Browse by UCL people
Group by: Type | Date
Number of items: 109.
2025
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Carceller, Fernando;
Bautista, Francisco;
Van Tinteren, Harm;
Castañeda, Alicia;
Surun, Aurore;
Wasti, Ajla;
Revon-Rivière, Gabriel;
... Frappaz, Didier; + view all
(2025)
Prognostic factors of early mortality in children and adolescents with relapsed/refractory solid tumors participating in dose-finding trials in the targeted and immune therapies era: An ITCC study.
European Journal of Cancer
, 227
, Article 115627. 10.1016/j.ejca.2025.115627.
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Gardiner, B;
Wardill, HR;
O'Connor, G;
Hargrave, D;
Lett, AM;
(2025)
The impact of fibre and prebiotic interventions on outcomes in cancer and haematopoietic stem cell transplantation: A systematic review.
Clinical Nutrition
, 44
pp. 86-100.
10.1016/j.clnu.2024.11.022.
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Kann, BH;
Vossough, A;
Brüningk, SC;
Familiar, AM;
Aboian, M;
Linguraru, MG;
Yeom, KW;
... Kazerooni, AF; + view all
(2025)
Artificial Intelligence for Response Assessment in Pediatric Neuro-Oncology (AI-RAPNO), part 1: review of the current state of the art.
The Lancet Oncology
, 26
(11)
e597-e606.
10.1016/S1470-2045(25)00484-X.
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Kazerooni, AF;
Familiar, AM;
Aboian, M;
Brüningk, SC;
Vossough, A;
Linguraru, MG;
Huang, RY;
... Nabavizadeh, A; + view all
(2025)
Artificial Intelligence for Response Assessment in Pediatric Neuro-Oncology (AI-RAPNO), part 2: challenges, opportunities, and recommendations for clinical translation.
The Lancet Oncology
, 26
(11)
e607-e618.
10.1016/S1470-2045(25)00489-9.
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Kilburn, Lindsay B;
Khuong-Quang, Dong-Anh;
Hansford, Jordan R;
Landi, Daniel;
van der Lugt, Jasper;
Leary, Sarah ES;
Driever, Pablo Hernaiz;
... Nysom, Karsten; + view all
(2025)
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial (vol 30, pg 207, 2024).
[Corrigendum].
NATURE MEDICINE
, 31
, Article 2454. 10.1038/s41591-025-03709-4.
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Nysom, Karsten;
Kilburn, Lindsay B;
Leary, Sarah ES;
Landi, Daniel B;
de Vos-Kerkhof, Evelien;
Perreault, Sebastien;
Witt, Olaf;
... Hargrave, Darren; + view all
(2025)
Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial.
Neuro-Oncology
, 27
(5)
10.1093/neuonc/noae274.
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Nysom, Karsten;
Witt, Olaf;
Hargrave, Darren;
(2025)
Response to letter from Dr. Avery.
Neuro-Oncology
, Article noaf273. 10.1093/neuonc/noaf273.
(In press).
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Pereira, Rita;
Mackay, Alan;
Grabovska, Yura;
Bradley, Amelia;
Bloom, Tabitha;
Nicoll, James;
Boche, Delphine;
... Clarke, Matthew; + view all
(2025)
The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations.
Clinical Cancer Research
, 31
pp. 3259-3275.
10.1158/1078-0432.CCR-24-1256.
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Stone, Thomas J;
Pickles, Jessica C;
Ogunbiyi, Olumide;
Yasin, Shireena A;
Taylor, Catherine A;
Ahmed, Saira W;
Chalker, Jane;
... Jacques, Thomas S; + view all
(2025)
The tumour microenvironment of pilocytic astrocytoma evolves over time via enrichment for microglia.
Acta Neuropathologica Communications
, 13
, Article 30. 10.1186/s40478-024-01922-9.
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2024
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Azizi, Amedeo A;
Hargrave, Darren;
Passos, Joao;
Wolkenstein, Pierre;
Rosenbaum, Thorsten;
Santoro, Claudia;
Rosenmayr, Verena;
... Hernandez, Hector Salvador; + view all
(2024)
Consensus recommendations on management of selumetinib-associated adverse events in pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas.
Neuro-Oncology Practice
, 11
(5)
pp. 515-531.
10.1093/nop/npae038.
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Bull, Kim S;
Stubley, Shelly;
Freeman, Anita;
Liossi, Christina;
Darlington, Anne-Sophie E;
Grootenhuis, Martha A;
Hargrave, Darren;
... Kennedy, Colin R; + view all
(2024)
Experiences of families post treatment for childhood brain tumours during medical clinic consultations regarding health-related quality of life, unmet needs and communication barriers: A qualitative exploration.
Pediatric Blood & Cancer
, 71
(11)
, Article e31253. 10.1002/pbc.31253.
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El-Ayadi, M;
Druivenga, K;
Perwein, T;
Nussbaumer, G;
Spreafico, F;
Massimino, M;
Fadel, S;
... Kramm, CM; + view all
(2024)
General support of physical exercise programs in pediatric oncology but differences in perception by childhood cancer care professionals at European and North-African/Arab centers.
EJC Paediatric Oncology
, 3
, Article 100147. 10.1016/j.ejcped.2024.100147.
(In press).
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Fangusaro, J;
Jones, DT;
Packer, RJ;
Gutmann, DH;
Milde, T;
Witt, O;
Mueller, S;
... Bandopadhayay, P; + view all
(2024)
Pediatric low-grade glioma: State-of-the-art and ongoing challenges.
Neuro-Oncology
, 26
(1)
pp. 25-37.
10.1093/neuonc/noad195.
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George, Sally L;
Lynn, Claire;
Stankunaite, Reda;
Hughes, Debbie;
Sauer, Carolin M;
Chalker, Jane;
Waqar Ahmed, Saira;
... Chesler, Louis; + view all
(2024)
Stratified Medicine Paediatrics: Cell free DNA and serial tumour sequencing identifies subtype specific cancer evolution and epigenetic states.
Cancer Discovery
10.1158/2159-8290.CD-24-0916.
(In press).
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Gill, SK;
Rose, HEL;
Wilson, M;
Rodriguez Gutierrez, D;
Worthington, L;
Davies, NP;
MacPherson, L;
... Peet, AC; + view all
(2024)
Characterisation of paediatric brain tumours by their MRS metabolite profiles.
NMR in Biomedicine
10.1002/nbm.5101.
(In press).
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Kameda-Smith, MM;
Green, K;
Hutton, DL;
ul Owase Jeelani, N;
Thompson, DNP;
Hargrave, D;
Aquilina, K;
(2024)
The role of reoperation in pediatric cerebellar pilocytic astrocytoma.
Journal of Neurosurgery: Pediatrics
, 34
(2)
pp. 169-175.
10.3171/2024.2.PEDS23236.
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Kilburn, Lindsay B;
Khuong-Quang, Dong-Anh;
Hansford, Jordan R;
Landi, Daniel;
van der Lugt, Jasper;
Leary, Sarah ES;
Driever, Pablo Hernaiz;
... Nysom, Karsten; + view all
(2024)
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.
[Corrigendum].
Nature Medicine
10.1038/s41591-024-02910-1.
(In press).
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McCabe, Martin G;
Geoerger, Birgit;
Chesler, Louis;
Hargrave, Darren;
Parsons, D Williams;
van Tilburg, Cornelis M;
Schleiermacher, Gudrun;
... George, Sally L; + view all
(2024)
Precision Medicine for Childhood Cancer: Current Limitations and Future Perspectives.
JCO Precision Oncology
, 8
, Article e2300117. 10.1200/PO.23.00117.
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Mueller, Sabine;
Fangusaro, Jason;
Thomas, Arzu Onar;
Jacques, Thomas S;
Bandopadhayay, Pratiti;
de Blank, Peter;
Packer, Roger J;
... Witt, Olaf; + view all
(2024)
Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma: Guidelines established by the International Pediatric Low-Grade Glioma Coalition Clinical Trial Working Group (Dec, 10.1093/neuonc/noad227, 2023).
[Corrigendum].
Neuro-Oncology
, 26
(5)
p. 984.
10.1093/neuonc/noae030.
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Mueller, Sabine;
Fangusaro, Jason;
Thomas, Arzu Onar;
Jacques, Thomas S;
Bandopadhayay, Pratiti;
de Blank, Peter;
Packer, Roger J;
... Witt, Olaf; + view all
(2024)
Corrigendum to: Consensus framework for conducting
phase I/II clinical trials for children, adolescents,
and young adults with pediatric low-grade glioma:
Guidelines established by the International Pediatric
Low-Grade Glioma Coalition Clinical Trial Working
Group.
[Corrigendum].
Neuro-Oncology
, 26
(5)
p. 983.
10.1093/neuonc/noae024.
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Nussbaumer, Gunther;
Benesch, Martin;
Grabovska, Yura;
Mackay, Alan;
Castel, David;
Grill, Jacques;
Alonso, Marta M;
... Kramm, Christof M; + view all
(2024)
Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile.
Neuro-Oncology
, 26
(9)
pp. 1723-1737.
10.1093/neuonc/noae080.
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O’Hare, Patricia;
Cooney, Tabitha;
de Blank, Peter;
Gutmann, David H;
Kieran, Mark;
Milde, Till;
Fangusaro, Jason;
... Hargrave, Darren R; + view all
(2024)
Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition: A modified Delphi approach to build international consensus-based definitions—International Pediatric Low-Grade Glioma Coalition.
Neuro-Oncology
10.1093/neuonc/noae074.
(In press).
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Payne, C;
Cressey, P;
Talianu, A;
Szychot, E;
Hargrave, D;
Thanou, M;
Pouliopoulos, AN;
(2024)
Bi-modal confirmation of liposome delivery to the brain after focused ultrasound-induced blood-brain barrier opening.
Heliyon
, 10
(22)
, Article e39972. 10.1016/j.heliyon.2024.e39972.
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van Tilburg, Cornelis M;
Kilburn, Lindsay B;
Perreault, Sébastien;
Schmidt, Rene;
Azizi, Amedeo A;
Cruz-Martínez, Ofelia;
Zápotocký, Michal;
... Witt, Olaf; + view all
(2024)
LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration.
BMC Cancer
, 24
(1)
, Article 147. 10.1186/s12885-024-11820-x.
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2023
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Bouffet, E;
Hansford, JR;
Garrè, ML;
Hara, J;
Plant-Fox, A;
Aerts, I;
Locatelli, F;
... Hargrave, DR; + view all
(2023)
Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations.
New England Journal of Medicine
, 389
(12)
pp. 1108-1120.
10.1056/NEJMoa2303815.
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Bouffet, Eric;
Geoerger, Birgit;
Moertel, Christopher;
Whitlock, James A;
Aerts, Isabelle;
Hargrave, Darren;
Osterloh, Lisa;
... Fox, Elizabeth; + view all
(2023)
Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600–Mutant Low-Grade Glioma.
Journal of Clinical Oncology
, 41
(3)
pp. 664-674.
10.1200/jco.22.01000.
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Dunkel, Ira J;
Doz, François;
Foreman, Nicholas K;
Hargrave, Darren;
Lassaletta, Alvaro;
André, Nicolas;
Hansford, Jordan R;
... Cohen, Kenneth; + view all
(2023)
Nivolumab With or Without Ipilimumab in Pediatric Patients With High-Grade CNS Malignancies: Safety, Efficacy, Biomarker, and Pharmacokinetics: CheckMate 908.
Neuro-Oncology
, 25
(8)
pp. 1530-1545.
10.1093/neuonc/noad031.
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Hardin, Emily C;
Schmid, Simone;
Sommerkamp, Alexander;
Bodden, Carina;
Heipertz, Anna-Elisa;
Sievers, Philipp;
Wittmann, Andrea;
... van Tilburg, Cornelis M; + view all
(2023)
LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients.
Neuro-Oncology
, 25
(11)
pp. 2087-2097.
10.1093/neuonc/noad078.
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Hargrave, Darren R;
Terashima, Keita;
Hara, Junichi;
Kordes, Uwe R;
Upadhyaya, Santhosh A;
Sahm, Felix;
Bouffet, Eric;
... all the Investigators involved in the high-grade glioma cohort; + view all
(2023)
Phase II Trial of Dabrafenib Plus Trametinib in Relapsed/Refractory BRAF V600-Mutant Pediatric High-Grade Glioma.
Journal of Clinical Oncology
10.1200/JCO.23.00558.
(In press).
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Higgins, Conor J;
Kite, Kerry-Anne;
Klein, Nigel;
Super, Michael;
McCurdy, Michael T;
Hargrave, Darren;
(2023)
A novel diagnostic method for a rare fungus: FcMBL facilitates Wickerhamomyces anomalus identification in an immunocompromised neonate.
Medical Mycology Case Reports
, 42
, Article 100614. 10.1016/j.mmcr.2023.100614.
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Jones, C;
Straathof, K;
Fouladi, M;
Hargrave, D;
Prados, M;
Resnick, A;
Doz, F;
... Mueller, S; + view all
(2023)
Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks.
Frontiers in Oncology
, 13
, Article 1167082. 10.3389/fonc.2023.1167082.
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Kilburn, LB;
Khuong-Quang, DA;
Hansford, JR;
Landi, D;
van der Lugt, J;
Leary, SES;
Driever, PH;
... Nysom, K; + view all
(2023)
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.
Nature Medicine
10.1038/s41591-023-02668-y.
(In press).
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Silva, AHD;
Habermann, S;
Craven, CL;
Bhagawati, D;
O’Hare, P;
Jorgensen, M;
Dahl, C;
... Aquilina, K; + view all
(2023)
Atypical teratoid rhabdoid tumours (ATRTs)—a 21-year institutional experience.
Child's Nervous System
, 39
pp. 1509-1518.
10.1007/s00381-023-05828-0.
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Stone, Thomas J;
Mankad, Kshitij;
Tan, AI Peng;
Jan, Wajanat;
Pickles, Jessica C;
Gogou, Maria;
Chalker, Jane;
... Jacques, Thomas S; + view all
(2023)
DNA methylation-based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification.
Neuropathology and Applied Neurobiology
, 49
(2)
, Article e12894. 10.1111/nan.12894.
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Whitlock, James A;
Geoerger, Birgit;
Dunkel, Ira J;
Roughton, Michael;
Choi, Jeea;
Osterloh, Lisa;
Russo, Mark;
(2023)
Dabrafenib, alone or in combination with trametinib, in BRAF V600–mutated pediatric Langerhans cell histiocytosis.
Blood Advances
, 7
(15)
pp. 3806-3815.
10.1182/bloodadvances.2022008414.
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2022
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Aquilina, K;
Chakrapani, A;
Carr, L;
Kurian, MA;
Hargrave, D;
(2022)
Convection-Enhanced Delivery in Children: Techniques and Applications.
Advances and Technical Standards in Neurosurgery
, 45
pp. 199-228.
10.1007/978-3-030-99166-1_6.
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Bowman, R;
Walters, B;
Smith, V;
Prise, KL;
Handley, SE;
Green, K;
Mankad, K;
... Thompson, DA; + view all
(2022)
Visual outcomes and predictors in optic pathway glioma: a single centre study.
Eye
10.1038/s41433-022-02096-1.
(In press).
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Chavaz, L;
Janssens, GO;
Bolle, S;
Mandeville, H;
Ramos-Albiac, M;
Van Beek, K;
Benghiat, H;
... von Bueren, AO; + view all
(2022)
Neurological Symptom Improvement After Re-Irradiation in Patients With Diffuse Intrinsic Pontine Glioma: A Retrospective Analysis of the SIOP-E-HGG/DIPG Project.
Frontiers in Oncology
, 12
, Article 926196. 10.3389/fonc.2022.926196.
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Collins-Sawaragi, YC;
Ferner, R;
Vassallo, G;
De Agrò, G;
Eccles, S;
Cadwgan, J;
Hargrave, D;
... Lascelles, K; + view all
(2022)
Location, symptoms, and management of plexiform neurofibromas in 127 children with neurofibromatosis 1, attending the National Complex Neurofibromatosis 1 service, 2018–2019.
American Journal of Medical Genetics, Part A
, 188
(6)
pp. 1723-1727.
10.1002/ajmg.a.62691.
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de Blank, Peter MK;
Gross, Andrea M;
Akshintala, Srivandana;
Blakeley, Jaishri O;
Bollag, Gideon;
Cannon, Ashley;
Dombi, Eva;
... Fisher, Michael J; + view all
(2022)
MEK Inhibitors for Neurofibromatosis Type 1 Manifestations: Clinical Evidence and Consensus.
Neuro-Oncology
, 24
(11)
pp. 1845-1856.
10.1093/neuonc/noac165.
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Gielen, GH;
Baugh, JN;
Van Vuurden, DG;
Veldhuijzen Van Zanten, SEM;
Hargrave, D;
Massimino, M;
Biassoni, V;
... Kramm, CM; + view all
(2022)
Pediatric high-grade gliomas and the WHO CNS Tumor Classification - Perspectives of pediatric neuro-oncologists and neuropathologists in light of recent updates.
Neuro-Oncology Advances
, 4
(1)
, Article vdac077. 10.1093/noajnl/vdac077.
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Green, Katherine;
Panagopoulou, Paraskevi;
D'Arco, Felice;
O'Hare, Patricia;
Bowman, Richard;
Walters, Bronwen;
Dahl, Christine;
... Opocher, Enrico; + view all
(2022)
A nationwide evaluation of bevacizumab-based treatments in pediatric low-grade glioma in the UK: safety, efficacy, visual morbidity, and outcomes.
Neuro-Oncology
, 25
(4)
pp. 774-785.
10.1093/neuonc/noac223.
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Izquierdo, Elisa;
Carvalho, Diana M;
Mackay, Alan;
Temelso, Sara;
Boult, Jessica KR;
Pericoli, Giulia;
Fernandez, Elisabet;
... Jones, Chris; + view all
(2022)
DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition.
Cancer Discovery
, 12
(3)
pp. 712-729.
10.1158/2159-8290.CD-20-0930.
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Morana, G;
Shaw, D;
MacDonald, SM;
Alapetite, C;
Ajithkumar, T;
Bhatia, A;
Brisse, H;
... Murray, MJ; + view all
(2022)
Imaging response assessment for CNS germ cell tumours: consensus recommendations from the European Society for Paediatric Oncology Brain Tumour Group and North American Children's Oncology Group.
The Lancet Oncology
, 23
(5)
e218-e228.
10.1016/S1470-2045(22)00063-8.
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Pearson, AD;
Allen, C;
Fangusaro, J;
Hutter, C;
Witt, O;
Weiner, S;
Reaman, G;
... Vassal, G; + view all
(2022)
Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
European Journal of Cancer
, 177
pp. 120-142.
10.1016/j.ejca.2022.09.036.
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Picariello, S;
Cerbone, M;
D’arco, F;
Gan, HW;
O’hare, P;
Aquilina, K;
Opocher, E;
... Spoudeas, HA; + view all
(2022)
A 40-Year Cohort Study of Evolving Hypothalamic Dysfunction in Infants and Young Children (<3 years) with Optic Pathway Gliomas.
Cancers
, 14
(3)
, Article 747. 10.3390/cancers14030747.
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Piccardo, A;
Albert, NL;
Borgwardt, L;
Fahey, FH;
Hargrave, D;
Galldiks, N;
Jehanno, N;
... Zucchetta, P; + view all
(2022)
Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [¹⁸F]FDG: version 1.0.
European Journal of Nuclear Medicine and Molecular Imaging
10.1007/s00259-022-05817-6.
(In press).
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Rodriguez, Daniel;
Calmon, Raphael;
Aliaga, Esther Sanchez;
Warren, Daniel;
Warmuth-Metz, Monika;
Jones, Chris;
Mackay, Alan;
... Jaspan, Timothy; + view all
(2022)
MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial.
Radiology
, 304
(1)
pp. 174-182.
10.1148/radiol.211464.
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2021
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Alves, CAPF;
Löbel, U;
Martin-Saavedra, JS;
Toescu, S;
Tsunemi, MH;
Teixeira, SR;
Mankad, K;
... D'Arco, F; + view all
(2021)
A Diagnostic Algorithm for Posterior Fossa Tumors in Children: A Validation Study.
American Journal of Neuroradiology
, 42
(5)
pp. 961-968.
10.3174/ajnr.A7057.
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Baugh, JN;
Gielen, GH;
Van Vuurden, DG;
Veldhuijzen Van Zanten, SEM;
Hargrave, D;
Massimino, M;
Biassoni, V;
... Kramm, CM; + view all
(2021)
Transitioning to molecular diagnostics in pediatric high-grade glioma: Experiences with the 2016 WHO classification of CNS tumors.
Neuro-Oncology Advances
, 3
(1)
, Article vdab113. 10.1093/noajnl/vdab113.
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Bhattacharya, D;
Chhabda, S;
Lakshmanan, R;
Tan, R;
Warne, R;
Benenati, M;
Michalski, A;
... Mankad, K; + view all
(2021)
Spectrum of neuroimaging findings post-proton beam therapy in a large pediatric cohort.
Child's Nervous System
, 37
pp. 435-446.
10.1007/s00381-020-04819-9.
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Campion, T;
Quirk, B;
Cooper, J;
Phipps, K;
Toescu, S;
Aquilina, K;
Green, K;
... Mankad, K; + view all
(2021)
Surveillance imaging of grade 1 astrocytomas in children: can duration and frequency of follow-up imaging and the use of contrast agents be reduced?
Neuroradiology
, 63
pp. 953-958.
10.1007/s00234-020-02609-3.
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Fangusaro, J;
Cefalo, MG;
Garre, ML;
Marshall, LV;
Massimino, M;
Benettaib, B;
Biserna, N;
... Warren, KE; + view all
(2021)
Phase 2 Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors.
Frontiers in Oncology
, 11
, Article 660892. 10.3389/fonc.2021.660892.
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Hill, CS;
Khan, M;
Phipps, K;
Green, K;
Hargrave, D;
Aquilina, K;
(2021)
Neurosurgical experience of managing optic pathway gliomas.
Child's Nervous System
10.1007/s00381-021-05060-8.
(In press).
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Izquierdo, E;
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