Browse by UCL people
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Number of items: 117.
Article
Alagaratnam, J;
De Francesco, D;
Zetterberg, H;
Heslegrave, A;
Toombs, J;
Kootstra, NA;
Underwood, J;
... Winston, A; + view all
(2021)
Correlation between cerebrospinal fluid and plasma neurofilament light protein in treated HIV infection: results from the COBRA study.
Journal of NeuroVirology
10.1007/s13365-021-01026-3.
(In press).
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Alagaratnam, J;
Stöhr, W;
Hamlyn, E;
Porter, K;
Toombs, J;
Heslegrave, A;
Zetterberg, H;
... Fidler, S; + view all
(2024)
Impact of interrupting antiretroviral therapy started during primary HIV-1 infection on plasma neurofilament light chain protein, a marker of neuronal injury: The SPARTAC trial.
Journal of Virus Eradication
, 10
(2)
, Article 100381. 10.1016/j.jve.2024.100381.
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Alagaratnam, J;
Stöhr, W;
Toombs, J;
Heslegrave, A;
Zetterberg, H;
Gisslén, M;
Pett, S;
... RIVER trial study group, .; + view all
(2021)
No evidence of neuronal damage as measured by neurofilament light chain in a HIV cure study utilising a kick-and-kill approach.
Journal of Virus Eradication
, 7
(3)
, Article 100056. 10.1016/j.jve.2021.100056.
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Alawode, DOT;
Heslegrave, AJ;
Ashton, NJ;
Karikari, TK;
Simrén, J;
Montoliu-Gaya, L;
Pannee, J;
... Zetterberg, H; + view all
(2021)
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease.
Journal of Internal Medicine
, 290
(3)
pp. 583-601.
10.1111/joim.13332.
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Ali, Muhammad;
Sung, Yun Ju;
Wang, Fengxian;
Fernández, Maria V;
Morris, John C;
Fagan, Anne M;
Blennow, Kaj;
... Cruchaga, Carlos; + view all
(2022)
Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk.
PLOS ONE
, 17
(5)
, Article e0267298. 10.1371/journal.pone.0267298.
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Alosco, ML;
Tripodis, Y;
Fritts, NG;
Heslegrave, A;
Baugh, CM;
Conneely, S;
Mariani, M;
... Stern, RA; + view all
(2018)
Cerebrospinal fluid tau, A beta, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.
Alzheimer's & Dementia
, 14
(9)
pp. 1159-1170.
10.1016/j.jalz.2018.05.004.
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Altmann, P;
De Simoni, D;
Kaider, A;
Ludwig, B;
Rath, J;
Leutmezer, F;
Zimprich, F;
... Rommer, PS; + view all
(2020)
Increased serum neurofilament light chain concentration indicates poor outcome in Guillain-Barré syndrome.
Journal of Neuroinflammation
, 17
, Article 86. 10.1186/s12974-020-01737-0.
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Arber, C;
Toombs, J;
Lovejoy, C;
Ryan, NS;
Paterson, RW;
Willumsen, N;
Gkanatsiou, E;
... Wray, S; + view all
(2020)
Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.
Molecular Psychiatry
, 25
pp. 2919-2931.
10.1038/s41380-019-0410-8.
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Ashton, NJ;
Suárez-Calvet, M;
Heslegrave, A;
Hye, A;
Razquin, C;
Pastor, P;
Sanchez-Valle, R;
... Zetterberg, H; + view all
(2019)
Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers.
Alzheimer's Research & Therapy
, 11
, Article 94. 10.1186/s13195-019-0545-5.
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Austin, K;
Lee, BJ;
Flood, TR;
Toombs, J;
Borisova, M;
Lauder, M;
Heslegrave, A;
... Smith, NA; + view all
(2021)
Serum neurofilament light concentration does not increase following exposure to low velocity football heading.
Science and Medicine in Football
, 5
(3)
pp. 188-194.
10.1080/24733938.2020.1853210.
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Banerjee, G;
Ambler, G;
Keshavan, A;
Paterson, RW;
Foiani, MS;
Toombs, J;
Heslegrave, A;
... Werring, DJ; + view all
(2020)
Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy.
Journal of Alzheimer's Disease
, 74
(4)
pp. 1189-1201.
10.3233/JAD-191254.
(In press).
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Banerjee, G;
Forsgard, N;
Ambler, G;
Keshavan, A;
Paterson, RW;
Foiani, MS;
Toombs, J;
... Werring, DJ; + view all
(2021)
Cerebrospinal fluid metallomics in cerebral amyloid angiopathy: an exploratory analysis.
Journal of Neurology
10.1007/s00415-021-10711-6.
(In press).
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Batzu, Lucia;
Rota, Silvia;
Hye, Abdul;
Heslegrave, Amanda;
Trivedi, Dhaval;
Gibson, Lucy L;
Farrell, Chloe;
... Aarsland, Dag; + view all
(2022)
Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson's disease.
npj Parkinson's Disease
, 8
, Article 154. 10.1038/s41531-022-00384-x.
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Benjamin, LA;
Paterson, RW;
Moll, R;
Pericleous, C;
Brown, R;
Mehta, PR;
Athauda, D;
... Efthymiou, M; + view all
(2021)
Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study.
EClinicalMedicine
, Article 101070. 10.1016/j.eclinm.2021.101070.
(In press).
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Brogueira Rodrigues, F;
Byrne, L;
Tortelli, R;
Johnson, E;
Wijeratne, P;
De Vita, E;
Ghazaleh, N;
... Wild, E; + view all
(2020)
Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington's disease.
Science Translational Medicine
, 12
(574)
10.1126/scitranslmed.abc2888.
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Byrne, LM;
Brogueira Rodrigues, F;
Johnson, E;
Wijeratne, P;
De Vita, E;
Alexander, D;
Palermo, G;
... Wild, E; + view all
(2018)
Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease.
Science Translational Medicine
, 10
(458)
, Article eaat7108. 10.1126/scitranslmed.aat7108.
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Byrne, LM;
Rodrigues, FB;
Johnson, EB;
Da Vita, E;
Blennow, K;
Scahill, RI;
Zetterberg, H;
... Wild, E; + view all
(2018)
Cerebrospinal fluid neurogranin and TREM2 in Huntington’s disease.
Scientific Reports
, Article 4260. 10.1038/s41598-018-21788-x.
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Carrol, D;
Busse, WW;
Frye, CJ;
Klaus, DR;
Bach, JC;
Floerke, H;
Bendlin, BB;
... Rosenkranz, MA; + view all
(2025)
Regional brain structural alterations in reward and salience networks in asthma.
Brain, Behavior, and Immunity
, 126
pp. 80-97.
10.1016/j.bbi.2025.01.028.
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Chelban, V;
Wilson, MP;
Warman Chardon, J;
Vandrovcova, J;
Zanetti, MN;
Zamba-Papanicolaou, E;
Efthymiou, S;
... SYNaPS Study Group, .; + view all
(2019)
PDXK mutations cause polyneuropathy responsive to PLP supplementation.
Annals of Neurology
10.1002/ana.25524.
(In press).
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Clarke, MTM;
Brinkmalm, A;
Foiani, MS;
Woollacott, IOC;
Heller, C;
Heslegrave, A;
Keshavan, A;
... Rohrer, JD; + view all
(2019)
CSF synaptic protein concentrations are raised in those with atypical Alzheimer's disease but not frontotemporal dementia.
Alzheimer's Research and Therapy
, 11
, Article 105. 10.1186/s13195-019-0564-2.
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Deming, Y;
Filipello, F;
Cignarella, F;
Cantoni, C;
Hsu, S;
Mikesell, R;
Li, Z;
... Cruchaga, C; + view all
(2019)
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Science Translational Medicine
, 11
(505)
, Article eaau2291. 10.1126/scitranslmed.aau2291.
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Ehler, J;
Petzold, A;
Wittstock, M;
Kolbaske, S;
Gloger, M;
Henschel, J;
Heslegrave, A;
... Sauer, M; + view all
(2019)
Correction: The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study.
PLoS One
, 14
(2)
, Article e0212830. 10.1371/journal.pone.0212830.
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Ehler, J;
Petzold, A;
Wittstock, M;
Kolbaske, S;
Gloger, M;
Henschel, J;
Heslegrave, A;
... Sauer, M; + view all
(2019)
The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study.
PLoS One
, 14
(1)
, Article e0211184. 10.1371/journal.pone.0211184.
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Foiani, MS;
Cicognola, C;
Ermann, N;
Woollacott, IOC;
Heller, C;
Heslegrave, AJ;
Keshavan, A;
... Rohrer, JD; + view all
(2019)
Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest.
Journal of Neurology, Neurosurgery and Psychiatry
10.1136/jnnp-2018-319266.
(In press).
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Foiani, MS;
Woollacott, IO;
Heller, C;
Bocchetta, M;
Heslegrave, A;
Dick, KM;
Russell, LL;
... Rohrer, JD; + view all
(2018)
Plasma tau is increased in frontotemporal dementia.
Journal of Neurology, Neurosurgery and Psychiatry
, 89
(8)
pp. 804-807.
10.1136/jnnp-2017-317260.
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Gafson, AR;
Savva, C;
Thorne, T;
David, M;
Gomez-Romero, M;
Lewis, MR;
Nicholas, R;
... Matthews, PM; + view all
(2019)
Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate.
Neurology: Neuroimmunology & NeuroInflammation
, 6
(3)
, Article e562. 10.1212/NXI.0000000000000562.
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Garcia-Reitboeck, P;
Phillips, A;
Piers, TM;
Villegas-Llerena, C;
Butler, M;
Mallach, A;
Rodrigues, C;
... Pocock, JM; + view all
(2018)
Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
Cell Reports
, 24
(9)
pp. 2300-2311.
10.1016/j.celrep.2018.07.094.
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Garland, P;
Morton, M;
Zolnourian, A;
Durnford, A;
Gaastra, B;
Toombs, J;
Heslegrave, AJ;
... Galea, I; + view all
(2021)
Neurofilament light predicts neurological outcome after subarachnoid haemorrhage.
Brain
10.1093/brain/awaa451.
(In press).
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Garland, P;
Morton, MJ;
Haskins, W;
Zolnourian, A;
Durnford, A;
Gaastra, B;
Toombs, J;
... Galea, I; + view all
(2020)
Haemoglobin causes neuronal damage in vivo which is preventable by haptoglobin.
Brain Communications
, 2
(1)
, Article fcz053. 10.1093/braincomms/fcz053.
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Georgiou, E;
Kagiava, A;
Sargiannidou, I;
Schiza, N;
Stavrou, M;
Richter, J;
Tryfonos, C;
... Kleopa, KA; + view all
(2023)
AAV9-mediated SH3TC2 gene replacement therapy targeted to Schwann cells for the treatment of CMT4C.
Molecular Therapy
10.1016/j.ymthe.2023.08.020.
(In press).
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Gisslen, M;
Heslegrave, A;
Veleva, E;
Yilmaz, A;
Andersson, L-M;
Hagberg, L;
Spudich, S;
... Zetterberg, H; + view all
(2019)
CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection.
Neurology, Neuroimmunology and Neuroinflammation
, 6
(1)
, Article e512. 10.1212/NXI.0000000000000512.
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Gorgoraptis, N;
Li, LM;
Whittington, A;
Zimmerman, KA;
Maclean, LM;
McLeod, C;
Ross, E;
... Sharp, DJ; + view all
(2019)
In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury.
Science Translational Medicine
, 11
(508)
, Article eaaw1993. 10.1126/scitranslmed.aaw1993.
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Graham, Neil;
Zimmerman, Karl;
Heslegrave, Amanda J;
Keshavan, Ashvini;
Moro, Federico;
Abed-Maillard, Samia;
Bernini, Adriano;
... Sharp, David; + view all
(2023)
Alzheimer's disease marker phospho-tau181 is not elevated in the first year after moderate-to-severe TBI.
Journal of Neurology, Neurosurgery & Psychiatry
10.1136/jnnp-2023-331854.
(In press).
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Graham, NSN;
Blissitt, G;
Zimmerman, K;
Friedland, D;
Dumas, ME;
Coady, E;
Heslegrave, A;
... Sharp, DJ; + view all
(2023)
ADVANCE-TBI study protocol: traumatic brain injury outcomes in UK military personnel serving in Afghanistan between 2003 and 2014 - a longitudinal cohort study.
BMJ open
, 13
(3)
, Article e069243. 10.1136/bmjopen-2022-069243.
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Graham, NSN;
Zimmerman, KA;
Moro, F;
Heslegrave, A;
Maillard, SA;
Bernini, A;
Miroz, J-P;
... Sharp, DJ; + view all
(2021)
Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury.
Science Translational Medicine
, 13
(613)
, Article eabg9922. 10.1126/scitranslmed.abg9922.
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Graham, NSN;
Zimmerman, KA;
Bertolini, G;
Magnoni, S;
Oddo, M;
Zetterberg, H;
Moro, F;
... Sharp, DJ; + view all
(2020)
Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol.
BMJ Open
, 10
(11)
, Article e042093. 10.1136/bmjopen-2020-042093.
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Gray, E;
Oeckl, P;
Amador, MDM;
Andreasson, U;
An, J;
Blennow, K;
Bowser, R;
... Otto, M; + view all
(2020)
A multi-center study of neurofilament assay reliability and inter-laboratory variability.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
, 21
(5-6)
pp. 452-458.
10.1080/21678421.2020.1779300.
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Guerreiro, R;
Bras, J;
Toombs, J;
Heslegrave, A;
Hardy, J;
Zetterberg, H;
(2015)
Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease.
Curr Genet Med Rep
, 3
19 - 25.
10.1007/s40142-014-0062-6.
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Hamilton, Calum Alexander;
O'Brien, John;
Heslegrave, Amanda;
Laban, Rhiannon;
Donaghy, Paul;
Durcan, Rory;
Lawley, Sarah;
... Thomas, Alan; + view all
(2023)
Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies.
Psychological Medicine
10.1017/S0033291723001952.
(In press).
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Heller, C;
Chan, E;
Foiani, MS;
Todd, E;
Russell, LL;
Greaves, CV;
Heslegrave, AJ;
... Rohrer, JD; + view all
(2020)
Plasma glial fibrillary acidic protein and neurofilament light chain are measures of disease severity in semantic variant primary progressive aphasia.
Journal of Neurology, Neurosurgery & Psychiatry
10.1136/jnnp-2020-325085.
(In press).
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Heller, C;
Foiani, MS;
Moore, K;
Convery, R;
Bocchetta, M;
Neason, M;
Cash, DM;
... GENFI; + view all
(2020)
Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia.
Journal of Neurology, Neurosurgery and Psychiatry
10.1136/jnnp-2019-321954.
(In press).
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Heslegrave, A;
Heywood, W;
Paterson, R;
Magdalinou, N;
Svensson, J;
Johansson, P;
Ohrfelt, A;
... Zetterberg, H; + view all
(2016)
Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease.
Molecular Neurodegeneration
, 11
, Article 3. 10.1186/s13024-016-0071-x.
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Heywood, WE;
Galimberti, D;
Bliss, E;
Sirka, E;
Paterson, RW;
Magdalinou, NK;
Carecchio, M;
... Mills, K; + view all
(2015)
Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay.
Molecular Neurodegeneration
, 10
, Article 64. 10.1186/s13024-015-0059-y.
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Heywood, WE;
Galimberti, D;
Bliss, E;
Sirka, E;
Paterson, RW;
Magdalinou, NK;
Carecchio, M;
... Mills, K; + view all
(2016)
Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay (vol 10, 64, 2015).
[Corrigendum].
Molecular Neurodegeneration
, 11
, Article 20. 10.1186/s13024-016-0086-3.
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Heywood, WE;
Hallqvist, J;
Heslegrave, AJ;
Zetterberg, H;
Fenoglio, C;
Scarpini, E;
Rohrer, JD;
... Mills, K; + view all
(2018)
CSF pro-orexin and amyloid-β38 expression in Alzheimer's disease and frontotemporal dementia.
Neurobiology of Aging
, 72
pp. 171-176.
10.1016/j.neurobiolaging.2018.08.019.
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Iwan, Katharina;
Patel, Nina;
Heslegrave, Amanda;
Borisova, Mina;
Lee, Laura;
Bower, Rebecca;
Mole, Sara E;
... Heywood, Wendy E; + view all
(2021)
Cerebrospinal fluid neurofilament light chain levels in CLN2 disease patients treated with enzyme replacement therapy normalise after two years on treatment.
F1000Research
, 10
, Article 614. 10.12688/f1000research.54556.2.
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Iwan, K;
Patel, N;
Heslegrave, A;
Borisova, M;
Lee, L;
Bower, R;
Mole, SE;
... Heywood, WE; + view all
(2021)
Cerebrospinal fluid neurofilament light levels in CLN2 disease patients treated with enzyme replacement therapy normalise after two years on treatment [version 1; peer review: 1 approved with reservations].
F1000Research
, 10
, Article 614. 10.12688/f1000research.54556.1.
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Jabbari, E;
Holland, N;
Chelban, V;
Jones, PS;
Lamb, R;
Rawlinson, C;
Guo, T;
... Morris, HR; + view all
(2019)
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome.
JAMA Neurology
, 77
(3)
pp. 377-387.
10.1001/jamaneurol.2019.4347.
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James, S-N;
Nicholas, JM;
Lane, CA;
Parker, TD;
Lu, K;
Keshavan, A;
Buchanan, SM;
... Fox, NC; + view all
(2021)
A population‐based study of head injury, cognitive function and pathological markers.
Annals of Clinical and Translational Neurology
10.1002/acn3.51331.
(In press).
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Jensen, CS;
Bahl, JM;
Østergaard, LB;
Høgh, P;
Wermuth, L;
Heslegrave, A;
Zetterberg, H;
... Simonsen, AH; + view all
(2019)
Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma.
Experimental Gerontology
, 121
pp. 91-98.
10.1016/j.exger.2019.04.003.
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Kagiava, A;
Karaiskos, C;
Lapathitis, G;
Heslegrave, A;
Sargiannidou, I;
Zetterberg, H;
Bosch, A;
(2023)
Gene replacement therapy in two Golgi-retained CMT1X mutants before and after the onset of demyelinating neuropathy.
Molecular Therapy - Methods and Clinical Development
, 30
pp. 377-393.
10.1016/j.omtm.2023.07.011.
(In press).
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Kagiava, A;
Karaiskos, C;
Richter, J;
Tryfonos, C;
Jennings, MJ;
Heslegrave, AJ;
Sargiannidou, I;
... Kleopa, KA; + view all
(2021)
AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy.
Gene Therapy
10.1038/s41434-021-00250-0.
(In press).
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Kagiava, A;
Richter, J;
Tryfonos, C;
Karaiskos, C;
Heslegrave, AJ;
Sargiannidou, I;
Rossor, AM;
... Kleopa, KA; + view all
(2019)
Gene replacement therapy after neuropathy onset provides therapeutic benefit in a model of CMT1X.
Human Molecular Genetics
, 28
(21)
pp. 3528-3542.
10.1093/hmg/ddz199.
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Kapoor, M;
Foiani, M;
Heslegrave, A;
Zetterberg, H;
Lunn, MP;
Malaspina, A;
Gillmore, JD;
... Reilly, MM; + view all
(2019)
Plasma neurofilament light chain concentration is increased and correlates with the severity of neuropathy in hereditary transthyretin amyloidosis.
Journal of the Peripheral Nervous System
, 24
(4)
pp. 314-319.
10.1111/jns.12350.
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Keddie, S;
Ziff, O;
Chou, MKL;
Taylor, RL;
Heslegrave, A;
Garr, E;
Lakdawala, N;
... Lunn, MP; + view all
(2020)
Laboratory biomarkers associated with COVID-19 severity and management.
Clinical Immunology
, 221
, Article 108614. 10.1016/j.clim.2020.108614.
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Keshavan, A;
Heslegrave, A;
Zetterberg, H;
Schott, JM;
(2018)
Stability of blood-based biomarkers of Alzheimer's disease over multiple freeze-thaw cycles.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
, 10
pp. 448-451.
10.1016/j.dadm.2018.06.001.
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Keshavan, A;
Heslegrave, A;
Zetterberg, H;
Schott, JM;
(2017)
Blood Biomarkers for Alzheimer's Disease: Much Promise, Cautious Progress.
Molecular Diagnosis & Therapy
, 21
(1)
pp. 13-22.
10.1007/s40291-016-0241-0.
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Keshavan, A;
Pannee, J;
Karikari, T;
Lantero Rodriguez, J;
Ashton, NJ;
Nicholas, JM;
Cash, D;
... Schott, J; + view all
(2021)
Population-based blood screening for pre-clinical Alzheimer's disease in a British birth cohort at age 70.
Brain
, 144
(2)
pp. 434-449.
10.1093/brain/awaa403.
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Keshavan, A;
Wellington, H;
Chen, Z;
Khatun, A;
Chapman, M;
Hart, M;
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Validation of remote collection and quantification of blood Neurofilament light in neurological diseases.
MedRxiv: Cold Spring Harbor, NY, USA.
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