Homer, JA; Koelln, RA; Barrow, AS; Gialelis, TL; Boiarska, Z; Steinohrt, NS; Lee, EF; ... Moses, JE; + view all Homer, JA; Koelln, RA; Barrow, AS; Gialelis, TL; Boiarska, Z; Steinohrt, NS; Lee, EF; Yang, WH; Johnson, RM; Chung, T; Habowski, AN; Vishwakarma, DS; Bhunia, D; Avanzi, C; Moorhouse, AD; Jackson, M; Tuveson, DA; Lyons, SK; Lukey, MJ; Fairlie, WD; Haider, SM; Steinmetz, MO; Prota, AE; Moses, JE; - view fewer (2024) Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chemical Science , 15 (11) pp. 3879-3892. 10.1039/d3sc05729a.

Preview	Text d3sc05729a.pdf - Published Version Download (5MB) | Preview
Preview	Text (Supplementary information) d3sc05729a1.pdf - Published Version Download (15MB) | Preview

Abstract

Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and exceptional product yields, ASCC streamlines the synthetic workflow, simplifies the purification process, and is ideally suited for discovering functional molecules. We showcase the versatility and practicality of the ASCC reaction as a tool for the late-stage derivatization of bioactive molecules and in the array synthesis of sulfonate-linked, high-potency, microtubule targeting agents (MTAs) that exhibit nanomolar anticancer activity against multidrug-resistant cancer cell lines. These findings underscore ASCC's promise as a robust platform for drug discovery.

Download activity - last month

Export as JSONCSVXML

Download activity - last 12 months

Export as CSVXMLJSON

Downloads by country - last 12 months

Export as JSONXMLCSV

Archive Staff Only

View Item