Roos, P;
von Essen, MR;
Nielsen, TT;
Johannsen, P;
Stokholm, J;
Bie, AS;
Waldemar, G;
... Nielsen, JE; + view all
(2018)
Inflammatory markers of CHMP2B-mediated frontotemporal dementia.
Journal of Neuroimmunology
, 324
pp. 136-142.
10.1016/j.jneuroim.2018.08.009.
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Abstract
Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.
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