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Dying cell-derived SAM switches off inflammation

De Maeyer, Roel PH; Gilroy, Derek W; (2022) Dying cell-derived SAM switches off inflammation. Nature Metabolism , 4 (4) pp. 414-415. 10.1038/s42255-022-00556-2. Green open access

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Abstract

The clearance of dying cells by macrophages releases mediators that switch off inflammation. Ampomah et al. reveal how an amino acid derived from apoptotic cargo changes the methylation epigenome of macrophages to take the brakes off an ERK-dependent pathway that terminates inflammatory responses.

Type: Article
Title: Dying cell-derived SAM switches off inflammation
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s42255-022-00556-2
Publisher version: https://doi.org/10.1038/s42255-022-00556-2
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Acute inflammation, Inflammatory diseases, Metabolism
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10148437
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