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Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease.

Guerreiro, R; Bras, J; Toombs, J; Heslegrave, A; Hardy, J; Zetterberg, H; (2015) Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease. Curr Genet Med Rep , 3 19 - 25. 10.1007/s40142-014-0062-6. Green open access

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Abstract

From a neuropathological perspective, elderly patients who die with a clinical diagnosis of sporadic Alzheimer's disease (AD) are a heterogeneous group with several different pathologies contributing to the AD phenotype. This poses a challenge when searching for low effect size susceptibility genes for AD. Further, control groups may be contaminated by significant numbers of preclinical AD patients, which also reduces the power of genetic association studies. Here, we discuss how cerebrospinal fluid and imaging biomarkers can be used to increase the chance of finding novel susceptibility genes and as a means to study the functional consequences of risk alleles.

Type: Article
Title: Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40142-014-0062-6
Publisher version: http://dx.doi.org/10.1007/s40142-014-0062-6
Additional information: © The Author(s) 2014. This article is published with open access at Springerlink.com This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Cerebrospinal fluid, Imaging biomarkers, Novel susceptibility genes, Risk alleles
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1462483
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