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Progression in multiple sclerosis is associated with low endogenous NCAM.

Gnanapavan, S; Ho, P; Heywood, W; Jackson, S; Grant, D; Rantell, K; Keir, G; ... Giovannoni, G; + view all (2013) Progression in multiple sclerosis is associated with low endogenous NCAM. J Neurochem , 125 (5) 766 - 773. 10.1111/jnc.12236. Green open access

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Abstract

Multiple sclerosis (MS) is a CNS disorder characterized by demyelination and neurodegeneration. Although hallmarks of recovery (remyelination and repair) have been documented in early MS, the regenerative capacity of the adult CNS per se remains uncertain with the wide held belief that it is either limited or non-existent. The neural cell adhesion molecule (NCAM) is a cell adhesion molecule that has been widely implicated in axonal outgrowth, guidance and fasciculation. Here, we used in vitro and in vivo of MS to investigate the role of NCAM in disease progression. We show that in health NCAM levels decrease over time, but this occurs acutely after demyelination and remains reduced in chronic disease. Our findings suggest that depletion of NCAM is one of the factors associated with or possibly responsible for disease progression in MS.

Type: Article
Title: Progression in multiple sclerosis is associated with low endogenous NCAM.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jnc.12236
Publisher version: http://dx.doi.org/10.1111/jnc.12236
Language: English
Additional information: © 2013 The Authors. Journal of Neurochemistry Published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Amino Acid Sequence, Animals, Disease Progression, Female, Humans, Male, Mice, Mice, Inbred C57BL, Middle Aged, Molecular Sequence Data, Multiple Sclerosis, Neural Cell Adhesion Molecules, Pregnancy, Rats, Rats, Sprague-Dawley, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1390247
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