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Article

Abdel-Aty, H; O'Shea, L; Amos, C; Brown, LC; Grist, E; Attard, G; Clarke, N; ... James, N; + view all (2023) The STAMPEDE2 Trial: a Site Survey of Current Patterns of Care, Access to Imaging and Treatment of Metastatic Prostate Cancer. Clinical Oncology , 35 (10) e628-e635. 10.1016/j.clon.2023.07.009. Green open access
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Abdel-Rahman, ME; Butler, J; Sydes, MR; Parmar, MK; Gordon, E; Harper, P; Williams, C; ... Coleman, MP; + view all (2014) No socioeconomic inequalities in ovarian cancer survival within two randomised clinical trials. Br J Cancer , 111 (3) pp. 589-597. 10.1038/bjc.2014.303. Green open access
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ACTIV-3/TICO LY-CoV555 Study Group; (2021) A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. The New England Journal of Medicine , 384 pp. 905-914. 10.1056/NEJMoa2033130. Green open access
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Adams, RA; Fisher, DJ; Graham, J; Seligmann, JF; Seymour, M; Kaplan, R; Yates, E; ... FOCUS4 Trial Investigators; + view all (2021) Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 10.1200/JCO.21.01436. (In press). Green open access
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Aggarwal, A; Court, LE; Hoskin, P; Jacques, I; Kroiss, M; Laskar, S; Lievens, Y; ... Langley, R; + view all (2023) ARCHERY: a prospective observational study of artificial intelligence-based radiotherapy treatment planning for cervical, head and neck and prostate cancer - study protocol. BMJ Open , 13 (12) , Article e077253. 10.1136/bmjopen-2023-077253. Green open access
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Ahmed, HU; El-Shater Bosaily, A; Brown, LC; Gabe, R; Kaplan, R; Parmar, MK; Collaco-Moraes, Y; ... PROMIS study group; + view all (2017) Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study. Lancet , 389 (10071) pp. 815-822. 10.1016/S0140-6736(16)32401-1. Green open access
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Ali, A; Hoyle, AP; Parker, CC; Brawley, CD; Cook, A; Amos, C; Calvert, J; ... STAMPEDE investigators; + view all (2021) Bone metastatic burden as a predictor of survival benefit from prostate radiotherapy in newly-diagnosed metastatic prostate cancer. JAMA oncology , 7 (4) pp. 555-563. 10.1001/jamaoncol.2020.7857. Green open access
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Ali, A; Plus 12 other authors, TPUWPO; Sydes, M; Clarke, NW; (2020) The Automated Bone Scan Index as a Predictor of Response to Prostate Radiotherapy in Men with Newly Diagnosed Metastatic Prostate Cancer: An Exploratory Analysis of STAMPEDE’s “M1|RT Comparison”. European Urology Oncology , 3 (4) pp. 412-419. 10.1016/j.euo.2020.05.003. Green open access
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Attard, G; Brown, LC; Clarke, NW; Parmar, MKB; James, ND; (2021) Should Patients with High-risk Localised or Locally Advanced Prostate Cancer Receive Abiraterone Acetate in Addition to Androgen Deprivation Therapy? Update on a Planned Analysis of the STAMPEDE Trial. European Urology , 80 (4) pp. 522-523. 10.1016/j.eururo.2021.06.023. Green open access
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Attard, G; Murphy, L; Clarke, NW; Sachdeva, A; Jones, C; Hoyle, A; Cross, W; ... McPhail, N; + view all (2023) Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol. The Lancet Oncology , 24 (5) pp. 443-456. 10.1016/S1470-2045(23)00148-1. Green open access
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Bailey, K; Ryan, A; Apostolidou, S; Fourkala, E; Burnell, M; Gentry-Maharaj, A; Kalsi, J; ... Menon, U; + view all (2015) Socioeconomic indicators of health inequalities and female mortality: a nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). BMC Public Health , 15 (253) , Article 1609. 10.1186/s12889-015-1609-5. Green open access
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Barthel, FM-S; Parmar, MKB; Royston, P; (2009) How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design - a reanalysis of 4 trials. Trials , 10 , Article 21. 10.1186/1745-6215-10-21. Green open access
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Bedia, Jacob S; Jacobs, Ian J; Ryan, Andy; Gentry-Maharaj, Aleksandra; Burnell, Matthew; Singh, Naveena; Manchanda, Ranjit; ... Skates, Steven J; + view all (2025) Estimating the ovarian cancer CA-125 preclinical detectable phase, in-vivo tumour doubling time, and window for detection in early stage: an exploratory analysis of UKCTOCS. eBioMedicine , 112 , Article 105554. 10.1016/j.ebiom.2024.105554. Green open access
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Bell, R; Brown, J; Parmar, M; Toi, M; Suter, T; Steger, GG; Pivot, X; ... Cameron, D; + view all (2017) Final efficacy and updated safety results of the randomized phase III BEATRICE trial evaluating adjuvant bevacizumab-containing therapy in triple-negative early breast cancer. Annals of Oncology , 28 (4) pp. 754-760. 10.1093/annonc/mdw665. Green open access
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Bird, SM; Strang, J; Ashby, D; Podmore, J; Robertson, JR; Welch, S; Meade, AM; (2017) External data required timely response by the Trial Steering-Data Monitoring Committee for the NALoxone InVEstigation (N-ALIVE) pilot trial. Contemporary Clinical Trials Communications , 5 pp. 100-106. 10.1016/j.conctc.2017.01.006. Green open access
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Blenkinsop, A; Parmar, MK; Choodari-Oskooei, B; (2019) Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework. Clinical Trials 10.1177/1740774518823551. (In press). Green open access
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Blyuss, O; Burnell, M; Ryan, A; Gentry-Maharaj, A; Marino, I; Kalsi, J; Manchanda, R; ... Menon, U; + view all (2018) Comparison of longitudinal CA125 algorithms as a first line screen for ovarian cancer in the general population. Clinical Cancer Research 10.1158/1078-0432.CCR-18-0208. (In press). Green open access
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Bouche, Gauthier; Gilbert, Duncan; Quartagno, Matteo; Dehbi, Hakim-Moulay; Merrick, Sophie; Barjesteh van Waalwijk van Doorn-Khosrovani, Sahar; Stephens, Richard; ... Langley, Ruth E; + view all (2025) Determining the optimal use of approved drugs in oncology. The Lancet Oncology , 26 (5) e282-e294. 10.1016/S1470-2045(25)00037-3.

Bratton, DJ; Parmar, MK; Phillips, PP; Choodari-Oskooei, B; (2016) Type I error rates of multi-arm multi-stage clinical trials: strong control and impact of intermediate outcomes. Trials , 17 , Article 309. 10.1186/s13063-016-1382-5. Green open access
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Bratton, DJ; Phillips, PP; Parmar, MK; (2013) A multi-arm multi-stage clinical trial design for binary outcomes with application to tuberculosis. BMC Medical Research Methodology , 13 , Article 139. 10.1186/1471-2288-13-139. Green open access
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Brown, LC; Ahmed, HU; Faria, R; El-Shater Bosaily, A; Gabe, R; Kaplan, RS; Parmar, M; ... Emberton, M; + view all (2018) Multiparametric MRI to improve detection of prostate cancer compared with transrectal ultrasound-guided prostate biopsy alone: the PROMIS study. Health Technology Assessment , 22 (39) xxxiii, 1-175. 10.3310/hta22390. Green open access
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Burdett, S; Fisher, DJ; Vale, CL; Bono, AV; Clarke, NW; Cognetti, F; Collette, L; ... Tierney, JF; + view all (2022) Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Individual Participant Data from Randomised Controlled Trials. European Urology , 81 (1) pp. 50-61. 10.1016/j.eururo.2021.09.028. Green open access
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Burdett, S; Boeve, L; Ingleby, F; Fisher, D; Rydzewska, L; Vale, C; van Andel, G; ... Tierney, J; + view all (2019) Prostate Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis. European Urology 10.1016/j.eururo.2019.02.003. (In press). Green open access
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Burdett, S; Rydzewska, L; Tierney, J; Fisher, D; Parmar, MKB; Arriagada, R; Pignon, JP; ... PORT Meta-analysis Trialists Group, .; + view all (2016) Postoperative radiotherapy for non-small cell lung cancer. Cochrane Database of Systematic Reviews , 10 , Article CD002142. 10.1002/14651858.CD002142.pub4. Green open access
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Burnell, M; Gentry-Maharaj, A; Glazer, C; Karpinskyj, C; Ryan, A; Apostolidou, S; Kalsi, J; ... Menon, U; + view all (2020) Serial endometrial thickness and risk of non-endometrial hormone-dependent cancers in postmenopausal women in UKCTOCS. Ultrasound in Obstetrics & Gynecology , 56 (2) pp. 267-275. 10.1002/uog.21894. Green open access
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Burnell, M; Gentry-Maharaj, A; Ryan, A; Apostolidou, S; Habib, M; Kalsi, J; Skates, S; ... Menon, U; + view all (2011) Impact on mortality and cancer incidence rates of using random invitation from population registers for recruitment to trials. Trials , 12 , Article 61. 10.1186/1745-6215-12-61. Green open access
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Burnell, M; Gentry-Maharaj, A; Skates, SJ; Ryan, A; Karpinskyj, C; Kalsi, J; Apostolidou, S; ... Menon, U; + view all (2021) UKCTOCS update: applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysis. Trials , 22 , Article 173. 10.1186/s13063-021-05125-8. Green open access
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Choodari-Oskooei, B; Bratton, DJ; Gannon, MR; Meade, AM; Sydes, MR; Parmar, MKB; (2020) Adding new experimental arms to randomised clinical trials: Impact on error rates. Clinical Trials 10.1177/1740774520904346. (In press). Green open access
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Choodari-Oskooei, B; Parmar, MK; Royston, P; Bowden, J; (2013) Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome. Trials , 14 , Article 23. 10.1186/1745-6215-14-23. Green open access
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Choodari-Oskooei, B; Royston, P; Parmar, MKB; (2015) The extension of total gain (TG) statistic in survival models: Properties and applications. BMC Medical Research Methodology , 15 (1) , Article 50. 10.1186/s12874-015-0042-x. Green open access
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Choudhury, T; Mozid, A; Hamshere, S; Yeo, C; Pellaton, C; Arnous, S; Saunders, N; ... Mathur, A; + view all (2017) An exploratory randomized control study of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with ischaemic cardiomyopathy: the REGENERATE-IHD clinical trial. European Journal of Heart Failure , 19 (1) pp. 138-147. 10.1002/ejhf.676. Green open access
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Choudry, F; Hamshere, S; Saunders, N; Veerapen, J; Bavnbek, K; Knight, C; Pellerin, D; ... Mathur, A; + view all (2016) A randomized double-blind control study of early intra-coronary autologous bone marrow cell infusion in acute myocardial infarction: the REGENERATE-AMI clinical trial†. European Heart Journal , 37 (3) pp. 256-263. 10.1093/eurheartj/ehv493. Green open access
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Clamp, AR; James, EC; McNeish, IA; Dean, A; Kim, J-W; O'Donnell, DM; Hook, J; ... Ledermann, JA; + view all (2019) Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal carcinoma treatment (ICON8): primary progression free survival analysis results from a GCIG phase 3 randomised controlled trial. The Lancet 10.1016/s0140-6736(19)32259-7. Green open access
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Clarke, Caroline S; Hunter, Rachael M; Gabrio, Andrea; Brawley, Christopher D; Ingleby, Fiona C; Dearnaley, David P; Matheson, David; ... James, Nicholas D; + view all (2022) Cost-utility analysis of adding abiraterone acetate plus prednisone/prednisolone to long-term hormone therapy in newly diagnosed advanced prostate cancer in England: Lifetime decision model based on STAMPEDE trial data. PLoS One , 17 (6) , Article e0269192. 10.1371/journal.pone.0269192. Green open access
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Clarke, NW; Ali, A; Ingleby, FC; Hoyle, A; Amos, CL; Attard, G; Brawley, CD; ... STAMPEDE investigators; + view all (2020) Corrigendum to Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial: Ann Oncol 2019; 30: 1992-2003. [Corrigendum]. Annals of Oncology , 31 (3) p. 442. 10.1016/j.annonc.2020.01.002. Green open access
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Clarke, NW; Ali, A; Ingleby, FC; Hoyle, A; Amos, CL; Attard, G; Brawley, CD; ... James, ND; + view all (2019) Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial. Annals of Oncology 10.1093/annonc/mdz396. (In press). Green open access
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Collinson, F; Qian, W; Fossati, R; Lissoni, A; Williams, C; Parmar, M; Ledermann, J; ... on behalf of the ICON1 collaborators; + view all (2014) Optimal treatment of early-stage ovarian cancer. Ann Oncol , 25 (6) pp. 1165-1171. 10.1093/annonc/mdu116. Green open access
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Dearnaley, DP; Jovic, G; Syndikus, I; Khoo, V; Cowan, RA; Graham, JD; Aird, EG; ... Sydes, MR; + view all (2014) Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial. The Lancet Oncology , 15 (4) 464 - 473. 10.1016/S1470-2045(14)70040-3. Green open access
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Dilley, J; Burnell, M; Gentry-Maharaj, A; Ryan, A; Neophytou, C; Apostolidou, S; Karpinskyj, C; ... Menon, U; + view all (2020) Ovarian cancer symptoms, routes to diagnosis and survival – Population cohort study in the ‘no screen’ arm of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Gynecologic Oncology 10.1016/j.ygyno.2020.05.002. (In press). Green open access
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Douin, David J; Siegel, Lianne; Grandits, Greg; Phillips, Andrew; Aggarwal, Neil R; Baker, Jason; Brown, Samuel M; ... ACTIV-3/Therapeutics for Inpatients with COVID-19 (TICO) Study G; + view all (2022) Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery. American Journal of Respiratory and Critical Care Medicine , 206 (6) pp. 730-739. 10.1164/rccm.202112-2836OC. Green open access
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Downing, A; Morris, EJ; Corrigan, N; Sebag-Montefiore, D; Finan, PJ; Thomas, JD; Chapman, M; ... Selby, P; + view all (2017) High hospital research participation and improved colorectal cancer survival outcomes: a population-based study. Gut , 66 (1) pp. 89-96. 10.1136/gutjnl-2015-311308. Green open access
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Eisen, T; Frangou, E; Oza, B; Ritchie, AWS; Smith, B; Kaplan, R; Davis, ID; ... Meade, A; + view all (2020) Adjuvant Sorafenib for Renal Cell Carcinoma at Intermediate or High Risk of Relapse: Results From the SORCE Randomized Phase III Intergroup Trial. Journal of Clinical Oncology , 38 (34) pp. 4064-4075. 10.1200/jco.20.01800. Green open access
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Embleton-Thirsk, A; Deane, E; Townsend, S; Farrelly, L; Popoola, B; Parker, J; Rustin, G; ... Kaplan, R; + view all (2019) Impact of retrospective data verification to prepare the ICON6 trial for use in a marketing authorization application. Clinical Trials , 16 (5) pp. 502-511. 10.1177/1740774519862528. Green open access
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Field, JK; Vulkan, D; Davies, MPA; Baldwin, DR; Brain, KE; Devaraj, A; Eisen, T; ... Duffy, SW; + view all (2021) Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis. The Lancet Regional Health - Europe , 10 , Article 100179. 10.1016/j.lanepe.2021.100179. Green open access
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Field, JK; Duffy, SW; Baldwin, DR; Brain, KE; Devaraj, A; Eisen, T; Green, BA; ... Hansell, DM; + view all (2016) The UK Lung Cancer Screening Trial: a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer. Health Technology Assessment , 20 (40) 10.3310/hta20400. Green open access
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Field, JK; Duffy, SW; Baldwin, DR; Whynes, DK; Devaraj, A; Brain, KE; Eisen, T; ... Hansell, DM; + view all (2016) UK Lung Cancer RCT Pilot Screening Trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening. Thorax , 71 (2) pp. 161-170. 10.1136/thoraxjnl-2015-207140. Green open access
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Fourkala, EO; Burnell, M; Cox, C; Ryan, A; Salter, LC; Gentry-Maharaj, A; Parmar, M; ... Menon, U; + view all (2014) Association of skirt size and postmenopausal breast cancer risk in older women: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). BMJ Open , 4 (9) , Article e005400. 10.1136/bmjopen-2014-005400. Green open access
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Gentry-Maharaj, A; Blyuss, O; Ryan, A; Burnell, M; Karpinskyj, C; Gunu, R; Kalsi, JK; ... Menon, U; + view all (2020) Multi-Marker Longitudinal Algorithms Incorporating HE4 and CA125 in Ovarian Cancer Screening of Postmenopausal Women. Cancers , 12 (7) , Article 1931. 10.3390/cancers12071931. Green open access
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Gentry-Maharaj, A; Glazer, C; Burnell, M; Ryan, A; Berry, H; Kalsi, J; Woolas, R; ... Menon, U; + view all (2017) Changing trends in reproductive/lifestyle factors in UK women: descriptive study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). BMJ Open , 7 (3) , Article e011822. 10.1136/bmjopen-2016-011822. Green open access
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Ghimire, Bhagabati; Landy, Rebecca; Maroni, Roberta; Smith, Samuel G; Debiram-Beecham, Irene; Sasieni, Peter D; Fitzgerald, Rebecca C; ... Offman, Judith; + view all (2023) Predictors of the experience of a Cytosponge test: analysis of patient survey data from the BEST3 trial. BMC Gastroenterology , 23 (1) , Article 7. 10.1186/s12876-022-02630-1. Green open access
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Ghorani, E; Quartagno, M; Blackhall, F; Gilbert, DC; O'Brien, M; Ottensmeier, C; Pizzo, E; ... on behalf of the REFINE-Lung, Investigators; + view all (2023) REFINE-Lung implements a novel multi-arm randomised trial design to address possible immunotherapy overtreatment. The Lancet Oncology , 24 (5) e219-e227. 10.1016/S1470-2045(23)00095-5. Green open access
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Gilbert, DC; Nankivell, M; Rush, H; Clarke, NW; Mangar, S; Al-Hasso, A; Rosen, S; ... Langley, RE; + view all (2023) A Repurposing Programme Evaluating Repurposing Transdermal Oestradiol Patches for the Treatment of Prostate Cancer Within the PATCH and STAMPEDE Trials: Current Results and Adapting Trial Design. Clinical Oncology 10.1016/j.clon.2023.10.054. (In press). Green open access
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Gilbert, DC; Duong, T; Kynaston, HG; Alhasso, AA; Cafferty, FH; Rosen, SD; Kanaga-Sundaram, S; ... Abel, PD; + view all (2017) Quality of life outcomes from the PATCH trial evaluating LHRH agonists versus transdermal oestradiol for androgen suppression in advanced prostate cancer. BJU International , 119 (5) pp. 667-675. 10.1111/bju.13687. Green open access
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Gilbert, DC; Duong, T; Sydes, M; Bara, A; Clarke, N; Abel, P; James, N; ... STAMPEDE and PATCH Trial Management Groups, .; + view all (2018) Transdermal oestradiol as a method of androgen suppression for prostate cancer within the STAMPEDE trial platform. BJU International , 121 (5) pp. 680-683. 10.1111/bju.14153. Green open access
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Gilson, C; Chowdhury, S; Parmar, MKB; Sydes, MR; STAMPEDE Investigators; (2017) Incorporating Biomarker Stratification into STAMPEDE: an Adaptive Multi-arm, Multi-stage Trial Platform. Clinical Oncology , 29 (12) pp. 778-786. 10.1016/j.clon.2017.10.004. Green open access
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Gilson, C; Ingleby, F; Gilbert, DC; Parry, MA; Atako, NB; Ali, A; Hoyle, A; ... Chowdhury, S; + view all (2020) Genomic Profiles of De Novo High- and Low-Volume Metastatic Prostate Cancer: Results From a 2-Stage Feasibility and Prevalence Study in the STAMPEDE Trial. JCO Precision Oncology , 4 pp. 882-897. 10.1200/po.19.00388. Green open access
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Glasbey, J; Beggs, A; Glimelius, B; Gray, R; Handley, K; Laurberg, S; Magill, L; ... Furniss, D; + view all (2024) Risk of Bowel Obstruction in Patients Undergoing Neoadjuvant Chemotherapy for High-risk Colon Cancer: A Nested Case-control-matched Analysis of an International, Multicenter, Randomized Controlled Trial (FOxTROT). Annals of Surgery , 280 (2) pp. 283-293. 10.1097/SLA.0000000000006145. Green open access
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González Martín, A; Oza, A; Embleton, AC; Pfisterer, J; Ledermann, J; Pujade-Lauraine, E; Kristensen, G; ... Perren, T; + view all (2019) Exploratory outcome analyses according to stage and/or residual disease in the ICON7 trial of carboplatin and paclitaxel with or without bevacizumab for newly diagnosed ovarian cancer. Gynecologic Oncology , 152 (1) 10.1016/j.ygyno.2018.08.036. Green open access
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Grieve, R; Abrams, K; Claxton, K; Goldacre, B; James, N; Nicholl, J; Parmar, M; ... Sculpher, M; + view all (2016) Cancer Drugs Fund requires further reform. BMJ , 354 , Article i5090. 10.1136/bmj.i5090. Green open access
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Hague, D; Townsend, S; Masters, L; Rauchenberger, M; Van Looy, N; Diaz Montana, C; Gannon, M; ... Sydes, M; + view all (2019) Changing platforms without stopping the train: experiences of data management and data management systems when adapting platform protocols by adding and closing comparisons. Trials , 20 , Article 294. 10.1186/s13063-019-3322-7. Green open access
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Hamshere, S; Arnous, S; Choudhury, T; Choudry, F; Mozid, A; Yeo, C; Barrett, C; ... Mathur, A; + view all (2015) Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: the REGENERATE-DCM clinical trial. European Heart Journal , 36 (44) pp. 3061-3069. 10.1093/eurheartj/ehv390. Green open access
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Hoyle, AP; Ali, A; James, ND; Cook, A; Parker, CC; de Bono, JS; Attard, G; ... STAMPEDE Investigators; + view all (2019) Abiraterone in "High-" and "Low-risk" Metastatic Hormone-sensitive Prostate Cancer. European Urology , 76 (6) pp. 719-728. 10.1016/j.eururo.2019.08.006. Green open access
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Jacobs, IJ; Menon, U; Ryan, A; Gentry-Maharaj, A; Burnell, M; Kalsi, JK; Amso, NN; ... Skates, SJ; + view all (2016) Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet , 387 (10022) pp. 945-956. 10.1016/S0140-6736(15)01224-6. Green open access
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James, ND; Spears, MR; Clarke, NW; Dearnaley, DP; Mason, MD; Parker, CC; Ritchie, AW; ... STAMPEDE Investigators; + view all (2016) Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial. JAMA Oncology , 2 (3) pp. 348-357. 10.1001/jamaoncol.2015.4350. Green open access
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James, ND; de Bono, JS; Spears, MR; Clarke, NW; Mason, MD; Dearnaley, DP; Ritchie, AWS; ... STAMPEDE Investigators; + view all (2017) Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy. The New England Journal of Medicine , 377 pp. 338-351. 10.1056/NEJMoa1702900. Green open access
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James, ND; Sydes, MR; Clarke, NW; Mason, MD; Dearnaley, DP; Spears, MR; Ritchie, AW; ... STAMPEDE investigators; + view all (2016) Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial. Lancet , 387 (10024) pp. 1163-1177. 10.1016/S0140-6736(15)01037-5. Green open access
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James, ND; Sydes, MR; Clarke, NW; Mason, MD; Parmar, MKB; (2016) STAMPEDE trial and patients with non-metastatic prostate cancer – Authors' reply. The Lancet , 388 (10041) pp. 235-236. 10.1016/S0140-6736(16)31041-8. Green open access
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James, ND; Sydes, MR; Clarke, NW; Parmar, MKB; Ritchie, ASWR; (2016) Response to ‘High Risk of Neutropenia for Hormone-naive Prostate Cancer Patients Receiving STAMPEDE-style Upfront Docetaxel Chemotherapy in Usual Clinical Practice’, by Tanguay et al. Clinical Oncology , 28 (10) pp. 666-667. 10.1016/j.clon.2016.07.004. Green open access
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Jinks, RC; Royston, P; Parmar, MK; (2015) Discrimination-based sample size calculations for multivariable prognostic models for time-to-event data. BMC Medical Research Methodology , 15 , Article 82. 10.1186/s12874-015-0078-y. Green open access
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Joharatnam-Hogan, N; Cafferty, F; Hubner, R; Swinson, D; Sothi, S; Gupta, K; Falk, S; ... Add-Aspirin Trial Management Group; + view all (2019) Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial. The Lancet Gastroenterology & Hepatology , 4 (11) pp. 854-862. 10.1016/S2468-1253(19)30289-4. Green open access
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Kalsi, J; Gentry‐maharaj, A; Ryan, A; Singh, N; Burnell, M; Massingham, S; Apostolidou, S; ... Menon, U; + view all (2021) Performance characteristics of the ultrasound strategy during incidence screening in the UK collaborative trial of ovarian cancer screening (UKCTOCS). Cancers , 13 (4) , Article 858. 10.3390/cancers13040858. Green open access
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Kalsi, JK; Ryan, A; Gentry-Maharaj, A; Margolin-Crump, D; Singh, N; Burnell, M; Benjamin, E; ... Menon, U; + view all (2021) Completeness and accuracy of national cancer and death registration for outcome ascertainment in trials—an ovarian cancer exemplar. Trials , 22 , Article 88. 10.1186/s13063-020-04968-x. Green open access
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Karpinskyj, C; Burnell, M; Gonzalez-Izquierdo, A; Ryan, A; Kalsi, J; Jacobs, I; Parmar, M; ... Gentry-Maharaj, A; + view all (2020) Socioeconomic Status and Ovarian Cancer Stage at Diagnosis: A Study Nested Within UKCTOCS. Diagnostics , 10 (2) , Article 89. 10.3390/diagnostics10020089. Green open access
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Keshtkar-Jahromi, Maryam; Anstrom, Kevin J; Barkauskas, Christina; Brown, Samuel M; Daar, Eric S; Fischer, William; Gibbs, Kevin W; ... Adam, Stacey J; + view all (2024) ACTIV trials: Lessons learned in trial design in the setting of an emergent pandemic. Journal of Clinical and Translational Science , 8 (1) , Article e151. 10.1017/cts.2024.1. Green open access
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Kommoss, S; Winterhoff, B; Oberg, A; Konecny, GE; Wang, C; Riska, SM; Fan, JB; ... Pfisterer, J; + view all (2017) Bevacizumab may differentially improve ovarian cancer outcome in patients with proliferative and mesenchymal molecular subtypes. Clinical Cancer Research , 23 (14) pp. 3794-3801. 10.1158/1078-0432.CCR-16-2196. Green open access
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Lacas, B; Bourhis, J; Overgaard, J; Zhang, Q; Grégoire, V; Nankivell, M; Zackrisson, B; ... MARCH Collaborative Group; + view all (2017) Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. Lancet Oncol , 18 (9) pp. 1221-1237. 10.1016/S1470-2045(17)30458-8. Green open access
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Langley, RE; Kynaston, HG; Alhasso, AA; Duong, T; Paez, EM; Jovic, G; Scrase, CD; ... Abel, PD; + view all (2016) A Randomised Comparison Evaluating Changes in Bone Mineral Density in Advanced Prostate Cancer: Luteinising Hormone-releasing Hormone Agonists Versus Transdermal Oestradiol. European Urology , 69 (6) pp. 1016-1025. 10.1016/j.eururo.2015.11.030. Green open access
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Langley, RE; Gilbert, DC; Duong, T; Clarke, NW; Nankivell, M; Rosen, SD; Mangar, S; ... Parmar, M; + view all (2021) Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme. The Lancet , 397 (10274) pp. 581-591. 10.1016/s0140-6736(21)00100-8. Green open access
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Ledermann, JA; Embleton, AC; Raja, F; Perren, TJ; Jayson, GC; Rustin, GJS; Kaye, SB; ... Collaborators, I; + view all (2016) Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet , 387 (10023) pp. 1066-1074. 10.1016/S0140-6736(15)01167-8. Green open access
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Ledermann, JA; Embleton-Thirsk, AC; Perren, TJ; Jayson, GC; Rustin, GJS; Kaye, SB; Hirte, H; ... ICON6 collaborators, .; + view all (2021) Cediranib in addition to chemotherapy for women with relapsed platinum-sensitive ovarian cancer (ICON6): overall survival results of a phase III randomised trial. ESMO Open , 6 (2) , Article 100043. 10.1016/j.esmoop.2020.100043. Green open access
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Li, Vivien; Leurent, Baptiste; Barkhof, Frederik; Braisher, Marie; Cafferty, Fay; Ciccarelli, Olga; Eshaghi, Arman; ... Chataway, Jeremy; + view all (2022) Designing Multi-arm Multistage Adaptive Trials for Neuroprotection in Progressive Multiple Sclerosis. Neurology 10.1212/WNL.0000000000200604. (In press). Green open access
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Limkin, Elaine; Blanchard, Pierre; Lacas, Benjamin; Bourhis, Jean; Parmar, Mahesh; Licitra, Lisa; Le, Quynh-Thu; ... MACH-NC* and MARCH** collaborative groups; + view all (2024) Season of radiotherapy and outcomes of head & neck cancer patients in the MACH-NC & MARCH meta-analyses. Radiotherapy & Oncology , 190 , Article 110011. 10.1016/j.radonc.2023.110011. Green open access
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Lynn, M; Goulden, B; Parmar, M; Knopp, P; Yeung, M; Giles, I; Davies, C; ... Davis, D; + view all (2020) Play attention! Therapeutic aspects to play in delirium prevention and management [version 1; peer review: 1 approved]. Wellcome Open Research , 5 , Article 277. 10.12688/wellcomeopenres.16199.1. Green open access
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Macnair, A; Love, SB; Murray, ML; Gilbert, DC; Parmar, MKB; Denwood, T; Carpenter, J; ... Cafferty, FH; + view all (2021) Accessing routinely collected health data to improve clinical trials: recent experience of access. Trials , 22 , Article 340. 10.1186/s13063-021-05295-5. Green open access
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Mason, MD; Clarke, NW; James, ND; Dearnaley, DP; Spears, MR; Ritchie, AWS; Attard, G; ... STAMPEDE Investigators, .; + view all (2017) Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial. Journal of Clincal Oncology , 35 (14) pp. 1530-1541. 10.1200/JCO.2016.69.0677. Green open access
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Mason, MD; Parulekar, WR; Sydes, MR; Brundage, M; Kirkbride, P; Gospodarowicz, M; Cowan, R; ... Warde, P; + view all (2015) Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer. Journal of Clinical Oncology , 33 (19) pp. 2143-2150. 10.1200/JCO.2014.57.7510. Green open access
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Mauguen, A; Pignon, JP; Burdett, S; Domerg, C; Fisher, D; Paulus, R; Mandrekar, SJ; ... Surrogate Lung Project Collaborative Group; + view all (2013) Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data. Lancet Oncology , 14 (7) 619 - 626. 10.1016/S1470-2045(13)70158-X. Green open access
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Meade, A; Oza, B; Frangou, E; Smith, B; Bryant, H; Kaplan, R; Choodari-Oskooei, B; ... Parmar, MKB; + view all (2021) RAMPART: A model for a regulatory-ready academic-led phase III trial in the adjuvant renal cell carcinoma setting. Contemporary Clinical Trials , 108 , Article 106481. 10.1016/j.cct.2021.106481. Green open access
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Meade, AM; Bird, SM; Strang, J; Pepple, T; Nichols, LL; Mascarenhas, M; Choo, L; (2017) Methods for delivering the UK's multi-centre prison-based naloxone-on-release pilot randomised trial (N-ALIVE): Europe's largest prison-based randomised controlled trial. Drug and Alcohol Review 10.1111/dar.12592. (In press). Green open access
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Mehta, AR; Carpenter, JR; Nicholas, JM; Chataway, J; Virgo, B; Parmar, MKB; Chandran, S; (2023) The role of placebo control in clinical trials for neurodegenerative diseases. [Letter]. Nature Medicine 10.1038/d41591-023-00080-0. Green open access
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Mehta, Arpan R; Pal, Suvankar; Chataway, Jeremy; Carpenter, James R; Parmar, Mahesh KB; Chandran, Siddharthan; (2022) Smarter adaptive platform clinical trials in neurology: a showcase for UK innovation. Brain , 145 (8) e64-e65. 10.1093/brain/awac169. Green open access
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Menon, Usha; Gentry-Maharaj, Aleksandra; Burnell, Matthew; Apostolidou, Sophia; Ryan, Andy; Kalsi, Jatinderpal K; Singh, Naveena; ... UKCTOCS team; + view all (2023) Insights from UKCTOCS for design, conduct and analyses of large randomised controlled trials. Health Technology Assessment pp. 1-38. 10.3310/CLDC7214. Green open access
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Menon, Usha; Gentry-Maharaj, Aleksandra; Burnell, Matthew; Ryan, Andy; Kalsi, Jatinderpal K; Singh, Naveena; Dawnay, Anne; ... Jacobs, Ian J; + view all (2023) Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial. Health Technology Assessment , 11 pp. 1-81. 10.3310/BHBR5832. Green open access
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Menon, U; Burnell, M; Sharma, A; Gentry-Maharaj, A; Fraser, L; Ryan, A; Parmar, M; ... UKCTOCS Group; + view all (2007) Decline in use of hormone therapy among postmenopausal women in the United Kingdom. Menopause , 14 (3) 462 - 467. 10.1097/01.gme.0000243569.70946.9d. Green open access
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Menon, U; Gentry-Maharaj, A; Burnell, M; Singh, N; Ryan, A; Karpinskyj, C; Carlino, G; ... Parmar, M; + view all (2021) Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. The Lancet 10.1016/s0140-6736(21)00731-5. (In press). Green open access
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Menon, U; Kalsi, JK; Gentry-Maharaj, A; Ryan, A; Burnell, M; Parmar, M; Fallowfield, L; ... Jacobs, I; + view all (2016) Reply to P.F. Pinsky, C.P. Crum, and M.W. McIntosh et al. [Rapid communication]. Journal of Clinical Oncology , 34 (2) pp. 201-202. 10.1200/JCO.2015.64.1365. Green open access
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Menon, U; McGuire, AJ; Raikou, M; Ryan, A; Davies, SK; Burnell, M; Gentry-Maharaj, A; ... Jacobs, IJ; + view all (2017) The cost-effectiveness of screening for ovarian cancer: results from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). British Journal of Cancer , 117 (5) pp. 619-627. 10.1038/bjc.2017.222. Green open access
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Menon, U; Ryan, A; Kalsi, J; Gentry-Maharaj, A; Dawnay, A; Habib, M; Apostolidou, S; ... Jacobs, I; + view all (2015) Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening. Journal of Clinical Oncology , 33 (18) pp. 2062-2071. 10.1200/JCO.2014.59.4945. Green open access
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Morrell, L; Hordern, J; Brown, L; Sydes, MR; Amos, CL; Kaplan, RS; Parmar, MKB; (2019) Mind the gap? The platform trial as a working environment. Trials , 20 (1) , Article 297. 10.1186/s13063-019-3377-5. Green open access
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Mulvenna, P; Nankivell, M; Barton, R; Faivre-Finn, C; Wilson, P; McColl, E; Moore, B; ... Langley, RE; + view all (2016) Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial. Lancet , 388 (10055) pp. 2004-2014. 10.1016/S0140-6736(16)30825-X. Green open access
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Murray, DD; Babiker, AG; Baker, JV; Barkauskas, CE; Brown, SM; Chang, CC; Davey, VJ; ... Lundgren, JD; + view all (2021) Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3). Clinical Trials 10.1177/17407745211049829. (In press). Green open access
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Nankivell, M; Langley, RE; Barton, R; Faivre-Finn, C; Wilson, P; McColl, E; Moore, B; ... Mulvenna, P; + view all (2017) How do the QUARTZ trial results inform future research for patients with brain metastases from non-small cell lung cancer? [Letter]. Translational Cancer Research , 6 (Supp. 02) S446-S447. 10.21037/tcr.2017.03.08. Green open access
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Nankivell, M; Stephens, R; Pugh, C; Mulvenna, P; Barton, R; Langley, R; Parmar, M; (2011) Releasing interim results from a randomised clinical trial: an example from the QUARTZ trial. Trials , 12 Sup , Article A125. 10.1186/1745-6215-12-S1-A125. Green open access
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Navani, N; Fisher, D; Tierney, JF; Stephens, RJ; Burdett, S; NSCLC Meta-analysis Collaborative Group, .; (2019) The accuracy of clinical staging of stage I-IIIa non-small cell lung cancer: An analysis based on individual participant data. Chest , 155 (3) pp. 502-509. 10.1016/j.chest.2018.10.020. Green open access
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Navani, N; Nankivell, M; Lawrence, DR; Lock, S; Makker, H; Baldwin, DR; Stephens, RJ; ... Lung-BOOST trial investigators, .; + view all (2015) Lung cancer diagnosis and staging with endobronchial ultrasound-guided transbronchial needle aspiration compared with conventional approaches: an open-label, pragmatic, randomised controlled trial. The Lancet Respiratory Medicine , 3 (4) 282 - 289. 10.1016/S2213-2600(15)00029-6. Green open access
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Noor, Nurulamin M; Love, Sharon B; Isaacs, Talia; Kaplan, Richard; Parmar, Mahesh KB; Sydes, Matthew R; (2022) Uptake of the multi-arm multi-stage (MAMS) adaptive platform approach: a trial-registry review of late-phase randomised clinical trials. BMJ Open , 12 (3) , Article e055615. 10.1136/bmjopen-2021-055615. Green open access
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Noor, NM; Pett, SL; Esmail, H; Crook, AM; Vale, CL; Sydes, MR; Parmar, MKB; (2020) Adaptive platform trials using multi-arm, multi-stage protocols: getting fast answers in pandemic settings [version 2; peer review: 2 approved]. F1000Research , 9 , Article 1109. 10.12688/f1000research.26253.2. Green open access
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Oza, B; Frangou, E; Smith, B; Bryant, H; Kaplan, R; Choodari-Oskooei, B; Powles, T; ... Meade, A; + view all (2021) RAMPART: A phase III multi-arm multi-stage trial of adjuvant checkpoint inhibitors in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse. Contemporary Clinical Trials , 108 , Article 106482. 10.1016/j.cct.2021.106482. Green open access
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Oza, Bhavna; Eisen, Tim; Frangou, Eleni; Stewart, Grant D; Bex, Axel; Ritchie, Alastair WS; Kaplan, Rick; ... Meade, Angela; + view all (2022) External Validation of the 2003 Leibovich Prognostic Score in Patients Randomly Assigned to SORCE, an International Phase III Trial of Adjuvant Sorafenib in Renal Cell Cancer. Journal of Clinical Oncology 10.1200/JCO.21.01090. (In press). Green open access
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Oza, AM; Cook, AD; Pfisterer, J; Embleton, A; Ledermann, JA; Pujade-Lauraine, E; Kristensen, G; ... ICON7, trial investigators; + view all (2015) Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial. Lancet Oncology , 16 (8) pp. 928-936. 10.1016/S1470-2045(15)00086-8. Green open access
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Papadatos-Pastos, D; Yuan, W; Pal, A; Crespo, M; Ferreira, A; Gurel, B; Prout, T; ... Minchom, A; + view all (2022) Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors. Journal for ImmunoTherapy of Cancer , 10 (6) , Article e004495. 10.1136/jitc-2022-004495. Green open access
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Parker, CC; Catton, CN; Clarke, N; Meidahl, P; Parmar, M; Parulekar, W; Sydes, M; (2024) Reply to "Letter to the Editor regarding "Timing of radiotherapy (RT) after radical prostatectomy (RP): Long-term outcomes in the RADICALS-RT trial [NCT00541047]", by C. C. Parker et al.". Annals of Oncology , 35 (8) pp. 752-753. 10.1016/j.annonc.2024.05.001. Green open access
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Parker, CC; Clarke, NW; Cook, AD; Petersen, PM; Catton, CN; Cross, WR; Kynaston, H; ... Sydes, MR; + view all (2024) Randomised Trial of No, Short-term, or Long-term Androgen Deprivation Therapy with Postoperative Radiotherapy After Radical Prostatectomy: Results from the Three-way Comparison of RADICALS-HD (NCT00541047). European Urology 10.1016/j.eururo.2024.07.026. (In press). Green open access
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Parker, CC; Petersen, PM; Cook, AD; Clarke, NW; Catton, C; Cross, WR; Kynaston, H; ... Sydes, MR; + view all (2024) Timing of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047). Annals of Oncology , 35 (7) pp. 656-666. 10.1016/j.annonc.2024.03.010. Green open access
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Parker, Chris C; James, Nicholas D; Brawley, Christopher D; Clarke, Noel W; Ali, Adnan; Amos, Claire L; Attard, Gerhardt; ... Sydes, Matthew R; + view all (2022) Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial. PLoS Medicine , 19 (6) , Article e1003998. 10.1371/journal.pmed.1003998. Green open access
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Parker, CC; Clarke, NW; Cook, AD; Kynaston, HG; Petersen, PM; Catton, C; Cross, W; ... Sydes, MR; + view all (2020) Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial. The Lancet , 396 (10260) pp. 1413-1421. 10.1016/S0140-6736(20)31553-1. Green open access
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Parker, CC; James, ND; Brawley, CD; Clarke, NW; Hoyle, AP; Ali, A; Ritchie, AWS; ... Systemic Therapy for Advanced or Metastatic Prostate cancer, .; + view all (2018) Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial. Lancet , 392 (10162) pp. 2353-2366. 10.1016/S0140-6736(18)32486-3. Green open access
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Parker, CC; James, ND; Brawley, CD; Clarke, NW; Parmar, MKB; (2019) Radiotherapy for metastatic prostate cancer – Authors' reply. The Lancet , 394 (10201) p. 830. 10.1016/S0140-6736(19)31829-X. Green open access
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Parmar, MK; Cafferty, FH; Sydes, MR; Choodari-Oskooei, B; Langley, RE; Brown, L; Phillips, PP; ... Royston, PJ; + view all (2017) Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols. Clinical Trials , 14 (5) pp. 451-461. 10.1177/1740774517725697. Green open access
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Parmar, MK; Strang, J; Choo, L; Meade, AM; Bird, SM; (2017) Randomized controlled pilot trial of naloxone-on-release to prevent post-prison opioid overdose deaths. Addiction , 112 (3) pp. 502-515. 10.1111/add.13668. Green open access
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Parmar, MKB; Noor, NM; Pett, SL; Esmail, H; Crook, AM; Vale, CL; Sydes, MR; (2020) Adaptive platform trials using multi-arm, multi-stage protocols: getting fast answers in pandemic settings [version 1; peer review: 2 approved]. F1000Research , 9 , Article 1109. 10.12688/f1000research.26253.1. Green open access
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Parmar, MKB; Sydes, MR; Morris, TP; (2016) How do you design randomised trials for smaller populations? A framework. BMC Medicine , 14 , Article 183. 10.1186/s12916-016-0722-3. Green open access
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Petersen, Peter Meidahl; Cook, Adrian D; Sydes, Matthew R; Clarke, Noel; Cross, William; Kynaston, Howard; Logue, John; ... Catton, Charles; + view all (2023) Salvage radiotherapy after radical prostatectomy: analysis of toxicity by dose-fractionation in the RADICALS-RT trial. International Journal of Radiation: Oncology - Biology - Physics 10.1016/j.ijrobp.2023.04.032. (In press). Green open access
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Petit, C; Lacas, B; Pignon, J-P; Le, QT; Grégoire, V; Grau, C; Hackshaw, A; ... MACH-NC and MARCH Collaborative Groups; + view all (2021) Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis. Lancet Oncology , 22 (5) pp. 727-736. 10.1016/S1470-2045(21)00076-0. Green open access
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Quartagno, M; Carpenter, JR; Walker, AS; Clements, M; Parmar, MKB; (2020) The DURATIONS randomised trial design: Estimation targets, analysis methods and operating characteristics. Clinical Trials 10.1177/1740774520944377. (In press). Green open access
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Quartagno, M; Walker, AS; Babiker, AG; Turner, RM; Parmar, MKB; Copas, A; White, IR; (2020) Handling an uncertain control group event risk in non-inferiority trials: non-inferiority frontiers and the power-stabilising transformation. Trials , 21 , Article 145. 10.1186/s13063-020-4070-4. Green open access
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Quartagno, M; Walker, AS; Carpenter, J; Phillips, P; Parmar, M; (2018) Rethinking non-inferiority: a practical trial design for optimising treatment duration. Clinical Trials , 15 (5) pp. 477-488. 10.1177/1740774518778027. Green open access
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Ranganathan, P; Chinnaswamy, G; Sengar, M; Gadgil, D; Thiagarajan, S; Bhargava, B; Booth, CM; ... National Cancer Grid of India; + view all (2021) The International Collaboration for Research methods Development in Oncology (CReDO) workshops: shaping the future of global oncology research. The Lancet Oncology , 22 (8) e369-e376. 10.1016/S1470-2045(21)00077-2. Green open access
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Royston, P; Barthel, FMS; Parmar, MKB; Choodari-Oskooei, B; Isham, V; (2011) Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit. Trials , 12 , Article 81. 10.1186/1745-6215-12-81. Green open access
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Royston, P; Choodari-Oskooei, B; Parmar, MKB; Rogers, JK; (2019) Combined test versus logrank/Cox test in 50 randomised trials. Trials , 20 (1) , Article 172. 10.1186/s13063-019-3251-5. Green open access
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Royston, P; Parmar, MKB; (2020) A simulation study comparing the power of nine tests of the treatment effect in randomized controlled trials with a time-to-event outcome. Trials , 21 , Article 315. 10.1186/s13063-020-4153-2. Green open access
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Royston, P; Parmar, MKB; (2016) Augmenting the logrank test in the design of clinical trials in which non-proportional hazards of the treatment effect may be anticipated. BMC Medical Research Methodology , 16 (1) 10.1186/s12874-016-0110-x. Green open access
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Royston, P; Parmar, MKB; (2014) An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect. Trials , 15 (1) 10.1186/1745-6215-15-314. Green open access
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Royston, P; Parmar, MKB; (2013) Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome. BMC MEDICAL RESEARCH METHODOLOGY , 13 , Article ARTN 152. 10.1186/1471-2288-13-152. Green open access
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Rush, HL; Murphy, L; Morgans, AK; Clarke, NW; Cook, AD; Attard, G; Macnair, A; ... Langley, RE; + view all (2021) Quality of Life in Men With Prostate Cancer Randomly Allocated to Receive Docetaxel or Abiraterone in the STAMPEDE Trial. Journal of Clinical Oncology 10.1200/JCO.21.00728. (In press). Green open access
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Rydzewska, LHM; Burdett, S; Vale, CL; Clarke, NW; Fizazi, K; Kheoh, T; Mason, MD; ... STOPCaP Abiraterone Collaborators; + view all (2017) Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis. European Journal of Cancer , 84 pp. 88-101. 10.1016/j.ejca.2017.07.003. Green open access
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Rydzewska, LHM; Burdett, S; Vale, CL; Parmar, MKB; Tierney, JF; (2018) Response to letter commenting on published paper: Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis. European Journal of Cancer , 94 pp. 218-229. 10.1016/j.ejca.2018.02.002. Green open access
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Sabin, T; Matcham, J; Bray, S; Copas, A; Parmar, MK; (2014) A quantitative process for enhancing end of phase 2 decisions. Statistics in Biopharmaceutical Research , 6 (1) 67 - 77. 10.1080/19466315.2013.852617. Green open access
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Schiavone, F; Bathia, R; Letchmanan, K; Masters, L; Amos, C; Bara, A; Brown, L; ... Sydes, MR; + view all (2019) This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols. Trials , 20 , Article 264. 10.1186/s13063-019-3216-8. Green open access
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Seligmann, JF; Fisher, DJ; Brown, LC; Adams, RA; Graham, J; Quirke, P; Richman, SD; ... FOCUS4 Trial Investigators, .; + view all (2021) Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring. Journal of Clinical Oncology 10.1200/JCO.21.01435. (In press). Green open access
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South, A; Bailey, J; Parmar, MKB; Vale, CL; (2019) Effectiveness and acceptability of methods of communicating the results of clinical research to lay and professional audiences: protocol for a systematic review. Systematic Reviews , 8 , Article 150. 10.1186/s13643-019-1065-x. Green open access
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South, A; Parulekar, WR; Sydes, MR; Chen, BE; Parmar, MK; Clarke, N; Warde, P; (2016) Estimating the Impact of Randomised Control Trial Results on Clinical Practice: Results from a Survey and Modelling Study of Androgen Deprivation Therapy plus Radiotherapy for Locally Advanced Prostate Cancer. European Urology Focus , 2 (3) pp. 276-283. 10.1016/j.euf.2015.11.004. Green open access
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STARSurg Collaborative; the EuroSurg Collaborative; (2024) Impact of postoperative cardiovascular complications on 30-day mortality after major abdominal surgery: an international prospective cohort study. Anaesthesia , 79 (7) pp. 715-724. 10.1111/anae.16220. Green open access
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Stephens, RJ; Langley, RE; Nankivell, M; Parmar, MKB; Mulvenna, P; Vail, A; (2014) Interim results in clinical trials: Do we need to keep all interim randomised clinical trial results confidential? Lung Cancer , 85 (2) 116 - 118. 10.1016/j.lungcan.2014.05.012. Green open access
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Stott, W; Campbell, S; Franchini, A; Blyuss, O; Zaikin, A; Ryan, A; Jones, C; ... Menon, U; + view all (2017) Self-reported transvaginal ultrasound visualization of normal ovaries in postmenopausal women is not reliable: results of expert review of archived images in UKCTOCS. Ultrasound Obstet Gynecol 10.1002/uog.18836. (In press). Green open access
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Stott, W; Gentry-Maharaj, A; Ryan, A; Amso, N; Seif, M; Jones, C; Jacobs, I; ... Burnell, M; + view all (2018) Audit of transvaginal sonography of normal postmenopausal ovaries by sonographers from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). F1000 Research , 7 , Article 1241. 10.12688/f1000research.15663.1. Green open access
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Sydes, MR; (2018) Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol. Annals Of Oncology , 29 (5) pp. 1235-1248. 10.1093/annonc/mdy072. Green open access
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Sydes, MR; (2015) Survival with Newly Diagnosed Metastatic Prostate Cancer in the “Docetaxel Era”: Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019). European Urology , 67 (6) pp. 1028-1038. 10.1016/j.eururo.2014.09.032. Green open access
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Sydes, MR; Johnson, AL; Meredith, SK; Rauchenberger, M; South, A; Parmar, MK; (2015) Sharing data from clinical trials: the rationale for a controlled access approach. Trials , 16 (1) , Article 104. 10.1186/s13063-015-0604-6. Green open access
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Sydes, MR; Parmar, MK; Mason, MD; Clarke, NW; Amos, C; Anderson, J; de Bono, J; ... James, ND; + view all (2012) Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial. Trials , 13 , Article 168. 10.1186/1745-6215-13-168. Green open access
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Sydes, MR; Parmar, MKB; James, ND; Clarke, NW; Dearnaley, DP; Mason, MD; Morgan, RC; ... Royston, P; + view all (2009) Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial. Trials , 10 , Article 39. 10.1186/1745-6215-10-39. Green open access
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Taylor, JA; Burnell, M; Ryan, A; Karpinskyj, C; Kalsi, JK; Taylor, H; Apostolidou, S; ... Gentry-Maharaj, A; + view all (2022) Association of hysterectomy and invasive epithelial ovarian and tubal cancer: a cohort study within UKCTOCS. BJOG: An International Journal of Obstetrics and Gynaecology , 129 (1) pp. 110-118. 10.1111/1471-0528.16943. Green open access
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Tierney, J; Vale, CL; Burdett, S; Fisher, D; Rydzewska, L; Parmar, MKB; (2017) Timely and reliable evaluation of the effects of interventions: a framework for adaptive meta-analysis (FAME). Trials , 18 (Suppl.1) , Article P351. 10.1186/s13063-017-1902-y. Green open access
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Tierney, JF; Fisher, DJ; Burdett, S; Stewart, LA; Parmar, MKB; (2020) Comparison of aggregate and individual participant data approaches to meta-analysis of randomised trials: An observational study. PLoS Med , 17 (1) , Article e1003019. 10.1371/journal.pmed.1003019. Green open access
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Tierney, JF; Fisher, DJ; Vale, CL; Burdett, S; Rydzewska, LH; Rogozińska, E; Godolphin, PJ; ... Parmar, MKB; + view all (2021) A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials. PLoS Medicine , 18 (5) , Article e1003629. 10.1371/journal.pmed.1003629. (In press). Green open access
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Tierney, JF; Pignon, JP; Gueffyier, F; Clarke, M; Askie, L; Vale, CL; Burdett, S; (2015) How individual participant data meta-analyses have influenced trial design, conduct, and analysis. Journal of Clinical Epidemiology , 68 (11) pp. 1325-1335. 10.1016/j.jclinepi.2015.05.024. Green open access
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Vale, CL; Burdett, S; Fisher, DJ; Navani, N; Parmar, MK; Copas, AJ; Tierney, JF; (2014) Should Tyrosine Kinase Inhibitors Be Considered for Advanced Non-Small-Cell Lung Cancer Patients With Wild Type EGFR? Two Systematic Reviews and Meta-Analyses of Randomized Trials. Clinical Lung Cancer , 16 (3) 173- 182.e4. 10.1016/j.cllc.2014.11.007. Green open access
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Vale, CL; Burdett, S; Rydzewska, LH; Albiges, L; Clarke, NW; Fisher, D; Fizazi, K; ... Tierney, JF; + view all (2016) Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data. The Lancet Oncology , 17 (2) pp. 243-256. 10.1016/S1470-2045(15)00489-1. Green open access
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Vale, CL; Fisher, D; Kneebone, A; Parker, C; Pearse, M; Richaud, P; Sargos, P; ... Tierney, JF; + view all (2020) Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data. The Lancet , 396 pp. 1422-1431. 10.1016/S0140-6736(20)31952-8. Green open access
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Vale, CL; Fisher, D; White, I; Carpenter, J; Burdett, S; Clarke, N; Fizazi, K; ... Tierney, J; + view all (2018) What is the optimal systemic treatment of men with metastatic, hormone-naive prostate cancer? A STOPCAP systematic review and network meta-analysis. Annals of Oncology , 29 (5) pp. 1249-1257. 10.1093/annonc/mdy071. Green open access
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Webb, AB; Berg, CD; Castle, PE; Crosby, D; Etzioni, R; Kessler, LG; Menon, U; ... Sasieni, PD; + view all (2024) Considerations for using potential surrogate endpoints in cancer screening trials. The Lancet Oncology , 25 (5) e183-e192. 10.1016/S1470-2045(24)00015-9. Green open access
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Wong, Charis; Dakin, Rachel S; Williamson, Jill; Newton, Judith; Steven, Michelle; Colville, Shuna; Stavrou, Maria; ... Chandran, Siddharthan; + view all (2022) Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease. BMJ Open , 12 (7) , Article e064173. 10.1136/bmjopen-2022-064173. Green open access
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Woods, BS; Sideris, E; Sydes, MR; Gannon, MR; Parmar, MKB; Alzouebi, M; Attard, G; ... Sculpher, MJ; + view all (2018) Addition of Docetaxel to First-line Long-term Hormone Therapy in Prostate Cancer (STAMPEDE): Modelling to Estimate Long-term Survival, Quality-adjusted Survival, and Cost-effectiveness. European Urology Oncology , 1 (6) pp. 449-458. 10.1016/j.euo.2018.06.004. Green open access
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Zakeri, K; Rotolo, F; Lacas, B; Vitzthum, LK; Le, Q-T; Gregoire, V; Overgaard, J; ... MARCH/MACH-NC Collaborative Group and the Head and Neck Cancer I; + view all (2020) Predictive classifier for intensive treatment of head and neck cancer. Cancer , 126 (24) pp. 5263-5273. 10.1002/cncr.33212. Green open access
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Zeissler, M-L; Li, V; Parmar, MKB; Carroll, CB; (2020) Is It Possible to Conduct a Multi-Arm Multi-Stage Platform Trial in Parkinson's Disease: Lessons Learned from Other Neurodegenerative Disorders and Cancer. Journal of Parkinson's Disease , 10 (2) pp. 413-428. 10.3233/JPD-191856. Green open access
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Proceedings paper

James, N; Woods, B; Sideris, E; Spears, MR; Dearnaley, DP; Mason, M; Clarke, N; ... Sculpher, M; + view all (2018) Addition of docetaxel to first-line long-term hormone therapy in prostate cancer (STAMPEDE): Long-term survival, quality-adjusted survival, and cost-effectiveness analysis. In: Figlin, Robert and Spielberg, Steven, (eds.) Proceedings of the 2018 Genitourinary Cancers Symposium. American Society of Clinical Oncology (ASCO): San Francisco, CA, USA. Green open access
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Working / discussion paper

Burnell, M; Gentry-Maharaj, A; Skates, S; Ryan, A; Karpinskyj, C; Kalsi, J; Apostolidou, S; ... Menon, U; + view all (2020) UKCTOCS Update: Applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysis. MedRxiv: Cold Spring Harbor, NY, USA. Green open access
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Conference item

Cook, A; Embleton, A; Jayson, G; Kaplan, R; Kristensen, G; Parmar, MK; Pfisterer, J; ... Perren, T; + view all (2017) ICON7: Ovarian cancer, platinum second-line chemotherapy and overall survival. Presented at: 42nd ESMO Congress (ESMO 2017), Madrid, Spain. Green open access
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Gentry-Maharaj, A; Skates, S; Sharma, A; Burnell, M; Ryan, A; Grant, S; Ford, J; ... Menon, U; + view all (2006) Risk of Ovarian Cancer (Roc) Algorithm Increases Specificity of Ca125 in Ovarian Cancer Screening. Presented at: International Gynecologic Cancer Society (IGCS), Santa Monica, CA, USA. Green open access
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Langley, RE; Duong, T; Clarke, NW; Kynaston, K; Rosen, SD; Nankivell, M; Dearnaley, D; ... Abel, P; + view all (2018) PATCH - Prostate adenocarcinoma: transcutaneous hormones. A randomised comparison evaluating cardiovascular morbidity and mortality of transdermal oestradiol versus luteinising hormone-releasing hormone agonists in advanced prostate cancer. Presented at: The British Associations of Urological Surgeons (BAUS) Annual Scientific Meeting, Liverpool, UK. Green open access
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This list was generated on Sun Sep 14 04:40:56 2025 BST.