UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Is Resolution the End of Inflammation?

Feehan, KT; Gilroy, DW; (2019) Is Resolution the End of Inflammation? Trends in Molecular Medicine , 25 (3) pp. 198-214. 10.1016/j.molmed.2019.01.006. Green open access

[thumbnail of Article]
Preview
Text (Article)
Feehan_TMM review- accepted - ARTICLE.pdf - Accepted Version

Download (433kB) | Preview
[thumbnail of Figure]
Preview
Text (Figure)
Feehan_TMM review - accpeted - FIGURE.pdf - Accepted Version

Download (32kB) | Preview

Abstract

Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an appreciation of targeting pathways by which inflammation is resolved has begun to rouse interest. Resolution of inflammation is driven by a complex set of mediators that regulate cellular events required to clear inflammatory cells from sites of infection or injury to restore tissue function. However, recent studies suggest that resolution is not the end of innate mediated immune responses to infection/injury. There is further immunological activity occurring after the resolution cascade is complete that alters the immune physiology of tissues, redefining what was once termed restorative homeostasis as adapted homeostasis.

Type: Article
Title: Is Resolution the End of Inflammation?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.molmed.2019.01.006
Publisher version: https://doi.org/10.1016/j.molmed.2019.01.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: resolution, post-resolution, adapted homeostasis, chronic inflammation, autoimmunity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10073010
Downloads since deposit
2,633Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item