UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols

Parmar, MK; Cafferty, FH; Sydes, MR; Choodari-Oskooei, B; Langley, RE; Brown, L; Phillips, PP; ... Royston, PJ; + view all (2017) Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols. Clinical Trials , 14 (5) pp. 451-461. 10.1177/1740774517725697. Green open access

[thumbnail of Parmar_Testing_many_treatments.pdf]
Preview
Text
Parmar_Testing_many_treatments.pdf - Accepted Version

Download (523kB) | Preview

Abstract

There is real need to change how we do some of our clinical trials, as currently the testing and development process is too slow, too costly and too failure-prone often we find that a new treatment is no better than the current standard. Much of the focus on the development and testing pathway has been in improving the design of phase I and II trials. In this article, we present examples of new methods for improving the design of phase III trials (and the necessary lead up to them) as they are the most time-consuming and expensive part of the pathway. Key to all these methods is the aim to test many treatments and/or pose many therapeutic questions within one protocol.

Type: Article
Title: Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1740774517725697
Publisher version: http://doi.org/10.1177/1740774517725697
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Multi-arm, multi-stage, platform, umbrella, basket, randomised trials
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1571668
Downloads since deposit
88Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item