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The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives

Walgrave, H; Zhou, L; De Strooper, B; Salta, E; (2021) The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives. Molecular Neurodegeneration , 16 , Article 76. 10.1186/s13024-021-00496-7. Green open access

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Abstract

Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from their initial discovery to the cumulative appreciation of their regulatory potential in healthy and diseased brain. However, systematic interrogation of putative therapeutic or toxic effects of microRNAs in (models of) Alzheimer’s disease is currently missing and fundamental research findings are yet to be translated into clinical applications. Here, we review the literature to summarize the knowledge on microRNA regulation in Alzheimer’s pathophysiology and to critically discuss whether and to what extent these increasing insights can be exploited for the development of microRNA-based therapeutics in the clinic.

Type: Article
Title: The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s13024-021-00496-7
Publisher version: https://doi.org/10.1186/s13024-021-00496-7
Language: English
Additional information: © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, microRNA, Alzheimer's disease, therapeutics, neurodegenerative diseases, AMYLOID PRECURSOR PROTEIN, CHRONIC HEPATITIS-C, NF-KAPPA-B, ADENOASSOCIATED VIRUS, CELLULAR-PHASE, NONCODING RNA, DOUBLE-BLIND, MOUSE MODEL, OPEN-LABEL, IN-VITRO
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ
URI: https://discovery.ucl.ac.uk/id/eprint/10141725
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