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Increased variability in reaction time is associated with amyloid beta pathology at age 70

Lu, K; Nicholas, JM; James, S; Lane, CA; Parker, TD; Keshavan, A; Keuss, SE; ... Crutch, SJ; + view all (2020) Increased variability in reaction time is associated with amyloid beta pathology at age 70. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring , 12 (1) , Article e12076. 10.1002/dad2.12076. Green open access

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Abstract

Introduction:We investigated whether life-course factors and neuroimaging biomarkers of Alzheimer’s disease pathology predict reaction time (RT) performance in older adults. Methods: Insight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2-choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra-individual variability in RT) and lifecourse predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ-positivity. Results: Cognitively normal Aβ-positive participants had 10% more variable RTs than Aβ-negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance. Discussion: This study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.

Type: Article
Title: Increased variability in reaction time is associated with amyloid beta pathology at age 70
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/dad2.12076
Publisher version: http://dx.doi.org/10.1002/dad2.12076
Language: English
Additional information: © 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: amyloid-positron emission tomography imaging, birth cohort, cognition, cognitive decline, dementia, healthy aging, preclinical Alzheimer’s disease, reaction time, variability
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/10107677
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