Voytyuk, I;
De Strooper, B;
Chávez-Gutiérrez, L;
(2017)
Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease.
Biological Psychiatry
, 83
(4)
10.1016/j.biopsych.2017.08.001.
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Abstract
The genetic evidence implicating amyloid-β in the initial stage of Alzheimer's disease is unequivocal. However, the long biochemical and cellular prodromal phases of the disease suggest that dementia is the result of a series of molecular and cellular cascades whose nature and connections remain unknown. Therefore, it is unlikely that treatments directed at amyloid-β will have major clinical effects in the later stages of the disease. We discuss the two major candidate therapeutic targets to lower amyloid-β in a preventive mode, i.e., γ- and β-secretase; the rationale behind these two targets; and the current state of the field.
| Type: | Article |
|---|---|
| Title: | Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.biopsych.2017.08.001 |
| Publisher version: | http://dx.doi.org/10.1016/j.biopsych.2017.08.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimer, Amyloid-β, Prevention, Therapy, β-Secretase, γ-Secretase |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1575395 |
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