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Decline in use of hormone therapy among postmenopausal women in the United Kingdom

Menon, U; Burnell, M; Sharma, A; Gentry-Maharaj, A; Fraser, L; Ryan, A; Parmar, M; ... UKCTOCS Group; + view all (2007) Decline in use of hormone therapy among postmenopausal women in the United Kingdom. Menopause , 14 (3) 462 - 467. 10.1097/01.gme.0000243569.70946.9d. Green open access

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Abstract

Objective: There has been controversy about the results of the Women's Health Initiative and the Million Women Study and uncertainty about their impact on hormone therapy (HT) use. This study documents recent trends in HT use in postmenopausal women in the United Kingdom.Design: Between April 2001 and September 2005, 202,638 postmenopausal women aged 50 to 74 and with no history of bilateral oophorectomy were recruited to the United Kingdom Collaborative Trial of Ovarian Cancer Screening. The proportion of women randomized each month who were using HT was calculated. The trend in HT use was assessed with reference to the publication of the Women's Health Initiative interim results (July 2002), the Million Women Study (August 2003), and advice from the UK Committee on Safety of Medicines (December 2003).Results: The median number of women recruited and randomized per month was 3,955 (mean 3,744). The proportion of randomized women using HT between April 2001 and June 2002 was 29%. This was followed by a steady monthly decline, and by February to September 2005, only 10% to 11% of newly recruited women were using HT. This trend was present in all age groups. However, in current users, the average duration of HT use remained steady at 10 to 11 years.Conclusions: There was a steady decline in HT use among postmenopausal women at recruitment into the United Kingdom Collaborative Trial of Ovarian Cancer Screening between April 2001 and September 2005. This is likely to reflect general trends in the UK population and is probably related to the premature closure of the large HT trials and the ensuing publicity.

Type: Article
Title: Decline in use of hormone therapy among postmenopausal women in the United Kingdom
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/01.gme.0000243569.70946.9d
Publisher version: http://dx.doi.org/10.1097/01.gme.0000243569.70946....
Language: English
Additional information: © 2007 The North American Menopause Society. This article is made available under the terms of the Creative Commons Attribution-NonCommercial licence (CC BY-NC), allowing you to share and adapt the work for non-commercial uses only whilst providing an appropriate attribution (you must give appropriate credit, provide a link to the license, and indicate if changes were made).
Keywords: Hormone therapy, change in use, united kingdom, united kingdom collaborative trial of ovarian cancer screening ukctocs, randomized controlled-trial, replacement therapy, breast-cancer, follow-up, health, cohort, publication, netherlands, menopause, symptoms
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
URI: https://discovery.ucl.ac.uk/id/eprint/168210
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