Browse by UCL people
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Number of items: 112.
Article
Allinson, James Peter;
Chaturvedi, Nishi;
Wong, Andrew;
Shah, Imran;
Donaldson, Gavin Christopher;
Wedzicha, Jadwiga Anna;
Hardy, Rebecca;
(2023)
Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study.
The Lancet
, 401
(10383)
pp. 1183-1193.
10.1016/S0140-6736(23)00131-9.
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Angelakopoulou, A;
Shah, T;
Sofat, R;
Shah, S;
Berry, DJ;
Cooper, J;
Palmen, J;
... Hingorani, AD; + view all
(2012)
Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.
European Heart Journal
, 33
(3)
393 - 407.
10.1093/eurheartj/ehr225.
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Anjum, S;
Fourkala, EO;
Zikan, M;
Wong, A;
Gentry-Maharaj, A;
Jones, A;
Hardy, R;
... Widschwendter, M; + view all
(2014)
A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival.
Genome Med
, 6
(6)
47 -.
10.1186/gm567.
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Bauermeister, S;
Orton, C;
Thompson, S;
Barker, RA;
Bauermeister, JR;
Ben-Shlomo, Y;
Brayne, C;
... Gallacher, JEJ; + view all
(2020)
The Dementias Platform UK (DPUK) Data Portal.
European Journal of Epidemiology
10.1007/s10654-020-00633-4.
(In press).
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Beaney, KE;
Cooper, JA;
McLachlan, S;
Wannamethee, SG;
Jefferis, BJ;
Whincup, P;
Ben-Shlomo, Y;
... Humphries, SE; + view all
(2016)
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids.
Cardiovascular Diabetology
, 15
, Article 115. 10.1186/s12933-016-0435-0.
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Beaney, KE;
Smith, AJP;
Folkersen, L;
Palmen, J;
Wannamethee, SG;
Jefferis, BJ;
Whincup, P;
... Consortium, U; + view all
(2017)
Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.
Disease Markers
, 2017
, Article 1096916. 10.1155/2017/1096916.
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Belloy, ME;
Eger, SJ;
Le Guen, Y;
Napolioni, V;
Deters, KD;
Yang, H-S;
Scelsi, MA;
... Alzheimer's Disease Neuroimaging Initiative; + view all
(2021)
KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers.
Neurobiology of Aging
, 101
pp. 123-129.
10.1016/j.neurobiolaging.2021.01.008.
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Bradfield, JP;
Kember, RL;
Ulrich, A;
Balkiyarova, Z;
Alyass, A;
Aris, IM;
Bell, JA;
... Widén, E; + view all
(2024)
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes.
Genome biology
, 25
(1)
, Article 22. 10.1186/s13059-023-03136-z.
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Buchanan, SM;
Parker, TD;
Lane, CA;
Keshavan, A;
Keuss, SE;
Lu, K;
James, S-N;
... Schott, JM; + view all
(2020)
Olfactory testing does not predict beta-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort.
Journal of Neurology
10.1007/s00415-020-10004-4.
(In press).
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Cartwright, R;
Franklin, L;
Tikkinen, KAO;
Kalliala, I;
Miotla, P;
Rechberger, T;
Offiah, I;
... Walley, A; + view all
(2021)
Genome Wide Association Study Identifies Two Novel Loci Associated with Female Stress and Urgency Urinary Incontinence.
The Journal of Urology
, Article 101097JU0000000000001822. 10.1097/JU.0000000000001822.
(In press).
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Casas, JP;
Hingorani, AD;
(2012)
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Lancet
, 379
(9822)
1214 - 1224.
10.1016/S0140-6736(12)60110-X.
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Charoen, P;
Nitsch, D;
Engmann, J;
Shah, T;
White, J;
Zabaneh, D;
Jefferis, B;
... Dudbridge, F; + view all
(2016)
Mendelian Randomisation study of the influence of eGFR on coronary heart disease.
Scientific Reports
, 6
, Article 28514. 10.1038/srep28514.
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Chen, J;
Spracklen, CN;
Marenne, G;
Varshney, A;
Corbin, LJ;
Luan, J;
Willems, SM;
... Barroso, I; + view all
(2021)
The trans-ancestral genomic architecture of glycemic traits.
Nature Genetics
, 53
(6)
pp. 840-860.
10.1038/s41588-021-00852-9.
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Christiansen, C;
Castillo-Fernandez, JE;
Domingo-Relloso, A;
Zhao, W;
El-Sayed Moustafa, JS;
Tsai, P-C;
Maddock, J;
... Bell, JT; + view all
(2021)
Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects.
Clinical Epigenetics
, 13
, Article 36. 10.1186/s13148-021-01018-4.
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Cooper, AJ;
Simmons, RK;
Kuh, D;
Brage, S;
Cooper, R;
NSHD scientific and data collection team, .;
(2015)
Physical activity, sedentary time and physical capability in early old age: British birth cohort study.
PLoS One
, 10
(5)
, Article e0126465. 10.1371/journal.pone.0126465.
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Dale, CE;
Fatemifar, G;
Palmer, TM;
White, J;
Prieto-Merino, D;
Zabaneh, D;
Engmann, JEL;
... Casas, JP; + view all
(2017)
Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis.
Circulation
, 135
(24)
pp. 2373-2388.
10.1161/CIRCULATIONAHA.116.026560.
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De Silva, NMG;
Borges, MC;
Hingorani, A;
Engmann, J;
Shah, T;
Zhang, X;
Luan, J;
... Lawlor, DA; + view all
(2019)
Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study.
Diabetes
10.2337/db18-1048.
(In press).
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Ehret, GB;
Ferreira, T;
Hassinen, M;
Havulinna, AS;
Hayward, C;
Hercberg, S;
Herzig, K-H;
... Munroe, PB; + view all
(2016)
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Nature Genetics
, 48
(10)
pp. 1171-1184.
10.1038/ng.3667.
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Elhakeem, A;
Hannam, K;
Deere, KC;
Hartley, A;
Clark, EM;
Moss, C;
Edwards, MH;
... Tobias, JH; + view all
(2017)
Physical activity producing low, but not medium or higher, vertical impacts is inversely related to BMI in older adults: findings from a multi cohort study.
The Journals of Gerontology series A
, 73
(5)
pp. 643-651.
10.1093/gerona/glx176.
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Elhakeem, A;
Hannam, K;
Deere, KC;
Hartley, A;
Clark, EM;
Moss, C;
Edwards, MH;
... Tobias, JH; + view all
(2018)
Correlates of high impact physical activity measured objectively in older British adults.
Journal of Public Health
, 40
(4)
pp. 727-737.
10.1093/pubmed/fdx171.
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Elhakeem, A;
Hannam, K;
Deere, KC;
Hartley, A;
Clark, EM;
Moss, C;
Edwards, MH;
... Tobias, JH; + view all
(2017)
Associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact physical activity in later life.
Preventive Medicine Reports
, 8
pp. 183-189.
10.1016/j.pmedr.2017.10.011.
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Elhakeem, A;
Hannam, K;
Deere, KC;
Wong, A;
Gaysin, T;
Kuh, D;
Cooper, R;
... Tobias, JH; + view all
(2019)
Day-to-day physical activity producing low gravitational impacts is associated with faster visual processing speed at age 69: cross-sectional study.
European Review of Aging and Physical Activity
, 16
, Article 9. 10.1186/s11556-019-0216-3.
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Fairoozy, RH;
Cooper, J;
White, J;
Giambartolomei, C;
Folkersen, L;
Wannamethee, SG;
Jefferis, BJ;
... UCLEB consortium, .; + view all
(2017)
Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene.
Atherosclerosis
, 261
pp. 60-68.
10.1016/j.atherosclerosis.2017.04.010.
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Fatih, N;
Chaturvedi, N;
Lane, CA;
Parker, TD;
Lu, K;
Cash, DM;
Malone, IB;
... James, S-N; + view all
(2022)
Sex-related differences in whole brain volumes at age 70 in association with hyperglycemia during adult life.
Neurobiology of Aging
, 112
pp. 161-169.
10.1016/j.neurobiolaging.2021.09.008.
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Franceschini, N;
Giambartolomei, C;
de Vries, PS;
Finan, C;
Bis, JC;
Huntley, RP;
Lovering, RC;
... O'Donnell, CJ; + view all
(2018)
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
Nature Communications
, 9
, Article 5141. 10.1038/s41467-018-07340-5.
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Gordillo-Marañón, M;
Zwierzyna, M;
Charoen, P;
Drenos, F;
Chopade, S;
Shah, T;
Engmann, J;
... Finan, C; + view all
(2021)
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics.
Nature Communications
, 12
, Article 6120. 10.1038/s41467-021-25731-z.
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Graff, M;
Scott, RA;
Justice, AE;
Young, KL;
Feitosa, MF;
Barata, L;
Winkler, TW;
... Kilpeläinen, TO; + view all
(2017)
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
PLoS Genetics
, 13
(4)
, Article e1006528. 10.1371/journal.pgen.1006528.
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Graham, Sarah E;
Clarke, Shoa L;
Wu, Kuan-Han H;
Kanoni, Stavroula;
Zajac, Greg JM;
Ramdas, Shweta;
Surakka, Ida;
... Willer, Cristen J; + view all
(2021)
The power of genetic diversity in genome-wide association studies of lipids.
Nature
, 600
pp. 675-679.
10.1038/s41586-021-04064-3.
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Green, Rebecca;
Lord, Jodie;
Xu, Jin;
Maddock, Jane;
Kim, Min;
Dobson, Richard;
Legido-Quigley, Cristina;
... Proitsi, Petroula; + view all
(2022)
Metabolic correlates of late midlife cognitive outcomes: findings from the 1946 British Birth Cohort.
Brain Communications
, 4
(1)
, Article fcab291. 10.1093/braincomms/fcab291.
(In press).
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Green, Rebecca E;
Lord, Jodie;
Scelsi, Marzia A;
Xu, Jin;
Wong, Andrew;
Naomi-James, Sarah;
Handy, Alex;
... Insight 46 study team; + view all
(2023)
Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease.
Alzheimer's Research and Therapy
, 15
, Article 38. 10.1186/s13195-023-01184-y.
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Hagg, S;
Zhan, Y;
Karlsson, R;
Gerritsen, L;
Ploner, A;
van der Lee, SJ;
Broer, L;
... Pedersen, NL; + view all
(2017)
Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.
Translational Psychiatry
, 7
, Article e1100. 10.1038/tp.2017.73.
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Hannam, K;
Deere, KC;
Hartley, A;
Clark, EM;
Coulson, J;
Ireland, A;
Moss, C;
... Tobias, JH; + view all
(2016)
A novel accelerometer-based method to describe day-to-day exposure to potentially osteogenic vertical impacts in older adults: findings from a multi-cohort study.
Osteoporosis International
, 28
(3)
pp. 1001-1011.
10.1007/s00198-016-3810-5.
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Hoggart, CJ;
Venturini, G;
Ascari, G;
Lamparter, D;
Macé, A;
Rüeger, S;
Bergmann, S;
... Frayling, TM; + view all
(2014)
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.
PLoS Genetics
, 10
(7)
, Article e1004508. 10.1371/journal.pgen.1004508.
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Holmes, MV;
Asselbergs, FW;
Palmer, TM;
Drenos, F;
Lanktree, MB;
Nelson, CP;
Dale, CE;
... Casas, JP; + view all
(2015)
Mendelian randomization of blood lipids for coronary heart disease.
Eur Heart J
, 36
(9)
539 - 550.
10.1093/eurheartj/eht571.
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Holmes, MV;
Dale, CE;
Zuccolo, L;
Silverwood, RJ;
Guo, Y;
Ye, Z;
Prieto-Merino, D;
... InterAct Consortium; + view all
(2014)
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
BMJ
, 349
, Article g4164. 10.1136/bmj.g4164.
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Horsfall, LJ;
Hardy, R;
Wong, A;
Kuh, D;
Swallow, DM;
(2014)
Genetic variation underlying common hereditary hyperbilirubinaemia (Gilbert's syndrome) and respiratory health in the 1946 British birth cohort.
Journal of Hepatology
, 61
(6)
pp. 1344-1351.
10.1016/j.jhep.2014.07.028.
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Hostettler, IC;
Bernal-Quiros, M;
Wong, A;
Sharma, N;
Wilson, D;
Seiffge, D;
Shakeshaft, C;
... Houlden, H; + view all
(2019)
C9orf72 and intracerebral haemorrhage.
Neurobiology of Aging
, 84
237.e1-237.e3.
10.1016/j.neurobiolaging.2019.07.007.
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Iurilli, MLC;
Zhou, B;
Bennett, JE;
Carrillo-Larco, RM;
Sophiea, MK;
Rodriguez-Martinez, A;
Bixby, H;
... Filippi, S; + view all
(2021)
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC).
eLife
, 10
, Article ARTN e60. 10.7554/eLife.60060.
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James, S-N;
Lane, CA;
Parker, TD;
Lu, K;
Collins, JD;
Murray-Smith, H;
Byford, M;
... Richards, M; + view all
(2018)
Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46.
BMC Research Notes
, 11
, Article 885. 10.1186/s13104-018-3995-0.
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James, S-N;
Nicholas, JM;
Lane, CA;
Parker, TD;
Lu, K;
Keshavan, A;
Buchanan, SM;
... Fox, NC; + view all
(2021)
A population‐based study of head injury, cognitive function and pathological markers.
Annals of Clinical and Translational Neurology
10.1002/acn3.51331.
(In press).
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James, S-N;
Wong, A;
Tillin, T;
Hardy, R;
Chaturvedi, N;
Richards, M;
(2019)
The effect of mid-life insulin resistance and type 2 diabetes on older-age cognitive state: the explanatory role of early-life advantage.
Diabetologia
, 62
pp. 1891-1900.
10.1007/s00125-019-4949-3.
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Johnson, W;
Ong, KK;
Elks, CE;
Wareham, NJ;
Wong, A;
Muniz-Terrera, G;
Hardy, R;
(2014)
Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study.
Nutrition & Diabetes
, 4
, Article e136. 10.1038/nutd.2014.33.
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Joshi, PK;
Pirastu, N;
Kentistou, KA;
Fischer, K;
Hofer, E;
Schraut, KE;
Clark, DW;
... Wilson, JF; + view all
(2017)
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.
Nature Communications
, 8
, Article 910. 10.1038/s41467-017-00934-5.
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Justice, AE;
Winkler, TW;
Feitosa, MF;
Graff, M;
Fisher, VA;
Young, K;
Barata, L;
... Cupples, LA; + view all
(2017)
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Nature Communications
, 8
, Article 14977. 10.1038/ncomms14977.
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Kanoni, S;
Graham, SE;
Wang, Y;
Surakka, I;
Ramdas, S;
Zhu, X;
Clarke, SL;
... Mauro, P; + view all
(2022)
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Genome biology
, 23
(1)
, Article 268. 10.1186/s13059-022-02837-1.
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Keshavan, A;
Pannee, J;
Karikari, T;
Lantero Rodriguez, J;
Ashton, NJ;
Nicholas, JM;
Cash, D;
... Schott, J; + view all
(2021)
Population-based blood screening for pre-clinical Alzheimer's disease in a British birth cohort at age 70.
Brain
, 144
(2)
pp. 434-449.
10.1093/brain/awaa403.
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Keuss, SE;
Parker, TD;
Lane, CA;
Hoskote, C;
Shah, S;
Cash, DM;
Keshavan, A;
... Schott, JM; + view all
(2019)
Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort.
BMJ Open
, 9
(7)
, Article e029502. 10.1136/bmjopen-2019-029502.
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Koike, S;
Gaysina, D;
Jones, PB;
Wong, A;
Richards, M;
(2018)
Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study.
Journal of Affective Disorders
, 229
pp. 437-442.
10.1016/j.jad.2017.12.044.
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Koike, S;
Richards, M;
Wong, A;
Hardy, R;
(2018)
Fat mass and obesity-associated (FTO) rs9939609 polymorphism modifies the relationship between body mass index and affective symptoms through the life course: a prospective birth cohort study.
Transational Psychiatry
, 8
, Article 62. 10.1038/s41398-018-0110-1.
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Kuh, D;
Wong, A;
Shah, I;
Moore, A;
Popham, M;
Curran, P;
Davis, D;
... Cooper, R; + view all
(2016)
The MRC National Survey of Health and Development reaches age 70: maintaining participation at older ages in a birth cohort study.
European Journal of Epidemiology
, 31
(11)
pp. 1135-1147.
10.1007/s10654-016-0217-8.
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Lane, CA;
Barnes, J;
Nicholas, JM;
Baker, JW;
Sudre, CH;
Cash, DM;
Parker, TD;
... Schott, JM; + view all
(2021)
Investigating the relationship between BMI across adulthood and late life brain pathologies.
Alzheimer's Research and Therapy
, 13
(1)
, Article 91. 10.1186/s13195-021-00830-7.
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Lane, CA;
Barnes, J;
Nicholas, JM;
Sudre, CH;
Cash, DM;
Malone, IB;
Parker, TD;
... Schott, JM; + view all
(2019)
Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort.
JAMA Neurology
, 77
(2)
pp. 175-183.
10.1001/jamaneurol.2019.3774.
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Lane, CA;
Barnes, J;
Nicholas, JM;
Sudre, CH;
Cash, DM;
Parker, TD;
Malone, IB;
... Schott, JM; + view all
(2019)
Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study.
Lancet Neurology
10.1016/S1474-4422(19)30228-5.
(In press).
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Lane, CA;
Parker, TD;
Cash, DM;
Macpherson, K;
Donnachie, E;
Murray-Smith, H;
Barnes, A;
... Schott, JM; + view all
(2017)
Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development.
BMC Neurology
, 17
, Article 75. 10.1186/s12883-017-0846-x.
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Lessof, C;
Cooper, R;
Wong, A;
Bendayan, R;
Caleyachetty, R;
Cheshire, H;
Cosco, T;
... Hardy, R; + view all
(2023)
Comparison of devices used to measure blood pressure, grip strength and lung function: A randomised cross-over study.
PLoS ONE
, 18
(12)
, Article e0289052. 10.1371/journal.pone.0289052.
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Levine, ME;
Lu, AT;
Chen, BH;
Hernandez, DG;
Singleton, AB;
Ferrucci, L;
Bandinelli, S;
... Horvath, S; + view all
(2016)
Menopause accelerates biological aging.
Proceedings of the National Academy of Sciences of the United States of America
, 113
(33)
pp. 9327-9332.
10.1073/pnas.1604558113.
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Lord, J;
Bradley, J;
Green, R;
Wong, A;
Xu, J;
Legido-Quigley, C;
Dobson, R;
... Proitsi, P; + view all
(2021)
Are metabolites linked to midlife cognition on the causal pathway to Alzheimer's Disease? A Mendelian randomization study.
Proceedings of the National Academy of Sciences of the United States of America
, 118
(16)
, Article e2009808118. 10.1073/pnas.2009808118.
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Lord, J;
Jermy, B;
Green, R;
Wong, A;
Xu, J;
Legido-Quigley, C;
Dobson, R;
... Proitsi, P; + view all
(2021)
Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.
Proceedings of the National Academy of Sciences (PNAS)
, 118
(16)
, Article e2009808118. 10.1073/pnas.2009808118.
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Lu, K;
Nicholas, JM;
Pertzov, Y;
Grogan, J;
Husain, M;
Pavisic, IM;
James, S-N;
... Crutch, SJ; + view all
(2021)
Dissociable effects of APOE ε4 and β-amyloid pathology on visual working memory.
Nature Aging
, 1
pp. 1002-1009.
10.1038/s43587-021-00117-4.
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Lu, K;
Nicholas, JM;
Collins, JD;
James, S-N;
Parker, TD;
Lane, CA;
Keshavan, A;
... Schott, JM; + view all
(2019)
Cognition at age 70: Life course predictors and associations with brain pathologies.
Neurology
, 93
10.1212/WNL.0000000000008534.
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