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Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease.

Lashley, T; Gami, P; Valizadeh, N; Li, A; Revesz, T; Balazs, R; (2014) Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease. Neuropathol Appl Neurobiol , 41 (4) pp. 497-506. 10.1111/nan.12183. Green open access

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Abstract

Genetic factors do not seem to account fully for Alzheimer disease (AD) pathogenesis. There is evidence for the contribution of environmental factors, whose effect may be mediated by epigenetic mechanisms. Epigenetics involves the regulation of gene expression independently of DNA sequence and these epigenetic changes are influenced by age and environmental factors, with DNA methylation being one of the best characterized epigenetic mechanisms. The human genome is predominantly methylated on CpG motifs, which results in gene silencing; however methylation within the body of the gene may mark active transcription. There is evidence suggesting an involvement of environmental factors in the pathogenesis of Alzheimer's disease (AD), which prompted our study examining DNA methylation in this disorder.

Type: Article
Title: Alterations in global DNA methylation and hydroxymethylation are not detected in Alzheimer's disease.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nan.12183
Publisher version: http:/d/x.doi.org/10.1111/nan.12183
Language: English
Additional information: © 2014 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Keywords: Alzheimer's disease, epigenetics, hydroxymethylation, methylation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1448191
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