UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

UKCTOCS Update: Applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysis

Burnell, M; Gentry-Maharaj, A; Skates, S; Ryan, A; Karpinskyj, C; Kalsi, J; Apostolidou, S; ... Menon, U; + view all (2020) UKCTOCS Update: Applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysis. MedRxiv: Cold Spring Harbor, NY, USA. Green open access

[thumbnail of Menon_2020.11.13.20231027.full.pdf]
Preview
Text
Menon_2020.11.13.20231027.full.pdf

Download (157kB) | Preview

Abstract

Background: During trials that span decades, new evidence including progress in statistical methodology, may require revision of original assumptions. An example is the continued use of a constant-effect approach to analyse the mortality reduction which is often delayed in cancer-screening trials. The latter led us to re-examine our approach for the upcoming primary mortality analysis(2020) of long-term follow-up of the United Kingdom Collaborative Trial of Ovarian Cancer Screening (LTFU UKCTOCS), having initially(2014) used the proportional hazards(PH) Cox-model. / Methods: We wrote to 12 experts in statistics/epidemiology/screening-trials, setting out current evidence, importance of pre-specification, previous mortality analysis (2014) and three possible choices for the follow-up analysis (2020) of the mortality outcome - (A)all data(2001-2020) using the Cox-model(2014) (B)new data(2015-2020) only (C)all data(2001-2020) using a test that allows for delayed effects. / Results: Of 11 respondents, eight supported changing the 2014-approach to allow for a potential delayed effect (optionC), suggesting various tests while three favoured retaining the Cox-model (optionA). Consequently, we opted for the Versatile test introduced in 2016 which maintains good power for early, constant or delayed effects. We retained the Royston-Parmar model to estimate absolute differences in disease-specific mortality at 5,10,15 and 18 years. / Conclusions: The decision to alter the follow-up analysis for the primary outcome on the basis of new evidence and using new statistical methodology for long-term follow-up is novel and has implications beyond UKCTOCS. There is an urgent need for consensus building on how best to design, test, estimate and report mortality outcomes from long-term randomised cancer screening trials. / Trial registration: (ISRCTN22488978, Registration date: 6/4/2000)

Type: Working / discussion paper
Title: UKCTOCS Update: Applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1101/2020.11.13.20231027
Publisher version: https://doi.org/10.1101/2020.11.13.20231027
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10135648
Downloads since deposit
11Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item