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Blocking FSH induces thermogenic adipose tissue and reduces body fat

Liu, P; Ji, Y; Yuen, T; Rendina-Ruedy, E; DeMambro, VE; Dhawan, S; Abu-Amer, W; ... Zaidi, M; + view all (2017) Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature , 546 (7656) pp. 107-112. 10.1038/nature22342. Green open access

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Abstract

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.

Type: Article
Title: Blocking FSH induces thermogenic adipose tissue and reduces body fat
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nature22342
Publisher version: http://dx.doi.org/10.1038/nature22342
Language: English
Additional information: Fat metabolism, Bone, Obesity
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, Follicle-Stimulating-Hormone, Brown-Fat, Bone Mass, Menopausal Transition, Osteoclast Formation, Ovariectomized Mice, Energy-Expenditure, White, Receptor, Obesity
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > SoP Pharmaceutical and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1567917
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