupp, N; Salta, E; Zoco, J; Blum, D; Buée, L; De Strooper, B; Fiers, M; - view fewer (2020) Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology. EMBO Molecular Medicine , Article e10606. 10.15252/emmm.201910606. (In press).

Sierksma, A; Lu, A; Salta, E; Vanden Eynden, E; Callaerts-Vegh, Z; D'Hooge, R; Blum, D; ... De Strooper, B; + view all Sierksma, A; Lu, A; Salta, E; Vanden Eynden, E; Callaerts-Vegh, Z; D'Hooge, R; Blum, D; Buée, L; Fiers, M; De Strooper, B; - view fewer (2018) Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology. Molecular Neurodegeneration , 13 (54) 10.1186/s13024-018-0285-1.

Sisay, S; Pryce, G; Jackson, SJ; Tanner, C; Ross, RA; Michael, GJ; Selwood, DL; ... Baker, D; + view all Sisay, S; Pryce, G; Jackson, SJ; Tanner, C; Ross, RA; Michael, GJ; Selwood, DL; Giovannoni, G; Baker, D; - view fewer (2013) Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis. PLoS One , 8 (10) , Article e76907. 10.1371/journal.pone.0076907.

Soldano, A; Okray, Z; Janovska, P; Tmejová, K; Reynaud, E; Claeys, A; Yan, J; ... Hassan, BA; + view all Soldano, A; Okray, Z; Janovska, P; Tmejová, K; Reynaud, E; Claeys, A; Yan, J; Atak, ZK; De Strooper, B; Dura, JM; Bryja, V; Hassan, BA; - view fewer (2013) The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. PLoS Biology , 11 (5) , Article e1001562. 10.1371/journal.pbio.1001562.

Soukup, S-F; Kuenen, S; Vanhauwaert, R; Manetsberger, J; Hernández-Díaz, S; Swerts, J; Schoovaerts, N; ... Verstreken, P; + view all Soukup, S-F; Kuenen, S; Vanhauwaert, R; Manetsberger, J; Hernández-Díaz, S; Swerts, J; Schoovaerts, N; Vilain, S; Gounko, NV; Vints, K; Geens, A; De Strooper, B; Verstreken, P; - view fewer (2016) A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals. Neuron , 92 (4) pp. 829-844. 10.1016/j.neuron.2016.09.037.

Spinazzi, M; De Strooper, B; (2016) PARL: The mitochondrial rhomboid protease. Seminars in Cell & Developmental Biology , 60 pp. 19-28. 10.1016/j.semcdb.2016.07.034.

Spinazzi, M; Radaelli, E; Horré, K; Arranz, AM; Gounko, NV; Agostinis, P; Maia, TM; ... De Strooper, B; + view all Spinazzi, M; Radaelli, E; Horré, K; Arranz, AM; Gounko, NV; Agostinis, P; Maia, TM; Impens, F; Morais, VA; Lopez-Lluch, G; Serneels, L; Navas, P; De Strooper, B; - view fewer (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proceedings of the National Academy of Sciences (PNAS) , 116 (1) pp. 277-286. 10.1073/pnas.1811938116.

Sri, S; Pegasiou, C-M; Cave, CA; Hough, K; Wood, N; Gomez-Nicola, D; Deinhardt, K; ... Vargas-Caballero, M; + view all Sri, S; Pegasiou, C-M; Cave, CA; Hough, K; Wood, N; Gomez-Nicola, D; Deinhardt, K; Bannerman, D; Perry, VH; Vargas-Caballero, M; - view fewer (2019) Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease. Acta Neuropathologica Communications , 7 , Article 25. 10.1186/s40478-019-0670-1.

Stevenson-Hoare, Joshua; Heslegrave, Amanda; Leonenko, Ganna; Fathalla, Dina; Bellou, Eftychia; Luckcuck, Lauren; Marshall, Rachel; ... Escott-Price, Valentina; + view all Stevenson-Hoare, Joshua; Heslegrave, Amanda; Leonenko, Ganna; Fathalla, Dina; Bellou, Eftychia; Luckcuck, Lauren; Marshall, Rachel; Sims, Rebecca; Morgan, Bryan Paul; Hardy, John; de Strooper, Bart; Williams, Julie; Zetterberg, Henrik; Escott-Price, Valentina; - view fewer (2022) Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease. Brain 10.1093/brain/awac128. (In press).

Stuart, CM; Varatharaj, A; Domjan, J; Philip, S; Galea, I; Adams, E; Ali, R; ... Zotova, E; + view all Stuart, CM; Varatharaj, A; Domjan, J; Philip, S; Galea, I; Adams, E; Ali, R; Cader, S; Chartres, S; Cornick, F; Darekar, A; Fenn, M; Furby, J; Guillochon, R; Halfpenny, C; Hillier, C; Hyde, R; Jacob, C; Jarman, E; Nabag, M; O’Neill, A; Perry, VH; Sayce, C; Spanoulis, A; Temple-Brown, C; Zotova, E; - view fewer (2020) Physical activity monitoring to assess disability progression in multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical , 6 (4) 10.1177/2055217320975185.

Szaruga, M; Munteanu, B; Lismont, S; Veugelen, S; Horré, K; Mercken, M; Saido, TC; ... Chávez-Gutiérrez, L; + view all Szaruga, M; Munteanu, B; Lismont, S; Veugelen, S; Horré, K; Mercken, M; Saido, TC; Ryan, NS; De Vos, T; Savvides, SN; Gallardo, R; Schymkowitz, J; Rousseau, F; Fox, NC; Hopf, C; De Strooper, B; Chávez-Gutiérrez, L; - view fewer (2017) Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions. Cell , 170 (3) pp. 443-456. 10.1016/j.cell.2017.07.004.

Szaruga, M; Veugelen, S; Benurwar, M; Lismont, S; Sepulveda-Falla, D; Lleo, A; Ryan, NS; ... Chávez-Gutiérrez, L; + view all Szaruga, M; Veugelen, S; Benurwar, M; Lismont, S; Sepulveda-Falla, D; Lleo, A; Ryan, NS; Lashley, T; Fox, NC; Murayama, S; Gijsen, H; De Strooper, B; Chávez-Gutiérrez, L; - view fewer (2015) Qualitative changes in human γ-secretase underlie familial Alzheimer's disease. Journal of Experimental Medicine , 212 (12) pp. 2003-2013. 10.1084/jem.20150892.

T

Thrupp, N; Sala Frigerio, C; Wolfs, L; Skene, NG; Fattorelli, N; Poovathingal, S; Fourne, Y; ... Fiers, M; + view all Thrupp, N; Sala Frigerio, C; Wolfs, L; Skene, NG; Fattorelli, N; Poovathingal, S; Fourne, Y; Matthews, PM; Theys, T; Mancuso, R; de Strooper, B; Fiers, M; - view fewer (2020) Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans. Cell Reports , 32 (13) , Article 108189. 10.1016/j.celrep.2020.108189.

Timmers, M; Barão, S; Van Broeck, B; Tesseur, I; Slemmon, J; De Waepenaert, K; Bogert, J; ... Streffer, JR; + view all Timmers, M; Barão, S; Van Broeck, B; Tesseur, I; Slemmon, J; De Waepenaert, K; Bogert, J; Shaw, LM; Engelborghs, S; Moechars, D; Mercken, M; Van Nueten, L; Tritsmans, L; de Strooper, B; Streffer, JR; - view fewer (2017) BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants. Journal of Alzheimer's Disease , 56 (4) pp. 1437-1449. 10.3233/JAD-160829.

U

Ungureanu, AA; Benilova, I; Krylychkina, O; Braeken, D; De Strooper, B; Van Haesendonck, C; Dotti, CG; Ungureanu, AA; Benilova, I; Krylychkina, O; Braeken, D; De Strooper, B; Van Haesendonck, C; Dotti, CG; Bartic, C; - view fewer (2016) Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons. Scientific Reports , 6 , Article 25841. 10.1038/srep25841.

V

Vandenabeele, M; Veys, L; Lemmens, S; Hadoux, X; Gelders, G; Masin, L; Serneels, L; ... De Groef, L; + view all Vandenabeele, M; Veys, L; Lemmens, S; Hadoux, X; Gelders, G; Masin, L; Serneels, L; Theunis, J; Saito, T; Saido, TC; Jayapala, M; De Boever, P; De Strooper, B; Stalmans, I; van Wijngaarden, P; Moons, L; De Groef, L; - view fewer (2021) The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathologica Communications , 9 , Article 6. 10.1186/s40478-020-01102-5.

Vargas-Caballero, M; Willaime-Morawek, S; Gomez-Nicola, D; Perry, VH; Bulters, D; Mudher, A; (2016) The use of human neurons for novel drug discovery in dementia research. Expert Opinion on Drug Discovery , 11 (4) pp. 355-367. 10.1517/17460441.2016.1154528.

Veugelen, S; Saito, T; Saido, TC; Chavez-Gutierrez, L; De Strooper, B; (2016) Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Ab Peptide Seeds. Neuron , 90 (2) pp. 410-416. 10.1016/j.neuron.2016.03.010.

Vilain, S; Esposito, G; Haddad, D; Schaap, O; Dobreva, MP; Vos, M; Van Meensel, S; ... Verstreken, P; + view all Vilain, S; Esposito, G; Haddad, D; Schaap, O; Dobreva, MP; Vos, M; Van Meensel, S; Morais, VA; De Strooper, B; Verstreken, P; - view fewer (2012) The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. PLoS Genetics , 8 (1) , Article e1002456. 10.1371/journal.pgen.1002456.

Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A; Abrams, John M; Adam, Dieter; Agostini, Massimiliano; ... Galluzzi, Lorenzo; + view all Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A; Abrams, John M; Adam, Dieter; Agostini, Massimiliano; Agostinis, Patrizia; Alnemri, Emad S; Altucci, Lucia; Amelio, Ivano; Andrews, David W; Aqeilan, Rami I; Arama, Eli; Baehrecke, Eric H; Balachandran, Siddharth; Bano, Daniele; Barlev, Nickolai A; Bartek, Jiri; Bazan, Nicolas G; Becker, Christoph; Bernassola, Francesca; Bertrand, Mathieu JM; Bianchi, Marco E; Blagosklonny, Mikhail V; Blander, J Magarian; Blandino, Giovanni; Blomgren, Klas; Borner, Christoph; Bortner, Carl D; Bove, Pierluigi; Boya, Patricia; Brenner, Catherine; Broz, Petr; Brunner, Thomas; Damgaard, Rune Busk; Calin, George A; Campanella, Michelangelo; Candi, Eleonora; Carbone, Michele; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chen, Guo-Qiang; Chen, Quan; Chen, Youhai H; Cheng, Emily H; Chipuk, Jerry E; Cidlowski, John A; Ciechanover, Aaron; Ciliberto, Gennaro; Conrad, Marcus; Cubillos-Ruiz, Juan R; Czabotar, Peter E; D'Angiolella, Vincenzo; Daugaard, Mads; Dawson, Ted M; Dawson, Valina L; De Maria, Ruggero; De Strooper, Bart; Debatin, Klaus-Michael; Deberardinis, Ralph J; Degterev, Alexei; Del Sal, Giannino; Deshmukh, Mohanish; Di Virgilio, Francesco; Diederich, Marc; Dixon, Scott J; Dynlacht, Brian D; El-Deiry, Wafik S; Elrod, John W; Engeland, Kurt; Fimia, Gian Maria; Galassi, Claudia; Ganini, Carlo; Garcia-Saez, Ana J; Garg, Abhishek D; Garrido, Carmen; Gavathiotis, Evripidis; Gerlic, Motti; Ghosh, Sourav; Green, Douglas R; Greene, Lloyd A; Gronemeyer, Hinrich; Häcker, Georg; Hajnóczky, György; Hardwick, J Marie; Haupt, Ygal; He, Sudan; Heery, David M; Hengartner, Michael O; Hetz, Claudio; Hildeman, David A; Ichijo, Hidenori; Inoue, Satoshi; Jäättelä, Marja; Janic, Ana; Joseph, Bertrand; Jost, Philipp J; Kanneganti, Thirumala-Devi; Karin, Michael; Kashkar, Hamid; Kaufmann, Thomas; Kelly, Gemma L; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N; Klionsky, Daniel J; Kluck, Ruth; Krysko, Dmitri V; Kulms, Dagmar; Kumar, Sharad; Lavandero, Sergio; Lavrik, Inna N; Lemasters, John J; Liccardi, Gianmaria; Linkermann, Andreas; Lipton, Stuart A; Lockshin, Richard A; López-Otín, Carlos; Luedde, Tom; MacFarlane, Marion; Madeo, Frank; Malorni, Walter; Manic, Gwenola; Mantovani, Roberto; Marchi, Saverio; Marine, Jean-Christophe; Martin, Seamus J; Martinou, Jean-Claude; Mastroberardino, Pier G; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Gerry; Melino, Sonia; Miao, Edward A; Moll, Ute M; Muñoz-Pinedo, Cristina; Murphy, Daniel J; Niklison-Chirou, Maria Victoria; Novelli, Flavia; Núñez, Gabriel; Oberst, Andrew; Ofengeim, Dimitry; Opferman, Joseph T; Oren, Moshe; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M; Pentimalli, Francesca; Pereira, David M; Pervaiz, Shazib; Peter, Marcus E; Pinton, Paolo; Porta, Giovanni; Prehn, Jochen HM; Puthalakath, Hamsa; Rabinovich, Gabriel A; Rajalingam, Krishnaraj; Ravichandran, Kodi S; Rehm, Markus; Ricci, Jean-Ehrland; Rizzuto, Rosario; Robinson, Nirmal; Rodrigues, Cecilia MP; Rotblat, Barak; Rothlin, Carla V; Rubinsztein, David C; Rudel, Thomas; Rufini, Alessandro; Ryan, Kevin M; Sarosiek, Kristopher A; Sawa, Akira; Sayan, Emre; Schroder, Kate; Scorrano, Luca; Sesti, Federico; Shao, Feng; Shi, Yufang; Sica, Giuseppe S; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stephanou, Anastasis; Stockwell, Brent R; Strapazzon, Flavie; Strasser, Andreas; Sun, Liming; Sun, Erwei; Sun, Qiang; Szabadkai, Gyorgy; Tait, Stephen WG; Tang, Daolin; Tavernarakis, Nektarios; Troy, Carol M; Turk, Boris; Urbano, Nicoletta; Vandenabeele, Peter; Vanden Berghe, Tom; Vander Heiden, Matthew G; Vanderluit, Jacqueline L; Verkhratsky, Alexei; Villunger, Andreas; von Karstedt, Silvia; Voss, Anne K; Vousden, Karen H; Vucic, Domagoj; Vuri, Daniela; Wagner, Erwin F; Walczak, Henning; Wallach, David; Wang, Ruoning; Wang, Ying; Weber, Achim; Wood, Will; Yamazaki, Takahiro; Yang, Huang-Tian; Zakeri, Zahra; Zawacka-Pankau, Joanna E; Zhang, Lin; Zhang, Haibing; Zhivotovsky, Boris; Zhou, Wenzhao; Piacentini, Mauro; Kroemer, Guido; Galluzzi, Lorenzo; - view fewer (2023) Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death & Differentiation , 30 pp. 1097-1154. 10.1038/s41418-023-01153-w.

Vos, M; Geens, A; Böhm, C; Deaulmerie, L; Swerts, J; Rossi, M; Craessaerts, K; ... Verstreken, P; + view all Vos, M; Geens, A; Böhm, C; Deaulmerie, L; Swerts, J; Rossi, M; Craessaerts, K; Leites, EP; Seibler, P; Rakovic, A; Lohnau, T; De Strooper, B; Fendt, SM; Morais, VA; Klein, C; Verstreken, P; - view fewer (2017) Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency. Journal of Cell Biology , 216 (3) , Article 695. 10.1083/jcb.201511044.

Voytyuk, I; De Strooper, B; Chávez-Gutiérrez, L; (2017) Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease. Biological Psychiatry , 83 (4) 10.1016/j.biopsych.2017.08.001.

Voytyuk, I; Mueller, SA; Herber, J; Snellinx, A; Moechars, D; van Loo, G; Lichtenthaler, SF; Voytyuk, I; Mueller, SA; Herber, J; Snellinx, A; Moechars, D; van Loo, G; Lichtenthaler, SF; De Strooper, B; - view fewer (2018) BACE2 distribution in major brain cell types and identification of novel substrates. Life Science Alliance , 1 (1) , Article e201800026. 10.26508/lsa.201800026.

W

Walgrave, H; Penning, A; Tosoni, G; Snoeck, S; Davie, K; Davis, E; Wolfs, L; ... Salta, E; + view all Walgrave, H; Penning, A; Tosoni, G; Snoeck, S; Davie, K; Davis, E; Wolfs, L; Sierksma, A; Mars, M; Bu, T; Thrupp, N; Zhou, L; Moechars, D; Mancuso, R; Fiers, M; Howden, AJM; De Strooper, B; Salta, E; - view fewer (2023) microRNA-132 regulates gene expression programs involved in microglial homeostasis. iScience , 26 (6) , Article 106829. 10.1016/j.isci.2023.106829.

Walgrave, H; Zhou, L; De Strooper, B; Salta, E; (2021) The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives. Molecular Neurodegeneration , 16 , Article 76. 10.1186/s13024-021-00496-7.

Walgrave, H; Balusu, S; Snoeck, S; Vanden Eynden, E; Craessaerts, K; Thrupp, N; Wolfs, L; ... Salta, E; + view all Walgrave, H; Balusu, S; Snoeck, S; Vanden Eynden, E; Craessaerts, K; Thrupp, N; Wolfs, L; Horré, K; Fourne, Y; Ronisz, A; Silajdžić, E; Penning, A; Tosoni, G; Callaerts-Vegh, Z; D'Hooge, R; Thal, DR; Zetterberg, H; Thuret, S; Fiers, M; Frigerio, CS; De Strooper, B; Salta, E; - view fewer (2021) Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease. Cell Stem Cell 10.1016/j.stem.2021.05.001. (In press).

Wiseman, FK; Pulford, LJ; Barkus, C; Liao, F; Portelius, E; Webb, R; Chávez-Gutiérrez, L; ... Fisher, EMC; + view all Wiseman, FK; Pulford, LJ; Barkus, C; Liao, F; Portelius, E; Webb, R; Chávez-Gutiérrez, L; Cleverley, K; Noy, S; Sheppard, O; Collins, T; Powell, C; Sarell, CJ; Rickman, M; Choong, X; Tosh, JL; Siganporia, C; Whittaker, HT; Stewart, F; Szaruga, M; London Down syndrome consortium, .; Murphy, MP; Blennow, K; de Strooper, B; Zetterberg, H; Bannerman, D; Holtzman, DM; Tybulewicz, VLJ; Fisher, EMC; - view fewer (2018) Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP. Brain , 141 (8) pp. 2457-2474. 10.1093/brain/awy159.

Wouters, Yessica; Jaspers, Tom; Rue, Laura; Serneels, Lutgarde; De Strooper, Bart; Dewilde, Maarten; (2022) VHHs as tools for therapeutic protein delivery to the central nervous system. Fluids and Barriers of the CNS , 19 (1) , Article 79. 10.1186/s12987-022-00374-4.

Wouters, Y; Jaspers, T; De Strooper, B; Dewilde, M; (2020) Identification and in vivo characterization of a brain-penetrating nanobody. Fluids Barriers CNS , 17 , Article 62. 10.1186/s12987-020-00226-z.

Y

Yshii, Lidia; Pasciuto, Emanuela; Bielefeld, Pascal; Mascali, Loriana; Lemaitre, Pierre; Marino, Marika; Dooley, James; ... Liston, Adrian; + view all Yshii, Lidia; Pasciuto, Emanuela; Bielefeld, Pascal; Mascali, Loriana; Lemaitre, Pierre; Marino, Marika; Dooley, James; Kouser, Lubna; Verschoren, Stijn; Lagou, Vasiliki; Kemps, Hannelore; Gervois, Pascal; de Boer, Antina; Burton, Oliver T; Wahis, Jerome; Verhaert, Jens; Tareen, Samar; Roca, Carlos P; Singh, Kailash; Whyte, Carly E; Kerstens, Axelle; Callaerts-Vegh, Zsuzsanna; Poovathingal, Suresh; Prezzemolo, Teresa; Wierda, Keimpe; Dashwood, Amy; Xie, Junhua; Van Wonterghem, Elien; Creemers, Eline; Aloulou, Meryem; Gsell, Willy; Abiega, Oihane; Munck, Sebastian; Vandenbroucke, Roosmarijn E; Bronckaers, Annelies; Lemmens, Robin; De Strooper, Bart; Van Den Bosch, Ludo; Himmelreich, Uwe; Fitzsimons, Carlos P; Holt, Matthew G; Liston, Adrian; - view fewer (2022) Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nature Immunology , 23 pp. 878-891. 10.1038/s41590-022-01208-z.

Z

Zamparo, I; Francia, S; Franchi, SA; Redolfi, N; Costanzi, E; Kerstens, A; Fukutani, Y; ... Lodovichi, C; + view all Zamparo, I; Francia, S; Franchi, SA; Redolfi, N; Costanzi, E; Kerstens, A; Fukutani, Y; Battistutta, R; Polverino de Laureto, P; Munck, S; De Strooper, B; Matsunami, H; Lodovichi, C; - view fewer (2019) Axonal Odorant Receptors Mediate Axon Targeting. Cell Reports , 29 (13) 4334-4348.e7. 10.1016/j.celrep.2019.11.099.

Zhou, L; McInnes, J; Wierda, K; Holt, M; Herrmann, AG; Jackson, RJ; Wang, Y-C; ... Verstreken, P; + view all Zhou, L; McInnes, J; Wierda, K; Holt, M; Herrmann, AG; Jackson, RJ; Wang, Y-C; Swerts, J; Beyens, J; Miskiewicz, K; Vilain, S; Dewachter, I; Moechars, D; De Strooper, B; Spires-Jones, TL; De Wit, J; Verstreken, P; - view fewer (2017) Tau association with synaptic vesicles causes presynaptic dysfunction. Nat Commun , 8 , Article 15295. 10.1038/ncomms15295.

This list was generated on Fri Nov 7 00:35:34 2025 GMT.