Browse by UCL people
Group by: Type | Date
Number of items: 79.
2025
Bi, Dongquan;
Copas, Andrew;
Li, Fan;
Kahan, Brennan C;
(2025)
A scoping review identified additional considerations for defining estimands in cluster randomised trials.
Journal of Clinical Epidemiology
, Article 112015. 10.1016/j.jclinepi.2025.112015.
(In press).
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Chan, An-Wen;
Boutron, Isabelle;
Hopewell, Sally;
Moher, David;
Schulz, Kenneth F;
Collins, Gary S;
Tunn, Ruth;
... Hróbjartsson, Asbjørn; + view all
(2025)
SPIRIT 2025 statement: updated guideline for protocols of randomized trials.
Nature Medicine
, 31
pp. 1784-1792.
10.1038/s41591-025-03668-w.
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Chan, An-Wen;
Boutron, Isabelle;
Hopewell, Sally;
Moher, David;
Schulz, Kenneth F;
Collins, Gary S;
Tunn, Ruth;
... Hróbjartsson, Asbjørn; + view all
(2025)
SPIRIT 2025 Statement:
Updated Guideline for Protocols of Randomized Trials.
Journal of the American Medical Association (JAMA)
, Article Special Communication. 10.1001/jama.2025.4486.
(In press).
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Chan, An-Wen;
Boutron, Isabelle;
Hopewell, Sally;
Moher, David;
Schulz, Kenneth F;
Collins, Gary S;
Tunn, Ruth;
... Hróbjartsson, Asbjørn; + view all
(2025)
SPIRIT 2025 statement: updated guideline for protocols of randomised trials.
BMJ
, 389
, Article e081477. 10.1136/bmj-2024-081477.
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Clark, Timothy P;
Wicentowski, Richard H;
Cro, Suzie;
Sydes, Matthew R;
Kahan, Brennan C;
(2025)
Are estimands being correctly used? A review of UK research protocols.
Trials
, 26
, Article 310. 10.1186/s13063-025-08991-8.
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Hopewell, Sally;
Chan, An-Wen;
Collins, Gary S;
Hrobjartsson, Asbjorn;
Moher, David;
Schulz, Kenneth F;
Tunn, Ruth;
... Boutron, Isabelle; + view all
(2025)
CONSORT 2025 Statement: Updated Guideline for Reporting Randomized Trials.
JAMA
10.1001/jama.2025.4347.
(In press).
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Hopewell, Sally;
Chan, An-Wen;
Collins, Gary S;
Hróbjartsson, Asbjørn;
Moher, David;
Schulz, Kenneth F;
Tunn, Ruth;
... Boutron, Isabelle; + view all
(2025)
CONSORT 2025 statement: updated guideline for reporting randomized trials.
Nature Medicine
, 31
pp. 1776-1783.
10.1038/s41591-025-03635-5.
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Hopewell, Sally;
Chan, An-Wen;
Collins, Gary S;
Hróbjartsson, Asbjørn;
Moher, David;
Schulz, Kenneth F;
Tunn, Ruth;
... Boutron, Isabelle; + view all
(2025)
CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials.
BMJ
, 389
, Article e081124. 10.1136/bmj-2024-081124.
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Hopewell, Sally;
Chan, An-Wen;
Collins, Gary S;
Hróbjartsson, Asbjørn;
Moher, David;
Schulz, Kenneth F;
Tunn, Ruth;
... Boutron, Isabelle; + view all
(2025)
CONSORT 2025 statement: updated guideline for reporting randomised trials.
BMJ
, 389
, Article e081123. 10.1136/bmj-2024-081123.
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Hopewell, Sally;
Chan, An-Wen;
Collins, Gary S;
Hróbjartsson, Asbjørn;
Moher, David;
Schulz, Kenneth F;
Tunn, Ruth;
... Boutron, Isabelle; + view all
(2025)
CONSORT 2025 statement: updated guideline for reporting randomized trials: a Korean translation.
Ewha Medical Journal
, 48
(3)
, Article e50. 10.12771/emj.2025.00409.
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Hróbjartsson, Asbjørn;
Boutron, Isabelle;
Hopewell, Sally;
Moher, David;
Schulz, Kenneth F;
Collins, Gary S;
Tunn, Ruth;
... Chan, An-Wen; + view all
(2025)
SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials.
BMJ
, 389
, Article e081660. 10.1136/bmj-2024-081660.
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Kahan, Brennan C;
Devane, Declan;
(2025)
Estimands: what they are and why we should use them.
Journal of Clinical Epidemiology
, Article 112054. 10.1016/j.jclinepi.2025.112054.
(In press).
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Kahan, Brennan C;
Juszczak, Edmund;
Beller, Elaine;
Birchenall, Megan;
Chan, An-Wen;
Hall, Sophie;
Little, Paul;
... Montgomery, Alan; + view all
(2025)
Guidance for protocol content and reporting of factorial randomised trials: explanation and elaboration of the CONSORT 2010 and SPIRIT 2013 extensions.
BMJ
, 388
, Article e080785. 10.1136/bmj-2024-080785.
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Li, Fan;
Tong, Jiaqi;
Fang, Xi;
Cheng, Chao;
Kahan, Brennan C;
Wang, Bingkai;
(2025)
Model-Robust Standardization in Cluster-Randomized Trials.
Statistics in Medicine
, 44
(20-22)
, Article e70270. 10.1002/sim.70270.
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Noor, NM;
Estevinho, MM;
Solitano, V;
Yuan, Y;
Kahan, BC;
Jairath, V;
(2025)
Applying the estimand framework to inflammatory bowel disease clinical trials.
The Lancet Gastroenterology and Hepatology
, 10
(5)
pp. 406-409.
10.1016/S2468-1253(25)00004-4.
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2024
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Hemming, Karla;
Thompson, Jacqueline Y;
Taljaard, Monica;
Watson, Samuel I;
Kasza, Jessica;
Thompson, Jennifer A;
Kahan, Brennan C;
(2024)
Re-analysis of data from cluster randomised trials to explore the impact of model choice on estimates of odds ratios: study protocol.
Trials
, 25
(1)
, Article 818. 10.1186/s13063-024-08653-1.
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Kahan, Brennan C;
Blette, Bryan S;
Harhay, Michael O;
Halpern, Scott D;
Jairath, Vipul;
Copas, Andrew;
Li, Fan;
(2024)
Demystifying estimands in cluster-randomised trials.
Statistical Methods in Medical Research
10.1177/09622802241254197.
(In press).
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2023
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Cro, Suzie;
Kahan, Brennan C;
Patel, Akshaykumar;
Henley, Ania;
C, Joanna;
Hellyer, Paul;
Kumar, Manos;
... Goulão, Beatriz; + view all
(2023)
Starting a conversation about estimands with public partners involved in clinical trials: a co-developed tool.
Trials
, 24
, Article 443. 10.1186/s13063-023-07469-9.
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Edwards, Mark R;
Forbes, Gordon;
Walker, Neil;
Morton, Dion G;
Mythen, Monty G;
Murray, Dave;
Anderson, Iain;
... FLO-ELA investigators; + view all
(2023)
Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery.
Trials
, 24
(1)
, Article 313. 10.1186/s13063-023-07275-3.
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Goulao, Beatriz;
Duncan, Anne;
Innes, Karen;
Ramsay, Craig R;
Kahan, Brennan C;
(2023)
Using re-randomisation designs to increase the efficiency and applicability of retention studies within trials: a case study.
Trials
, 24
, Article 299. 10.1186/s13063-023-07323-y.
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Kahan, BC;
Hall, SS;
Beller, EM;
Birchenall, M;
Chan, AW;
Elbourne, D;
Little, P;
... Montgomery, AA; + view all
(2023)
Reporting of Factorial Randomized Trials: Extension of the CONSORT 2010 Statement.
JAMA: Journal of the American Medical Association
, 330
(21)
pp. 2106-2114.
10.1001/jama.2023.19793.
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Kahan, BC;
Hall, SS;
Beller, EM;
Birchenall, M;
Elbourne, D;
Juszczak, E;
Little, P;
... Montgomery, AA; + view all
(2023)
Consensus Statement for Protocols of Factorial Randomized Trials Extension of the SPIRIT 2013 Statement.
JAMA Network Open
, 6
(12)
, Article e2346121. 10.1001/jamanetworkopen.2023.46121.
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Kahan, Brennan C;
Cro, Suzie;
Li, Fan;
Harhay, Michael O;
(2023)
Eliminating ambiguous treatment effects using estimands.
American Journal of Epidemiology
, 192
(6)
, Article kwad036. 10.1093/aje/kwad036.
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Kahan, Brennan C;
Li, Fan;
Blette, Bryan;
Jairath, Vipul;
Copas, Andrew;
Harhay, Michael;
(2023)
Informative cluster size in cluster-randomised trials: A case study from the TRIGGER trial.
Clinical Trials
10.1177/17407745231186094.
(In press).
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Kahan, Brennan C;
White, Ian R;
Edwards, Mark;
Harhay, Michael O;
(2023)
Using modified intention-to-treat as a principal stratum estimator for failure to initiate treatment.
Clinical Trials
10.1177/17407745231160074.
(In press).
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Uddin, Masuma;
Bashir, Nasir Z;
Kahan, Brennan C;
(2023)
Evaluating whether the proportional odds models to analyse ordinal outcomes in COVID-19 clinical trials is providing clinically interpretable treatment effects: A systematic review.
Clinical Trials
10.1177/17407745231211272.
(In press).
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Yelland, Lisa N;
Louise, Jennie;
Kahan, Brennan C;
Morris, Tim P;
Lee, Katherine J;
Sullivan, Thomas R;
(2023)
Handling misclassified stratification variables in the analysis of randomised trials with continuous outcomes.
Statistics in Medicine
10.1002/sim.9818.
(In press).
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2022
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Campbell, David;
McDonald, Cassandra;
Cro, Suzie;
Jairath, Vipul;
Kahan, Brennan C;
(2022)
Access to unpublished protocols and statistical analysis plans of randomised trials.
Trials
, 23
(1)
, Article 674. 10.1186/s13063-022-06641-x.
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Clark, TP;
Kahan, BC;
Phillips, A;
White, I;
Carpenter, JR;
(2022)
Estimands: bringing clarity and focus to research questions in clinical trials.
BMJ Open
, 12
(1)
, Article e052953. 10.1136/bmjopen-2021-052953.
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Cro, S;
Kahan, BC;
Rehal, S;
Chis Ster, A;
Carpenter, JR;
White, IR;
Cornelius, VR;
(2022)
Evaluating how clear the questions being investigated in randomised trials are: systematic review of estimands.
BMJ
, 378
, Article e070146. 10.1136/bmj-2022-070146.
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Kahan, Brennan C;
Morris, Tim P;
Goulão, Beatriz;
Carpenter, James;
(2022)
Estimands for factorial trials.
Statistics in Medicine
10.1002/sim.9510.
(In press).
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Kahan, Brennan C;
White, Ian R;
Edwards, Mark;
Harhay, Michael O;
(2022)
A simple principal stratum estimator for failure to initiate treatment.
arXiv
10.48550/arXiv.2206.10453.
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Kahan, Brennan C;
White, Ian R;
Hooper, Richard;
Eldridge, Sandra;
(2022)
Re-randomisation trials in multi-episode settings: Estimands and independence estimators.
Statistical Methods in Medical Research
10.1177/09622802221094140.
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Pham, Tra My;
Tweed, Conor D;
Carpenter, James R;
Kahan, Brennan C;
Nunn, Andrew J;
Crook, Angela M;
Esmail, Hanif;
... White, Ian R; + view all
(2022)
Rethinking intercurrent events in defining estimands for tuberculosis trials.
Clinical Trials
10.1177/17407745221103853.
(In press).
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Walker, SP;
Bintcliffe, O;
Keenan, E;
Stadon, L;
Evison, M;
Haris, M;
Nagarajan, T;
... Maskell, NA; + view all
(2022)
Randomised trial of indwelling pleural catheters for refractory transudative pleural effusions.
European Respiratory Journal
, 59
(2)
, Article 2101362. 10.1183/13993003.01362-2021.
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White, Ian;
Choodari-Oskooei, Babak;
Sydes, Matthew R;
Kahan, Brennan;
McCabe, Leanne;
Turkova, Anna;
Esmail, Hanif;
... Ford, Deborah; + view all
(2022)
Combining factorial and multi-arm multi-stage platform designs to evaluate multiple interventions efficiently.
Clinical Trials
10.1177/17407745221093577.
(In press).
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2021
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Kahan, BC;
Morris, TP;
(2021)
Redressing the balance: Covariate adjustment in randomised trials.
BJOG: An International Journal of Obstetrics and Gynaecology
, 128
(10)
p. 1573.
10.1111/1471-0528.16759.
|
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Kahan, BC;
Morris, TP;
White, IR;
Carpenter, J;
Cro, S;
(2021)
Estimands in published protocols of randomised trials: urgent improvement needed.
Trials
, 22
(1)
, Article 686. 10.1186/s13063-021-05644-4.
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Kahan, BC;
White, IR;
Eldridge, S;
Hooper, R;
(2021)
Independence estimators for re-randomisation trials in multi-episode settings: a simulation study.
BMC Medical Research Methodology
, 21
, Article 235. 10.1186/s12874-021-01433-4.
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Pham, TM;
White, IR;
Kahan, BC;
Morris, TP;
Stanworth, SJ;
Forbes, G;
(2021)
A comparison of methods for analyzing a binary composite endpoint with partially observed components in randomized controlled trials.
Statistics in Medicine
10.1002/sim.9203.
(In press).
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PRISM trial group;
(2021)
Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial.
The Lancet Respiratory Medicine
, 9
(11)
pp. 1221-1230.
10.1016/S2213-2600(21)00089-8.
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2020
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Bhatnagar, R;
Luengo-Fernandez, R;
Kahan, BC;
Rahman, NM;
Miller, RF;
Maskell, NA;
(2020)
Thoracoscopy and talc poudrage compared with intercostal drainage and talc slurry infusion to manage malignant pleural effusion: the TAPPS RCT.
Health Technol Assess
, 24
(26)
pp. 1-90.
10.3310/hta24260.
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Bhatnagar, R;
Piotrowska, HEG;
Laskawiec-Szkonter, M;
Kahan, BC;
Luengo-Fernandez, R;
Pepperell, JCT;
Evison, MD;
... Maskell, NA; + view all
(2020)
Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial.
Journal of the American Medical Association
, 20
(323)
pp. 60-69.
10.1001/jama.2019.19997.
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Cro, S;
Forbes, G;
Johnson, NA;
Kahan, BC;
(2020)
Evidence of unexplained discrepancies between planned and conducted statistical analyses: a review of randomised trials.
BMC Medicine
, 18
, Article 137. 10.1186/s12916-020-01590-1.
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Cro, S;
Morris, TP;
Kahan, BC;
Cornelius, VR;
Carpenter, JR;
(2020)
A four-step strategy for handling missing outcome data in randomised trials affected by a pandemic.
BMC Medical Research Methodology
, 20
(1)
, Article 208. 10.1186/s12874-020-01089-6.
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Forbes, G;
Newton, S;
Cantalapiedra Calvete, C;
Birch, J;
Dodds, J;
Steed, L;
Rivas, C;
... Ball, E; + view all
(2020)
MEMPHIS: a smartphone app using psychological approaches for women with chronic pelvic pain presenting to gynaecology clinics: a randomised feasibility trial.
BMJ Open
, 10
(3)
, Article e030164. 10.1136/bmjopen-2019-030164.
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Kahan, BC;
Ahmad, T;
Forbes, G;
Cro, S;
(2020)
Public availability and adherence to prespecified statistical analysis approaches was low in published randomized trials.
Journal of Clinical Epidemiology
, 128
pp. 29-34.
10.1016/j.jclinepi.2020.07.015.
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Kahan, BC;
Forbes, G;
Cro, S;
(2020)
How to design a pre-specified statistical analysis approach to limit p-hacking in clinical trials: the Pre-SPEC framework.
BMC Medicine
, 18
, Article 253. 10.1186/s12916-020-01706-7.
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Kahan, BC;
Morris, TP;
White, IR;
Tweed, CD;
Cro, S;
Dahly, D;
Pham, TM;
... Carpenter, JR; + view all
(2020)
Treatment estimands in clinical trials of patients hospitalised for COVID-19: ensuring trials ask the right questions.
BMC Medicine
, 18
(1)
, Article 286. 10.1186/s12916-020-01737-0.
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Kim, J;
Troxel, AB;
Halpern, SD;
Volpp, KG;
Kahan, BC;
Morris, TP;
Harhay, MO;
(2020)
Analysis of multicenter clinical trials with very low event rates.
Trials
, 21
(1)
, Article 917. 10.1186/s13063-020-04801-5.
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2019
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Edwards, MR;
Forbes, G;
MacDonald, N;
Berdunov, V;
Mihaylova, B;
Dias, P;
Thomson, A;
... OPTIMISE II investigators, .; + view all
(2019)
Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery.
BMJ Open
, 9
, Article e023455. 10.1136/bmjopen-2018-023455.
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Peden, CJ;
Stephens, T;
Martin, G;
Kahan, BC;
Thomson, A;
Rivett, K;
Wells, D;
... Enhanced Peri-Operative Care for High-risk patients (EPOCH) tria, .; + view all
(2019)
Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial.
The Lancet
, 393
(10187)
pp. 2213-2221.
10.1016/S0140-6736(18)32521-2.
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2018
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Bhatnagar, R;
Keenan, EK;
Keenan, EK;
Morley, AJ;
Kahan, BC;
Stanton, AE;
Haris, M;
... Maskell, NA; + view all
(2018)
Outpatient Talc Administration by Indwelling Pleural Catheter for Malignant Effusion.
The New England Journal of Medicine
, 378
(14)
pp. 1313-1322.
10.1056/NEJMoa1716883.
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Greenberg, L;
Jairath, V;
Pearse, R;
Kahan, BC;
(2018)
Pre-specification of statistical analysis approaches in published clinical trial protocols was inadequate.
Journal of Clinical Epidemiology
, 101
pp. 53-60.
10.1016/j.jclinepi.2018.05.023.
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Kahan, BC;
Morris, TP;
Harris, E;
Pearse, R;
Hooper, R;
Eldridge, S;
(2018)
Re-randomization increased recruitment and provided similar treatment estimates as parallel designs in trials of febrile neutropenia.
Journal of Clinical Epidemiology
, 97
pp. 14-19.
10.1016/j.jclinepi.2018.02.002.
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Rivas, CA;
Ball, E;
Taylor, SJC;
Birch, J;
Gibson, HAL;
Rogozinska, E;
Dodds, J;
... Cantalapiedra Calvete, C; + view all
(2018)
Smartphone App Using Mindfulness Meditation for Women With Chronic Pelvic Pain (MEMPHIS): Protocol for a Randomized Feasibility Trial.
JMIR Res Protoc
, 7
(1)
, Article e8. 10.2196/resprot.7720.
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2017
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Kahan, BC;
Koulenti, D;
Arvaniti, K;
Beavis, V;
Campbell, D;
Chan, M;
Moreno, R;
(2017)
Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries.
Intensive Care Medicine
, 43
(7)
pp. 971-979.
10.1007/s00134-016-4633-8.
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2016
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Cho, G;
Anie, KA;
Buckton, J;
Kiilu, P;
Layton, M;
Alexander, L;
Hemmaway, C;
... Meredith, S; + view all
(2016)
SWIM (sickle with ibuprofen and morphine) randomised controlled trial fails to recruit: lessons learnt.
BMJ OPEN
, 6
(6)
10.1136/bmjopen-2016-011276.
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Kahan, BC;
Doré, CJ;
Murphy, MF;
Jairath, V;
(2016)
Bias was reduced in an open-label trial through the removal of subjective elements from the outcome definition.
Journal of Clinical Epidemiology
, 77
pp. 38-43.
10.1016/j.jclinepi.2016.05.008.
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Kahan, BC;
Rushton, H;
Morris, TP;
Daniel, RM;
(2016)
A comparison of methods to adjust for continuous covariates in the analysis of randomised trials.
BMC Medical Research Methodology
, 16
(42)
10.1186/s12874-016-0141-3.
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Taylor, SJC;
Carnes, D;
Homer, K;
Kahan, BC;
Hounsome, N;
Eldridge, S;
Spencer, A;
... Underwood, M; + view all
(2016)
Novel Three-Day, Community-Based, Nonpharmacological Group Intervention for Chronic Musculoskeletal Pain (COPERS): A Randomised Clinical Trial.
PLoS Medicine
, 13
(6)
, Article e1002040. 10.1371/journal.pmed.1002040.
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2015
|
Bhatnagar, R;
Kahan, BC;
Morley, AJ;
Keenan, EK;
Miller, RF;
Rahman, NM;
Maskell, NA;
(2015)
The efficacy of indwelling pleural catheter placement versus placement plus talc sclerosant in patients with malignant pleural effusions managed exclusively as outpatients (IPC-PLUS): study protocol for a randomised controlled trial.
Trials
, 16
, Article 48. 10.1186/s13063-015-0563-y.
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Jairath, V;
Kahan, BC;
Gray, A;
Dore, CJ;
Mora, A;
James, MW;
Stanley, AJ;
... Murphy, MF; + view all
(2015)
Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial.
The Lancet
, 386
(9989)
pp. 137-144.
10.1016/S0140-6736(14)61999-1.
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Kahan, BC;
Forbes, AB;
Dore, CJ;
Morris, TP;
(2015)
A re-randomisation design for clinical trials.
BMC Medical Research Methodology
, 15
(1)
p. 96.
10.1186/s12874-015-0082-2.
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Kahan, BC;
Rehal, S;
Cro, S;
(2015)
Risk of selection bias in randomised trials.
Trials
, 16
(1)
, Article 405. 10.1186/s13063-015-0920-x.
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Kahan, BC;
Rehal, S;
Cro, S;
(2015)
Blinded Outcome Assessment Was Infrequently Used and Poorly Reported in Open Trials.
PLoS ONE
, 10
(6)
, Article e0131926. 10.1371/journal.pone.0131926.
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2014
|
Bhatnagar, R;
Laskawiec-Szkonter, M;
Piotrowska, HEG;
Kahan, BC;
Hooper, CE;
Davies, HE;
Harvey, JE;
... Maskell, NA; + view all
(2014)
Evaluating the efficacy of thoracoscopy and talc poudrage versus pleurodesis using talc slurry (TAPPS trial): protocol of an open-label randomised controlled trial.
BMJ Open
, 4
(11)
, Article e007045. 10.1136/bmjopen-2014-007045.
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Kahan, BC;
(2014)
Accounting for centre-effects in multicentre trials with a binary outcome – when, why, and how?
BMC Medical Research Methodology
, 14
(1)
, Article 20. 10.1186/1471-2288-14-20.
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 |
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Kahan, BC;
Cro, S;
Doré, CJ;
Bratton, DJ;
Rehal, S;
Maskell, NA;
Rahman, N;
(2014)
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The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies.
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Morris, TP;
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A Clinical Score (RAPID) to Identify Those at Risk for Poor Outcome at Presentation in Patients With Pleural Infection.
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Restrictive vs Liberal Blood Transfusion for Acute Upper Gastrointestinal Bleeding: Rationale and Protocol for a Cluster Randomized Feasibility Trial.
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Update on the transfusion in gastrointestinal bleeding (TRIGGER) trial: statistical analysis plan for a cluster-randomised feasibility trial.
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Assessing potential sources of clustering in individually randomised trials.
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2012
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Reporting and analysis of trials using stratified randomisation in leading medical journals: review and reanalysis.
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