Browse by UCL people
Group by: Type | Date
Number of items: 144.
2025
Farrell, C;
Buhidma, Y;
Mumford, P;
Heywood, WE;
Hällqvist, J;
Flores-Aguilar, L;
Andrews, EJ;
... Wiseman, FK; + view all
(2025)
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease.
Acta Neuropathologica
, 149
(1)
, Article 49. 10.1007/s00401-025-02889-0.
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Giblin, Ashling;
Cammack, Alexander J;
Blomberg, Niek;
Anoar, Sharifah;
Mikheenko, Alla;
Carcole, Mireia;
Atilano, Magda L;
... Isaacs, Adrian M; + view all
(2025)
Neuronal polyunsaturated fatty acids are protective in ALS/FTD.
Nature Neuroscience
, 28
(4)
pp. 737-747.
10.1038/s41593-025-01889-3.
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Giblin, Ashling;
Cammack, Alexander J;
Blomberg, Niek;
Anoar, Sharifah;
Mikheenko, Alla;
Carcole, Mireia;
Atilano, Magda L;
... Isaacs, Adrian M; + view all
(2025)
Neuronal polyunsaturated fatty acids are protective in ALS/FTD (Feb, 10.1038/s41593-025-01889-3, 2025).
[Corrigendum].
Nature Neuroscience
, 28
(4)
p. 913.
10.1038/s41593-025-01926-1.
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Miki, Yasuo;
Inoue, Yutaka;
Mori, Fumiaki;
Tada, Mari;
Yoshida, Mari;
Lashley, Tammaryn;
Warner, Thomas T;
... Wakabayashi, Koichi; + view all
(2025)
TAF15 and Transportin 1 in Intranuclear Inclusions of Neuronal Intranuclear Inclusion Disease.
Neuropathology and Applied Neurobiology
, 51
(3)
, Article e70021. 10.1111/nan.70021.
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2024
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Fu, Bin;
Brock, Emma E;
Andrews, Rebecca;
Breiter, Jonathan C;
Tian, Ru;
Toomey, Christina E;
Lachica, Joanne;
... Lee, Steven F; + view all
(2024)
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
The Journal of Physical Chemistry B
, 128
(15)
pp. 3585-3597.
10.1021/acs.jpcb.4c00174.
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Hruska-Plochan, Marian;
Wiersma, Vera I;
Betz, Katharina M;
Mallona, Izaskun;
Ronchi, Silvia;
Maniecka, Zuzanna;
Hock, Eva-Maria;
... Polymenidou, Magdalini; + view all
(2024)
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD.
Nature
10.1038/s41586-024-07042-7.
(In press).
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Kac, Przemysław R;
González-Ortiz, Fernando;
Emeršič, Andreja;
Dulewicz, Maciej;
Koutarapu, Srinivas;
Turton, Michael;
An, Yang;
... Karikari, Thomas K; + view all
(2024)
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology.
Nature Communications
, 15
(1)
, Article 2615. 10.1038/s41467-024-46876-7.
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Luo, Huihui;
Gustavsson, Emil K;
Macpherson, Hannah;
Dominik, Natalia;
Zhelcheska, Kristina;
Montgomery, Kylie;
Anderson, Claire;
... Chen, Zhongbo; + view all
(2024)
Letter to the editor on: Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions by Park et al. (2022).
Acta Neuropathol Commun
, 12
(1)
, Article 2. 10.1186/s40478-023-01706-7.
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Michno, Wojciech;
Bowman, Andrew;
Jha, Durga;
Minta, Karolina;
Ge, Junyue;
Koutarapu, Srinivas;
Zetterberg, Henrik;
... Hanrieder, Jörg; + view all
(2024)
Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer’s Disease Brain.
ACS Chemical Neuroscience
10.1021/acschemneuro.4c00006.
(In press).
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2023
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Banerjee, Gargi;
Collinge, John;
Fox, Nick C;
Lashley, Tammaryn;
Mead, Simon;
Schott, Jonathan M;
Werring, David J;
(2023)
Clinical considerations in early-onset cerebral amyloid angiopathy.
Brain
10.1093/brain/awad193.
(In press).
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De Schepper, Sebastiaan;
Ge, Judy Z;
Crowley, Gerard;
Ferreira, Laís SS;
Garceau, Dylan;
Toomey, Christina E;
Sokolova, Dimitra;
... Hong, Soyon; + view all
(2023)
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.
Nature Neuroscience
10.1038/s41593-023-01257-z.
(In press).
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Fodder, Katherine;
Murthy, Megha;
Rizzu, Patrizia;
Toomey, Christina E;
Hasan, Rahat;
Humphrey, Jack;
Raj, Towfique;
... Bettencourt, Conceição; + view all
(2023)
Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes.
Acta Neuropathologica
10.1007/s00401-023-02583-z.
(In press).
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Jiang, Xinwa;
Gatt, Ariana;
Lashley, Tammaryn;
(2023)
HnRNP Pathologies in Frontotemporal Lobar Degeneration.
Cells
, 12
(12)
, Article 1633. 10.3390/cells12121633.
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Murthy, Megha;
Rizzu, Patrizia;
Heutink, Peter;
Mill, Jonathan;
Lashley, Tammaryn;
Bettencourt, Conceição;
(2023)
Epigenetic Age Acceleration in Frontotemporal Lobar Degeneration: A Comprehensive Analysis in the Blood and Brain.
Cells
, 12
(14)
, Article 1922. 10.3390/cells12141922.
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Murthy, Megha;
Shireby, Gemma;
Miki, Yasuo;
Viré, Emmanuelle;
Lashley, Tammaryn;
Warner, Thomas T;
Mill, Jonathan;
(2023)
Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue.
Neuropathology and Applied Neurobiology
, 49
(1)
, Article e12872. 10.1111/nan.12872.
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Rueda-Carrasco, Javier;
Sokolova, Dimitra;
Lee, Sang-Eun;
Childs, Thomas;
Jurčáková, Natália;
Crowley, Gerard;
De Schepper, Sebastiaan;
... Hong, Soyon; + view all
(2023)
Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.
The EMBO Journal
, Article e113246. 10.15252/embj.2022113246.
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Tetter, Stephan;
Arseni, Diana;
Murzin, Alexey G;
Buhidma, Yazead;
Peak-Chew, Sew Y;
Garringer, Holly J;
Newell, Kathy L;
... Ryskeldi-Falcon, Benjamin; + view all
(2023)
TAF15 amyloid filaments in frontotemporal lobar degeneration.
Nature
10.1038/s41586-023-06801-2.
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Verma, N;
Velmurugan, GV;
Winford, E;
Coburn, H;
Kotiya, D;
Leibold, N;
Radulescu, L;
... Despa, F; + view all
(2023)
Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas.
Communications biology
, 6
(1)
, Article 2. 10.1038/s42003-022-04398-2.
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2022
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Brown, Anna-Leigh;
Wilkins, Oscar G;
Keuss, Matthew J;
Hill, Sarah E;
Zanovello, Matteo;
Lee, Weaverly Colleen;
Bampton, Alexander;
... Fratta, Pietro; + view all
(2022)
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.
Nature
, 603
pp. 131-137.
10.1038/s41586-022-04436-3.
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De Boni, Laura;
Watson, Aurelia Hays;
Zaccagnini, Ludovica;
Wallis, Amber;
Zhelcheska, Kristina;
Kim, Nora;
Sanderson, John;
... Bartels, Tim; + view all
(2022)
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Acta Neuropathologica
10.1007/s00401-022-02406-7.
(In press).
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Hasan, R;
Humphrey, J;
Bettencourt, C;
Newcombe, J;
Lashley, T;
Fratta, P;
Raj, T;
(2022)
Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions.
Acta Neuropathologica
, 143
pp. 383-401.
10.1007/s00401-021-02399-9.
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Hatton, Christopher;
Ghanem, Simona S;
Koss, David J;
Abdi, Ilham Y;
Gibbons, Elizabeth;
Guerreiro, Rita;
Bras, Jose;
... Erskine, Daniel; + view all
(2022)
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Brain
, 145
(4)
pp. 1257-1263.
10.1093/brain/awac002.
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Koutarapu, Srinivas;
Ge, Junyue;
Jha, Durga;
Blennow, Kaj;
Zetterberg, Henrik;
Lashley, Tammaryn;
Michno, Wojciech;
(2022)
Correlative chemical imaging identifies amyloid peptide signatures of neuritic plaques and dystrophy in human sporadic Alzheimer's disease.
Brain Connectivity
10.1089/brain.2022.0047.
(In press).
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Mehta, Puja R;
Lashley, Tammaryn;
Fratta, Pietro;
Bampton, Alexander;
(2022)
Markers of cognitive resilience and a framework for investigating clinical heterogeneity in ALS.
Journal of Pathology
, 257
(3)
pp. 251-254.
10.1002/path.5897.
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Michno, Wojciech;
Koutarapu, Srinivas;
Camacho, Rafael;
Toomey, Christina;
Stringer, Katie;
Minta, Karolina;
Ge, Junyue;
... Hanrieder, Jörg; + view all
(2022)
Chemical traits of cerebral amyloid angiopathy in familial British-, Danish-, and non-Alzheimerʼs dementias.
Journal of Neurochemistry
10.1111/jnc.15694.
(In press).
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Miki, Yasuo;
Tanji, Kunikazu;
Shinnai, Kana;
Tanaka, Makoto;
Altay, Firat;
Foti, Sandrine C;
Strand, Catherine;
... Wakabayashi, Koichi; + view all
(2022)
Pathological substrate of memory impairment in multiple system atrophy.
Neuropathology and Applied Neurobiology
, 48
(7)
, Article e12844. 10.1111/nan.12844.
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Rostagno, Agueda;
Cabrera, Erwin;
Lashley, Tammaryn;
Ghiso, Jorge;
(2022)
N-terminally truncated A beta 4-x proteoforms and their relevance for Alzheimer's pathophysiology.
Translational Neurodegeneration
, 11
(1)
, Article 30. 10.1186/s40035-022-00303-3.
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Schweighauser, Manuel;
Arseni, Diana;
Bacioglu, Mehtap;
Huang, Melissa;
Lövestam, Sofia;
Shi, Yang;
Yang, Yang;
... Scheres, Sjors HW; + view all
(2022)
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Nature
, 605
pp. 310-314.
10.1038/s41586-022-04650-z.
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Sidhu, Rahul;
Gatt, Ariana;
Fratta, Pietro;
Lashley, Tammaryn;
Bampton, Alexander;
(2022)
HnRNP K mislocalisation in neurons of the dentate nucleus is a novel neuropathological feature of neurodegenerative disease and ageing.
Neuropathology and Applied Neurobiology
10.1111/nan.12793.
(In press).
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Toomey, Christina E;
Heywood, Wendy E;
Evans, James R;
Lachica, Joanne;
Pressey, Sarah N;
Foti, Sandrine C;
Al Shahrani, Mesfer;
... Gandhi, Sonia; + view all
(2022)
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.
Acta Neuropathologica Communications
, 10
(1)
, Article 134. 10.1186/s40478-022-01424-6.
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Wagner, Jessica;
Degenhardt, Karoline;
Veit, Marleen;
Louros, Nikolaos;
Konstantoulea, Katerina;
Skodras, Angelos;
Wild, Katleen;
... Neher, Jonas J; + view all
(2022)
Medin co-aggregates with vascular amyloid-beta in Alzheimer's disease.
Nature
10.1038/s41586-022-05440-3.
(In press).
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Yang, Yang;
Shi, Yang;
Schweighauser, Manuel;
Zhang, Xianjun;
Kotecha, Abhay;
Murzin, Alexey G;
Garringer, Holly J;
... Goedert, Michel; + view all
(2022)
Structures of α-synuclein filaments from human brains with Lewy pathology.
Nature
, 610
pp. 791-795.
10.1038/s41586-022-05319-3.
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Zhang, Fangrong;
Rakhimbekova, Anastasia;
Lashley, Tammaryn;
Madl, Tobias;
(2022)
Brain regions show different metabolic and protein arginine methylation phenotypes in frontotemporal dementias and Alzheimer's disease.
Progress in Neurobiology
, 221
, Article 102400. 10.1016/j.pneurobio.2022.102400.
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2021
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Arber, C;
Lovejoy, C;
Harris, L;
Willumsen, N;
Alatza, A;
Casey, JM;
Lines, G;
... Wray, S; + view all
(2021)
Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis.
Cell Reports
, 34
(2)
, Article 108615. 10.1016/j.celrep.2020.108615.
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Bampton, A;
Gatt, A;
Humphrey, J;
Cappelli, S;
Bhattacharya, D;
Foti, S;
Brown, A-L;
... Lashley, T; + view all
(2021)
HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing.
Acta Neuropathologica
10.1007/s00401-021-02340-0.
(In press).
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Bettencourt, C;
Miki, Y;
Piras, IS;
de Silva, R;
Foti, SC;
Talboom, JS;
Revesz, T;
... Holton, JL; + view all
(2021)
MOBP and HIP1 in multiple system atrophy: new α‐synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.
Neuropathology and Applied Neurobiology
, 47
(5)
pp. 640-652.
10.1111/nan.12688.
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Camporesi, E;
Lashley, T;
Gobom, J;
Lantero-Rodriguez, J;
Hansson, O;
Zetterberg, H;
Blennow, K;
(2021)
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers.
Acta Neuropathologica Communications
, 9
, Article 19. 10.1186/s40478-021-01119-4.
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Chebli, J;
Rahmati, M;
Lashley, T;
Edeman, B;
Oldfors, A;
Zetterberg, H;
Abramsson, A;
(2021)
The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish.
Scientific Reports
, 11
, Article 19115. 10.1038/s41598-021-98487-7.
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Chen, CD;
Joseph-Mathurin, N;
Sinha, N;
Zhou, A;
Li, Y;
Friedrichsen, K;
McCullough, A;
... Benzinger, TLS; + view all
(2021)
Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease.
Acta Neuropathologica
, 142
pp. 689-706.
10.1007/s00401-021-02342-y.
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Chia, R;
Sabir, MS;
Bandres-Ciga, S;
Saez-Atienzar, S;
Reynolds, RH;
Gustavsson, E;
Walton, RL;
... Scholz, SW; + view all
(2021)
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.
Nature Genetics
, 53
pp. 294-30353.
10.1038/s41588-021-00785-3.
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De Rossi, P;
Lewis, AJ;
Furrer, J;
De Vos, L;
Demeter, T;
Zbinden, A;
Zhong, W;
... Polymenidou, M; + view all
(2021)
FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade.
EMBO Reports
, Article e53877. 10.15252/embr.202153877.
(In press).
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Gkanatsiou, E;
Nilsson, J;
Toomey, CE;
Vrillon, A;
Kvartsberg, H;
Portelius, E;
Zetterberg, H;
... Brinkmalm, G; + view all
(2021)
Amyloid pathology and synaptic loss in pathological aging.
Journal of Neurochemistry
10.1111/jnc.15487.
(In press).
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Lantero-Rodriguez, J;
Snellman, A;
Benedet, AL;
Mila-Aloma, M;
Camporesi, E;
Montoliu-Gaya, L;
Ashton, NJ;
... Blennow, K; + view all
(2021)
P-tau235: a novel biomarker for staging preclinical Alzheimer's disease.
EMBO Molecular Medicine
, Article e15098. 10.15252/emmm.202115098.
(In press).
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Lashley, T;
Tossounian, M-A;
Costello Heaven, N;
Wallworth, S;
Peak-Chew, S;
Bradshaw, A;
Cooper, JM;
... Gout, I; + view all
(2021)
Extensive Anti-CoA Immunostaining in Alzheimer’s Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A.
Frontiers in Cellular Neuroscience
, 15
, Article 739425. 10.3389/fncel.2021.739425.
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Ly, H;
Verma, N;
Sharma, S;
Kotiya, D;
Despa, S;
Abner, EL;
Nelson, PT;
... Despa, F; + view all
(2021)
The association of circulating amylin with β‐amyloid in familial Alzheimer's disease.
Alzheimer's & Dementia
, 7
(1)
, Article e12130. 10.1002/trc2.12130.
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Nazir, FH;
Camporesi, E;
Brinkmalm, G;
Lashley, T;
Toomey, CE;
Kvartsberg, H;
Zetterberg, H;
... Becker, B; + view all
(2021)
Molecular forms of neurogranin in cerebrospinal fluid.
Journal of Neurochemistry
10.1111/jnc.15252.
(In press).
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O'Connor, A;
Abel, E;
Fraser, MR;
Ryan, NS;
Jiménez, DA;
Koriath, C;
Chávez-Gutiérrez, L;
... Fox, NC; + view all
(2021)
A novel presenilin 1 duplication mutation (Ile168dup) causing Alzheimer's disease associated with myoclonus, seizures and pyramidal features.
Neurobiology of Aging
, 103
137.e1-137.e5.
10.1016/j.neurobiolaging.2021.01.032.
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Rostagno, A;
Calero, M;
Holton, JL;
Revesz, T;
Lashley, T;
Ghiso, J;
(2021)
Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan.
Neurobiology of Disease
, 158
, Article 105452. 10.1016/j.nbd.2021.105452.
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Shi, Y;
Zhang, W;
Yang, Y;
Murzin, AG;
Falcon, B;
Kotecha, A;
van Beers, M;
... Scheres, SHW; + view all
(2021)
Structure-based classification of tauopathies.
Nature
, 598
pp. 359-363.
10.1038/s41586-021-03911-7.
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Stepanchuk, AA;
Barber, PA;
Lashley, T;
Joseph, JT;
Stys, PK;
(2021)
Quantitative detection of grey and white matter amyloid pathology using a combination of K114 and CRANAD-3 fluorescence.
Neurobiology of Disease
, 161
, Article 105540. 10.1016/j.nbd.2021.105540.
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Walsh, P;
Sudre, CH;
Fiford, CM;
Ryan, NS;
Lashley, T;
Frost, C;
Barnes, J;
(2021)
The age-dependent associations of white matter hyperintensities and neurofilament light in early- and late-stage Alzheimer's disease.
Neurobiology of Aging
, 97
pp. 10-17.
10.1016/j.neurobiolaging.2020.09.008.
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Willumsen, N;
Poole, T;
Nicholas, JM;
Fox, NC;
Ryan, NS;
Lashley, T;
(2021)
Variability in the type and layer distribution of cortical A beta pathology in familial Alzheimer's disease.
Brain Pathology
10.1111/bpa.13009.
(In press).
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Yap, SY;
Frias, B;
Wren, MC;
Schöll, M;
Fox, NC;
Årstad, E;
Lashley, T;
(2021)
Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease.
Brain
10.1093/brain/awab120.
(In press).
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2020
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Adams-Carr, KL;
Bocchetta, M;
Neason, M;
Holton, JL;
Lashley, T;
Warren, JD;
Rohrer, JD;
(2020)
A case of TDP-43 type C pathology presenting as nonfluent variant primary progressive aphasia.
Neurocase
, 26
(1)
pp. 1-6.
10.1080/13554794.2019.1690665.
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Arber, C;
Toombs, J;
Lovejoy, C;
Ryan, NS;
Paterson, RW;
Willumsen, N;
Gkanatsiou, E;
... Wray, S; + view all
(2020)
Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.
Molecular Psychiatry
, 25
pp. 2919-2931.
10.1038/s41380-019-0410-8.
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Bampton, A;
Gittings, LM;
Fratta, P;
Lashley, T;
Gatt, A;
(2020)
The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis.
Acta Neuropathologica
10.1007/s00401-020-02203-0.
(In press).
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Bettencourt, C;
Foti, SC;
Miki, Y;
Botia, J;
Chatterjee, A;
Warner, TT;
Revesz, T;
... Holton, JL; + view all
(2020)
White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy.
Acta Neuropathologica
, 139
pp. 135-156.
10.1007/s00401-019-02074-0.
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Bettencourt, C;
Piras, IS;
Foti, SC;
Talboom, J;
Miki, Y;
Lashley, T;
Balazs, R;
... Holton, JL; + view all
(2020)
Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis.
Acta Neuropathologica Communications
, 8
, Article 71. 10.1186/s40478-020-00946-1.
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Blennow, K;
Chen, C;
Cicognola, C;
Wildsmith, KR;
Manser, PT;
Bohorquez, SMS;
Zhang, Z;
... Höglund, K; + view all
(2020)
Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.
Brain
, 143
(2)
, Article 79. 10.1093/brain/awz346.
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Bocchetta, M;
Iglesias Espinosa, MDM;
Lashley, T;
Warren, JD;
Rohrer, JD;
(2020)
In vivo staging of frontotemporal lobar degeneration TDP-43 type C pathology.
Alzheimer's Research & Therapy
, 12
(1)
, Article 34. 10.1186/s13195-020-00600-x.
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Chen, Z;
Yan Yau, W;
Jaunmuktane, Z;
Tucci, A;
Sivakumar, P;
Gagliano Taliun, SA;
Turner, C;
... Houlden, H; + view all
(2020)
Neuronal intranuclear inclusion disease is genetically heterogeneous.
Annals of Clinical and Translational Neurology
, 7
(9)
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