Higgins, Conor J;
Kite, Kerry-Anne;
Klein, Nigel;
Super, Michael;
McCurdy, Michael T;
Hargrave, Darren;
(2023)
A novel diagnostic method for a rare fungus: FcMBL facilitates Wickerhamomyces anomalus identification in an immunocompromised neonate.
Medical Mycology Case Reports
, 42
, Article 100614. 10.1016/j.mmcr.2023.100614.
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Abstract
Fungemia negatively impacts patient outcomes, current diagnostics lack sensitivity to identify emerging rare mycoses, and fungal infections are increasing in prevalence, variety, and resistance. We report a case of Wickerhamomyces anomalus in an immunocompromised neonate in which FcMBL bead-based matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) resulted in species identification roughly 30 hours before standard pathogen identification methods. Deploying FcMBL bead-based MALDI-TOF MS may improve the speed and accuracy of identification, and therefore treatment, of rare pathogens.
| Type: | Article |
|---|---|
| Title: | A novel diagnostic method for a rare fungus: FcMBL facilitates Wickerhamomyces anomalus identification in an immunocompromised neonate |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mmcr.2023.100614 |
| Publisher version: | https://doi.org/10.1016/j.mmcr.2023.100614 |
| Language: | English |
| Additional information: | /© 2023 The Authors. Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Wickerhamomyces anomalus, FcMBL, Fungemia, MALDI-TOF MSNeonate, Case report |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10180033 |
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