UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial

Dearnaley, DP; Jovic, G; Syndikus, I; Khoo, V; Cowan, RA; Graham, JD; Aird, EG; ... Sydes, MR; + view all (2014) Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial. The Lancet Oncology , 15 (4) 464 - 473. 10.1016/S1470-2045(14)70040-3. Green open access

[thumbnail of 1-s2.0-S1470204514700403-main.pdf]
Preview
PDF
1-s2.0-S1470204514700403-main.pdf

Download (394kB)

Abstract

The aim of this trial was to compare dose-escalated conformal radiotherapy with control-dose conformal radiotherapy in patients with localised prostate cancer. Preliminary findings reported after 5 years of follow-up showed that escalated-dose conformal radiotherapy improved biochemical progression-free survival. Based on the sample size calculation, we planned to analyse overall survival when 190 deaths occurred; this target has now been reached, after a median 10 years of follow-up.

Type: Article
Title: Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1470-2045(14)70040-3
Publisher version: http://dx.doi.org/10.1016/S1470-2045(14)70040-3
Language: English
Additional information: Copyright 2014 © Dearnaley et al. Open Access article distributed under the terms of CC BY.
Keywords: Aged, Aged, 80 and over, Androgen Antagonists, Chemotherapy, Adjuvant, Disease Progression, Disease-Free Survival, Dose Fractionation, Humans, Intention to Treat Analysis, Kallikreins, Kaplan-Meier Estimate, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Proportional Hazards Models, Prostate-Specific Antigen, Prostatic Neoplasms, Radiotherapy, Conformal, Risk Factors, Time Factors, Treatment Outcome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1427382
Downloads since deposit
133Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item