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Corticospinal tract degeneration and temporal lobe atrophy in frontotemporal lobar degeneration TDP-43 type C pathology

Miki, Y; Ling, H; Crampsie, S; Mummery, CJ; Rohrer, JD; Jaunmuktane, Z; Lashley, T; (2020) Corticospinal tract degeneration and temporal lobe atrophy in frontotemporal lobar degeneration TDP-43 type C pathology. Neuropathology and Applied Neurobiology , 46 (3) pp. 296-299. 10.1111/nan.12582. Green open access

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Abstract

Frontotemporal lobar degeneration (FTLD) consists of a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders that chiefly affect frontal and temporal lobes. Clinical presentation in FTLD includes behavioural variant frontotemporal dementia, progressive nonfluent aphasia and semantic dementia (SD). Pathologically, FTLD is subdivided based on accumulation of abnormal intracellular proteins including transactivation response DNA-binding protein 43 kDa (TDP-43) [1, 2]. TDP-43 pathology in FTLD is classified into five pathological subgroups depending on its morphological features: TDP-43 type A, B, C, D and E [2, 3].

Type: Article
Title: Corticospinal tract degeneration and temporal lobe atrophy in frontotemporal lobar degeneration TDP-43 type C pathology
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nan.12582
Publisher version: https://doi.org/10.1111/nan.12582
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10083772
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