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Metabolomic correlates of central adiposity and earlier life body mass index

Wulaningsih, W; Proitsi, P; Wong, A; Kuh, D; Hardy, R; (2019) Metabolomic correlates of central adiposity and earlier life body mass index. Journal of Lipid Research 10.1194/jlr.P085944. (In press). Green open access

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Abstract

Body mass index (BMI) is correlated with circulating metabolites but few studies discuss other adiposity measures and little is known about metabolomic correlates of body mass index from early life. We investigated associations between different adiposity measures, BMI from childhood through adulthood, and metabolites quantified from serum using 1H NMR spectroscopy in 900 British men and women aged 60-64. We assessed BMI, waist-to-hip ratio (WHR), and android-to-gynoid fat ratio (AGR) and BMI from childhood through adulthood. Linear regression with Bonferroni adjustment was performed to assess adiposity and metabolites. Of 233 metabolites, 168, 126, and 133 were associated with BMI, WHR and AGR at age 60-64, respectively. Associations were strongest for high density lipoprotein (HDL), particularly HDL particle size, e.g. there was 0.08 SD decrease in HDL diameter (95% CI: 0.07-0.10) with each unit increase in BMI. BMI-adjusted AGR or WHR were associated with 31 metabolites where there was no metabolome-wide association with BMI. We identified inverse associations between BMI at age 7 and glucose or glycoprotein at age 60-64 and relative large LDL cholesterol ester with post-adolescent BMI gains. In summary, we identified metabolomic correlates of central adiposity and earlier life BMI. These findings support opportunities to leverage metabolomics in early prevention of cardiovascular risk attributable to body fatness.

Type: Article
Title: Metabolomic correlates of central adiposity and earlier life body mass index
Open access status: An open access version is available from UCL Discovery
DOI: 10.1194/jlr.P085944
Publisher version: https://doi.org/10.1194/jlr.P085944
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Epidemiology, Lipids, Lipoproteins/Metabolism, Nutrition, Obesity, metabolomics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Social Research Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/10071045
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