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Probing gamma-secretase-substrate interactions at the single amino acid residue level

Chavez-Gutierrez, L; De Strooper, B; (2016) Probing gamma-secretase-substrate interactions at the single amino acid residue level. EMBO Journal , 35 (15) pp. 1597-1599. 10.15252/embj.201694978. Green open access

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Abstract

Intramembrane proteolysis by γ‐secretases plays major roles in disease pathology and cellular signalling, yet the dynamics of these enzyme complexes and how they recognize substrates remains poorly understood. New work in The EMBO Journal utilizes photo‐affinity cross‐linking to map APP interactions to different γ‐secretase subunits, suggesting a succession of recruitment and engagement steps that lead up to substrate cleavage.

Type: Article
Title: Probing gamma-secretase-substrate interactions at the single amino acid residue level
Open access status: An open access version is available from UCL Discovery
DOI: 10.15252/embj.201694978
Publisher version: http://doi.org/10.15252/embj.201694978
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ
URI: https://discovery.ucl.ac.uk/id/eprint/1541549
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