Cerofolini, L;
Ravera, E;
Bologna, S;
Wiglenda, T;
Böddrich, A;
Purfürst, B;
Benilova, I;
... Luchinat, C; + view all
(2020)
Mixing Aβ(1–40) and Aβ(1–42) peptides generates unique amyloid fibrils.
Chemical Communications
10.1039/d0cc02463e.
(In press).
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Abstract
Recent structural studies show distinct morphologies for the fibrils of Aβ(1–42) and Aβ(1–40), which are believed not to co-fibrillize. We describe here a novel, structurally-uniform 1 : 1 mixed fibrillar species, which differs from both pure fibrils. It forms preferentially even when Aβ(1–42) : Aβ(1–40) peptides are mixed in a non-stoichiometric ratio.
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