Browse by UCL people
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Number of items: 114.
Article
Ahmed, Ahmed Abdullah;
Chen, Shuang;
Roman-Escorza, Maria;
Angell, Richard;
Oxenford, Sally;
McConville, Matthew;
Barton, Naomi;
... Neidle, Stephen; + view all
(2024)
Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling.
Scientific Reports
, 14
, Article 3447. 10.1038/s41598-024-54080-2.
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Akere, A;
Chen, SH;
Liu, X;
Chen, Y;
Dantu, SC;
Pandini, A;
Bhowmik, D;
(2020)
Structure-based enzyme engineering improves donor-substrate recognition of Arabidopsis thaliana Glycosyltransferases.
Biochemical Journal
, 477
(15)
pp. 2791-2805.
10.1042/BCJ20200477.
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Alanazi, Abeer FR;
Haider, Shozeb;
Parkinson, Gary N;
(2024)
The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements.
Medicinal Chemistry Research
, 33
pp. 2066-2078.
10.1007/s00044-024-03197-0.
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Alanazi, Abeer FR;
Parkinson, Gary N;
Haider, Shozeb;
(2024)
Structural Motifs at the Telomeres and Their Role in Regulatory Pathways.
Biochemistry
10.1021/acs.biochem.4c00023.
(In press).
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Allington, G;
Duy, PQ;
Ryou, J;
Singh, A;
Kiziltug, E;
Robert, S;
Kundishora, AJ;
... Jin, SC; + view all
(2022)
Genomic approaches to improve the clinical diagnosis and management of patients with congenital hydrocephalus.
Journal of Neurosurgery: Pediatrics
, 29
(2)
pp. 168-177.
10.3171/2021.8.PEDS21368.
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Allington, Garrett;
Mehta, Neel H;
Dennis, Evan;
Mekbib, Kedous Y;
Reeves, Benjamin;
Kiziltug, Emre;
Chen, Shuang;
... Kahle, Kristopher T; + view all
(2024)
De novo variants disrupt an LDB1-regulated transcriptional network in congenital ventriculomegaly.
Brain
, Article awae395. 10.1093/brain/awae395.
(In press).
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Allocco, AA;
Jin, SC;
Duy, PQ;
Furey, CG;
Zeng, X;
Dong, W;
Nelson-Williams, C;
... Kahle, KT; + view all
(2019)
Recessive Inheritance of Congenital Hydrocephalus With Other Structural Brain Abnormalities Caused by Compound Heterozygous Mutations in ATP1A3.
Frontiers in Cellular Neuroscience
, 13
, Article 425. 10.3389/fncel.2019.00425.
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Alnami, A;
Norton, RS;
Perez Pena, H;
Haider, S;
Kozielski, F;
(2021)
Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ.
Journal of Molecular Biology
, 433
(15)
, Article 167061. 10.1016/j.jmb.2021.167061.
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Barnes, MD;
Taracila, MA;
Rutter, JD;
Bethel, CR;
Galdadas, I;
Hujer, AM;
Caselli, E;
... Bonomo, RA; + view all
(2018)
Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa.
mBio
, 9
(6)
, Article e02085. 10.1128/mBio.02085-18.
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Bidaux, G;
Sgobba, M;
Lemonnier, L;
Borowiec, A-S;
Noyer, L;
Jovanovic, S;
Zholos, AV;
(2015)
Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel.
Biophysical Journal
, 109
(9)
pp. 1840-1851.
10.1016/j.bpj.2015.09.027.
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Bončina, M;
Hamon, F;
Islam, B;
Teulade-Fichou, MP;
Vesnaver, G;
Haider, S;
Lah, J;
(2015)
Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations.
Biophysical Journal
, 108
(12)
pp. 2903-2911.
10.1016/j.bpj.2015.05.001.
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Borsatto, Alberto;
Akkad, Obaeda;
Galdadas, Ioannis;
Ma, Shumeng;
Damfo, Shymaa;
Haider, Shozeb;
Kozielski, Frank;
... Gervasio, Francesco Luigi; + view all
(2022)
Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography.
eLife
, 11
, Article e81167. 10.7554/eLife.81167.
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Brunetti, Florencia;
Gutkind, Gabriel;
Gao, Lin;
Haider, Shozeb;
Bonomo, Robert A;
Power, Pablo;
(2025)
Impact of the double deletion ΔG242-T243 in KPC-2 in the effectiveness of ceftazidime-avibactam and imipenem-relebactam.
Antimicrobial Agents and Chemotherapy
, 69
(6)
, Article e0191524. 10.1128/aac.01915-24.
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Bux, K;
Shen, X;
Tariq, M;
Yin, J;
Moin, ST;
Bhowmik, D;
Haider, S;
(2021)
Inter-Subunit Dynamics Controls Tunnel Formation During the Oxygenation Process in Hemocyanin Hexamers.
Frontiers in Molecular Biosciences
, 8
, Article ARTN 710. 10.3389/fmolb.2021.710623.
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Chay, SK;
Keating, AV;
James, C;
Aliev, A;
Haider, S;
Craig, DQM;
(2018)
Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment.
RSC Advances
(8)
pp. 3564-3573.
10.1039/C7RA11015D.
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Chen, Shuang;
Akram, Ekram;
Liang, Hui;
Qiao, Weili;
Zhang, Yifei;
Haider, Shozeb;
Cao, Yufei;
(2025)
Insight into how PETase Functions at the Solid-Liquid Interface and an Activity-Stability Trade-Off.
Angewandte Chemie
, 137
(37)
, Article e202511131. 10.1002/ange.202511131.
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Chen, Shuang;
Akram, Ekram;
Liang, Hui;
Qiao, Weili;
Zhang, Yifei;
Shozeb, Haider;
Cao, Yufei;
(2025)
Insight into how PETase Functions at the Solid-Liquid Interface and an Activity-Stability Trade-Off.
Angewandte Chemie - International Edition
, 64
(37)
, Article e202511131. 10.1002/anie.202511131.
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Cho, E;
Rosa, M;
Anjum, R;
Mehmood, S;
Soban, M;
Mujtaba, M;
Bux, K;
... Haider, S; + view all
(2021)
Dynamic Profiling of β-Coronavirus 3CL Mpro Protease Ligand-Binding Sites.
Journal of Chemical Information and Modeling
, 61
(6)
pp. 3058-3073.
10.1021/acs.jcim.1c00449.
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Collie, GW;
Haider, SM;
Neidle, S;
Parkinson, GN;
(2010)
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex.
Nucleic Acids Res
, 38
(16)
5569 - 5580.
10.1093/nar/gkq259.
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Darbari, VC;
Ciccone, J;
Patel, JS;
Islam, B;
Agarwal, PK;
Haider, S;
(2020)
Electrostatic Switching Controls Channel Dynamics of the Sensor Protein VirB10 in A. tumefaciens Type IV Secretion System.
ACS Omega
, 5
(7)
pp. 3271-3281.
10.1021/acsomega.9b03313.
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Dong, W;
Jin, SC;
Allocco, A;
Zeng, X;
Sheth, AH;
Panchagnula, S;
Castonguay, A;
... Kahle, KT; + view all
(2020)
Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia.
iScience
, 23
(10)
, Article 101552. 10.1016/j.isci.2020.101552.
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Duran, D;
Zeng, X;
Jin, SC;
Choi, J;
Nelson-Williams, C;
Yatsula, B;
Gaillard, J;
... Kahle, KT; + view all
(2019)
Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation.
Neuron
, 101
10.1016/j.neuron.2018.11.041.
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Duy, Phan Q;
Jux, Bettina;
Zhao, Shujuan;
Mekbib, Kedous Y;
Dennis, Evan;
Dong, Weilai;
Nelson-Williams, Carol;
... Kahle, Kristopher T; + view all
(2024)
TRIM71 mutations cause a neurodevelopmental syndrome featuring ventriculomegaly and hydrocephalus.
Brain
, 147
(12)
pp. 4292-4305.
10.1093/brain/awae175.
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Furey, CG;
Choi, J;
Jin, SC;
Zeng, X;
Timberlake, AT;
Nelson-Williams, C;
Mansuri, MS;
... Kahle, KT; + view all
(2018)
De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.
Neuron
, 99
(2)
pp. 302-314.
10.1016/j.neuron.2018.06.019.
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Galdadas, I;
Carlino, L;
Ward, RA;
Hughes, SJ;
Haider, S;
Gervasio, FL;
(2021)
Structural basis of the effect of activating mutations on the EGF receptor.
eLife
, 10
, Article e65824. 10.7554/eLife.65824.
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Galdadas, I;
Lovera, S;
Pérez-Hernández, G;
Barnes, MD;
Healy, J;
Afsharikho, H;
Woodford, N;
... Haider, S; + view all
(2018)
Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance.
Scientific Reports
, 8
(1)
, Article 12916. 10.1038/s41598-018-31176-0.
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Galdadas, I;
Qu, S;
Oliveira, ASF;
Olehnovics, E;
Mack, AR;
Mojica, MF;
Agarwal, PK;
... Haider, S; + view all
(2021)
Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics.
eLife
, 10
10.7554/eLife.66567.
(In press).
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Gao, Chao;
Liu, Zhu;
Hou, Haitao;
Ding, Jieqin;
Chen, Xin;
Xie, Congbao;
Song, Zibing;
... Wei, Dengguo; + view all
(2020)
BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers.
Nucleic Acids Research
, 48
(20)
pp. 11259-11269.
10.1093/nar/gkaa870.
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Gera, S;
Sant, D;
Haider, S;
Korkmaz, F;
Kuo, T-C;
Mathew, M;
Perez-Pena, H;
... Zaidi, M; + view all
(2020)
First-in-class humanized FSH blocking antibody targets bone and fat.
Proceedings of the National Academy of Sciences of the United States of America
, 117
(46)
pp. 28971-28979.
10.1073/pnas.2014588117.
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Gluszynska, Agata;
Kosman, Joanna;
Chuah, Shang Shiuan;
Hoffmann, Marcin;
Haider, Shozeb;
(2024)
Carbazole Derivatives Binding to Bcl-2 Promoter Sequence G-quadruplex.
Pharmaceuticals
, 17
(7)
, Article 912. 10.3390/ph17070912.
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Głuszyńska, A;
Juskowiak, B;
Kuta-Siejkowska, M;
Hoffmann, M;
Haider, S;
(2018)
Carbazole ligands as c-myc G-quadruplex binders.
International Journal of Biological Macromolecules
, 114
pp. 479-490.
10.1016/j.ijbiomac.2018.03.135.
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Głuszyńska, A;
Juskowiak, B;
Kuta-Siejkowska, M;
Hoffmann, M;
Haider, S;
(2018)
Carbazole Derivatives' Binding to c-KIT G-Quadruplex DNA.
Molecules
, 23
(5)
, Article 1134. 10.3390/molecules23051134.
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Gu, J;
Agarwal, PK;
Bonomo, RA;
Haider, S;
(2025)
Evolutionary Dynamics and Functional Differences in Clinically Relevant Pen β-Lactamases from Burkholderia spp.
Journal of Chemical Information and Modeling
, 65
(10)
pp. 5086-5098.
10.1021/acs.jcim.5c00271.
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Guneri, Dilek;
Alexandrou, Effrosyni;
El Omari, Kamel;
Dvorakova, Zuzana;
Chikhale, Rupesh V;
Pike, Daniel TS;
Waudby, Christopher A;
... Waller, Zoe AE; + view all
(2024)
Structural insights into i-motif DNA structures in sequences from the insulin-linked polymorphic region.
Nature Communications
, 15
(1)
, Article 7119. 10.1038/s41467-024-50553-0.
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Guneri, Dilek;
Rosonovski, Summer;
Alexandrou, Effrosyni;
Chen, Shuang;
King, Jessica;
Waudby, Christopher A;
Haider, Shozeb;
... Waller, Zoë AE; + view all
(2025)
Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression.
Nucleic Acids Research
, 53
(20)
, Article gkaf1052. 10.1093/nar/gkaf1052.
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Haider, S;
(2018)
Computational Methods to Study G-Quadruplex-Ligand Complexes.
Journal of the Indian Institute of Science
, 98
(3)
pp. 325-339.
10.1007/s41745-018-0083-3.
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Haider, S;
Li, P;
Khiali, S;
Munnur, D;
Ramanathan, A;
Parkinson, GN;
(2018)
Holliday Junctions Formed from Human Telomeric DNA.
Journal of the American Chemical Society
, 140
(45)
pp. 15366-15374.
10.1021/jacs.8b08699.
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Haider, S;
Parkinson, GN;
Marsh, TC;
(2018)
G-Quadruplexes (GQU).
Journal of Nucleic Acids
, 2018
, Article 1079191. 10.1155/2018/1079191.
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Haldar, Susanta;
Zhang, Yashu;
Xia, Ying;
Islam, Barira;
Liu, Sisi;
Gervasio, FL;
Mulholland, AJ;
... Haider, S; + view all
(2022)
Mechanistic Insights into the Ligand-Induced Unfolding of an RNA G-Quadruplex.
Journal of the American Chemical Society
, 144
(2)
pp. 935-950.
10.1021/jacs.1c11248.
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Homer, JA;
Koelln, RA;
Barrow, AS;
Gialelis, TL;
Boiarska, Z;
Steinohrt, NS;
Lee, EF;
... Moses, JE; + view all
(2024)
Modular synthesis of functional libraries by accelerated SuFEx click chemistry.
Chemical Science
, 15
(11)
pp. 3879-3892.
10.1039/d3sc05729a.
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Indorato, R-L;
Talapatra, SK;
Lin, F;
Haider, S;
Mackay, SP;
Kozielski, F;
Skoufias, DA;
(2019)
Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes.
Molecular Cancer Therapeutics
, 18
(12)
pp. 2394-2406.
10.1158/1535-7163.MCT-19-0154.
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Islam, B;
Stadlbauer, P;
Gil-Ley, A;
Pérez-Hernández, G;
Haider, S;
Neidle, S;
Bussi, G;
... Sponer, J; + view all
(2017)
Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations.
Journal of Chemical Theory and Computation
, 13
(6)
pp. 2458-2480.
10.1021/acs.jctc.7b00226.
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Islam, B;
Stadlbauer, P;
Krepl, M;
Havrila, M;
Haider, S;
Sponer, J;
(2018)
Structural Dynamics of Lateral and Diagonal Loops of Human Telomeric G-Quadruplexes in Extended MD Simulations.
Journal of Chemical Theory and Computation
, 14
(10)
pp. 5011-5026.
10.1021/acs.jctc.8b00543.
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Islam, B;
Stadlbauer, P;
Krepl, M;
Koca, J;
Neidle, S;
Haider, S;
Sponer, J;
(2015)
Extended molecular dynamics of a c-kit promoter quadruplex.
Nucleic Acids Research
, 43
(18)
pp. 8673-8693.
10.1093/nar/gkv785.
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Islam, B;
Stadlbauer, P;
Neidle, S;
Haider, S;
Sponer, J;
(2016)
Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds?
Journal of Physical Chemistry B
, 120
(11)
pp. 2899-2912.
10.1021/acs.jpcb.6b01059.
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Jafaripour, SS;
Gharaghani, S;
Nazarshodeh, E;
Haider, S;
Saboury, AA;
(2020)
In silico drug repositioning of FDA-approved drugs to predict new inhibitors for alpha-synuclein aggregation.
Computational Biology and Chemistry
, 88
, Article 107308. 10.1016/j.compbiolchem.2020.107308.
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Jamal, Sehrish;
Moin, Syed Tarique;
Haider, Shozeb;
(2025)
Exploring the structural and functional dynamics of trimeric and tetrameric states of influenza encoded PB1-F2 viroporin through molecular dynamics simulations.
Journal of Molecular Graphics and Modelling
, 137
, Article 108983. 10.1016/j.jmgm.2025.108983.
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Ji, Y;
Liu, P;
Yuen, T;
Haider, S;
He, J;
Romero, R;
Chen, H;
... Zaidi, M; + view all
(2018)
Epitope-specific monoclonal antibodies to FSHβ increase bone mass.
Proceedings of the National Academy of Sciences
, 115
(9)
pp. 2192-2197.
10.1073/pnas.1718144115.
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Jin, SC;
Dong, W;
Kundishora, AJ;
Panchagnula, S;
Moreno-De-Luca, A;
Furey, CG;
Allocco, AA;
... Kahle, KT; + view all
(2020)
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.
Nature Medicine
, 26
(11)
pp. 1754-1765.
10.1038/s41591-020-1090-2.
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Jin, SC;
Homsy, J;
Zaidi, S;
Lu, Q;
Morton, S;
DePalma, SR;
Zeng, X;
... Brueckner, M; + view all
(2017)
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.
Nature Genetics
, 49
pp. 1593-1601.
10.1038/ng.3970.
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Jin, SC;
Lewis, SA;
Bakhtiari, S;
Zeng, X;
Sierant, MC;
Shetty, S;
Nordlie, SM;
... Kruer, MC; + view all
(2020)
Mutations disrupting neuritogenesis genes confer risk for cerebral palsy.
Nature Genetics
, 52
pp. 1046-1056.
10.1038/s41588-020-0695-1.
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Kazemzadeh, Hamid;
Bagheri, Mahsima;
Sepehri, Maryam;
Ebrahimi, Elham;
Wang, Huan;
Haider, Shozeb;
Kheirabadi, Mitra;
(2024)
Isolation and Characterization of the Vascular Endothelial Growth Factor Receptor Targeting ScFv Antibody Fragments Derived from Phage Display Technology.
ACS Omega
, 9
(20)
pp. 21964-21973.
10.1021/acsomega.3c10158.
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Khattab, A;
Yuen, T;
Al-Malki, S;
Yau, M;
Kazmi, D;
Sun, L;
Harbison, M;
... New, MI; + view all
(2016)
A rare CYP21A2 mutation in a congenital adrenal hyperplasia kindred displaying genotype-phenotype nonconcordance.
Annals of the New York Academy of Sciences
, 1364
(1)
, Article Special Issue:MARROW. 10.1111/nyas.12864.
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Khattab, A;
Haider, S;
Kumar, A;
Dhawan, S;
Alam, D;
Romero, R;
Burns, J;
... New, MI; + view all
(2017)
Clinical, genetic, and structural basis of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Proceedings of the National Academy of Sciences of the United States of America
, 114
(10)
E1933-E1940.
10.1073/pnas.1621082114/-/DCSupplemental.
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Khoshkhoo, S;
Wang, Y;
Chahine, Y;
Erson-Omay, EZ;
Robert, SM;
Kiziltug, E;
Damisah, EC;
... Kahle, KT; + view all
(2023)
Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy.
JAMA Neurology
, 80
(6)
pp. 578-587.
10.1001/jamaneurol.2023.0473.
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Kim, S-M;
Taneja, C;
Perez-Pena, H;
Ryu, V;
Gumerova, A;
Li, W;
Ahmad, N;
... Zaidi, M; + view all
(2020)
Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.
Proceedings of the National Academy of Sciences (PNAS)
, 117
(25)
pp. 14386-14394.
10.1073/pnas.2000950117.
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Krauss, IR;
Ramaswamy, S;
Neidle, S;
Haider, S;
Parkinson, GN;
(2016)
Structural Insights into the Quadruplex-Duplex 3 ' Interface Formed from a Telomeric Repeat: A Potential Molecular Target.
Journal of the American Chemical Society
, 138
(4)
pp. 1226-1233.
10.1021/jacs.5b10492.
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Kundishora, Adam J;
Allington, Garrett;
McGee, Stephen;
Mekbib, Kedous Y;
Gainullin, Vladimir;
Timberlake, Andrew T;
Nelson-Williams, Carol;
... Kahle, Kristopher T; + view all
(2023)
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts.
Nature Medicine
, 29
pp. 667-678.
10.1038/s41591-023-02238-2.
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Kundishora, AJ;
Peters, ST;
Pinard, A;
Duran, D;
Panchagnula, S;
Barak, T;
Miyagishima, DF;
... Kahle, KT; + view all
(2021)
DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease.
JAMA Neurology
, 78
(8)
pp. 993-1003.
10.1001/jamaneurol.2021.1681.
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Küry, S;
Zhang, J;
Besnard, T;
Caro-Llopis, A;
Zeng, X;
Robert, SM;
Josiah, SS;
... Isidor, B; + view all
(2022)
Rare pathogenic variants in WNK3 cause X-linked intellectual disability.
Genetics in Medicine
, 24
(9)
pp. 1941-1951.
10.1016/j.gim.2022.05.009.
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Lanphere, Conor;
Ciccone, Jonah;
Dorey, Adam;
Hagleitner-Ertuğrul, Nora;
Knyazev, Denis;
Haider, Shozeb;
Howorka, Stefan;
(2022)
Triggered Assembly of a DNA-Based Membrane Channel.
Journal of the American Chemical Society
, 144
(10)
pp. 4333-4344.
10.1021/jacs.1c06598.
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Liu, P;
Ji, Y;
Yuen, T;
Rendina-Ruedy, E;
DeMambro, VE;
Dhawan, S;
Abu-Amer, W;
... Zaidi, M; + view all
(2017)
Blocking FSH induces thermogenic adipose tissue and reduces body fat.
Nature
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