Guerreiro, R;
Bras, J;
Toombs, J;
Heslegrave, A;
Hardy, J;
Zetterberg, H;
(2015)
Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease.
Curr Genet Med Rep
, 3
19 - 25.
10.1007/s40142-014-0062-6.
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Abstract
From a neuropathological perspective, elderly patients who die with a clinical diagnosis of sporadic Alzheimer's disease (AD) are a heterogeneous group with several different pathologies contributing to the AD phenotype. This poses a challenge when searching for low effect size susceptibility genes for AD. Further, control groups may be contaminated by significant numbers of preclinical AD patients, which also reduces the power of genetic association studies. Here, we discuss how cerebrospinal fluid and imaging biomarkers can be used to increase the chance of finding novel susceptibility genes and as a means to study the functional consequences of risk alleles.
| Type: | Article |
|---|---|
| Title: | Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s40142-014-0062-6 |
| Publisher version: | http://dx.doi.org/10.1007/s40142-014-0062-6 |
| Additional information: | © The Author(s) 2014. This article is published with open access at Springerlink.com This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| Keywords: | Cerebrospinal fluid, Imaging biomarkers, Novel susceptibility genes, Risk alleles |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1462483 |
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