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Lipid Mediators in Inflammation

Bennett, M; Gilroy, DW; (2016) Lipid Mediators in Inflammation. Microbiology Spectrum , 4 (6) 10.1128/microbiolspec.MCHD-0035-2016. Green open access

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Abstract

Lipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties, thus making their role in inflammation distinct from that of other lipids derived from the same PUFA. This diversity arises from their synthesis, which occurs via discrete enzymatic pathways and because they elicit responses via different receptors. This review will collate the bioactive lipid research to date and summarize the major pathways involved in their biosynthesis and role in inflammation. Specifically, lipids derived from AA (prostanoids, leukotrienes, 5-oxo-6,8,11,14-eicosatetraenoic acid, lipoxins, and epoxyeicosatrienoic acids), EPA (E-series resolvins), and DHA (D-series resolvins, protectins, and maresins) will be discussed herein.

Type: Article
Title: Lipid Mediators in Inflammation
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1128/microbiolspec.MCHD-0035-2016
Publisher version: http://dx.doi.org/10.1128/microbiolspec.MCHD-0035-...
Language: English
Additional information: Copyright © 2016 American Society for Microbiology. All rights reserved.
Keywords: arachidonic acid, polyunsaturated fatty acids, eicosanoids, prostanoids, leukotrienes, lipoxins, epoxyeicosatrienoic acids, docosahexaenoic acid, resolvins, protectins, maresins, cytochrome p450
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
URI: https://discovery.ucl.ac.uk/id/eprint/1530515
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