Spinazzi, M;
De Strooper, B;
(2016)
PARL: The mitochondrial rhomboid protease.
Seminars in Cell & Developmental Biology
, 60
pp. 19-28.
10.1016/j.semcdb.2016.07.034.
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Abstract
The rhomboid family comprises evolutionary conserved intramembrane proteases involved in a wide spectrum of biologically relevant activities. A mitochondrion-localized rhomboid, called PARL in mammals, and conserved in yeast and Drosophila as RBD1/PCP1 and rho-7, respectively, plays an indispensable role in cell homeostasis as illustrated by the severe phenotypes caused by its genetic ablation in the various investigated species. Although several substrates of PARL have been proposed to explain these phenotypes, there remains a lot of controversy in this important area of research. We review here the putative functions and substrates of PARL and its orthologues in different species, highlighting areas of uncertainty, and discuss its potential involvement in some prevalent diseases such as type II diabetes and Parkinson’s disease.
| Type: | Article |
|---|---|
| Title: | PARL: The mitochondrial rhomboid protease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.semcdb.2016.07.034 |
| Publisher version: | https://doi.org/10.1016/j.semcdb.2016.07.034 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Cell Biology, Developmental Biology, Parl, Rhomboid, Mitochondria, Protease, Cell Death, Metabolism, M-AAA PROTEASE, MND2 Mutant Mice, Serine-Protease, Parkinsons-Disease, PINK1-Dependent Phosphorylation, Intramembrane Proteolysis, Activate Parkin, Ubiquitin, Cleavage, PINK1 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1541603 |
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