UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data.

Mauguen, A; Pignon, JP; Burdett, S; Domerg, C; Fisher, D; Paulus, R; Mandrekar, SJ; ... Surrogate Lung Project Collaborative Group; + view all (2013) Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data. Lancet Oncology , 14 (7) 619 - 626. 10.1016/S1470-2045(13)70158-X. Green open access

[thumbnail of 1-s2.0-S147020451370158X-main.pdf]
Preview
PDF
1-s2.0-S147020451370158X-main.pdf

Download (634kB)

Abstract

The gold standard endpoint in clinical trials of chemotherapy and radiotherapy for lung cancer is overall survival. Although reliable and simple to measure, this endpoint takes years to observe. Surrogate endpoints that would enable earlier assessments of treatment effects would be useful. We assessed the correlations between potential surrogate endpoints and overall survival at individual and trial levels.

Type: Article
Title: Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1470-2045(13)70158-X
Publisher version: http://dx.doi.org/10.1016/S1470-2045(13)70158-X
Language: English
Additional information: Copyright © 2013 Elsevier Ltd. PMCID: PMC3732017
Keywords: Biological Markers, Carcinoma, Non-Small-Cell Lung, Chemoradiotherapy, Chemotherapy, Adjuvant, Humans, Lung Neoplasms, Prognosis, Radiotherapy, Adjuvant, Randomized Controlled Trials as Topic, Survival Rate
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1406787
Downloads since deposit
116Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item