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The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies

Kahan, BC; Jairath, V; Doré, CJ; Morris, TP; (2014) The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies. Trials , 15 , Article 139. 10.1186/1745-6215-15-139. Green open access

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Abstract

Adjustment for prognostic covariates can lead to increased power in the analysis of randomized trials. However, adjusted analyses are not often performed in practice.

Type: Article
Title: The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1745-6215-15-139
Publisher version: http://dx.doi.org/10.1186/1745-6215-15-139
Language: English
Additional information: © 2014 Kahan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1428523
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