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Chronic inflammation in the etiology of disease across the life span

Furman, D; Campisi, J; Verdin, E; Carrera-Bastos, P; Targ, S; Franceschi, C; Ferrucci, L; ... Slavich, GM; + view all (2019) Chronic inflammation in the etiology of disease across the life span. Nature Medicine , 25 (12) pp. 1822-1832. 10.1038/s41591-019-0675-0. Green open access

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Abstract

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.

Type: Article
Title: Chronic inflammation in the etiology of disease across the life span
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41591-019-0675-0
Publisher version: https://doi.org/10.1038/s41591-019-0675-0
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cancer, Cultural evolution, Evolutionary genetics, Inflammation, Translational immunology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10088235
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