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The Nature of Shared Cortical Variability

Lin, IC; Okun, M; Carandini, M; Harris, KD; (2015) The Nature of Shared Cortical Variability. Neuron , 87 (3) pp. 644-656. 10.1016/j.neuron.2015.06.035. Green open access

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Abstract

Neuronal responses of sensory cortex are highly variable, and this variability is correlated across neurons. To assess how variability reflects factors shared across a neuronal population, we analyzed the activity of many simultaneously recorded neurons in visual cortex. We developed a simple model that comprises two sources of shared variability: a multiplicative gain, which uniformly scales each neuron's sensory drive, and an additive offset, which affects different neurons to different degrees. This model captured the variability of spike counts and reproduced the dependence of pairwise correlations on neuronal tuning and stimulus orientation. The relative contributions of the additive and multiplicative fluctuations could vary over time and had marked impact on population coding. These observations indicate that shared variability of neuronal populations in sensory cortex can be largely explained by two factors that modulate the whole population.

Type: Article
Title: The Nature of Shared Cortical Variability
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2015.06.035
Publisher version: http://dx.doi.org/10.1016/j.neuron.2015.06.035
Language: English
Additional information: This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/)
Keywords: Action Potentials, Animals, Cats, Mice, Models, Neurological, Photic Stimulation, Visual Cortex
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ
URI: https://discovery.ucl.ac.uk/id/eprint/1472416
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