Browse by UCL people
Group by: Type | Date
Number of items: 55.
Article
Akbar, AN;
Gilroy, DW;
(2020)
Aging immunity may exacerbate COVID-19.
Science
, 369
(6501)
pp. 256-257.
10.1126/science.abb0762.
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Audzevich, T;
Bashford-Rogers, R;
Mabbott, NA;
Frampton, D;
Freeman, TC;
Potocnik, A;
Kellam, P;
(2017)
Pre/pro-B cells generate macrophage populations during homeostasis and inflammation.
Proceedings of The National Academy of Sciences of The United States of America (PNAS)
, 114
(20)
E3954-E3963.
10.1073/pnas.1616417114.
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Bennett, M;
Gilroy, DW;
(2016)
Lipid Mediators in Inflammation.
Microbiology Spectrum
, 4
(6)
10.1128/microbiolspec.MCHD-0035-2016.
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Buters, TP;
Hameeteman, P;
Jansen, IME;
van Hindevoort, FC;
Ten Voorde, W;
Grievink, HW;
Schoonakker, M;
... Moerland, M; + view all
(2021)
Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers.
Clinical Pharmacology & Therapeutics
10.1002/cpt.2516.
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Buters, TP;
Hameeteman, PW;
Jansen, IME;
van Hindevoort, FC;
Ten Voorde, W;
Florencia, E;
Osse, M;
... Moerland, M; + view all
(2021)
Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.
British Journal of Clinical Pharmacology
10.1111/bcp.14999.
(In press).
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Bystrom, J;
Thomson, SJ;
Johansson, J;
Edin, ML;
Zeldin, DC;
Gilroy, DW;
Smith, AM;
(2013)
Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn's Disease?
PLOS ONE
, 8
(9)
, Article e75107. 10.1371/journal.pone.0075107.
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Bystrom, J;
Wray, JA;
Sugden, MC;
Holness, MJ;
Swales, KE;
Warner, TD;
Edin, ML;
... Bishop-Bailey, D; + view all
(2011)
Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity.
PLOS ONE
, 6
(10)
, Article e26591. 10.1371/journal.pone.0026591.
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Caxaria, S;
Bharde, S;
Fuller, AM;
Evans, R;
Thomas, B;
Celik, P;
Dell'Accio, F;
... Sikandar, S; + view all
(2023)
Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia.
Proceedings of the National Academy of Sciences of the United States of America
, 120
(17)
, Article e2211631120. 10.1073/pnas.2211631120.
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Chambers, ES;
Vukmanovic-Stejic, M;
Shih, BB;
Trahair, H;
Subramanian, P;
Devine, OP;
Glanville, J;
... Akbar, AN; + view all
(2021)
Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging.
Nature Aging
, 1
(1)
pp. 101-113.
10.1038/s43587-020-00010-6.
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China, L;
Freemantle, N;
Forrest, E;
Kallis, Y;
Ryder, SD;
Wright, G;
Portal, AJ;
... O'Brien, A; + view all
(2021)
A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis.
The New England Journal of Medicine
, 384
(9)
pp. 808-817.
10.1056/NEJMoa2022166.
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China, L;
Maini, A;
Skene, SS;
Shabir, Z;
Sylvestre, Y;
Colas, RA;
Ly, L;
... O'Brien, A; + view all
(2017)
Albumin Counteracts Immune-Suppressive Effects of Lipid Mediators in Patients With Advanced Liver Disease.
Clinical Gastroenterology and Hepatology
, 16
(5)
pp. 738-747.
10.1016/j.cgh.2017.08.027.
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China, L;
Muirhead, N;
Skene, SS;
Shabir, Z;
De Maeyer, RPH;
Maini, AA;
Gilroy, DW;
(2016)
ATTIRE: Albumin To prevenT Infection in chronic liveR failurE: study protocol for a single-arm feasibility trial.
BMJ Open
, 6
(1)
, Article e010132. 10.1136/bmjopen-2015-010132.
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China, L;
Skene, SS;
Bennett, K;
Shabir, Z;
Hamilton, R;
Bevan, S;
Chandler, T;
... O'Brien, A; + view all
(2018)
ATTIRE: Albumin to Prevent Infection in Chronic Liver Failure: Study Protocol for an Interventional Randomised Controlled Trial.
BMJ Open
, 8
(10)
, Article e023754. 10.1136/bmjopen-2018-023754.
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China, L;
Skene, SS;
Shabir, Z;
Maini, A;
Sylvestre, Y;
Bennett, K;
Bevan, S;
... O'Brien, A; + view all
(2018)
Administration of Albumin Solution Increases Serum Levels of Albumin in Patients With Chronic Liver Failure in a Single-Arm Feasibility Trial.
Clinical Gastroenterology and Hepatology
, 16
(5)
pp. 748-755.
10.1016/j.cgh.2017.09.012.
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Collins, GB;
Gilroy, D;
(2023)
Older and wiser: The benefits to neonates of aged neutrophils.
Immunity
, 56
(6)
pp. 1157-1159.
10.1016/j.immuni.2023.05.012.
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Collins, George;
de Souza Carvalho, Jhonatan;
Gilroy, Derek W;
(2023)
The translation potential of harnessing the resolution of inflammation.
Journal of Allergy and Clinical Immunology
, 152
(2)
pp. 356-358.
10.1016/j.jaci.2023.06.008.
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De Gaetano, M;
Tighe, C;
Gahan, K;
Zanetti, A;
Chen, J;
Newson, J;
Cacace, A;
... Guiry, PJ; + view all
(2021)
Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A₄ Mimetics (QNX-sLXms).
Journal of Medicinal Chemistry
10.1021/acs.jmedchem.1c00403.
(In press).
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De Maeyer, Roel PH;
Gilroy, Derek W;
(2022)
Dying cell-derived SAM switches off inflammation.
Nature Metabolism
, 4
(4)
pp. 414-415.
10.1038/s42255-022-00556-2.
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De Maeyer, R;
Van De Merwe, R;
Louie, R;
Bracken, O;
Devine, O;
Goldstein, D;
Uddin, M;
... Gilroy, D; + view all
(2020)
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly.
Nature Immunology
, 21
pp. 615-625.
10.1038/s41590-020-0646-0.
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Feehan, KT;
Bridgewater, HE;
Stenkiewicz-Witeska, J;
De Maeyer, RPH;
Ferguson, J;
Mack, M;
Brown, J;
... Gilroy, DW; + view all
(2024)
Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia.
Nature Communications
, 15
(1)
, Article 4326. 10.1038/s41467-024-48138-y.
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Feehan, KT;
Gilroy, DW;
(2019)
Is Resolution the End of Inflammation?
Trends in Molecular Medicine
, 25
(3)
pp. 198-214.
10.1016/j.molmed.2019.01.006.
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Fullerton, JN;
Gilroy, DW;
(2016)
Resolution of inflammation: a new therapeutic frontier.
Nature Reviews Drug Discovery
, 15
(8)
pp. 551-567.
10.1038/nrd.2016.39.
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Fullerton, JN;
O'Brien, AJ;
Gilroy, DW;
(2014)
Lipid mediators in immune dysfunction after severe inflammation.
Trends Immunol
, 35
(1)
pp. 12-21.
10.1016/j.it.2013.10.008.
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Fullerton, JN;
Segre, E;
De Maeyer, RP;
Maini, AA;
Gilroy, DW;
(2016)
Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation.
Journal of Visualized Experiments
(111)
10.3791/53913.
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Furman, D;
Campisi, J;
Verdin, E;
Carrera-Bastos, P;
Targ, S;
Franceschi, C;
Ferrucci, L;
... Slavich, GM; + view all
(2019)
Chronic inflammation in the etiology of disease across the life span.
Nature Medicine
, 25
(12)
pp. 1822-1832.
10.1038/s41591-019-0675-0.
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George, MJ;
Jasmin, NH;
Cummings, VT;
Richard-Loendt, A;
Launchbury, F;
Woollard, K;
Turner-Stokes, T;
... Gilroy, DW; + view all
(2021)
Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction.
JACC: Basic to Translational Science
10.1016/j.jacbts.2021.01.013.
(In press).
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Gilroy, D;
newson, J;
Motwani, M;
Kendall, A;
Nicolaou, A;
Muccioli, G;
Alhouayek, M;
... de Maeyer, R; + view all
(2017)
Inflammatory resolution triggers a prolonged phase of immune suppression through COX-1/mPGES-1 derived prostaglandin E2.
Cell Reports
, 20
(16)
pp. 3162-3175.
10.1016/j.celrep.2017.08.098.
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Gilroy, D;
Pereira, B;
De Maeyer, R;
covre, L;
Nehar-Belaid, D;
Lanna, A;
Ward, S;
... Akbar, A; + view all
(2020)
Sestrins induce natural killer function in senescent-like CD8+ T cells.
Nature Immunology
, 21
pp. 684-694.
10.1038/s41590-020-0643-3.
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Gilroy, DW;
Bishop-Bailey, D;
(2019)
Lipid mediators in immune regulation and resolution.
British Journal of Pharmacology
, 176
(8)
pp. 1009-1023.
10.1111/bph.14587.
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Gilroy, DW;
De Maeyer, RPH;
Tepper, M;
O'Brien, A;
Uddin, M;
Chen, J;
Goldstein, DR;
(2020)
Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19.
Pharmacology & Therapeutics
, Article 107745. 10.1016/j.pharmthera.2020.107745.
(In press).
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Gilroy, DW;
Edin, ML;
De Maeyer, RP;
Bystrom, J;
Newson, J;
Lih, FB;
Stables, M;
... Bishop-Bailey, D; + view all
(2016)
CYP450-derived oxylipins mediate inflammatory resolution.
Proceedings of the National Academy of Sciences of the United States of America
, 113
(23)
E3240-E3249.
10.1073/pnas.1521453113.
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Glanville, JRW;
Jalali, P;
Flint, JD;
Patel, AA;
Maini, AA;
Wallace, JL;
Hosin, AA;
(2021)
Potent anti-inflammatory effects of an H2 S-releasing naproxen (ATB-346) in a human model of inflammation.
The FASEB Journal
, 35
(10)
, Article e21913. 10.1096/fj.201902918RR.
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Irwandi, Rizky Aditya;
Marruganti, Crystal;
Collins, George;
Carvalho, Jhonatan de Souza;
Gilroy, Derek;
D'Aiuto, Francesco;
(2024)
The translational potential of inflammation-induced skin blister human models in exploring the pathogenesis of periodontitis and its systemic health implications.
Frontiers in Immunology
, 15
, Article 1469828. 10.3389/fimmu.2024.1469828.
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Jenner, W;
Motwani, M;
Veighey, K;
Newson, J;
Audzevich, T;
Nicolaou, A;
Murphy, S;
... Gilroy, DW; + view all
(2014)
Characterisation of leukocytes in a human skin blister model of acute inflammation and resolution.
PLoS One
, 9
(3)
, Article e89375. 10.1371/journal.pone.0089375.
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Jensen, MP;
George, M;
Gilroy, D;
Sofat, R;
(2021)
Beyond Dexamethasone, Emerging Immuno-Thrombotic Therapies for COVID-19.
British Journal of Clinical Pharmacology
, 87
(3)
pp. 845-857.
10.1111/bcp.14540.
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Lanna, Alessio;
Vaz, Bruno;
D'Ambra, Clara;
Valvo, Salvatore;
Vuotto, Claudia;
Chiurchiu, Valerio;
Devine, Oliver;
... Karin, Michael; + view all
(2022)
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory.
Nature Cell Biology
, 24
pp. 1461-1474.
10.1038/s41556-022-00991-z.
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Lanna, A;
Gomes, DC;
Muller-Durovic, B;
McDonnell, T;
Escors, D;
Gilroy, DW;
Lee, JH;
... Akbar, AN; + view all
(2017)
A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.
Nature Immunology
, 18
(3)
pp. 354-363.
10.1038/ni.3665.
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Lubin, Ruth;
Patel, Amit A;
Mackerodt, Jonas;
Zhang, Yan;
Gvili, Rotem;
Mulder, Kevin;
Dutertre, Charles-Antoine;
... Yona, Simon; + view all
(2024)
The lifespan and kinetics of human dendritic cell subsets and their precursors in health and inflammation.
Journal of Experimental Medicine (JEM)
, 221
(11)
, Article e20220867. 10.1084/jem.20220867.
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Maini, AA;
Becares, N;
China, L;
Tittanegro, TH;
Patel, A;
De Maeyer, RPH;
Zakeri, N;
... O'Brien, A; + view all
(2021)
Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway.
JHEP Reports
, 3
(6)
, Article 100332. 10.1016/j.jhepr.2021.100332.
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Maini, AA;
George, MJ;
Motwani, MP;
Day, RM;
Gilroy, DW;
O'Brien, AJ;
(2016)
A Comparison of Human Neutrophils Acquired from Four Experimental Models of Inflammation.
PLOS ONE
, 11
(10)
10.1371/journal.pone.0165502.
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Motwani, M;
Bennett, F;
Norris, P;
Maini, A;
George, MJ;
Newson, J;
Henderson, A;
... Gilroy, D; + view all
(2018)
Potent anti-inflammatory and pro-resolving effects of anabasum in a human model of self-resolving acute inflammation.
Clinical Pharmacology and Therapeutics
, 104
(4)
pp. 675-686.
10.1002/cpt.980.
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Motwani, M;
Colas, R;
George, M;
Flint, J;
Dalli, J;
Richard-Loendt, A;
De Maeyer, RPH;
... Gilroy, D; + view all
(2018)
Pro-Resolving Mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.
Journal of Clinical Investigation
, 3
(6)
, Article e94463. 10.1172/jci.insight.94463.
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Motwani, MP;
Flint, JD;
De Maeyer, RP;
Fullerton, JN;
Smith, AM;
Marks, DJ;
Gilroy, DW;
(2016)
Novel translational model of resolving inflammation triggered by UV-killed E. coli.
The Journal of Pathology: Clinical Research
, 2
(3)
pp. 154-165.
10.1002/cjp2.43.
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Motwani, MP;
Newson, J;
Kwong, S;
Richard-Loendt, A;
Colas, R;
Dalli, J;
Gilroy, DW;
(2017)
Prolonged immune alteration following resolution of acute inflammation in humans.
PLoS One
, 12
(10)
, Article e0186964. 10.1371/journal.pone.0186964.
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Ng, Michael TH;
Borst, Rowie;
Gacaferi, Hamez;
Davidson, Sarah;
Ackerman, Jessica E;
Johnson, Peter A;
Machado, Caio C;
... Dakin, Stephanie G; + view all
(2024)
A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution.
Nature Communications
, 15
(1)
, Article 1394. 10.1038/s41467-024-45341-9.
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O'Brien, A;
China, L;
Massey, KA;
Nicolaou, A;
Winstanley, A;
Newson, J;
Hobbs, A;
... Gilroy, DW; + view all
(2016)
Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences.
Liver International
, 36
(6)
pp. 837-846.
10.1111/liv.12876.
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O'Brien, AJ;
Fullerton, JN;
Massey, KA;
Auld, G;
Sewell, G;
James, S;
Newson, J;
... Gilroy, DW; + view all
(2014)
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E-2.
Nature Medicine
, 20
(5)
pp. 518-523.
10.1038/nm.3516.
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Pallett, Laura J;
Swadling, Leo;
Diniz, Mariana;
Maini, Alexander A;
Schwabenland, Marius;
Gasull, Adrià Dalmau;
Davies, Jessica;
... Maini, Mala K; + view all
(2023)
Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS.
Nature
, 614
pp. 334-342.
10.1038/s41586-022-05645-6.
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Patel, AA;
Zhang, Y;
Fullerton, JN;
Boelen, L;
Rongvaux, A;
Maini, AA;
Bigley, V;
... Yona, S; + view all
(2017)
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation.
Journal of Experimental Medicine
, 214
(7)
pp. 1913-1923.
10.1084/jem.20170355.
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Paul-Clark, MJ;
van Cao, T;
Moradi-Bidhendi, N;
Cooper, D;
Gilroy, DW;
(2004)
15-epi-lipoxin A(4)-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
, 200
(1)
pp. 69-78.
10.1084/jem.20040566.
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Reynolds, CJ;
Swadling, L;
Gibbons, JM;
Pade, C;
Jensen, MP;
Diniz, MO;
Schmidt, NM;
... Boyton, RJ; + view all
(2020)
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
Science Advances
, 5
(54)
, Article eabf3698. 10.1126/sciimmunol.abf3698.
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Swadling, L;
Diniz, MO;
Schmidt, NM;
Amin, OE;
Chandran, A;
Shaw, E;
Pade, C;
... Maini, MK; + view all
(2022)
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Nature
, 601
pp. 110-117.
10.1038/s41586-021-04186-8.
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Conference item
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Maini, AA;
China, L;
Gilroy, DW;
O'Brien, A;
(2017)
Progression of cirrhotic liver disease towards acute-on-chronic liver failure triggers changes in innate immune cell phenotype and their response to pro-inflammatory stimuli.
Presented at: Annual General Meeting of the British-Society-of-Gastroenterology (BSG), Manchester, UK.
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Thesis
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Fullerton, JN;
(2016)
The Role of Prostaglandin E2 in Critical Illness-Induced Immune Dysfunction.
Doctoral thesis , UCL (University College London).
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Motwani, Madhur Parmanand;
(2017)
Immunomodulatory effect of specialised pro-resolving mediators in humans.
Doctoral thesis (Ph.D), UCL (University College London).
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