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Serum neurofilament light concentration does not increase following exposure to low velocity football heading

Austin, K; Lee, BJ; Flood, TR; Toombs, J; Borisova, M; Lauder, M; Heslegrave, A; ... Smith, NA; + view all (2020) Serum neurofilament light concentration does not increase following exposure to low velocity football heading. Science and Medicine in Football 10.1080/24733938.2020.1853210. (In press). Green open access

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Abstract

OBJECTIVES: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 days after heading incident at ball velocities reflecting basic training drills. METHODS: Forty-four males were randomized into either control (n = 8), 10 header (n = 12), 20 header (n = 12) or 40 header (n = 12) groups. Linear and angular head accelerations were quantified during heading. Venous blood samples were taken at baseline, 6 h, 24 h and 7 days after heading. Serum NF-L was quantified using Quanterix NF-L assay kit on the Simoa HD-1 Platform. RESULTS: erum NF-L did not alter over time (p = 0.44) and was not influenced by number of headers [p = 0.47; mean (95% CI) concentrations at baseline 6.00 pg · ml^{− 1} (5.00–7.00 pg · ml^{− 1}); 6 h post 6.50 pg · ml^{− 1} (5.70–7.29 pg · ml^{− 1}); 24 h post 6.07 pg · ml^{− 1} (5.14–7.01 pg · ml^{− 1}); and 7 days post 6.46 pg · ml^{− 1} (5.45–7.46 pg · ml^{− 1})]. There was no relationship between percentage change in NF-L and summed session linear and angular head accelerations. CONCLUSION: In adult men, heading frequency or impact biomechanics did not affect NF-L response during a single session of headers at ball velocities reflective of basic training tasks.

Type: Article
Title: Serum neurofilament light concentration does not increase following exposure to low velocity football heading
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/24733938.2020.1853210
Publisher version: https://doi.org/10.1080/24733938.2020.1853210
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Soccer, heading, brain injury, axonal damage, biomechanics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10118876
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