UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Resolution of inflammation: a new therapeutic frontier

Fullerton, JN; Gilroy, DW; (2016) Resolution of inflammation: a new therapeutic frontier. Nature Reviews Drug Discovery , 15 (8) pp. 551-567. 10.1038/nrd.2016.39. Green open access

[img]
Preview
Text
Fullerton_Resolution of inflammation AAM Edited (markup) version.pdf - Accepted version

Download (1MB) | Preview

Abstract

Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes — a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field.

Type: Article
Title: Resolution of inflammation: a new therapeutic frontier
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrd.2016.39
Publisher version: http://www.nature.com/nrd/journal/v15/n8/full/nrd....
Language: English
Additional information: Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Pharmacology & Pharmacy, NF-KAPPA-B, Chronic Granulomatous-disease, Necrosis-factor-alpha, Experimental Autoimmune-thyroiditis, Neutrophil Extracellular Traps, Melanocyte-stimulating Hormone, Persistent Lcmv Infection, Apoptotic Cell Clearance, Messenger-RNA Decay, Acute Lung Injury
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
URI: https://discovery.ucl.ac.uk/id/eprint/1488818
Downloads since deposit
907Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item