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Inflammatory markers of CHMP2B-mediated frontotemporal dementia

Roos, P; von Essen, MR; Nielsen, TT; Johannsen, P; Stokholm, J; Bie, AS; Waldemar, G; ... Nielsen, JE; + view all (2018) Inflammatory markers of CHMP2B-mediated frontotemporal dementia. Journal of Neuroimmunology , 324 pp. 136-142. 10.1016/j.jneuroim.2018.08.009. Green open access

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Abstract

Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

Type: Article
Title: Inflammatory markers of CHMP2B-mediated frontotemporal dementia
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jneuroim.2018.08.009
Publisher version: https://doi.org/10.1016/j.jneuroim.2018.08.009
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Autosomal dominantly inherited frontotemporal dementia, CHMP2B, Chromosome 3-linked frontotemporal dementia (FTD-3), Inflammation, TREM2
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10060515
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