Browse by UCL people
Group by: Type | Date
Number of items: 58.
Article
Bilip, M;
Shah, S;
Mathiyalakan, M;
Tagalakis, A;
Hart, SL;
Maeshima, R;
Eaton, S;
... Stoker, AW; + view all
(2020)
Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells.
Journal of Drug Targeting
10.1080/1061186X.2019.1710157.
(In press).
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Boyd, AC;
Guo, S;
Huang, L;
Kerem, B;
Oren, YS;
Walker, AJ;
Hart, SL;
(2020)
New approaches to genetic therapies for cystic fibrosis.
Journal of Cystic Fibrosis
, 19
(S1)
S54-S59.
10.1016/j.jcf.2019.12.012.
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Bryant, Dale;
Barberan-Martin, Sara;
Maeshima, Ruhina;
Torres, Ignacio Del Valle;
Rabii, Mohammad;
Baird, William;
Sauvadet, Aimie;
... Kinsler, Veronica A; + view all
(2024)
RNA therapy for oncogenic NRAS-driven naevi induces apoptosis.
Journal of Investigative Dermatology
10.1016/j.jid.2024.04.031.
(In press).
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Dalbay, Melis T;
Shahaj, Eriomina;
Guerrini, Ileana;
Lee, Dani Do Hyang;
Straatman-Iwanowska, Anna;
Mitchison, Hannah M;
Baines, Deborah L;
... Hart, Stephen L; + view all
(2025)
Characterisation of primary ciliary dyskinesia model generated from BMI1 transduced basal epithelial cells.
Journal of Cell Science
, Article jcs.263886. 10.1242/jcs.263886.
(In press).
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Du, Z;
Munye, MM;
Tagalakis, AD;
Manunta, MD;
Hart, SL;
(2014)
The role of the helper lipid on the DNA transfection efficiency of lipopolyplex formulations.
Sci Rep
, 4
7107 - ?.
10.1038/srep07107.
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Fernando, O;
Tagalakis, AD;
Shiekh Hassan Awwad, S;
Brocchini, S;
Khaw, PT;
Hart, S;
Yu-Wai-Man, C;
(2018)
Development of targeted siRNA nanocomplexes to prevent fibrosis in experimental glaucoma filtration surgery.
Molecular Therapy
, 26
(12)
pp. 2812-2822.
10.1016/j.ymthe.2018.09.004.
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Graham, C;
Hart, S;
(2021)
CRISPR/Cas9 gene editing therapies for cystic fibrosis.
Expert Opinion on Biological Therapy
, 21
(6)
pp. 767-780.
10.1080/14712598.2021.1869208.
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Guri-Lamce, Ina;
Alrokh, Yara;
Graham, Carina;
Maeshima, Ruhina;
Rognoni, Emanuel;
Caley, Matthew;
Łaczmański, Łukasz;
... Jacków-Malinowska, Joanna; + view all
(2024)
Lipid Nanoparticles Efficiently Deliver the Base Editor ABE8e for COL7A1 Correction in Dystrophic Epidermolysis Bullosa Fibroblasts In Vitro.
Journal of Investigative Dermatology
10.1016/j.jid.2024.03.027.
(In press).
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Harrison, P;
Hart, S;
(2018)
Gene editing and gene regulation with CRISPR.
Experimental Physiology
, 103
(4)
pp. 437-438.
10.1113/EP086864.
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Harrison, PT;
Hart, S;
(2018)
A beginner's guide to gene editing.
Experimental Physiology
, 103
(4)
pp. 439-448.
10.1113/EP086047.
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Hart, SL;
(2017)
Prospects for RNA delivery with nanotechnologies.
[Editorial comment].
Gene Therapy
, 24
(3)
p. 121.
10.1038/gt.2017.15.
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Hart, SL;
(2014)
Cystic fibrosis findings.
International Innovation
(131)
pp. 78-80.
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Hart, SL;
Harrison, PT;
(2017)
Genetic therapies for cystic fibrosis lung disease.
Current Opinion in Pharmacology
, 34
pp. 119-124.
10.1016/j.coph.2017.10.006.
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Hodges, RJ;
Jenkins, RG;
Wheeler-Jones, CPD;
Copeman, DM;
Bottoms, SE;
Bellingan, GJ;
Nanthakumar, CB;
... McAnulty, RJ; + view all
(2004)
Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production.
AM J PATHOL
, 165
(5)
1663 - 1676.
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Irving, E;
Tagalakis, AD;
Maeshima, R;
Hart, SL;
Eaton, S;
Lehtonen, A;
Stoker, AW;
(2020)
The liposomal delivery of hydrophobic oxidovanadium complexes imparts highly effective cytotoxicity and differentiating capacity in neuroblastoma tumour cells.
Scientific Reports
, 10
(1)
, Article 16660. 10.1038/s41598-020-73539-6.
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Ivanova, R;
Benton, DCH;
Munye, MM;
Rangseesorranan, S;
Hart, SL;
Moss, GWJ;
(2019)
A Nanosensor Toolbox for Rapid, Label-Free Measurement of Airway Surface Liquid and Epithelial Cell Function.
ACS Applied Materials and Interfaces
10.1021/acsami.8b14122.
(In press).
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Jacobsen, MC;
Dusart, PJ;
Kotowicz, K;
Bajaj-Elliott, M;
Hart, SL;
Klein, NJ;
Dixon, GL;
(2016)
A critical role for ATF2 transcription factor in the regulation of E-selectin expression in response to non-endotoxin components of Neisseria meningitidis.
Cellular Microbiology
, 18
(1)
pp. 66-79.
10.1111/cmi.12483.
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Kenny, GD;
Bienemann, AS;
Tagalakis, AD;
Pugh, JA;
Welser, K;
Campbell, F;
Tabor, AB;
... Hart, SL; + view all
(2013)
Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the brain.
Biomaterials
, 34
(36)
pp. 9190-9200.
10.1016/j.biomaterials.2013.07.081.
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Kenny, GD;
Villegas-Llerena, C;
Tagalakis, AD;
Campbell, F;
Welser, K;
Botta, M;
Tabor, AB;
... Hart, SL; + view all
(2012)
Multifunctional receptor-targeted nanocomplexes for magnetic resonance imaging and transfection of tumours.
Biomaterials
, 33
(29)
7241 - 7250.
10.1016/j.biomaterials.2012.06.042.
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Kwok, A;
McCarthy, D;
Hart, SL;
Tagalakis, AD;
(2016)
Systematic Comparisons of Formulations of Linear Oligolysine Peptides with siRNA and Plasmid DNA.
Chemical Biology and Drug Design
, 87
(5)
pp. 747-763.
10.1111/cbdd.12709.
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Lee, DDH;
Cardinale, D;
Nigro, E;
Butler, CR;
Rutman, A;
Fassad, MR;
Hirst, RA;
... O'Callaghan, C; + view all
(2021)
Higher throughput drug screening for rare respiratory diseases: Readthrough therapy in primary ciliary dyskinesia.
European Respiratory Journal
10.1183/13993003.00455-2020.
(In press).
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Lee, MY;
Wang, H-Z;
White, TW;
Brooks, T;
Pittman, A;
Halai, H;
Petrova, A;
... Di, W-L; + view all
(2020)
Allele-Specific Small Interfering RNA Corrects Aberrant Cellular Phenotype in Keratitis-Ichthyosis-Deafness Syndrome Keratinocytes.
Journal of Investigative Dermatology
, 140
(5)
1035-1044.e7.
10.1016/j.jid.2019.09.022.
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Maeshima, Ruhina;
Tagalakis, Aristides D;
Gyftaki-Venieri, Dafni;
Jones, Stuart A;
Rye, Philip D;
Tøndervik, Anne;
Åstrand, O Alexander H;
(2024)
Low Molecular Weight Alginate Oligosaccharides as Alternatives to PEG for Enhancement of the Diffusion of Cationic Nanoparticles Through Cystic Fibrosis Mucus.
Advanced Healthcare Materials
, Article 2400510. 10.1002/adhm.202400510.
(In press).
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Maeshima, R;
Moulding, D;
Stoker, AW;
Hart, SL;
(2020)
MYCN Silencing by RNA Interference Induces Neurogenesis and Suppresses Proliferation in Models of Neuroblastoma with Resistance to Retinoic Acid.
Nucleic Acid Therapeutics
, 30
(4)
pp. 237-248.
10.1089/nat.2019.0831.
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Manunta, MDI;
McAnulty, RJ;
Tagalakis, AD;
Bottoms, SE;
Campbell, F;
Hailes, HC;
Laurent, GJ;
... Hart, SL; + view all
(2011)
Nebulisation of Receptor-Targeted Nanocomplexes for Gene Delivery to the Airway Epithelium.
PLoS ONE
, 6
(10)
, Article e26768. 10.1371/journal.pone.0026768.
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Manunta, MDI;
McAnulty, RJ;
Tagalakis, AD;
Bottoms, SE;
Campbell, F;
Hailes, HC;
Laurent, GJ;
... Hart, SL; + view all
(2011)
Nebulisation of Receptor-Targeted Nanocomplexes for Gene Delivery to the Airway Epithelium.
PLoS ONE
, 6
(10)
, Article e26768. 10.1371/journal.pone.0026768.
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Manunta, MDI;
McAnulty, RJ;
Tagalakis, AD;
Bottoms, SE;
Campbell, F;
Hailes, HC;
Tabor, AB;
... Hart, SL; + view all
(2011)
Nebulisation of Receptor-Targeted Nanocomplexes for Gene Delivery to the Airway Epithelium.
PLOS ONE
, 6
(10)
, Article e26768. 10.1371/journal.pone.0026768.
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Manunta, MDI;
Tagalakis, AD;
Attwood, M;
Aldossary, AM;
Barnes, JL;
Munye, MM;
Weng, A;
... Hart, SL; + view all
(2017)
Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis.
Scientific Reports
, 7
, Article 700. 10.1038/s41598-017-00662-2.
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Meng, J;
Tagalakis, AD;
Hart, SL;
(2020)
Silencing E3 Ubiqutin ligase ITCH as a potential therapy to enhance chemotherapy efficacy in p53 mutant neuroblastoma cells.
Scientific Reports
, 10
(1)
, Article 1046. 10.1038/s41598-020-57854-6.
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Meng, QH;
Irvine, S;
Tagalakis, AD;
McAnulty, RJ;
McEwan, JR;
Hart, SL;
(2013)
Inhibition of neointimal hyperplasia in a rabbit vein graft model following non-viral transfection with human iNOS cDNA.
Gene Therapy
, 20
(10)
979 -986.
10.1038/gt.2013.20.
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Mohammadi, A;
Kudsiova, L;
Mustapa, MFM;
Campbell, F;
Vlaho, D;
Welser, K;
Story, H;
... Hailes, HC; + view all
(2019)
The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems.
Organic and Biomolecular Chemistry
10.1039/c8ob02374c.
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Munye, MM;
Ravi, J;
Tagalakis, AD;
McCarthy, D;
Ryadnov, MG;
Hart, SL;
(2015)
Role of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector.
Sci Rep
, 5
, Article 9292. 10.1038/srep09292.
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Munye, MM;
Shoemark, A;
Hirst, RA;
Delhove, JM;
Sharp, TV;
McKay, TR;
O'Callaghan, C;
... Hart, SL; + view all
(2017)
BMI-1 extends proliferative potential of human bronchial epithelial cells whilst retaining their mucociliary differentiation capacity.
American Journal of Physiology - Lung Cellular and Molecular Physiology
, 312
(2)
L258-L267.
10.1152/ajplung.00471.2016.
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Munye, MM;
Tagalakis, AD;
Barnes, JL;
Brown, RE;
McAnulty, RJ;
Howe, SJ;
Hart, SL;
(2016)
Minicircle DNA Provides Enhanced and Prolonged Transgene Expression Following Airway Gene Transfer.
Scientific Reports
, 6
, Article 23125. 10.1038/srep23125.
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Onoufriadis, A;
Shoemark, A;
Munye, MM;
James, CT;
Schmidts, M;
Patel, M;
Rosser, EM;
... Mitchison, HM; + view all
(2013)
Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm.
Journal of Medical Genetics
10.1136/jmedgenet-2013-101938.
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Sama, S;
Woith, E;
Walther, W;
Jerz, G;
Chen, W;
Hart, S;
Melzig, MF;
(2018)
Targeted suicide gene transfections reveal promising results in nu/nu mice with aggressive neuroblastoma.
Journal of Controlled Release
, 275
pp. 208-216.
10.1016/j.jconrel.2018.02.031.
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Song, H;
Hart, SL;
Du, Z;
(2021)
Assembly strategy of liposome and polymer systems for siRNA delivery.
International Journal of Pharmaceutics
, 592
, Article 120033. 10.1016/j.ijpharm.2020.120033.
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Spencer, H;
Rampling, D;
Aurora, P;
Bonnet, D;
Hart, SL;
Jaffe, A;
(2005)
Transbronchial biopsies provide longitudinal evidence for epithelial chimerism in children following sex mismatched lung transplantation.
THORAX
, 60
(1)
60 - 62.
10.1136/thx.2004.029678.
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Tagalakis, A;
Jayarajan, V;
Maeshima, R;
Ho, K;
Syed, F;
Wu, L-P;
M. Aldossary, A;
... Hart, S; + view all
(2021)
Integrin-Targeted, Short Interfering RNA Nanocomplexes for Neuroblastoma Tumor-Specific Delivery Achieve MYCN Silencing with Improved Survival.
Advanced Functional Materials
10.1002/adfm.202104843.
(In press).
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Tagalakis, A;
van Haasteren, J;
Aldossary, A;
Rosa, L;
Munye, M;
McCarthy, D;
Hart, S;
(2016)
SiRNA and CRISPR/Cas9 Mediated Knockout of alpha ENAC.
Molecular Therapy
, 24
(Suppl 1)
S11.
10.1016/S1525-0016(16)32832-5.
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Tagalakis, AD;
Castellaro, S;
Zhou, H;
Bienemann, A;
Munye, MM;
McCarthy, D;
White, EA;
(2015)
A method for concentrating lipid peptide DNA and siRNA nanocomplexes that retains their structure and transfection efficiency.
Int J Nanomedicine
, 10
2673 - 2683.
10.2147/IJN.S78935.
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Tagalakis, AD;
Kenny, GD;
Bienemann, AS;
McCarthy, D;
Munye, MM;
Taylor, H;
Wyatt, ML;
... Hart, SL; + view all
(2014)
PEGylation improves the receptor-mediated transfection efficiency of peptide-targeted, self-assembling, anionic nanocomplexes.
J Control Release
, 174
pp. 177-187.
10.1016/j.jconrel.2013.11.014.
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Tagalakis, AD;
Lee, DH;
Bienemann, AS;
Zhou, H;
Munye, MM;
Saraiva, L;
McCarthy, D;
... Hart, SL; + view all
(2014)
Multifunctional, self-assembling anionic peptide-lipid nanocomplexes for targeted siRNA delivery.
Biomaterials
, 35
(29)
pp. 8406-8415.
10.1016/j.biomaterials.2014.06.003.
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Tagalakis, AD;
Maeshima, R;
Yu-Wai-Man, C;
Meng, J;
Syed, F;
Wu, LP;
Aldossary, AM;
... Hart, SL; + view all
(2017)
Peptide and nucleic acid-directed self-assembly of cationic nanovehicles through giant unilamellar vesicle modification: targetable nanocomplexes for in vivo nucleic acid delivery.
Acta Biomaterialia
10.1016/j.actbio.2017.01.048.
(In press).
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Tagalakis, AD;
Munye, MM;
Ivanova, R;
Chen, H;
Smith, CM;
Aldossary, AM;
Rosa, LZ;
... Hart, SL; + view all
(2018)
Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung.
Thorax
, 73
(9)
pp. 847-856.
10.1136/thoraxjnl-2017-210670.
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Vilà-González, Marta;
Pinte, Laetitia;
Fradique, Ricardo;
Causa, Erika;
Kool, Heleen;
Rodrat, Mayuree;
Morell, Carola Maria;
... Vallier, Ludovic; + view all
(2024)
In vitro platform to model the function of ionocytes in the human airway epithelium.
Respiratory Research
, 25
(1)
, Article 180. 10.1186/s12931-024-02800-7.
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Walker, Amy J;
Graham, Carina;
Greenwood, Miriam;
Woodall, Maximillian;
Maeshima, Ruhina;
O’Hara-Wright, Michelle;
Sanz, David J;
... Hart, Stephen L; + view all
(2023)
Molecular and functional correction of a deep intronic splicing mutation in CFTR by CRISPR-Cas9 gene editing.
Molecular Therapy - Methods & Clinical Development
, 31
, Article 101140. 10.1016/j.omtm.2023.101140.
(In press).
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Writer, MJ;
Kyrtatos, PG;
Bienemann, AS;
Pugh, JA;
Lowe, AS;
Villegas-Llerena, C;
Kenny, GD;
... Hart, SL; + view all
(2012)
Lipid peptide nanocomplexes for gene delivery and magnetic resonance imaging in the brain.
Journal of Controlled Release
, 162
(2)
340 - 348.
10.1016/j.jconrel.2012.07.002.
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Young, E;
Gould, D;
Hart, S;
(2020)
Toward gene therapy in rheumatoid arthritis.
Expert Review of Precision Medicine and Drug Development
, 5
(3)
pp. 123-133.
10.1080/23808993.2020.1736942.
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Yu Wai Man, C;
Tagalakis, AD;
Meng, JH;
Bouremel, Y;
Lee, RM;
Virasami, A;
Hart, SL;
(2017)
Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery.
JAMA Ophthalmology
, 135
(11)
pp. 1147-1155.
10.1001/jamaophthalmol.2017.3407.
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Yu-Wai-Man, C;
Owen, N;
Lees, J;
Tagalakis, AD;
Hart, SL;
Webster, AR;
Orengo, CA;
(2017)
Genome-wide RNA-Sequencing analysis identifies a distinct fibrosis gene signature in the conjunctiva after glaucoma surgery.
Scientific Reports
, 7
, Article 5644. 10.1038/s41598-017-05780-5.
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Yu-Wai-Man, C;
Tagalakis, AD;
Manunta, MD;
Hart, SL;
Khaw, PT;
(2016)
Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis.
Scientific Reports
, 6
, Article 21881. 10.1038/srep21881.
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Book chapter
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Hart, SL;
Walker, AJ;
(2019)
New Genetic Approaches to Treating Diseases of the Skin.
In: Hoeger, PH and Kinsler, V and Yan, AC and Harper, J and Oranje, AP and Bodemer, C and Larralde, M and luk, D and Mendiratta, V and Purvis, D, (eds.)
Harper's Textbook of Pediatric Dermatology, 2 Volume Set.
Wiley-Blackwell
(In press).
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Hart, SL;
Walker, AJ;
Harrison, PT;
(2019)
New genetic approaches to treating cystic fibrosis.
In: Scherman, D, (ed.)
Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology.
World Scientific: London, UK.
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Maeshima, Ruhina;
Jacobs, Amy I;
Dalbay, Melis T;
Hart, Stephen L;
(2024)
BMI1 Transduction of Human Airway Epithelial Cells for Expansion of Proliferation and Differentiation.
In:
Cilia. Methods in Molecular Biology.
(pp. 225-237).
Humana Press: New York, NY, USA.
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Conference item
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Yu-Wai-Man, C;
Fernando, O;
Tagalakis, A;
Hart, S;
Khaw, PT;
(2018)
Development of targeted siRNA nanotherapeutics to prevent fibrosis in experimental glaucoma filtration surgery.
Presented at: ARVO Annual Meeting 2018, Honolulu, Hawaii.
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Thesis
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Aldossary, Ahmad Mohammad;
(2018)
Correction of the ΔF508 mutation in the CFTR Gene by CRISPR/Cas9 system.
Doctoral thesis (Ph.D), UCL (University College London).
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Baird, William;
(2019)
Genetic therapy for congenital melanocytic naevi.
Doctoral thesis (Ph.D), UCL (University College London).
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